Clinical trials: Cardiac Infection
Postoperative Complications
Impact of Etomidate vs. Propofol on Infectious Complications Post Cardiac Surgery
The aim of this retrospective before-after-study is to evaluate the potential association of etomidate vs. propofol as an induction agent for major cardiac surgery on infectious post-operative complications.
- Trial name
- NCT04281706
- Testing
- Etomidate vs Propofol as induction agent
- Where
- Germany
- Volunteers
- 1,495 people
- Sponsor
- Charite University, Berlin, Germany
Infectious Endocarditis
Hyperbaric Oxygen Treatment in Humans With Gram Positive Cocci Endocarditis
Infectious endocarditis (IE) is defined as an infection anywhere on the endocardium, most often localised to the cardiac valves. It is an infection with an increasing incidence and in Denmark with 6-700 new cases annually.
- Trial name
- ENDOHOT (NCT04691440)
- Testing
- Hyperbaric oxygen
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- Ole Hyldegaard
Congenital Heart Disease, Bronchopneumonia
Research on Body Voice AI Recognition System for Children's Health Management
The purpose of this research is to develop a body voice artificial intelligence (AI) recognition device, also referred to as an AI-assisted body sound identification device, by utilizing a deep learning-based novel AI algorithm…
- Conditions
- Congenital Heart Disease, Bronchopneumonia, Abdominal Disease
- Trial name
- NCT06542120
- Testing
- Heart Auscultation and Echocardiography, Chest Auscultation and Chest imaging examinations, Abdominal Auscultation and Abdominal imaging examinations
- Where
- 5 sites in China
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Antimicrobial Prophylaxis
A Pilot Study of Daptomycin for Antimicrobial Prophylaxis
The goals of the study are to evaluate the feasibility of using daptomycin as a prophylactic antimicrobial agent in patients undergoing cardiac surgery, to determine the rates of surgical site infection, and to evaluate the…
- Trial name
- NCT00572260
- Testing
- daptomycin 6 mg/kg IV
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Duke University
Congenital Heart Disease
Hepatitis C in Adults Who Underwent Congenital Heart Surgery Before Screening
This is a retrospective chart review. We hypothesize that patients who have undergone congenital heart surgery, prior to screening of blood products have a significant risk of hepatitis C infection and all such patients would…
- Trial name
- NCT00359099
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Emory University
Any Condition Underlying Critical Illness
SWedish Intensive Care Biobank
The goal of this observational study is to understand the genetic and molecular risk factors for developing critical illness in adult intensive care unit (ICU) patients in Sweden.
- Trial name
- SWIC-B (NCT07582601)
- Volunteers
- 25,000 people
- Sponsor
- Uppsala University
Infections, Cardiac Arrest
Steroids and Post-resuscitation Infectious (Septic) Complications
Postresuscitation disease is characterized by post-insult systemic inflammation, adrenal insufficiency, and circulatory failure.
- Trial name
- NCT02408939
- Testing
- Stress-dose hydrocortisone
- Where
- 5 sites in France, Greece
- Volunteers
- 191 people
- Sponsor
- University of Athens
Rheumatic Heart Disease
Rheumatic Heart Disease Research and Screening in Nepal: A Feasibility Study
Rheumatic Heart Disease (RHD) remains a significant public health problem in lower and middle-income countries, accounting for over 300,000 deaths world-wide.
- Trial name
- NCT05250154
- Where
- Nepal
- Volunteers
- 2,438 people
- Sponsor
- University of Washington
Heart Rate, Variability
Heart Rate Variability in Febrile Young Infants
Febrile infants younger than 3 months old present a diagnostic dilemma to the emergency physician. Tension remains between the need for early aggressive intervention among patients with suspected sepsis and the global phenomena…
- Conditions
- Heart Rate, Variability, Triage, Decision Support Techniques
- Trial name
- HRV (NCT04103151)
- Testing
- Single lead ECG
- Where
- Singapore
- Volunteers
- 330 people
- Sponsor
- KK Women's and Children's Hospital
Septic Shock
Ivabradine for Heart Rate Control In Septic Shock
Septic shock is a major health problem, with several million cases annually worldwide and a mortality approaching 45%. Tachycardia is associated with excess mortality during septic shock.
- Trial name
- IRISS (NCT04031573)
- Testing
- Ivabradine
- Where
- France
- Volunteers
- 429 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
INFECTION
Topical Use of Vancomycin in Reducing Sternal Wound Infection in Cardiac Surgery (SWI Trial)
The purpose of this research is to determine if using the antibiotic vancomycin as a preventative topical (on the surface of the skin) treatment during open-heart surgery will reduce the risk of developing a sternal wound…
- Trial name
- SWI (NCT02374853)
- Testing
- Vancomycin, No Vancomycin
- Volunteers
- 1,037 people
- Sponsor
- University of Alberta
CRBSI - Catheter Related Bloodstream Infection, Central Venous Catheter
Complications and Failure of Centrally Inserted Central Catheters in Cardiac Surgical Patients
Central venous catheters, or CVCs, are medical devices used to deliver medications and blood products directly into a patient's large veins.
- Conditions
- CRBSI - Catheter Related Bloodstream Infection, Central Venous Catheter, Catheter Failure, Central Venous Catheter Complications
- Trial name
- CICC-CS (NCT07138690)
- Where
- Italy
- Volunteers
- 480 people
- Sponsor
- Azienda Ospedaliero-Universitaria Careggi
Heart Failure
Vaccination Against Influenza Pre-discharge in Heart Failure
In patients with heart failure (HF), influenza vaccination should be considered to prevent HF hospitalizations. However, vaccination rates among patients with HF are low, in part because of subjective but common concerns about…
- Trial name
- NCT06725927
- Testing
- Influenza vaccination
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Wroclaw Medical University
Cardiovascular Diseases, Atherosclerosis
Examining the Link Between Heart Disease and HIV Infection in Women
Recent studies have shown that HIV infected individuals have an increased risk of developing heart disease, but the reason for this is not fully understood.
- Conditions
- Cardiovascular Diseases, Atherosclerosis, Acquired Immunodeficiency Syndrome, HIV Infections
- Trial name
- NCT00312468
- Volunteers
- 1,011 people
- Sponsor
- Albert Einstein College of Medicine
Infectious Disease, Endocarditis
Real-life Use of Cefazolin for the Treatment of Meticillin-susceptible Staphylococcal Infective Endocarditis: Comparison to a Treatment Cohort With Penicillin M
Retrospective, regional, multicenter study (including the Annecy-Genevois Hospital Center, the Chambéry Métropole Savoie Hospital Center, and the Grenoble University Hospital Center), comparing a cohort of patients treated with…
- Trial name
- CEFASTA (NCT05474118)
- Where
- France
- Volunteers
- 192 people
- Sponsor
- Centre Hospitalier Annecy Genevois
Heart Failure, Infection
Improve Management of Heart Failure With Procalcitonin
Patients presenting to the Emergency Department with shortness of breath and (suspected) heart failure will be screened and randomized to either a standard of care or a procalcitonin-guided arm.
- Trial name
- IMPACT-EU (NCT02392689)
- Testing
- Procalcitonin
- Where
- 15 sites in Denmark, Germany and 2 more
- Volunteers
- 759 people
- Sponsor
- Brahms AG
Peripheral Vascular Disease, Abdominal Aortic Aneurysm
Glycemic Control to Prevent Cardiac Morbidity in Vascular Surgery
Aggressive intraoperative and postoperative management of blood glucose may substantially decrease perioperative cardiovascular and infectious complications in diabetic and non-diabetic patients undergoing vascular surgery.
- Trial name
- NCT00328094
- Testing
- continuous intravenous insulin infusion
- Where
- United States
- Volunteers
- 242 people
- Sponsor
- Beth Israel Deaconess Medical Center
Arterial Occlusive Diseases, Atherosclerosis
Potential Role of CMV in Restenosis Following Angioplasty, in Atherosclerosis, and in Endothelial Dysfunction
The purpose of this study is to investigate whether the susceptibility of subjects to atherosclerosis is influenced by prior CMV exposure, whether the susceptability to endothelial dysfunction in patients with and in patients…
- Conditions
- Arterial Occlusive Diseases, Atherosclerosis, Coronary Disease, Cytomegalovirus Infections
- Trial name
- NCT00001531
- Where
- United States
- Volunteers
- 355 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Rheumatic Heart Disease, Cardiopulmonary Bypass
Thymosin α1 Use in Rheumatic Heart Disease Patients Undergoing Cardiac Surgery on Cardiopulmonary Bypass
Rheumatic heart disease usually accompanied by weakened immune function. And the cardiopulmonary bypass further aggravating the decline of immune function.
- Conditions
- Rheumatic Heart Disease, Cardiopulmonary Bypass, Immunotherapy
- Trial name
- NCT05487469
- Testing
- Thymosin Alpha1, Blank Control
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Nanjing Medical University
Covid19, Cardiac Complication
One-year Cardiac Follow-up of Patients With COVID-19 Pneumonia
The primary objective of the study is to assess the cardiac status of COVID-19 pneumonia patients during 1 year after discharge
- Trial name
- NCT04501822
- Testing
- Evaluation of clinical, instrumental and laboratory diagnostics tests
- Where
- Russia
- Volunteers
- 380 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
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