Clinical trials: Cardiac Infection
Coronary Artery Disease, Human Immunodeficiency Virus
Inflammatory Pathogenesis of Coronary Atherosclerosis in HIV
The investigators are studying whether an anti-inflammatory intervention improves impaired coronary endothelial function (CEF) in HIV+ people with no clinical coronary artery disease (CAD).
- Trial name
- NCT02624180
- Testing
- Colchicine
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Johns Hopkins University
Covid19, Thymic Hypoplasia
Is Thymus Size of Infants Who Born to COVID-19 Positive Mothers Associated With Neonatal Morbidities?
COVID-19 infected pregnant women is thought to have variable degrees of inflammatory response against the disease. Investigators of present study, suggested that fetuses are affected from the possible fetal inflammatory syndrome…
- Trial name
- NCT04470739
- Testing
- chest x-ray
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
HIV-infection, Coronary Heart Disease
A Prospective Observational Trial to Determine Cardiovascular Diseases in HIV-infected Patients
The HIV/HEART study (HIVH) is an ongoing, prospective, multicentre trial that was conducted to assess the incidence, the prevalence and the clinical course of cardiovascular diseases (CVD) in HIV-infected patients.
- Conditions
- HIV-infection, Coronary Heart Disease, Myocardial Infarction, HIV-encephalopathy
- Trial name
- HIV-HEART10 (NCT02291081)
- Testing
- Comprehensive non invasive cardiovascular examination
- Where
- 7 sites in Germany
- Volunteers
- 1,519 people
- Sponsor
- University Hospital, Essen
Sepsis, Post Cardiac Surgery Low Output Syndrome Requiring Inotropic/Vasopressor Therapy
Comparison of Central Venous Oxygen Saturation Measurements by Non-invasive Mespere Venous Oximeter and Central Venous Catheter
The intent of this study is to validate the venous blood oxygenation measurements of the Mespere VA Oximeter compared to the saturations measured by venous blood sampling through an inserted central vein catheter, which is…
- Conditions
- Sepsis, Post Cardiac Surgery Low Output Syndrome Requiring Inotropic/Vasopressor Therapy, Cardiogenic Shock Post Myocardial Infarction, Hypoxemic Respiratory Failure.
- Trial name
- NCT01788956
- Testing
- Mespere Venous Oximeter, Co-Oximeter
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Mespere Lifesciences Inc.
Congestive Heart Failure
The Epidemiology of Ventricular Assist Device-Related Infections
Infections often occur after ventricular assist devices (VADs) are placed. These infections can be very serious. The goal of this study is to understand why these infections occur.
- Trial name
- NCT01471795
- Where
- 13 sites in United States
- Volunteers
- 150 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Cardiac Surgery, Wound Infection
The Use of PlCO-Vacuum-System on Sternal Wounds
The use of a vacuum-assisted wound closure system (PICO, Fa. Smith \& Nephew) is being investigated to determine whether it reduces the incidence of sternal wound healing disorders compared to conventional wound care with plaster.
- Conditions
- Cardiac Surgery, Wound Infection, Wound Healing Disorder
- Trial name
- PICO sternal (NCT06713629)
- Testing
- cardiac surgery via median sternotomy
- Where
- 2 sites in Germany
- Volunteers
- 256 people
- Sponsor
- University of Giessen
H1N1 Influenza Virus, Chronic Pulmonary Disease
Immunogenicity, Safety, and Tolerability of an MF59-Adjuvanted Versus Non-Adjuvanted Influenza Vaccines in Patients With Chronic Pulmonary Disease, Chronic Heart Disease, or Diabetes Mellitus
This is a phase III, randomized, controlled, open label study with two vaccine regimens. The study will assess the relative safety and immunogenicity of vaccine regimens comparing adjuvanted versus non-adjuvanted formulations of…
- Conditions
- H1N1 Influenza Virus, Chronic Pulmonary Disease, Chronic Heart Disease, Diabetes Mellitus
- Trial name
- NCT01032395
- Testing
- Focetria®, Fluad®, Begrivac®
- Where
- 2 sites in Brazil
- Volunteers
- 342 people, healthy volunteers welcome
- Sponsor
- Chiltern Pesquisa Clinica Ltda
Non Communicable Diseases, Heart Failure
Nurse-assisted Intervention "eHealth@ Hospital -2-home"
A randomized controlled trial with non-communicable disease patients from two medical hospitals in Norway will be recruited prior to hospital discharge.
- Conditions
- Non Communicable Diseases, Heart Failure, Colon Rectal Cancer
- Trial name
- Ehealth@H2H (NCT05750953)
- Testing
- eHealth@Hospital-2-Home
- Where
- Norway
- Volunteers
- 204 people
- Sponsor
- University of Stavanger
Surgical Site Infection (SSI), Mediastinitis
Use of Platelet-Rich Plasma to Reduce Sternal Wound Complications After CABG With Median Sternotomy
The goal of this clinical trial is to learn whether applying autologous platelet-rich plasma (PRP) to the sternal wound during heart surgery improves wound healing and reduces complications after surgery.
- Conditions
- Surgical Site Infection (SSI), Mediastinitis, Delayed Wound Healing
- Trial name
- NCT07352020
- Testing
- Autologous Platelet-Rich Plasma (PRP) Application, Standard Sternal Wound Closure
- Where
- Pakistan
- Volunteers
- 98 people
- Sponsor
- Shaheed Zulfiqar Ali Bhutto Medical University
Rheumatic Heart Disease
Accelerating Delivery of rheUmatic Heart Disease Preventive iNterventions in Northern Uganda
The goal of this prospective study is to evaluate the feasibility, sustainability, and public health impact of a district-based program for secondary prevention of Rheumatic Heart Disease (RHD) in Uganda.
- Trial name
- ADUNU (NCT05783375)
- Testing
- ADUNU program for delivery of RHD care services
- Where
- Uganda
- Volunteers
- 221 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
HIV Infections, Type 2 Diabetes
Exercise and Pioglitazone for HIV-Metabolic Syndromes
The purpose is to examine the safety and efficacy of 16wks of pioglitazone (Actos; 30mg/d) with and without aerobic and strength exercise training for reducing glucose intolerance and central adiposity in HIV-infected people.
- Conditions
- HIV Infections, Type 2 Diabetes, Obesity, HIV
- Trial name
- NCT00639457
- Testing
- Pioglitazone, Exercise training
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Cardiomyopathies, Sepsis
Translational Approaches to Septic Cardiomyopathy
This translational study will assess the association between septic cardiomyopathy (measured via left ventricular global longitudinal strain) and (a) inflammatory cytokine profiles, and (b) the behavior of cardiomyocytes derived…
- Conditions
- Cardiomyopathies, Sepsis, Septic Shock
- Trial name
- TASC01 (NCT03252613)
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Samuel Brown
COVID-19 Associated Cardiac Involvement, Remodeling, Left Ventricle
Myocardial Protection in Patients With Post-acute Inflammatory Cardiac Involvement Due to COVID-19
Long COVID or Postacute sequelae of COVID-19 infection (PASC) are increasingly recognised complications, defined by lingering symptoms, not present prior to the infection, typically persisting for more than 4 weeks.
- Conditions
- COVID-19 Associated Cardiac Involvement, Remodeling, Left Ventricle, Remodeling, Vascular, Left Ventricular Dysfunction
- Trial name
- MYOFLAME-19 (NCT05619653)
- Testing
- Prednisolone, Losartan
- Where
- 5 sites in Austria, Germany
- Volunteers
- 279 people
- Sponsor
- Valentina Puentmann
Human Immunodeficiency Virus, Ischemic Heart Disease
Omacor and Cardiovascular Risk Factors in HIV Patients on HAART Treatment
The purpose of this study is to evaluate the effect of Omacor 4g/day on blood lipid parameters and on the function and stiffness of blood vessels in HIV infected patients on Antiretroviral Therapy (HAART)
- Trial name
- NCT00296153
- Testing
- Omega-3-acid ethyl esters 90
- Where
- Denmark
- Volunteers
- 51 people
- Sponsor
- Pronova BioPharma
Heart Failure, Influenza
Influenza Vaccine To Prevent Adverse Vascular Events (RCT-IVVE)
A multi-centre, randomized, placebo controlled, trial. Participants at high-risk for vascular events from the network of INTER- CHF will be randomized to inactivated influenza vaccine or placebo and followed prospectively over…
- Trial name
- RCT-IVVE (NCT02762851)
- Testing
- Sterile saline, inactivated trivalent influenza vaccine
- Where
- 13 sites in Cameroon, China and 11 more
- Volunteers
- 5,000 people
- Sponsor
- McMaster University
Wounds and Injuries, Wound Infection
Effects of Early Postoperative Showering After Coronary Artery Bypass Grafting Using Bilateral Internal Thoracic Artery
The study to evaluate effects of early postoperative showering after coronary artery bypass grafting using bilateral internal thoracic artery
- Trial name
- NCT06237283
- Testing
- Early shower
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Sejong General Hospital
Post Procedural Infection, Pacemaker Electrode Infection
Post-procedure Antibiotic Prophylaxis for Cardiac Electrical Device Implantation: ABxFREE Study
This study is a multi-center open-label randomized study, and we sought to investigate the redundancy of post-procedural prophylactic antibiotics in cardiac implantable electronic device implantation.
- Conditions
- Post Procedural Infection, Pacemaker Electrode Infection, Antibiotics, Implantable Defibrillator User
- Trial name
- ABxFREE (NCT04146883)
- Testing
- Antibiotics
- Where
- Taiwan
- Volunteers
- 800 people
- Sponsor
- National Cheng-Kung University Hospital
DiGeorge Syndrome, Congenital Heart Defects
Infection in DiGeorge Following CHD Surgery
We propose a retrospective review of patients with DiGeorge syndrome having undergone cardiac surgery to evaluate the incidence of blood stream and/or surgical site infection.
- Trial name
- NCT00278005
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Children's Healthcare of Atlanta
Rheumatic Heart Disease
Screening and Secondary Prevention Rheumatic Heart Disease Study
After basic clinical screening including history and physical, Point of care ultrasound will be performed to look at Mitral, Aortic and Tricuspid Valves for regurgitation or stenosis.
- Trial name
- S2-RHD (NCT05991219)
- Where
- Pakistan
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- National Institute of Cardiovascular Diseases, Pakistan
HIV, Coronary Artery Disease
Metformin for HIV Inflammation
This proposal seeks to assess the impact of 24 weeks of metformin on non-calcified plaques and calcified plaques assessed by coronary CT angiography, and on whether these changes can be explained by metformin-induced phenotypic…
- Trial name
- NCT02383563
- Testing
- metformin extended release
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Hawaii
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