Clinical trials: Cardiac Infection
Sepsis, Respiratory Failure
Use of Lactate-to-Albumin, CRP-to-Albumin, and Procalcitonin-to-Albumin Ratios to Predict Mortality in ICU Patients
This observational study aims to determine whether three blood test ratios - lactate-to-albumin, CRP-to-albumin, and procalcitonin-to-albumin - can predict in-hospital mortality among critically ill adults.
- Conditions
- Sepsis, Respiratory Failure, Cardiac Arrest, Circulatory Failure
- Trial name
- LAR-CAR-PAR (NCT07242027)
- Where
- Poland
- Volunteers
- 212 people
- Sponsor
- Medical University of Silesia
Sepsis, Cancer, Heart Attack, Heart Failure, Abdominal Surgery, Trauma, Diabetes, Lung Disease, Gynaecology, Fertility, Cardiac Surgery,
Medical Record Study on Adverse Events Requiring a Higher Level of Care in Flemish Hospitals
An adverse event (AE) is defined as unintended injury or complication, which results in disability, death or prolongation of hospital stay, and is caused by healthcare management (including omissions) rather than the patient's…
- Trial name
- NCT02044718
- Where
- Belgium
- Volunteers
- 878 people
- Sponsor
- Hasselt University
Pneumonia, Syncope
Quasi-Randomized Evaluation of the UCLA Next Day Clinic (NDC)
The Next Day Clinic (NDC) is a quality improvement initiative that will be launched and operated by UCLA Health starting July 22, 2024. Its goals are to improve patient care and safety and to maximize cost effectiveness.
- Conditions
- Pneumonia, Syncope, Congestive Heart Failure, Cellulitis
- Trial name
- NDC (NCT06526884)
- Testing
- Next Day Clinic
- Where
- United States
- Volunteers
- 570 people
- Sponsor
- University of California, Los Angeles
Sepsis, Asthma
Evaluation of Essential Surgical Skills-Emergency Maternal and Child Health Training
The aim of the proposed study is to determine if specific training in management of general, obstetric, neonatal and pediatric emergencies results in a change in practice of doctors working in emergency departments of public…
- Conditions
- Sepsis, Asthma, Heart Failure, Seizure
- Trial name
- NCT00880204
- Testing
- ESS-EMCH training
- Where
- 2 sites in Pakistan
- Volunteers
- 36 people
- Sponsor
- Child Advocacy International
Septic Shock, Acute Respiratory Distress Syndrome
CytOSorb TreatMent Of Critically Ill PatientS Registry
Registry intended to provide a data repository and reporting infrastructure for the surveillance of CytoSorb device use in real-world critical care settings, and to serve as an objective, comprehensive, and scientifically-based…
- Conditions
- Septic Shock, Acute Respiratory Distress Syndrome, Trauma, Rhabdomyolysis
- Trial name
- COSMOS (NCT05146336)
- Testing
- CytoSorb
- Where
- 28 sites in Austria, Germany and 4 more
- Volunteers
- 3,000 people
- Sponsor
- CytoSorbents, Inc
COVID-19, Cardiovascular Diseases
WORLD HEART FEDERATION (WHF) COVID-19 and Cardiovascular Disease Survey
A global study for a better understanding of the cardiovascular conditions that increase the risk of developing severe COVID-19, and a better characterization of cardiovascular complications in hospitalized patients with COVID-19.
- Trial name
- WHF (NCT04475471)
- Where
- 32 sites in Argentina, Bangladesh and 15 more
- Volunteers
- 5,200 people
- Sponsor
- Public Health Foundation of India
Electrocardiogram Repolarisation Abnormality, Gonococcal Infection
Thorough QT/QTC (TQT) Clinical Trial to Evaluate the Effect of Zoliflodacin on Cardiac Repolarization in Healthy Male and Female Subjects
The Phase I Thorough QT/QTc (TQT) study will be performed in a single center, the Vince \& Associates Clinical Research, Inc., clinical trials unit (CTU), in 72 healthy male or female subjects, aged 18 to 45 years inclusive, to…
- Trial name
- NCT03613649
- Testing
- AZD0914, Moxifloxacin
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
COVID-19, Coronary Microvascular Dysfunction
COVID-19 Microvascular Evaluation Trial
The COMET trial is an observational, cross-sectional study aimed at comparing the incidence of coronary microvascular dysfunction (CMD) in patients with stable angina who have a history of severe COVID-19 infection requiring…
- Trial name
- COMET-19 (NCT05841485)
- Testing
- Assessment of coronary microvascular dysfunction using intracoronary pressure-temperature wire
- Where
- Lithuania
- Volunteers
- 102 people
- Sponsor
- Lithuanian University of Health Sciences
COVID-19
Acute Effects of Oral Ketone Ester on Cardiac Function in Patients With COVID-19
Based on Chinese studies, cardiac injury occurs in 20-30% of hospitalized patients and contributes to 40% of deaths. There are many possible mechanisms of cardiac injury in COVID-19 patients and increased myocardial oxygen demand…
- Trial name
- KetoCOVID (NCT04573764)
- Testing
- D-beta-hydroxybutyrate-(R)-1,3 butanediol monoester
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- Steno Diabetes Center Copenhagen
Long COVID-19, Post-COVID-19 Syndrome
Exercise and Post-COVID/ Long-COVID: Effects of Different Training Modalities on Various Parameters in People Affected by the Sequelae of COVID-19
The current COVID-19 pandemic is the most severe health crisis of the 21st century. This is not only due to the deaths caused by the disease.
- Conditions
- Long COVID-19, Post-COVID-19 Syndrome, COVID-19
- Trial name
- NCT05204511
- Testing
- endurance training, concurrent training
- Where
- Austria
- Volunteers
- 66 people
- Sponsor
- University of Vienna
Hepatitis
A Controlled Prospective Study of Transfusion-Associated Hepatitis
This protocol represents a continuation of a series of prospective studies to define the incidence and etiology of transfusion-associated hepatitis (TAH) and to examine the impact on TAH of various modifications in the selection…
- Trial name
- NCT00004848
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Adenovirus, Anesthesia
Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care
Understudied drugs will be administered to children per standard of care as prescribed by their treating caregiver and only biological sample collection during the time of drug administration will be involved.
- Conditions
- Adenovirus, Anesthesia, Anxiety, Anxiolysis
- Trial name
- PTN_POPS (NCT01431326)
- Testing
- The POPS study is collecting PK data on children prescribed the following drugs of interest per standard of care:
- Where
- 52 sites in United States, Canada and 3 more
- Volunteers
- 3,520 people
- Sponsor
- Daniel Benjamin
Ventilator-associated Pneumonia, Cardiac Arrests With Shockable Rhythm
Antibiotherapy During Therapeutic Hypothermia to Prevent Infectious Complications
Mild therapeutic hypothermia is currently recommended in management of cardiac arrests with shockable rhythm. In mechanically ventilated patients who were resuscitated after out-of-hospital cardiac arrests, mild therapeutic…
- Conditions
- Ventilator-associated Pneumonia, Cardiac Arrests With Shockable Rhythm, Mild Therapeutic Hypothermia, Preventive Antibiotics
- Trial name
- ANTHARTIC (NCT02186951)
- Testing
- Amoxicillin - clavulanic acid
- Where
- 16 sites in France
- Volunteers
- 197 people
- Sponsor
- University Hospital, Limoges
Rheumatic Heart Disease
A Long-term Follow up Study for Patients Who Participated in the GOAL Trial (GOAL-Post)
GOAL-Post is comprised of two studies that will help refine recommendations for the duration of secondary prophylaxis for children diagnosed with latent RHD, which is currently not known
- Trial name
- NCT05211024
- Testing
- Penicillin G Benzathine
- Where
- Uganda
- Volunteers
- 1,423 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
COVID-19
The Role of Ultrasound in COVID-19
The study is a prospective clinical cohort study of consecutive patients hospitalized at all hospitals of greater Copenhagen with a laboratory confirmed diagnosis of COVID-19.
- Trial name
- NCT04377035
- Where
- Denmark
- Volunteers
- 305 people
- Sponsor
- University Hospital, Gentofte, Copenhagen
Post-COVID-19 Syndrome
Effectiveness of Supportive Psychotherapy Through Internet-Based Teleconsultation on Psychological and Somatic Symptoms, Neutrophil-Lymphocyte Ratio, and Heart Rate Variability in Post Covid-19 Syndrome Patients
The goal of this clinical trial is to learn about the effectiveness of supportive psychotherapy in post covid-19 syndrome patients. The main questions it aims to answer are: 1.
- Trial name
- NCT05648123
- Testing
- Supportive Psychotherapy
- Where
- Indonesia
- Volunteers
- 77 people
- Sponsor
- Universitas Indonesia
Human Immunodeficiency Virus, Lipodystrophy
Growth Hormone Dynamics and Cardiac Steatosis in HIV
Cardiac steatosis is increased among individuals with HIV, and may predispose to cardiac mechanical dysfunction and subsequent heart failure. The pathogenesis and treatment of cardiac steatosis is not well understood.
- Conditions
- Human Immunodeficiency Virus, Lipodystrophy, Cardiac Disease
- Trial name
- NCT03826160
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Massachusetts General Hospital
Primary Ovarian Insufficiency, Cardiovascular Diseases
Associations of Combinations of Single-nucleotide Polymorphisms in Women With Premature Ovarian Failure
Research objective. To study the associations between combinations of single nucleotide polymorphisms and behavioural risk factors with non-communicable diseases and adverse outcomes in women with premature ovarian failure.
- Conditions
- Primary Ovarian Insufficiency, Cardiovascular Diseases, Menopause, Premature, Coronary Disease
- Trial name
- NCT04943354
- Testing
- Taking a person's venous blood
- Where
- Russia
- Volunteers
- 238 people, healthy volunteers welcome
- Sponsor
- Ryazan State Medical University
Critical Illness, Sepsis
Pancreatic Exocrine Insufficiency and Pancreatic Enzyme Supplementation in Critically Ill Adult Patients
Malnutrition is a frequent problem in critically ill patients that is associated with detrimental clinical outcomes. To provide adequate nutritional support, current studies focused mostly on the choice of delivery timing…
- Conditions
- Critical Illness, Sepsis, Diabetes, Cardiac Arrest
- Trial name
- NCT01753024
- Testing
- Enteral nutrition (EN)
- Where
- 2 sites in China
- Volunteers
- 362 people
- Sponsor
- Shanghai 10th People's Hospital
COVID-19
Pilot Clinical Trial of the Safety and Efficacy of Telmisartan for the Mitigation of Pulmonary and Cardiac Complications in COVID-19 Patients
This study will enroll 40 symptomatic outpatients tested positive for Coronavirus 2019 (COVID-19). Patients to be randomized 1:1 to Telmisartan (40 mg) vs placebo to be administered orally once daily x 21 days.
- Trial name
- NCT04360551
- Testing
- Telmisartan 40mg
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Hawaii
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