Clinical trials: Cardiac Inflammation
Coronary Artery Disease, Metabolic Syndrome
Super-Rehab: Can we Achieve Coronary Artery Disease Regression?
The Super Rehab: Can we Achieve Coronary Artery Disease Regression? (a feasibility study) proposes to test the use of a novel lifestyle intervention (Super Rehab), in addition to standard care, for patients with both coronary…
- Trial name
- NCT05563584
- Testing
- Super Rehab
- Where
- United Kingdom
- Volunteers
- 31 people
- Sponsor
- Royal United Hospitals Bath NHS Foundation Trust
Chronic Heart Failure
Efficacy and Safety of Allogeneic Mesenchymal Precursor Cells (Rexlemestrocel-L) for the Treatment of Heart Failure
The primary objective of this study is to determine whether transendocardial delivery of allogeneic human bone marrow-derived mesenchymal precursor cells (MPCs [rexlemestrocel-L]) is effective in the treatment of chronic heart…
- Trial name
- DREAM HF-1 (NCT02032004)
- Testing
- Rexlemestrocel-L
- Where
- 59 sites in United States, Canada
- Volunteers
- 565 people
- Sponsor
- Mesoblast, Inc.
Sepsis, Septic Cardiomyopathy
Identification of Cardiovascular and Molecular Prognostic Factors for the Mid- and Long-term Outcome of Sepsis
Sepsis is a life-threatening condition which can affect people of any age. An infection triggers a host response resulting in organ failure.
- Conditions
- Sepsis, Septic Cardiomyopathy, Cardiomyopathies
- Trial name
- ICROS (NCT03620409)
- Where
- Germany
- Volunteers
- 308 people, healthy volunteers welcome
- Sponsor
- Jena University Hospital
Postoperative Cardiorespiratory Failure
Hypertonic Saline-hetastarch in Cardiac Surgery
Cardiopulmonary bypass(CPB) is associated with increased fluid extravasation and edema formation. A continuous infusion of a mixture of hypertonic saline/hydroxyethyl starch (HSH)during CPB reduced fluid extravasation and total…
- Trial name
- HH (NCT00469716)
- Testing
- Hypertonic saline (7.2%) hetastarch (6 %)(200/0.5)
- Where
- Norway
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
ST-elevation Myocardial Infarction (STEMI), In-stent Restenosis
Functional Milk Supplementation to Reduce In-Stent Restenosis in STEMI Patients (SMASOEA Trial)
This randomized, double-blind, controlled clinical trial will evaluate the effects of daily supplementation with functionalized bovine milk, enriched with bioactive peptides and optimized lipid profile, on coronary in-stent…
- Trial name
- SMASOEA (NCT07176104)
- Testing
- Functional Bovine Milk, Non-Functional Bovine Milk
- Where
- Italy
- Volunteers
- 140 people
- Sponsor
- Raffaele Marfella
Atherosclerosis of Artery, Coronary Artery Disease
Effects of aSPIrin Versus Aspirin Plus Low-dose RIvaroxaban on Carotid aTherosclerotic Plaque Inflammation
Primary Study Objective : To compare the effects of low-dose rivaroxaban plus aspirin versus aspirin on atherosclerotic plaque inflammation using serial FDG Positron Emission Tomography/Computed Tomography(PET-CT) imaging of…
- Conditions
- Atherosclerosis of Artery, Coronary Artery Disease, Peripheral Arterial Disease, Carotid Stenosis
- Trial name
- SPIRIT (NCT05797376)
- Testing
- Rivaroxaban 2.5mg
- Where
- South Korea
- Volunteers
- 92 people
- Sponsor
- Asan Medical Center
Stress
The Effect of Massage Therapy to Control Night Shift Related Stress
Background: The sympathetic and parasympathetic branches (SNS and PNS) of the autonomic nervous system (ANS), keep our body in a state of balance, which can be disturbed in situations of uncontrolled stress.
- Trial name
- NCT02247089
- Testing
- Massage Therapy, Journal reading (No massage therapy)
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Inflammation, Cardiac Surgical Procedures
Inflammatory Responses to Lipid Emulsions in Children Before and After Open Heart Surgery
This study is a blinded, randomized, controlled prospective trial comparing immune response (sepsis, inflammatory response, pulmonary vasoconstriction) in 2 groups of infants less than 3-month old receiving pre and post…
- Trial name
- NCT00336908
- Testing
- a combination of MCT, LCT , and Fish Oil
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- University of Alberta
Myocardial Infarction, Myocardial Injury
Lymphatic Organs and Myocardium After Myocardial Infarction
The adaptive immune response plays an important role in myocardial healing and remodeling after acute myocardial infarction in patients. Therefore, the involved lymphocytes represent a novel target for therapeutic interventions.
- Conditions
- Myocardial Infarction, Myocardial Injury, Myocardial Inflammation
- Trial name
- LOMI (NCT05519735)
- Testing
- Multimodality Imaging
- Where
- 2 sites in Germany
- Volunteers
- 57 people
- Sponsor
- Wuerzburg University Hospital
POSTOPERATIVE DELIRIUM AND POSTOPERATIVE COGNITIVE DECLINE, Heart Rate Variability
Predicting Postoperative Delirium With Heart Rate Variability Obtained by Analgesia Nociception Index
The aim of this pilot study is to establish a correlation between perioperative heart rate variability (HRV) as an expression of the shift in the balance of the autonomic nervous system and the occurrence of postoperative…
- Conditions
- POSTOPERATIVE DELIRIUM AND POSTOPERATIVE COGNITIVE DECLINE, Heart Rate Variability, Biomarkers
- Trial name
- DANI (NCT06709482)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Medical University Innsbruck
Human Immunodeficiency Virus (HIV), Vitamin D Deficiency
Study of Vitamin D and Effect on Heart Disease and Insulin Resistance
The purpose of this study is to evaluate how Vitamin D affects endothelial function, inflammation, lipids, insulin resistance, vitamin D levels, and parathyroid hormone (PTH).
- Conditions
- Human Immunodeficiency Virus (HIV), Vitamin D Deficiency, HIV Infections
- Trial name
- NCT01093417
- Testing
- Vitamin D
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University Hospitals Cleveland Medical Center
Neutrophil Lymphocyte Ratio, Serum Createnine
Does Preconditioning Affects Other Organs in Patients Undergoing Open Heart Surgery ?
An association between white blood cell count (WBC), neutrophil-lymphocyte ratio , and inflammatory process is well known . Ischemic preconditioning reduces the inflammation
- Conditions
- Neutrophil Lymphocyte Ratio, Serum Createnine, Mechanical Ventilation
- Trial name
- NCT03097692
- Testing
- ischemic preconditioning, Pharmacologic preconditionig
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Acute Decompensated Heart Failure
Low Level Tragus Stimulation in Acute Decompensated Heart Failure
Acute Decompensated Heart Failure (ADHF) is a major cause of morbidity and mortality. It is associated with increased systemic inflammation.
- Trial name
- TREAT-HF (NCT02898181)
- Testing
- Neuromodulation
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Oklahoma
Cardiovascular Diseases, Hypertension
Biochemical and Genetic Markers of Hypertension in Women
To investigate biochemical and genetic markers of inflammation and endothelial dysfunction as determinants of hypertension.
- Conditions
- Cardiovascular Diseases, Hypertension, Heart Diseases, Inflammation
- Trial name
- NCT00090467
- Volunteers
- 1,600 people
- Sponsor
- Brigham and Women's Hospital
Inflammatory Response
Removal Of CytoKines With cytoSorbenTs After Inflammatory Response Reaction During Cardiac Surgery
Detailed knowledge about the association between systemic inflammation and endothelial progenitor cell (EPCs) activation during extracorporeal circulation (ECC) is lacking.
- Trial name
- ROCKSTAR (NCT06286280)
- Testing
- cytokine adsorber (CytoSorb®)
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- University of Giessen
Cardiovascular Diseases, Atherosclerosis
Inflammation Genomics and Atherosclerosis - Ancillary to CARDIA
To examine the associations of common variation in inflammation/thrombosis genes with intermediate quantitative phenotypes and subclinical coronary atherosclerosis in the Coronary Artery Risk Factor Development in Young Adults…
- Conditions
- Cardiovascular Diseases, Atherosclerosis, Coronary Arteriosclerosis, Inflammation
- Trial name
- NCT00046605
- Volunteers
- 3,600 people
- Sponsor
- University of Washington
Cardiovascular Diseases, Coronary Disease
Genetic Markers of CHD Risk in Men and Women
To investigate the association of selected genetic markers of inflammation and endothelial activation with the occurrence of non-fatal acute myocardial infarction (MI).
- Conditions
- Cardiovascular Diseases, Coronary Disease, Heart Diseases, Myocardial Infarction
- Trial name
- NCT00090454
- Sponsor
- State University of New York at Buffalo
Atrial Fibrillation, Inflammation
Impact of Inflammatory Indexes and Gene Scores in Prediction of Atrial Fibrillation
Because of the high recurrence rates following electrical cardioversion and high morbidity in AF patients there is a need to explore prediction models for AF recurrence following ECV.
- Conditions
- Atrial Fibrillation, Inflammation, Genetic Predisposition to Disease
- Trial name
- IERV (NCT06399666)
- Testing
- Blood sampling
- Where
- 2 sites in Sweden
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- Vrinnevi Hospital
Heart Failure, Diastolic, Coronary Artery Disease
Assessment of Functional Capacity and Inflammatory Markers in Women With Heart Failure With Preserved Ejection Fraction
This study assesses the impact of diastolic heart failure on exercise capacity in women who have a previous coronary condition. All the participants will go through the same evaluation.
- Conditions
- Heart Failure, Diastolic, Coronary Artery Disease, Inflammation
- Trial name
- NCT02649400
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Federal University of São Paulo
Heart Failure With Preserved Ejection Fraction
EXercise and Activin Inhibition to Modulate InflammatioN Effects on Heart Failure and Cognition (EXAMINE-HFC)
The goal of this clinical trial is to learn if therapy with activin ligand-trap biological therapy (an investigational drug) combined with exercise training can improve exercise capacity and cognitive function in heart failure…
- Trial name
- EXAMINE-HFC (NCT07202000)
- Testing
- Activin ligand-trap biological therapy
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Massachusetts General Hospital