Clinical trials: Cardiac Inflammation
Coronary Artery Disease, Acute Coronary Syndrome
PET/CT for the Quantification of Atherosclerotic Plaque Inflammation
This is a single-centre prospective trial with 140 patients employing [18F]-fluorodeoxyglucose positron emission computed tomography (FDG PET/CT) and advance motion correction and image fusion algorithms to create motion frozen…
- Trial name
- QAEK (NCT01553513)
- Testing
- [18F]-FDG positron emission computed tomography, Invasive coronary angiography, Intravascular ultrasound and virtual histology
- Where
- Germany
- Volunteers
- 140 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Amyloid Cardiomyopathy
Genistein in trAnSthyretin recePtor Amyloid caRdiomyopathy
This Phase 1b/2a study aims to investigate the safety and efficacy of genistein in patients with Transthyretin (TTR) Amyloidosis.
- Trial name
- GASPAR (NCT06634108)
- Testing
- Genistein
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Coronary Disease With Diabetes Mellitus
Effects of SGLT2 Inhibitor in Diabetic Patients With Coronary Artery Disease
The aim of this study is to explore the effect of newly added SGLT2I medication or placebo, to standard medication regimen in diabetic patients with documented stable coronary disease.
- Trial name
- NCT03398577
- Testing
- Dapagliflozin 10 MG [Farxiga]
- Where
- Israel
- Volunteers
- 61 people
- Sponsor
- Sheba Medical Center
ST Elevation Myocardial Infarction, Inflammatory Response
Pulse Glucocorticoid Therapy in Patients With ST-Segment Elevation Myocardial Infarction
The overall primary objective of the PULSE-MI trial is to test the hypothesis that administration of single-dose glucocorticoid pulse therapy in the pre-hospital setting reduces final infarct size in patients with ST-segment…
- Conditions
- ST Elevation Myocardial Infarction, Inflammatory Response, Myocardial Reperfusion Injury, Myocardial Injury
- Trial name
- PULSE-MI (NCT05462730)
- Testing
- Methylprednisolone, Isotonic saline
- Where
- Denmark
- Volunteers
- 530 people
- Sponsor
- Thomas Engstrom
Acute Myocardial Infarction, Sudden Cardiac Death
Risk Indicators in Patients With Ventricular Fibrillation During Acute Myocardial Infarction
Sudden cardiac death is in most cases triggered by ischemia-related ventricular tachyarrhythmias and accounts for 50% of deaths from cardiovascular disease in developed countries.
- Trial name
- NCT00175942
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- Heidelberg University
Left Ventricular Systolic Dysfunction, Septic Shock
Simplified Assessment of Left Ventricular Systolic Function in Septic Shock Patients
The assessment of left ventricular systolic function is based on the measurement of left ventricular ejection function (LVEF) by the Simpson biplane method.
- Trial name
- MAPSE (NCT04963686)
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Heart Failure
Micronutrient Supplementation in Patients With Heart Failure
There is some evidence to suggest that patients with heart failure may have a reduced dietary intake of vitamins and essential minerals (micronutrients) and that this may worsen the function of the heart.
- Trial name
- MINT-HF (NCT01005303)
- Testing
- Forceval plus 50 micrograms Vitamin D3
- Where
- United Kingdom
- Volunteers
- 79 people
- Sponsor
- Belfast Health and Social Care Trust
Metabolic Diseases, Endocrine System Diseases
Effect of Fish Oil (Omega-3 Fatty Acids) on Arteries
The overall objective of LUCHAR Specific Aims 4.1 and 4.2 is to assess the additional contribution of cardiovascular disease (CVD) risk markers to traditional biomedical risk factors in the prediction of pre-clinical CVD.
- Conditions
- Metabolic Diseases, Endocrine System Diseases, Heart Disease, Vascular Diseases
- Trial name
- NCT00935766
- Testing
- Omega-3
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Denver Health and Hospital Authority
ACS (Acute Coronary Syndrome), Myocardial Infarction (MI)
TIRANA-ACS: A Prospective Registry Study for the Targeted Investigation of Residual Inflammation After Non-ST/ ST Elevation Acute Coronary Syndrome
This prospective observational study aims to evaluate the prognostic significance of the neutrophil-to-lymphocyte ratio (NLR) as a predictor of mortality in patients following an episode of Acute Coronary Syndrome (ACS).
- Conditions
- ACS (Acute Coronary Syndrome), Myocardial Infarction (MI), Myocardial Inflammation, Inflammation Biomarkers
- Trial name
- TIRANA (ACS) (NCT07026708)
- Where
- Albania
- Volunteers
- 1,600 people
- Sponsor
- University Hospital Centre Mother Teresa
Inflammation
The Prognosis of Patients After PCI：a Multi-center Study in China
Coronary artery disease (CAD) is caused by myocardial ischemia, hypoxia or necrosis due to coronary artery stenosis, spasm or obstruction.
- Trial name
- NCT05614050
- Where
- China
- Volunteers
- 2,400 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Coronary Artery Disease
Uric Acid Levels and Endothelial Functions
Uric acid is a risk factor for coronary artery disease (CED) in postmenopausal women but the association with inflammation and coronary microvascular endothelial dysfunction is not well-defined.
- Trial name
- NCT02862522
- Testing
- Questionnaire of overall health
- Where
- United States
- Volunteers
- 229 people
- Sponsor
- Mayo Clinic
Coronary Artery Disease
Coronary Artery Disease: a Case- Control Study
Atherosclerosis is a chronic inflammatory condition, which is associated by the involvement of several pathological events, and alteration in the serum levels of pro- and anti-inflammatory, and lipid markers.
- Trial name
- NCT03075566
- Testing
- Healthy subjects, Patients
- Where
- Tunisia
- Volunteers
- 517 people, healthy volunteers welcome
- Sponsor
- Nadia Bouzidi, PhD
Septic Shock, Sepsis
Effects of Dexmedetomidine on Sublingual Microcirculation and Vascular Waterfall Phenomenon in Patients With Septic Shock
This prospective, multicenter, single-arm, open-label interventional pilot study aims to evaluate the short-term physiological effects of intravenous dexmedetomidine on sublingual microcirculation and vascular-waterfall…
- Conditions
- Septic Shock, Sepsis, Critical Illness
- Trial name
- DEX-MICRO (NCT07657715)
- Testing
- Dexmedetomidine Intravenous Infusion
- Where
- 2 sites in China
- Volunteers
- 20 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Type2 Diabetes, Heart Failure
Impact of a Short-term Treatment With Canagliflozin (Canacardia-HF)
It is a mechanistic proof-of-concept study to demonstrate how SGLT-2 inhibitors (Canagliflozin) may have a beneficial role on cardiac energetic efficiency.
- Trial name
- Canacardia (NCT03298009)
- Testing
- Canagliflozin 100mg, PET imaging
- Sponsor
- Université de Sherbrooke
Coronary Artery Disease, Acute Coronary Syndrome
Colchicine in Percutaneous Coronary Intervention
Inflammation in the arteries of the heart may increase the risk of cardiac death. The proposed research seeks to identify the potential beneficial role of a safe anti-inflammatory medication, colchicine, on reducing damage caused…
- Trial name
- Colchicine-PCI (NCT02594111)
- Where
- United States
- Volunteers
- 714 people
- Sponsor
- VA Office of Research and Development
Dementia, Inflammation
Anthocyanins as Dementia Prevention?
The aim of this project is to study the safety and efficacy of anthocyanins in improving key dementia-related mechanisms and cognitive functioning in older people at risk for dementia.
- Conditions
- Dementia, Inflammation, Mild Cognitive Impairment, Coronary Artery Disease
- Trial name
- ACID (NCT03419039)
- Testing
- Anthocyanins
- Where
- Norway
- Volunteers
- 212 people
- Sponsor
- Helse Stavanger HF
HIV Infection, Inflammation
Impact of Mediterranean Diet in Cardiovascular Risk Among People With HIV
This study (VIHMET) aims to explore how dietary changes, specifically the adoption of a Mediterranean diet, can improve health outcomes in people living with HIV (PLWH) who are on antiretroviral therapy (ART).
- Conditions
- HIV Infection, Inflammation, Cardiovascular Risk, Mediterranean Diet
- Trial name
- VIHMED (NCT06757309)
- Testing
- Mediterranean Diet
- Where
- Spain
- Volunteers
- 64 people
- Sponsor
- Parc de Salut Mar
Acute Coronary Syndrome
Inflammation Reduction by TREhalose AdminisTration
Arterial wall inflammation has been consistently suggested to serve a causal role in promoting atherosclerosis and predisposing to hard cardiovascular outcomes.
- Trial name
- IR-TREAT (NCT03700424)
- Testing
- Trehalose, Normal saline
- Where
- Iran
- Volunteers
- 15 people
- Sponsor
- Mashhad University of Medical Sciences
Cardiac Surgery Under Extra Corporeal Circulation
Immune Responses and Pulmonary Complications After Cardiac Surgery With Cardiopulmonary Bypass
Cardiac surgery under cardiopulmonary bypass (CPB) is associated with a high incidence of postoperative pulmonary complications (PPCs; 10% to 30% incidence).
- Trial name
- IIRIS (NCT07865533)
- Testing
- Blood sample collection, Bronchoalveolar lavage fluid collection
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Septic Shock and Use of Vasopressin
Effect of Adding Vasopressin on Cardiac Output, Blood Pressure, Diuresis, and Tissue Perfusion Indices in Patients With Septic Shock
In patients with septic shock, vasopressin is increasingly used in combination with norepinephrine, but its timing of initiation remains heterogeneous and its clinical hemodynamic effects are still insufficiently characterized.
- Trial name
- VASO-PHENO (NCT07697144)
- Where
- 8 sites in France
- Volunteers
- 200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris