Clinical trials: Cardiac Inflammation
Coronary Artery Disease
Myocardial and Arterial Phenotype of Coronary Artery Disease
The CAD-MAP (Myocardial and Arterial Phenotype of Coronary Artery Disease) registry is initiated with the goal to describe the cardiac imaging map including epicardial coronary artery, coronary microcirculation and myocardium…
- Trial name
- CAD-MAP (NCT06202300)
- Testing
- Inflammation burden
- Where
- 2 sites in China
- Volunteers
- 5,000 people
- Sponsor
- Beijing Anzhen Hospital
Inflammation Plaque, Atherosclerotic, Coronary Disease
Comparison of Fimasartan Versus Amlodipine Therapy on Carotid PlaquE Inflammation
The purpose of this study is to evaluate the effects of angiotensin receptor 1 blocker versus calcium channel blocker on atherosclerotic plaque inflammation using serial FDG PET/CT imaging of carotid artery.
- Conditions
- Inflammation Plaque, Atherosclerotic, Coronary Disease, Renin-Angiotensin System
- Trial name
- FACE (NCT02378064)
- Testing
- 6-month treatment
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- CHEOL WHAN LEE, M.D., Ph.D
Coronary Artery Disease, Diabetes Mellitus, Type 2
PIPAF Platelets in the Pathogenesis of Ageing Associated Frailty
This is a prospective observational study aimed at testing the existence of an association between frailty, inflammatory status, and degree of platelet activation and reactivity in elderly subjects with type 2 diabetes or…
- Conditions
- Coronary Artery Disease, Diabetes Mellitus, Type 2, Alzheimer Disease
- Trial name
- PIPAF (NCT05798637)
- Testing
- Standard of care
- Where
- 2 sites in Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera di Perugia
Acute Kidney Injury, Cardiac Surgery
Prediction of Acute Kidney Injury After Cardiac Surgery With Cardiopulmonary Bypass
Acute kidney injury (AKI) is a common and serious complication following cardiac surgery performed under cardiopulmonary bypass and is associated with increased morbidity, mortality, and prolonged hospital stay.
- Conditions
- Acute Kidney Injury, Cardiac Surgery, Cardiopulmonary Bypass Surgery, Cardiac Surgery Associated - Acute Kidney Injury
- Trial name
- AKI-CPB (NCT07343830)
- Where
- Turkey (Türkiye)
- Volunteers
- 455 people
- Sponsor
- Ataturk University
Heart Failure, Systemic Inflammation
A Research Study Looking Into How Ziltivekimab Works Compared to Placebo in Participants With Heart Failure and Inflammation
The study is being done to see if ziltivekimab can be used to treat participants living with heart failure and inflammation. Participants will either get ziltivekimab (active medicine) or placebo (inactive substance that looks…
- Trial name
- ATHENA (NCT06200207)
- Testing
- Ziltivekimab
- Where
- 217 sites in United States, Argentina and 14 more
- Volunteers
- 673 people
- Sponsor
- Novo Nordisk A/S
Heart Diseases, Diabetes
Fast Food Study: Assessment of the Effects of Fast-Food on Inflammatory Markers
The purpose of this research study is to determine whether eating a fast food meal (high in saturated fat) will result in greater increases in inflammatory markers than eating a meal with low levels of saturated fat and higher…
- Conditions
- Heart Diseases, Diabetes, Obesity
- Trial name
- NCT00233311
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Septic Shock, Sepsis
Sepsis in the ICU-II
Sepsis-induced cardiac dysfunction (SIMD) is a well-known phenomenon yet its diagnosis remains elusive with no accepted definition, or defining pathophysiological mechanism associated with this disease.
- Conditions
- Septic Shock, Sepsis, Cardiomyopathies, Organ Failure, Multiple
- Trial name
- NCT04695119
- Testing
- Exposure is septic shock (defined according to Sepsis-III) and standard treatment according to departmental protocols.
- Where
- 4 sites in France, Sweden
- Volunteers
- 379 people
- Sponsor
- Linkoeping University
Diastolic Dysfunction, Septic Shock
Diastolic Dysfunction in Septic Shock and Cardiomyopathy Genetic Variants
Sepsis is a life-threatening infection with increasing incidence, and its spectrum of disease can involve cardiac dysfunction, which further adds to mortality.
- Conditions
- Diastolic Dysfunction, Septic Shock, Cardiomyopathies
- Trial name
- SepticHeartG (NCT05552521)
- Testing
- Echocardiography
- Where
- Portugal
- Volunteers
- 100 people
- Sponsor
- Hospital Garcia de Orta
Systemic Inflammatory Response Syndrome, Coronary Arteriosclerosis
Cleansing of Suction Blood in Cardiac Surgery for Reduced Inflammatory Response
Cardiac surgery using heart and lung machine produces an inflammatory reaction in the body. This leads in few percent of cases to heart, lung, and kidney disturbances that potentially causes death.
- Trial name
- NCT00159926
- Testing
- Cell saver, No cell saver
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Heart Failure
A Pilot Study of Probiotic Saccharomyces Boulardii Use in Chronic Heart Failure Patients. Estudo PROICA
The purpose of this study is to evaluate the feasibility, safety and effects in inflammatory response of the therapy with a probiotic agent, the yeast Saccharomyces boulardii (SB), in chronic heart failure patients.
- Trial name
- PROICA (NCT01500343)
- Testing
- Saccharomyces boulardii
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Universidade Federal Fluminense
Heart Attack, Cardiovascular Diseases
Stress Management and Resiliency Training Following Acute Myocardial Infarction
The goal of this pilot study is to use total body PET/CT imaging to examine the relationships between stress, amygdala activation, and arterial wall inflammation in participants before and after participating in a multi-modal…
- Trial name
- NCT05415735
- Testing
- Stress Management and Resiliency Training Program
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of California, Davis
Aortic Stenosis, Inflammation
Inflammation and Thrombosis in Patients With Severe Aortic Stenosis After Transcatheter Aortic Valve Replacement (TAVR)
The central hypothesis of this study is that TAVR leads to platelet deposition and inflammatory cell activation that can be attenuated by the potent anti-platelet and/or pleiotropic effects of ticagrelor.
- Conditions
- Aortic Stenosis, Inflammation, Thrombosis
- Trial name
- NCT02486367
- Testing
- Clopidogrel, Ticagrelor
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University Hospitals Cleveland Medical Center
Stable Coronary Artery Disease, Percutaneous Coronary Intervention
Effect of Berberine for Endothelial Function and Intestinal Microflora in Patients With Coronary Artery Disease
The purpose of this study is to conduct a single-center, randomized, open-label, controlled, dose-escalating, parallel-group study, evaluating the effects and change of endothelial function and gut microbiota after berberine…
- Trial name
- NCT04434365
- Testing
- Berberine, Aspirin, Clopidogrel
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Peking Union Medical College Hospital
Atherosclerosis, Coronary Disease
Effects of Angiotensin-Converting Enzyme Inhibitor (Ramipril) Therapy on Blood Vessel Inflammation
This study will determine the effects of angiotensin-converting enzyme (ACE) inhibitor (trade name Ramipril) therapy on inflammation and stiffness of artery walls.
- Conditions
- Atherosclerosis, Coronary Disease, Vasculitis
- Trial name
- NCT00005928
- Testing
- Ramipril
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Myocardial Inflammation, Myocardial Infarction
Mer-TK in Human Cardiac Cells
The relationship between the immune system and the myocardium after myocardial ischemia is an evolving field of research. Crosstalk occurs between macrophages and cardiac myocytes to promote cardio-protection and resolution of…
- Trial name
- NCT04322630
- Testing
- Change in Soluble MER Concentration
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Cardiovascular Disease, Healthcare Associated Infectious Disease
Optimizing Prevention of Healthcare-Acquired Infections After Cardiac Surgery (HAI)_2
The investigators will conduct qualitative interviews of hospital personnel regarding HAI prevention practices, and use coded data from these interviews to assist in developing standardized practices.
- Conditions
- Cardiovascular Disease, Healthcare Associated Infectious Disease, Sternal Superficial Wound Infection, Deep Sternal Infection
- Trial name
- NCT02073760
- Testing
- There is no intervention. The investigators are interviewing cardiac surgery staff with knowledge of infection prevention.
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Heart Failure
A Pharmacogenomic Study of Candesartan in Heart Failure
The purpose of this study is to evaluate the impact of genetic variations on the response to candesartan in patients with heart failure who are already treated with an ACE inhibitor.
- Trial name
- NCT00400582
- Testing
- Candesartan up to 32 mg daily
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- Montreal Heart Institute
Cardiomyopathies, Sepsis
Translational Approaches to Septic Cardiomyopathy
This translational study will assess the association between septic cardiomyopathy (measured via left ventricular global longitudinal strain) and (a) inflammatory cytokine profiles, and (b) the behavior of cardiomyocytes derived…
- Conditions
- Cardiomyopathies, Sepsis, Septic Shock
- Trial name
- TASC01 (NCT03252613)
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Samuel Brown
Heart Rate, Heart Rate Variability
Air Pollution, Epigenetics and Cardiovascular Health: A Human Intervention Trial
In this study, the pills formulated are being used to try to ameliorate the effect of air pollution on epigenetic changes, specifically DNA methylation, potentially linked with particulate matter air pollution inhalation and…
- Conditions
- Heart Rate, Heart Rate Variability, Inflammation
- Trial name
- EPI-Air (NCT01864824)
- Testing
- methyl donor
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Myocardial Infarction
COlchicine for Left VEntricular Remodeling Treatment in Acute Myocardial Infarction
Inflammatory processes have been identified as key mediators of ischemia/ reperfusion injury in ST-segment elevation myocardial infarction.
- Trial name
- COVERT-MI (NCT03156816)
- Testing
- Colchicine group (experimental arm)
- Where
- 8 sites in France
- Volunteers
- 194 people
- Sponsor
- Hospices Civils de Lyon