Clinical trials: Cardiac Inflammation
Myocardial Ischaemic Syndrome, Coronary Heart Disease
Protective Effect of PCSK9 Inhibitor Against Negative Inflammatory Response and Organ Dysfunction After Coronary Artery Bypass Grafting (PANDA VIII)
This is a multi-center, randomized controlled study to investigate whether early offering PCSK9 inhibitor can protect against negative inflammatory response and organ dysfunction after coronary artery bypass grafting (CABG).
- Trial name
- PANDA (NCT06730802)
- Testing
- PCSK9 inhibitor, Statin
- Where
- 2 sites in China
- Volunteers
- 400 people
- Sponsor
- Nanjing Medical University
Congential Cardiac Surgery
Study of the Corelation Between Circulating Nuclearsome and SIRS Happened After Congential Cardiac Surgery
In this study，the investigators want to determine the corelation between circulating nuclearsome and the development of SIRS occured after congenital cardiac surgery, including the serverity of organ damage and inflamation.
- Trial name
- NCT02325765
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shanghai Children's Medical Center
Shock, Sepsis
Hemodynamic Evaluation of Preload Responsiveness in Children by Using PiCCO
The purpose of this study is To assess the value of dynamics (SVV, PPV) and static indices (GEDVI, ITBVI, CVP) of preload and its combination with contractility (CI,SV, ventricular power, dP/dtmax, CFI, GEF) and lung water…
- Conditions
- Shock, Sepsis, Systemic Inflammatory Response Syndrome, Low Cardiac Output
- Trial name
- PreloaDren (NCT01157299)
- Where
- 7 sites in Spain
- Volunteers
- 100 people
- Sponsor
- Hospital Universitario La Paz
Systemic Inflammatory Response Syndrome, Cardiac Diseases
Dexamethasone for Cardiac Surgery Trial
This is a multicenter, randomized, double-blind trial, comparing clinical outcomes after the administration of high-dose dexamethasone versus placebo in patients undergoing heart surgery with the use of cardiopulmonary bypass.
- Conditions
- Systemic Inflammatory Response Syndrome, Cardiac Diseases, Postoperative Complications
- Trial name
- NCT00293592
- Testing
- Dexamethasone
- Where
- Netherlands
- Volunteers
- 4,500 people
- Sponsor
- UMC Utrecht
Atrial Fibrillation
Quantification of Endothelial Thrombogenicity in Patients With Atrial Fibrillation
Atrial fibrillation (AF) is the most common cardiac arrhythmia. Because of its major impact on the general morbidity and risk of stroke, AF is a great concern for public health.
- Trial name
- REMI-2 (NCT02756429)
- Testing
- blood samples
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Hospices Civils de Lyon
Myocardial Infarction, Inflammation
IRon Nanoparticle Enhanced MRI in the Assessment of Myocardial infarctioN
Ferumoxytol is an example of a 'smart' magnetic resonance contrast agent that consists of ultrasmall superparamagnetic particles of iron oxide (USPIOs) and is avidly taken up by macrophages.
- Trial name
- IRNMAN (NCT01995799)
- Testing
- Ferumoxytol enhanced MRI
- Where
- 2 sites in United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Edinburgh
Septic Shock
Esmolol Effects on Heart and Inflammation in Septic Shock
Beta adrenergic system, over-activated in septic shock patients, is a key modulator of the inflammatory response. Experimental works demonstrated that Esmolol, an highly selective beta-1 blocker, reduces heart rate and regulates…
- Trial name
- ESMOSEPSIS (NCT02068287)
- Testing
- Esmolol
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Central Hospital, Nancy, France
Paroxysmal Atrial Fibrillation, Persistent Atrial Fibrillation
Inflammatory and Endothelial Function Response, and Arrhythmia Recurrence Following Catheter Ablation for Atrial Fibrillation
Current international guidelines recommend a three-month blanking period after pulmonary vein isolation (PVI) for atrial fibrillation (AF).
- Trial name
- NCT04269785
- Testing
- Cryoballoon ablation, Radiofrequency ablation
- Sponsor
- Karan Saraf
Septic Shock
LANdiolol MIcrocirculatory Effects During Septic chOc (MILANOS)
The objectives of this study are to evaluate the effect of continuous intravenous Landiolol injection (from 0.5 to 10 µg/kg/min during 12 hours ) up to a 15% decrease in Heart Rate (HR) on microcirculatory vascular reactivity vs.
- Trial name
- MILANOS (NCT04931225)
- Testing
- Landiolol
- Where
- France
- Volunteers
- 44 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Inflammation, Coronary Artery Disease
Regional Activation of Leukocytes in Coronary Artery Disease
This study aims to evaluate the role of leukocyte activation in coronary artery disease
- Trial name
- REAL-CAD (NCT02376738)
- Where
- 2 sites in Netherlands
- Volunteers
- 97 people
- Sponsor
- Sint Franciscus Gasthuis
Heart Failure With Normal Ejection Fraction
Neuromodulation to Treat Patients With Heart Failure With Preserved Ejection Fraction
Heart failure with preserved ejection fraction (HFpEF) is a leading cause of mortality in the elderly. Outcomes of patients with HFpEF are poor and so far, no treatment has been shown to decrease morbidity or mortality.
- Trial name
- NCT03327649
- Testing
- low level transcutaneous vagus nerve stimulation
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- University of Oklahoma
Sepsis
Arterial Blood Pressure-complexity in Septic Patients
Arterial blood pressure (ABP) is regulated by multiple, interconnected feedback loops resulting in a variable and complex time course.
- Trial name
- NCT00793078
- Where
- Germany
- Volunteers
- 72 people
- Sponsor
- University Hospital, Bonn
HIV (Human Immunodeficiency Virus)
Stimulant and Polysubstance Use, Inflammation, and Sex Effects on Myocardial Disease in HIV
This observational research study is studying how substance use impacts scarring and inflammation of the heart. This study involves one study visit for a cardiac MRI.
- Trial name
- SPISE (NCT07461350)
- Where
- 4 sites in United States
- Volunteers
- 400 people
- Sponsor
- University of California, San Francisco
Febrile Neutropenia, Endocarditis
Diagnosis of Septicaemia by Detection of Microbial DNA in Blood in Severe Infections
The primary purpose is to improve and quicken the microbial diagnosis in severe infections, since only one third of the cases are documented by blood cultures and adequate anti-infective therapy in the 48 hours reduced mortality…
- Conditions
- Febrile Neutropenia, Endocarditis, Severe Sepsis
- Trial name
- EVAMICA (NCT00709358)
- Testing
- Detection of microbial DNA in blood by SeptiFast®, detection of microbial DNA in blood by blood culture
- Where
- France
- Volunteers
- 2,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Endocarditis, Bacteremia
Efficacy and Safety of Dalbavancin Compared to Standard of Care Antibiotic Therapy for the Completion of Treatment of Patients With Complicated Bacteremia or Infective Endocarditis
This study will compare dalbavancin to standard of care (SOC) antibiotic therapy for the completion of therapy in patients with complicated bacteremia or infective endocarditis.
- Trial name
- NCT03148756
- Testing
- Dalbavancin, Standard of Care
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- AbbVie
Septic Shock, Sepsis
Effects of Anisodamine on Sublingual Microcirculation and Vascular Waterfall Phenomenon in Patients With Septic Shock
This prospective, multicenter, single-arm, open-label interventional pilot study aims to evaluate the short-term physiological effects of intravenous anisodamine on sublingual microcirculation and vascular-waterfall parameters in…
- Conditions
- Septic Shock, Sepsis, Critical Illness
- Trial name
- ANISO-MICRO (NCT07657702)
- Testing
- Anisodamine intravenous infusion
- Where
- China
- Volunteers
- 20 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Atrial Fibrillation, Inflammation
Markers of Oxidative Stress Present in Blood in Patients With Atrial Fibrillation
Atrial fibrillation is an abnormal heart beat that starts in the upper parts of the heart and can cause stroke or death, if untreated.
- Conditions
- Atrial Fibrillation, Inflammation, Atrial Flutter
- Trial name
- NCT00142194
- Where
- 2 sites in United States
- Volunteers
- 47 people
- Sponsor
- Emory University
Coronary Artery Disease, Overweight
Targeting Inflammation Using Salsalate in CardioVascular Disease
The hypothesis is that western lifestyle, with sedentary behaviors and caloric excess promote a chronic, subacute inflammatory state that participates in the development and progression of atherosclerosis.
- Trial name
- TINSAL-CVD (NCT00624923)
- Testing
- Salsalate
- Where
- 5 sites in United States
- Volunteers
- 340 people
- Sponsor
- Joslin Diabetes Center
Coronary Artery Disease
Effects of DES Platforms on Markers of Endothelial Damage and Inflammation
Percutaneous coronary intervention (PCI) with stenting may induce endothelial damage/dysfunction and inflammatory reactions, which in turn delay healing and endothelialization and may lead to restenosis and atherosclerosis within…
- Trial name
- PLATFORM (NCT01489202)
- Testing
- platinum chromium everolimus-eluting stent, cobalt chromium everolimus-eluting stent
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- University of Roma La Sapienza
Heart; Dysfunction Postoperative, Cardiac Surgery, Cytokine Release Syndrome
Study of the Clinical Scoring System and Cytokines for Prediction of Inflammatory Response in Major Surgery
Cardiac surgery with cardiopulmonary bypass (CPB) and hepatic surgery are major operations, associated with a systemic inflammatory response syndrome.
- Trial name
- NCT01353157
- Where
- Thailand
- Volunteers
- 20 people
- Sponsor
- Khon Kaen University