Clinical trials: Cardiac Inflammation
Cardiac Sarcoidosis
Diagnostic Utility of SGLT1/2 Inhibition to Facilitate Myocardial Glucose Suppression
This is a pilot mechanistic study of the diagnostic utility of sodium-glucose cotransporter-1/2 inhibition (SGLT1/2) on myocardial glucose suppression on FDG PET/CT.
- Trial name
- NCT06510894
- Testing
- Sotagliflozin
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Myocardial Infarction (MI)
Evaluating Metabolic and Anti-inflammatory Effect of Genistein on Post-myocardial Infarction Patients
The goal of this clinical trial is to learn if genistein works to provide a beneficial effect to show lipid lowering effect and anti-inflammatory effects and slow the progression of atherosclerosis in post-myocardial infarction…
- Trial name
- NCT06689566
- Testing
- genistein
- Where
- Taiwan
- Volunteers
- 73 people
- Sponsor
- National Taiwan University Hospital
Coronary Artery Aneurysm, Abdominal Aortic Aneurysm
Inflammation and Clotting Abnormalities in Aneurysmal Coronary Artery Disease
The main objective of the CARE-ANEURYSM project is to evaluate inflammation and clotting abnormalities in patients with aneurysmal coronary artery disease in relation to patients with abdominal aortic aneurysm or coronary artery…
- Conditions
- Coronary Artery Aneurysm, Abdominal Aortic Aneurysm, Coronary Disease
- Trial name
- CARE-ANUERYSM (NCT05183373)
- Testing
- Evaluation of inflammation and clotting
- Where
- Poland
- Volunteers
- 180 people
- Sponsor
- John Paul II Hospital, Krakow
Acute Coronary Syndromes (ACS), Chronic Coronary Syndrome
Effects of Icosapent Ethyl on Coronary Plaque, Inflammation, and Ventricular Remodeling
Even with standard treatments like statins, patients with coronary artery disease often face a residual risk of further heart events.
- Conditions
- Acute Coronary Syndromes (ACS), Chronic Coronary Syndrome, Coronary Artery Disease, Atherosclerosis Cardiovascular Disease
- Trial name
- NCT07641257
- Volunteers
- 420 people
- Sponsor
- Ruijin Hospital
HIV-1 Seropositive, Inflammation
Study of the Effect of SNPs in p53 and p53 Response Elements on the Inflammatory Response to DNA Damage
Background: Research has shown that certain proteins in cells may be linked to higher risks of developing inflammations, tumors, and other medical problems.
- Conditions
- HIV-1 Seropositive, Inflammation, Cancer, Cardiomyopathy
- Trial name
- NCT01143519
- Where
- United States
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Congential Cardiac Surgery
Study of the Corelation Between Circulating Nuclearsome and SIRS Happened After Congential Cardiac Surgery
In this study，the investigators want to determine the corelation between circulating nuclearsome and the development of SIRS occured after congenital cardiac surgery, including the serverity of organ damage and inflamation.
- Trial name
- NCT02325765
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shanghai Children's Medical Center
Septic Shock
Ivabradine for Heart Rate Control In Septic Shock
Septic shock is a major health problem, with several million cases annually worldwide and a mortality approaching 45%. Tachycardia is associated with excess mortality during septic shock.
- Trial name
- IRISS (NCT04031573)
- Testing
- Ivabradine
- Where
- France
- Volunteers
- 429 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Selenium Level
Effect of Heart-lung-machine on Selenium Status of Cardiac Surgical Patients Undergoing Coronary Bypass Surgery
Since selenium has demonstrated significant characteristics for a series of biochemical processes, for antioxidant activity and immune stimulation, this observational study should represent the effect of heart-lung-machine on…
- Trial name
- SEOPCAB (NCT01409057)
- Where
- Germany
- Volunteers
- 46 people
- Sponsor
- RWTH Aachen University
Systemic Inflammatory Response Syndrome, Myocardial Ischemia
Inflammatory Response During Anesthesia and Surgery
The purpose of this study is to investigate the effects of total intravenous anesthesia versus volatile anesthesia on the perioperative inflammatory response during and after major surgery.
- Trial name
- IRAS (NCT00356746)
- Where
- Netherlands
- Volunteers
- 120 people
- Sponsor
- UMC Utrecht
Atrial Fibrillation
Vitamin C and Atrial Fibrillation After Cardiac Surgery
The purpose of this study is to determine if vitamin C decreases the chance of developing atrial fibrillation, a type of arrhythmia or irregular heartbeat, following cardiac surgery.
- Trial name
- NCT01580683
- Testing
- Ascorbic Acid
- Where
- United States
- Sponsor
- Regional Hospital of Scranton
Myocardial Infarction, Inflammation
Inflammatory Cell Trafficking After Myocardial Infarction
Myocardial infarction (heart attack) is usually the consequence of rupture of a fatty 'plaque' in a heart artery. The presence of this fat and debris causes the propagation of a blood clot and blockage of the artery.
- Trial name
- NCT01127113
- Testing
- Infusion of investigational product, Cardiac magnetic resonance imaging
- Where
- United Kingdom
- Sponsor
- University of Edinburgh
Atherosclerosis, Myocardial Infarction
Residual Inflammation and Plaque Progression Long-term Evaluation
Inflammation drives atherosclerotic plaque rupture triggering most acute coronary syndromes. Despite advances in diagnosis and management of atherosclerosis, patients with myocardial infarction (MI) remain at increased risk of…
- Conditions
- Atherosclerosis, Myocardial Infarction, Coronary Artery Disease, Inflammation
- Trial name
- RIPPLE (NCT04073810)
- Testing
- PET imaging, Coronary CT angiography, Cardiac MRI
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Cambridge
Irreversible Pulpitis, Reversible Pulpitis
In Vivo Pulp Thermal Changes During Different Slenderization Techniques
The goal of this study is to learn about the temperature rise inside the living part of a tooth (the pulp) during different ways of removing a small amount of enamel (the hard outer layer of the tooth), a procedure called…
- Conditions
- Irreversible Pulpitis, Reversible Pulpitis, Thermal Injury, Pulp Hyperemia
- Trial name
- IPR (NCT07391124)
- Testing
- High-Speed Air-Driven Drill (Airotor and Bur), Orthodontic IPR Kit (Oscillating System)
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- Armed Forces Institute of Dentistry, Pakistan
Myocardial Inflammation, Rheumatoid Arthritis
Myocardial Inflammation in Rheumatoid Arthritis: A Descriptive Study
Rheumatoid arthritis (RA) patients have a higher prevalence of subclinical atherosclerosis than the general population. In addition, RA patients experience higher rates of heart failure with preserved ejection fraction (HFpEF).
- Conditions
- Myocardial Inflammation, Rheumatoid Arthritis, Coronary Artery Disease, Myocardial Strain
- Trial name
- NCT03776682
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Mayo Clinic
Non-Obstructive Coronary Atherosclerosis
PericOronary INflammaTion in Non-Obstructive Coronary Artery Disease
Among patients with ischemic heart disease who are referred for coronary angiography, a substantial proportion have non-obstructive coronary artery disease (CAD).
- Trial name
- POINT-NOCAD (NCT05031520)
- Testing
- Coronary computed tomography angiography (CCTA), Isovue, Nitroglycerin
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- NYU Langone Health
Myocarditis
Magnetic Resonance Imaging in Myocarditis
The purpose of this study is the assess the diagnostic performance of magnetic resonance imaging in patients with suspected myocarditis by applying different imaging sequences at different MR scanners
- Trial name
- MyoRacer (NCT02177630)
- Testing
- Endomyocardial Biopsy
- Where
- Germany
- Volunteers
- 129 people
- Sponsor
- Heart Center Leipzig - University Hospital
Cardiopulmonary Bypass, Cardiac Surgery Associated - Acute Kidney Injury
Increased Adsorption Membranes During Cardiopulmonary Bypass
Our project intends to reduce cardiac surgery associated - acute kidney injury (CSA-AKI) in non emergent patients with the use of an increased adsorption membrane (oXiris®) connected to the cardiopulmonary bypass (CPB) circuit…
- Conditions
- Cardiopulmonary Bypass, Cardiac Surgery Associated - Acute Kidney Injury, Systemic Inflammatory Response Syndrome, Acute Kidney Injury
- Trial name
- NCT02518087
- Testing
- oXiris®
- Where
- 3 sites in Spain
- Volunteers
- 340 people
- Sponsor
- Hospital Universitari de Bellvitge
Acute Myocardial Infarction
Sweat Analysis as Prognosticator After Heart Attack
This study characterizes non-invasive body inflammation response in sweat and blood of patients suffering from acute myocardial infarction and explores the potential of non-invasive sweat analysis a an innovative approach for…
- Trial name
- SWEATHEART (NCT05843006)
- Testing
- Examination and analysis of sweat and blood samples at baseline and at follow up, Examination and analysis of sweat and blood samples at baseline
- Where
- Sweden
- Volunteers
- 24 people
- Sponsor
- Region Örebro County
Coronary Disease, Heart Valve Diseases
CTI-01 (Ethyl Pyruvate) Safety and Complication Prevention in Cardiac Surgery Patients on Cardiopulmonary Bypass (CPB)
Over 500,000 patients undergo cardiac surgery with CPB in the United States annually. Although mortality rates have decreased with advances in perioperative care, many patients are affected by postoperative organ dysfunction.
- Trial name
- NCT00107666
- Testing
- CTI-01 (ethyl pyruvate)
- Where
- 17 sites in United States
- Volunteers
- 150 people
- Sponsor
- Critical Therapeutics
Atrial Fibrillation, Biomarker
The Application of Biomarkers in the Care of Patients With Atrial Fibrillation
From 2020 to 2023, we established a longitudinal AF patient cohort with comprehensive clinical data collection. In our previous work, we utilized the Milliplex platform to screen 52 circulating biomarkers and identified several…
- Trial name
- NCT07565337
- Where
- Taiwan
- Sponsor
- National Taiwan University Hospital