Clinical trials: Cardiac Infection
COPD
Feasibility Study of a Non-invasive Device to Quickly, Easily and Accurately Measure Respiration in a Clinical Setting
Healthcare facilities worldwide still measure respiration manually by counting and timing chest movements. In clinical departments that are fast-paced in nature and that have either high patient volumes or require more accurate…
- Trial name
- NCT04182711
- Testing
- Device
- Where
- Singapore
- Volunteers
- 150 people
- Sponsor
- Changi General Hospital
Cancer
Study to Determine if the Flu Vaccine Increases the Risk of Muscle Damage in Participants Taking Drugs That Block Certain Proteins Made by Some Types of Immune System Cells
A retrospective, observational study conducted on cancer patients receiving a drug that blocks certain proteins made by some types of immune system cells
- Trial name
- NCT03644498
- Testing
- Non-Interventional
- Where
- United States
- Volunteers
- 1,056 people
- Sponsor
- Bristol-Myers Squibb
Heart Failure, Healthcare Associated Infection
Ventricular Assist Device (VAD) Infection Prevention Survey
Annually, more than 250,000 patients in the U.S. with end-stage heart failure stand to benefit from ventricular assist device (VAD) therapy.
- Conditions
- Heart Failure, Healthcare Associated Infection, Ventricular Assist Device
- Trial name
- NCT03843021
- Testing
- VAD Infection Prevention Survey
- Where
- United States
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Anemia, Hematologic Diseases
Safety and Effectiveness of Two Blood Transfusion Strategies in Surgical Patients With Cardiovascular Disease
The purpose of this study is to compare liberal red blood cell transfusion therapy with restrictive red blood cell transfusion therapy in surgical patients with cardiovascular disease or risk factors.
- Conditions
- Anemia, Hematologic Diseases, Cardiovascular Diseases, Heart Diseases
- Trial name
- FOCUS (NCT00071032)
- Testing
- Liberal (10 g/dL) Transfusion Strategy, Restrictive (Symptomatic) Transfusion Strategy
- Where
- United States
- Volunteers
- 2,016 people
- Sponsor
- Rutgers, The State University of New Jersey
Renal Disease, Liver Diseases
Outcomes of Children After Hospitalization in Intensive Care Unit
More than 10,000 children are hospitalized in an PICU every year in Canada. While most of them will survive their PICU hospitalization and their critical illness, some children will not recover to their pre-illness level.
- Conditions
- Renal Disease, Liver Diseases, Heart Diseases, Trauma Injury
- Trial name
- APCI (NCT06124092)
- Testing
- neurocognitive tests
- Where
- 8 sites in Canada
- Volunteers
- 690 people
- Sponsor
- St. Justine's Hospital
HIV Infection, Cardiovascular Diseases (CVD)
Colchicine to Reduce Coronary Artery Inflammation in People With HIV
The purpose of this study is to evaluate whether colchicine can reduce coronary artery inflammation in people living with HIV and high cardiovascular risk.
- Trial name
- COLCOHIV (NCT07704164)
- Testing
- Colchicine 0.5 mg
- Where
- 4 sites in Spain
- Volunteers
- 90 people
- Sponsor
- Instituto de Investigación Hospital Universitario La Paz
Malaria, Vivax
Tafenoquine Thorough QTc Study in Healthy Subjects
This will be a randomized, single-blind, placebo controlled, parallel group study. Approximately 260 subjects will be enrolled in five groups.
- Trial name
- NCT01928914
- Testing
- Tafenoquine 300mg, Tafenoquine 600mg, Tafenoquine 1200mg
- Where
- 2 sites in United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
HIV Infections, Cardiovascular Disease
Myocardial Function & FFA Metabolism in HIV Metabolic Syndrome
We hypothesize that the hearts of HIV+ people with The Metabolic Syndrome use and oxidize fats and sugars inappropriately, and that this may impair the heart's ability to pump blood.
- Conditions
- HIV Infections, Cardiovascular Disease, Insulin Resistance, HIV Lipodystrophy
- Trial name
- WU197 (NCT00656851)
- Testing
- Pioglitazone, Exercise Training
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Dilated Cardiomyopathy, Kaposi's Sarcoma-Associated Herpesvirus Infection
The Effects of Sirolimus in Patients With Dilated Cardiomyopathy Infected With Kaposi Sarcoma-associated Virus
Evaluating the efficacy of sirolimus (compared to standard therapy alone) in the treatment of dilated cardiomyopathy infected with Kaposi Sarcoma-associated virus -- a multicenter randomized controlled study.
- Trial name
- SDCMK (NCT06236022)
- Testing
- Sirolimus
- Where
- China
- Volunteers
- 276 people
- Sponsor
- Tongji Hospital
Acute Myocarditis
Hospital Registry of Acute Myocarditis: Evolution of the Proportion of Positive SARS-COV-2 (COVID19) Cases
To date, the effects of SARS-Cov-2 (Covid-19) on the myocardium and the role it plays in the evolution towards an acute myocarditis are badly understood.
- Trial name
- MYOCOVID (NCT04375748)
- Testing
- Performing routine care (clinical and paraclinical tests), Examinations for the research:
- Where
- 65 sites in France, Martinique and 2 more
- Volunteers
- 756 people
- Sponsor
- University Hospital, Toulouse
Rheumatic Heart Disease, Mitral Stenosis
The Effect of Ramipril in Suppressing ST2 Expression in Rheumatic Mitral Stenosis Patients
Objective propose: to investigate the effect of Ramipril in suppressing ST2 (suppression of tumorigenicity 2) in the cardiac mitral valve in patients with Rheumatic Heart Disease.
- Conditions
- Rheumatic Heart Disease, Mitral Stenosis, Rheumatic Mitral Stenosis, Fibrosis; Heart
- Trial name
- NCT03991910
- Testing
- Ramipril 5Mg Oral Capsule
- Where
- Indonesia
- Volunteers
- 66 people
- Sponsor
- Universitas Indonesia
Septic Shock, Stroke Hemorrhagic
Oral Bedtime Melatonin in Critically Ill Patients
Oxidative stress is one of the main mechanisms causing harm in severe infection with septic shock, ischemia-reperfusion injury in resuscitated cardiac arrest and ischemic and hemorrhagic stroke.
- Conditions
- Septic Shock, Stroke Hemorrhagic, Strokes Thrombotic, Cardiac Arrest
- Trial name
- Mel-ICU (NCT06156059)
- Testing
- Oral Bedtime Melatonin
- Volunteers
- 160 people
- Sponsor
- Hospital San Carlos, Madrid
Anxiety, COVID-19 Pandemic
SMILE: Clinical Trial to Evaluate Mindfulness as Intervention for Racial and Ethnic Populations During COVID-19
The goal of this clinical trial is to evaluate the SMILE app, a Digital Health Platform (DHP), that will deliver a mindfulness intervention, designed to mitigate COVID-19 related stress.
- Trial name
- SMILE (NCT06242080)
- Testing
- Mindfulness
- Where
- United States
- Volunteers
- 398 people
- Sponsor
- University of North Carolina, Chapel Hill
Heart Rhythm Disorder, Covid19
Effect of Social Isolation on Physical Activity Level, and Kinesophobia in Heart Rhythm Disorders During Pandemic
The aim of our study is to examine the effect of social isolation on physical activity level, health literacy and kinesophobia in heart rhythm disorders.
- Conditions
- Heart Rhythm Disorder, Covid19, Social Isolation
- Trial name
- NCT04818697
- Where
- Turkey (Türkiye)
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Coronary Artery Disease, Coronary Artery Bypass Grafting
Comparative Outcomes of Mammary Artery Harvesting: Infection, Occlusion Rates and Thoracic Pain Assessment
The COMFORT Trial is a randomized controlled superiority trial comparing skeletonized (SK) versus non-skeletonized (non-SK) harvesting of the left internal mammary artery (LIMA) to left anterior descending artery (LAD) graft in…
- Conditions
- Coronary Artery Disease, Coronary Artery Bypass Grafting, Surgical Site Infection
- Trial name
- COMFORT (NCT07720661)
- Testing
- Skeletonized LIMA Harvesting, Non-Skeletonized LIMA Harvesting
- Sponsor
- Hamilton Health Sciences Corporation
Rheumatic Heart Disease, Congenital Heart Disease
Effect of Simvastatin on Cardiac Function
It is well know that statins have been used to low cholesterol to prevent and treat coronary artery disease for many years. It was also reported that statins could protect endothelial function and cardiac function during coronary…
- Conditions
- Rheumatic Heart Disease, Congenital Heart Disease, Aneurysm, Heart Valve Disease
- Trial name
- NCT01178710
- Testing
- Simvastatin
- Where
- China
- Volunteers
- 151 people
- Sponsor
- Sun Yat-sen University
Surgical Site Infection
The Use of Ceftaroline as Surgical Prophylaxis in Surgery With Risk of MRSA Infection
The study is a randomized double-blinded study comparing ceftaroline to standard of care therapy with cefazolin and vancomycin as surgical prophylaxis for high risk orthopedic and cardiac surgeries.
- Trial name
- PREVTAROLINE (NCT02307006)
- Testing
- Ceftaroline, Cefazolin / Vancomycin
- Where
- 2 sites in United States
- Volunteers
- 500 people
- Sponsor
- University of Cincinnati
Wound Infection
A Comparison Of The 3M TM S Surgical Skin Closure System To The Standard Vicryl Suture Closure of Sternotomy Incisions During Cardiac Surgery
Following closure of surgical incisions, wounds may develop redness, swelling, and drainage which may result in increased pain and infection.
- Trial name
- NCT00576745
- Testing
- Vicryl Suture, 3M TM S Surgical Skin Closure System
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- American Heart Association
Complication, Postoperative
Perioperative Fluid Management: Goal-directed Versus Restrictive Strategy
There is no ideal "cookbook recipe" for fluid prescription that would fit every surgical patient. In this study, the investigators working hypothesis is that the adoption of an integrative algorithm for perioperative fluid and…
- Trial name
- NCT02625701
- Testing
- Goal-directed therapy, Restrictive fluid therapy
- Where
- Switzerland
- Volunteers
- 400 people
- Sponsor
- University Hospital, Geneva
Use of Subcutaneous ICDs Following Infection
The Use of Subcutaneous Implantable Cardiac Defibrillators (ICDs) Following Extraction of Conventional ICDs
Implantable cardiac defibrillators (ICDs) are devices that are put into patients at high risk of sudden cardiac death. They are used to treat life threatening heart rhythm disorders.
- Trial name
- SUBTRACT (NCT01665131)
- Testing
- Cameron Health S-ICD SQ-RX
- Volunteers
- 50 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
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