Clinical trials: Cardiac Inflammation
Heart Transplant, Periodontitis
Effect of Non-Surgical Periodontal Therapy on Inflammation in Heart Transplant Recipients
Heart transplant recipients frequently exhibit chronic low-grade systemic inflammation, which can contribute to allograft dysfunction and cardiovascular complications.
- Conditions
- Heart Transplant, Periodontitis, Gingivitis, Systemic Inflammation
- Trial name
- NCT07791927
- Testing
- Full-mouth periodontal debridement
- Volunteers
- 20 people
- Sponsor
- Baskent University
Sepsis, Respiratory Failure
Use of Lactate-to-Albumin, CRP-to-Albumin, and Procalcitonin-to-Albumin Ratios to Predict Mortality in ICU Patients
This observational study aims to determine whether three blood test ratios - lactate-to-albumin, CRP-to-albumin, and procalcitonin-to-albumin - can predict in-hospital mortality among critically ill adults.
- Conditions
- Sepsis, Respiratory Failure, Cardiac Arrest, Circulatory Failure
- Trial name
- LAR-CAR-PAR (NCT07242027)
- Where
- Poland
- Volunteers
- 212 people
- Sponsor
- Medical University of Silesia
Heart Failure
A Pharmacogenomic Study of Candesartan in Heart Failure
The purpose of this study is to evaluate the impact of genetic variations on the response to candesartan in patients with heart failure who are already treated with an ACE inhibitor.
- Trial name
- NCT00400582
- Testing
- Candesartan up to 32 mg daily
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- Montreal Heart Institute
Sepsis, Need of Cardiac Surgery
International Registry on the Use of the CytoSorb Adsorber
Registry on the use of the CytoSorb® adsorber in ICU patients.
- Trial name
- CytoSorb (NCT02312024)
- Testing
- Use of CytoSorb adsorber
- Where
- 19 sites in Austria, Germany and 1 more
- Volunteers
- 1,434 people
- Sponsor
- Jena University Hospital
Sepsis, Asthma
Evaluation of Essential Surgical Skills-Emergency Maternal and Child Health Training
The aim of the proposed study is to determine if specific training in management of general, obstetric, neonatal and pediatric emergencies results in a change in practice of doctors working in emergency departments of public…
- Conditions
- Sepsis, Asthma, Heart Failure, Seizure
- Trial name
- NCT00880204
- Testing
- ESS-EMCH training
- Where
- 2 sites in Pakistan
- Volunteers
- 36 people
- Sponsor
- Child Advocacy International
Systemic Inflammatory Response Syndrome (SIRS), Leukocyte Disorders
Effects of Cardiopulmonary Bypass (CPB)-Leukocyte Filtration on Interleukins Serum Levels and Pulmonary Function
To test the hypothesis that leukocyte filtering during cardiopulmonary bypass (CPB) might reduce the inflammatory response and protect the lungs against the acute injury
- Conditions
- Systemic Inflammatory Response Syndrome (SIRS), Leukocyte Disorders, Complications Due to Coronary Artery Bypass Graft
- Trial name
- PulmFunction (NCT01469676)
- Testing
- Filtering group LG-6, Pall Biomedical Products
- Volunteers
- 22 people
- Sponsor
- University of Sao Paulo
Acute Respiratory Distress Syndrome, Sepsis
Cardiovascular Magnetic Resonance Prognosticators in Pediatric Oncology Patients With Sepsis
The overall purpose of this protocol is to identify subacute sepsis-associated cardiac disease in pediatric patients with cancer by CMR and evaluate the CMR findings during their follow-up.
- Conditions
- Acute Respiratory Distress Syndrome, Sepsis, Cardiovascular Shock
- Trial name
- NCT05930418
- Testing
- Cardiac MRI
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- St. Jude Children's Research Hospital
Fabry Disease
Effect of Agalsidase Alfa on Cardiac Inflammation in Patients With Fabry Disease: A [18F]-FDG PET-CMR Study
This is a prospective observational study. All patients will initiate and maintain treatment with agalsidase alfa during the study period.
- Trial name
- NCT07235709
- Where
- South Korea
- Volunteers
- 25 people
- Sponsor
- Yonsei University
Coronary Disease With Diabetes Mellitus
Effects of SGLT2 Inhibitor in Diabetic Patients With Coronary Artery Disease
The aim of this study is to explore the effect of newly added SGLT2I medication or placebo, to standard medication regimen in diabetic patients with documented stable coronary disease.
- Trial name
- NCT03398577
- Testing
- Dapagliflozin 10 MG [Farxiga]
- Where
- Israel
- Volunteers
- 61 people
- Sponsor
- Sheba Medical Center
Coronary Artery Disease, Atherosclerosis, Coronary
HIV Infection And Evolvement of Atherosclerotic Plaque
In a prospective multi-center observational study, 200 HIV-infected patients treated with antiretroviral treatment (ART) and who suffered from coronary artery disease (CAD) will be enrolled.
- Conditions
- Coronary Artery Disease, Atherosclerosis, Coronary, Hiv, HIV Infections
- Trial name
- HIVE (NCT04810364)
- Testing
- Quantitative coronary angiography, intravascular imaging with percutaneous intervention
- Where
- 2 sites in Russia
- Volunteers
- 1,000 people
- Sponsor
- Central Clinical Hospital of the Russian Academy of Sciences
HIV/AIDS, Myocardial Infarction
Inflammation and Cardiovascular Health in Women
Systemic immune activation and inflammation are believed to play a significant role in the development and clinical course of myocardial infarction (MI).
- Trial name
- NCT04224181
- Testing
- Cardiac PET, 99mTc-tilmanocept SPECT/CT, Contrast Enhanced Coronary and Aortic Computed Tomography Angiography
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Heart Surgery
Macrophage Migration Inhibitory Factor (MIF)- Cardiac Surgery
It has been repeatedly demonstrated that cardiac surgery with the use of extracorporeal circulation elicits a systemic inflammatory response and provokes ischemia-reperfusion related oxidative stress which could further lead to…
- Trial name
- NCT01267721
- Testing
- Blood sampling
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- RWTH Aachen University
Colchicine, Diabetes Mellitus, Type 2
Dose-finding Study of Colchicine in Type 2 Diabetic Patients With Coronary Artery Disease
This study is designed to investigate dose-dependent effects of low dose colchicine on inflammatory responses, endothelial function in type 2 diabetic patients with coronary artery disease and leukocyte activation.
- Conditions
- Colchicine, Diabetes Mellitus, Type 2, Coronary Artery Disease, White Blood Cell
- Trial name
- DRC-04 (NCT03376698)
- Testing
- Colchicine 0.5 mg, Colchicine 0.25 mg
- Where
- 5 sites in Japan
- Volunteers
- 54 people
- Sponsor
- University of the Ryukyus
Altered Mental Status, Sepsis
Pre-hospital Ventilation Clinical Study
This study will collect and characterize ventilator use during patient care with a ZOLL 731 Series ventilator in a pre-hospital setting.
- Conditions
- Altered Mental Status, Sepsis, Heart Failure, Hemorrhage
- Trial name
- NCT05604430
- Testing
- 731 Series Ventilator
- Where
- 5 sites in United States
- Volunteers
- 500 people
- Sponsor
- Zoll Medical Corporation
Postoperative Complications, Cardiovascular Complication
Perioperative Inflammatory Response Assessment in High-risk Patients Undergoing Noncardiac Surgery
Postoperative cardiovascular complications are common after noncardiac surgery. The association between perioperative inflammation and the occurrence of cardiovascular complications after surgery is still unknown.
- Conditions
- Postoperative Complications, Cardiovascular Complication, Myocardial Ischemia, Inflammation
- Trial name
- INSIGHT (NCT04753307)
- Testing
- Laboratory measurements
- Where
- Austria
- Volunteers
- 1,400 people
- Sponsor
- Medical University of Vienna
Sepsis, Cardiomyopathies
Adjunctive DobutAmine in sePtic Cardiomyopathy With Tissue Hypoperfusion
Sepsis induces both a systolic and diastolic cardiac dysfunction. The prevalence of this septic cardiomyopathy ranges between 30 and 60% according to the timing of assessment and definition used.
- Conditions
- Sepsis, Cardiomyopathies, Hypoperfusion, Left Ventricular Systolic Dysfunction
- Trial name
- ADAPT (NCT04166331)
- Testing
- Dobutamine
- Where
- 21 sites in France
- Volunteers
- 136 people
- Sponsor
- University Hospital, Limoges
End Stage Kidney Disease, Fibrosis Myocardial
Validating Novel, Non-contrast Cardiac MRI Imaging in Haemodialysis Patients
There are currently no good ways of measuring levels of scarring in the hearts of patients with advanced kidney disease and patients on dialysis, although recent research has shown a new cardiac MRI technique, called native T1…
- Trial name
- CONFIRM (NCT03586518)
- Testing
- Cardiac MRI scan, Echocardiogram, Cardiac explantation
- Where
- United Kingdom
- Volunteers
- 9 people
- Sponsor
- University of Leicester
Systemic Inflammatory Response Syndrome, Coronary Arteriosclerosis
Cleansing of Suction Blood in Cardiac Surgery for Reduced Inflammatory Response
Cardiac surgery using heart and lung machine produces an inflammatory reaction in the body. This leads in few percent of cases to heart, lung, and kidney disturbances that potentially causes death.
- Trial name
- NCT00159926
- Testing
- Cell saver, No cell saver
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Sepsis, Ivabradine
Effect of Heart Rate Control With Ivabradine on Hemodynamic in Patients With Sepsis
Sepsis, a life-threatening syndrome, is often accompanied by tachycardia in spite of adequate volume resuscitation to correct hypovolemia and vasopressor medication to correct hypotension.
- Conditions
- Sepsis, Ivabradine, Hemodynamics, Heart Rate Control
- Trial name
- NCT05882708
- Testing
- Ivabradine
- Where
- 3 sites in China
- Volunteers
- 172 people
- Sponsor
- Second Affiliated Hospital of Guangzhou Medical University
Coronary Heart Disease
Study of the Arachidonate 5-Lipoxygenase Enzyme in Affecting the Risk for Coronary Heart Disease
The purpose of this study is to determine whether a particular substance involved in inflammation, called leukotrienes, is involved in causing heart disease to occur or to progress.
- Trial name
- NCT00379808
- Testing
- montelukast
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Florida