Clinical trials: Cardiac Infection
Coronary Disease, Heart Valve Diseases
CTI-01 (Ethyl Pyruvate) Safety and Complication Prevention in Cardiac Surgery Patients on Cardiopulmonary Bypass (CPB)
Over 500,000 patients undergo cardiac surgery with CPB in the United States annually. Although mortality rates have decreased with advances in perioperative care, many patients are affected by postoperative organ dysfunction.
- Trial name
- NCT00107666
- Testing
- CTI-01 (ethyl pyruvate)
- Where
- 17 sites in United States
- Volunteers
- 150 people
- Sponsor
- Critical Therapeutics
Endocarditis Infective
Study of the Prognosis of Infectious Endocarditis (EPEI)
Infectious endocarditis (IE) is the localization and proliferation of blood-borne germs in the endocardium. It remains a complicated disease to manage due to its low incidence, diagnostic difficulties, the change in epidemiology…
- Trial name
- EPEI (NCT03211975)
- Testing
- To study the evolution of the prognosis of infectious endocarditis on native valves and on prostheses
- Where
- France
- Volunteers
- 645 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Respiratory Disease
The Effect of Vitamin E Supplementation on Hospital Stay Duration in Non-cyanotic Heart Disease Children With Lower Respiratory Tract Infections
Congenital heart disease can lead to serious health issues, particularly an increased risk of infections, specifically respiratory infections. Lower respiratory tract infections are the fifth leading cause of death globally.
- Trial name
- NCT06926712
- Testing
- Vitamin E
- Volunteers
- 260 people
- Sponsor
- Assiut University
HIV Infections, Heart Disease
Pilot Placebo Controlled Study With Lovaza in Cardiovascular Disease
Several studies have shown that there is an increased risk of heart disease in people with HIV. In this study the investigators are looking at the effect of Lovaza (Omega-3 fatty acid) on improving endothelial function and…
- Trial name
- NCT01001767
- Testing
- Lovaza
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University Hospitals Cleveland Medical Center
Rheumatic Fever, Rheumatic Diseases
Effectiveness of Chronic Self-management Education on Behavioral and Clinical Outcomes
Study Design, Setting, and Period A one-group quasi-experimental study using a pre-test and post-test will be implemented on a convenient sample design to examine the effectiveness of chronic disease self-management education in…
- Trial name
- NCT06400628
- Testing
- Self-management education
- Where
- Ethiopia
- Volunteers
- 166 people
- Sponsor
- Jimma University
Cardiac Arrest With Successful Resuscitation, Mechanical Ventilation
Study of Ventilator Associated Event During Intensive Care After Resuscitated Cardiac Arrest.
The aim is to describe the incidence, characteristics, risk factors and outcome of complications acquired under mechanical ventilation (called ventilator-associated events) according to the new CDC criteria, in a population of…
- Trial name
- VAE-ACR (NCT06466980)
- Testing
- Ventilator associated event
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Centre Hospitalier Sud Francilien
Bacterial Endocarditis, Bacteremia
Daptomycin in the Treatment of Subjects With Infective Endocarditis or Bacteremia Due to S. Aureus
The purpose of this study is to compare the safety and efficacy of daptomycin, an antibiotic, to standard therapy in subjects who have infective endocarditis or bacteremia due to Staphylococcus aureus (S. aureus).
- Trial name
- NCT00093067
- Testing
- daptomycin
- Sponsor
- Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Human Immunodeficiency Virus (HIV), Cardiovascular Disease (CVD)
The Effects of Statin Therapy on Coronary Flow Reserve and Inflammatory Markers in HIV-Positive Patients
The purpose of this study is to determine whether the use of rosuvastatin in Human Immunodeficiency Virus (HIV) infected individuals lowers inflammation in blood vessels, improves blood circulation in the small arteries that…
- Trial name
- NCT02234492
- Testing
- Rosuvastatin
- Where
- 2 sites in Canada
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Ottawa Heart Institute Research Corporation
Postoperative Wound Infection, Postoperative Outcome
Effect of Perioperative Hemodynamic Optimization on the Immune Function Parameters of Peripheral Blood Monocytes After Cardiac Surgery
Cardiac surgery patients have a high risk to suffer from postoperative infections. Some studies have shown, that humoral and cellular factors are associated with perioperative immunodysfunction and can increase the risk of…
- Trial name
- Algebra (NCT01184430)
- Testing
- Pulse contour cardiac output device
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Charite University, Berlin, Germany
Heart Failure, Congestive, Renal Failure Acute Chronic
Effect of a Focused Point-of-care Ultrasonography Screening Protocol in Hospitalized Patients
This research project aims to establish a real-time focused ultrasound examination protocol for routine assessment of hospitalized patients, including evaluations of the inferior vena cava (IVC), pericardial effusion…
- Conditions
- Heart Failure, Congestive, Renal Failure Acute Chronic, Liver Cirrhosis, Sepsis
- Trial name
- NCT07656428
- Where
- Taiwan
- Volunteers
- 9,000 people
- Sponsor
- National Taiwan University Hospital
Acne Vulgaris, Allergic Rhinitis
MedlinePlus Health Prescriptions: Developing a Pragmatic Approach for Clinic Use
The specific aim of this proposed pilot study is to compare two standardized processes (paper and electronic) to deliver a customized MedlinePlus health information prescription.
- Conditions
- Acne Vulgaris, Allergic Rhinitis, Anxiety, Asthma
- Trial name
- NCT01050465
- Testing
- health information prescription
- Volunteers
- 907 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Endocarditis, Bacterial
Short-course Antibiotic Treatment in Gram-positive Cocci Infective Endocarditis
Background: it is well known that most serious complications of infective endocarditis (IE) appear in the so-called "critical phase" of the disease, which are the first days after diagnosis.
- Trial name
- SATIE (NCT04222257)
- Testing
- Antibiotics
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Carmen Olmos Blanco
Septic Shock, Hypotension
Esmolol to Treat the Hemodynamic Effects of Septic Shock
The main purpose of this study is to determine the effects of controlling the heart rate of patients with septic shock using an intravenous medication called esmolol.
- Conditions
- Septic Shock, Hypotension, Tachycardia
- Trial name
- NCT02369900
- Testing
- Esmolol, Saline
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Beth Israel Deaconess Medical Center
Acute Heart Failure, NSTEMI - Non-ST Segment Elevation MI
Metabolomics and Microbiomics in Cardiovascular Diseases
"MEtabolomics and MicrObiomics in caRdIovAscular diseases Mannheim (MEMORIAM) " is a single-center, prospective and observational study investigating to identify disease-specific metabolic, respectively microbiomic, patterns of…
- Conditions
- Acute Heart Failure, NSTEMI - Non-ST Segment Elevation MI, STEMI - ST Elevation Myocardial Infarction, Myocardial Infarction, Acute
- Trial name
- MEMORIA (NCT04146701)
- Testing
- Blood draw
- Where
- Germany
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- Universitätsmedizin Mannheim
Covid19, Non Ischemic Myocardial Injury
MYocardial DOmmages Related to COVID-19
Myocardial injury, as assessed by elevation of cardiac troponins (Tnc), is frequent among patients with COVID-19. Although rare autopsy cases reported COVID-19 related myocardial inflammation, the origin of Tnc elevation is…
- Conditions
- Covid19, Non Ischemic Myocardial Injury, Myocardial Infarction, Myocarditis
- Trial name
- DOMY COVID (NCT04498065)
- Testing
- Biological data, Clinical data
- Where
- France
- Volunteers
- 273 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Stroke, Acute Coronary Syndrome
Factors Associated With Perioperative Outcomes in Non-emergency Surgery
This epidemiological study investigates the association of recent stroke, acute coronary syndrome or pneumonia and adverse perioperative outcomes following elective non-cardiac and cardiac surgery using routinely collected UK…
- Conditions
- Stroke, Acute Coronary Syndrome, Pneumonia
- Trial name
- NCT02455492
- Testing
- stroke or myocardial infarction or pneumonia
- Volunteers
- 266,436 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Organ Failure, Multiple, Inflammation
Red Cell Rejuvenation for the Attenuation of Transfusion Associated Organ Injury in Cardiac Surgery
The REDJUVENATE Trial proposes to test the hypothesis that postoperative organ injury and inflammation will be less if patients undergoing cardiac surgery who are at risk of large volume blood transfusion (defined as the…
- Conditions
- Organ Failure, Multiple, Inflammation, Sepsis
- Trial name
- NCT03167788
- Testing
- rejuvesol Solution, Standard Care
- Where
- United Kingdom
- Sponsor
- University of Leicester
Rheumatic Heart Disease, Anticoagulant Adverse Reaction
The Clinical Influence of Developing a Sustainable Cardiac Surgery Service to Reduce the Burden of Rheumatic Heart Disease in Sub-Saharan Africa
In this bi-directional program of education, training and research activities based on sustainable development goals aim is to develop cardiac surgery service in Ethiopia.
- Trial name
- RHD-CaSS (NCT04556188)
- Testing
- Cardiac surgery
- Where
- 4 sites in Ethiopia, Norway
- Volunteers
- 200 people
- Sponsor
- Helse Nord-Trøndelag HF
HIV - Human Immunodeficiency Virus
Coronary Artery Calcium Score in HIV Mexican Population (The CACsHIVMex Study)
The risk of atherosclerotic cardiovascular disease is increased in people with HIV infection, including young patients and those with few traditional cardiovascular risk factors.
- Trial name
- CACsHIVMex (NCT07662161)
- Testing
- Simple coronary CT scan
- Where
- Mexico
- Volunteers
- 384 people
- Sponsor
- Instituto Mexicano del Seguro Social
Infectious Endocarditis
Long-term Clinico-radiological Evolution of Patients With Brain Lesions During Infectious Endocarditis
Primary objective: To describe the evolution of cerebral lesions in IE patients (number of patients with abnormal cerebral MRI in acute phase of IE and during follow-up).
- Trial name
- POST-IMAGE (NCT02252900)
- Testing
- Magnetic resonance imaging
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
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