Clinical trials: Cardiac Inflammation
Coronary Artery Disease (CAD), Oxidative Stress
Ginger in the Modulation of Inflammatory Cytokines and Oxidative Stress in Patients With Coronary Artery Disease
The study aims to evaluate the effect of ginger supplementation on inflammatory cytokines and markers of oxidative stress in patients with Coronary Artery Disease (CAD).
- Conditions
- Coronary Artery Disease (CAD), Oxidative Stress, Inflammation
- Trial name
- NCT07596979
- Testing
- Ginger
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Universidade Federal Fluminense
Chronic Kidney Disease Mineral and Bone Disorder, Cognitive Function
REducing Systemic Inflammation With LOw-dose Colchicine to ImproVE Cardiovascular Calcification in Chronic Kidney Disease: A Pilot Randomized Open-Label Trial
This pilot randomized, open-label, outcome blinded clinical trial is to evaluate the preliminary effects of low-dose Colchicine (LoDoCo) on coronary artery calcification (CAC) progression in adults with chronic kidney disease…
- Conditions
- Chronic Kidney Disease Mineral and Bone Disorder, Cognitive Function, Vascular Calcification, Coronary Artery Calcification
- Trial name
- RESOLVE-CKD (NCT07654231)
- Testing
- Low-dose Colchicine at 0.5mg daily, Usual Care
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Texas Southwestern Medical Center
Surgery-Complications
Crystalloid Fluids and Cardiac Surgery
All cardiac patients admitted to the intensive care unit after surgery received crystalloid fluids as standard care procedure. 3 crystalloid fluids can be used during their stay: Normal Saline, PlasmaLyte or Ringer's Lactate.
- Trial name
- NCT05834257
- Testing
- Normal Saline for fluid resuscitation, PlasmaLyte for fluid resuscitation, Ringer's Lacatate for fluid resusciation
- Where
- Canada
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Obesity, Bariatric Surgery Candidate
Modulation of the Inflammatory Response in Bariatric Surgery
This study will evaluate how different anesthesia techniques affect inflammation after bariatric surgery. Patients will be randomly assigned to receive one of three approaches: opioid-free anesthesia, intravenous anesthesia with…
- Conditions
- Obesity, Bariatric Surgery Candidate, Inflammation, Postoperative Pain
- Trial name
- MRICBx3 (NCT06915558)
- Testing
- Opioid-Free Anesthesia (OFA), Opioid-Based Intravenous Anesthesia (OBA-IV), Opioid-Based Inhalational Anesthesia (OBA-Inh)
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- Hospital HM Nou Delfos
COVID-19, Chronic Heart Failure
Intermittent Hypoxic-hyperoxic Training in Patients With Cardiovascular Pathology After COVID-19 Infection.
Aim of this prospective, interventional, single-center, randomized study is to evaluate the efficacy and safety of intermittent hypoxic-hyperoxic training (IHHT) as a rehabilitation method in patients with cardiovascular…
- Conditions
- COVID-19, Chronic Heart Failure, Hypertension, Arrhythmia
- Trial name
- NCT05379608
- Testing
- Intermittent hypoxic-hyperoxic training, Intermittent hypoxic-hyperoxic training/control
- Where
- Russia
- Volunteers
- 43 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Congenital Heart Disease in Children, Inflammatory Response
STeroids to REduce Systemic Inflammation After Infant Heart Surgery
This study's objective is to determine the pharmacokinetics (PK)/pharmacodynamics (PD), safety and efficacy of methylprednisolone in infants undergoing heart surgery with cardiopulmonary bypass.
- Trial name
- STRESS (NCT03229538)
- Testing
- Methylprednisolone, Isotonic saline
- Where
- 23 sites in United States
- Volunteers
- 1,263 people
- Sponsor
- Kevin Hill
Cardiotoxicity, Anthracycline Related Cardiotoxicity in Breast Cancer
ANTthracycline-induced Inflammation and OXidative Stress: 10-year Follow-up
The goal of this observational study is to learn about the long-term effects of anthracycline chemotherapy on inflammation, oxidative stress, and heart function in adult women with breast cancer.
- Conditions
- Cardiotoxicity, Anthracycline Related Cardiotoxicity in Breast Cancer, Breast Cancer
- Trial name
- ANTIOX-10 (NCT07680855)
- Volunteers
- 17 people
- Sponsor
- University of Chile
Cardiomyopathies, Myocarditis
CMP-MYTHiC Trial and Registry - CardioMyoPathy With MYocarditis THerapy With Colchicine
Two-parallel groups randomized, single-blinded, multi-center phase III controlled trial in patients with chronic inflammatory cardiomyopathy to assess the efficacy of colchicine and associated prospective registry to assess the…
- Conditions
- Cardiomyopathies, Myocarditis, Inflammatory Cardiomyopathy, Heart Failure
- Trial name
- CMP-MYTHiC (NCT06158698)
- Testing
- Colchicine
- Where
- 10 sites in Italy
- Volunteers
- 80 people
- Sponsor
- Niguarda Hospital
Inflammation Vascular
Glycemic Control on Coronary Inflammation Evaluated by FAI in ACS
This study aimed to clarify the relationship between blood glucose control and the FAI based pericoronary inflammation in low-risk ACS patients with or without diabetes.
- Trial name
- NCT05590858
- Where
- China
- Volunteers
- 309 people
- Sponsor
- RenJi Hospital
HIV
Effects of Newly-Initiated QUAD Therapy on Aortic/Coronary Inflammation in ART-Naïve Infected Patients
The main aims of this study are to determine whether: a) ART-naïve HIV+ subjects have increased artherosclerotic plaque inflammation/vulnerability, b) newly-initiated QUAD/Stribild therapy will decrease plaque…
- Trial name
- Quad (NCT01766726)
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Myocardial Infarction, Inflammation
Inflammation in Type 2 Myocardial Infarction
Type 2 myocardial infarction (MI) is defined as myocardial necrosis that results from an imbalance of myocardial oxygen supply and demand.
- Conditions
- Myocardial Infarction, Inflammation, Critical Illness
- Trial name
- NCT02385487
- Where
- United States
- Sponsor
- NYU Langone Health
Shock, Cardiogenic, Extra-Corporeal-Life-Support ( ECLS)
Impact of Adrenoreceptor Expressions on Inflammatory Pattern in Refractory Cardiogenic Shock Under VA ECMO
Refractory cardiogenic shock is characterized by a decreased in cardiac output with hypo-responsiveness to increasing doses of catecholamines resulting in a profound tissular ischemia.
- Conditions
- Shock, Cardiogenic, Extra-Corporeal-Life-Support ( ECLS), Autonomic Nervous System Diseases, Inflammation
- Trial name
- ADRECMO (NCT03327493)
- Testing
- Biological
- Where
- France
- Volunteers
- 48 people
- Sponsor
- Central Hospital, Nancy, France
Acute Cellular Graft Rejection, Cardiac Sarcoidosis
[68Ga]Ga-PentixaFor PET/CT in Acute Myocardial Inflammation
Acute myocardial inflammation is an heterogenic syndrome involving different clinical pathologies with different outcome. For the purpose of this study protocol, we focuse on three entities of this syndrome, namely the acute…
- Conditions
- Acute Cellular Graft Rejection, Cardiac Sarcoidosis, Myocarditis Due to Drug
- Trial name
- NCT05499637
- Testing
- [68Ga]Ga-PentixaFor PET/CT
- Where
- Switzerland
- Volunteers
- 25 people
- Sponsor
- John O. Prior
Cardiac Arrhythmia
New Onset Cardiac Arrhythmias in Septic Patients in Critical Care Setting, Predictors and Outcomes.
New Onset Cardiac Arrhythmias in Septic Patients in Critical Care Setting, Predictors and Outcomes
- Trial name
- NCT06351956
- Volunteers
- 72 people
- Sponsor
- Assiut University
Breast Cancer, Colon Cancer
Stress-Reducing Intervention in Patients With Colorectal and Breast Cancer
The goal of this interventional study is to test the heart-rate variability biofeedback intervention (HRV BI) in 2 cohorts of patients.
- Trial name
- SRI-BrCa_CRC (NCT06281145)
- Testing
- Heart-rate variability biofeedback intervention
- Where
- Slovakia
- Volunteers
- 100 people
- Sponsor
- Comenius University
Septic Shock
Assessment of Cardiac Output and Stroke Volume in Septic Shock Patients
The aim of this research is to compare the accuracy and reliability of electrical cardiometry versus transthoracic echocardiography in measuring cardiac output and stroke volume in patients with septic shock, to evaluate the…
- Trial name
- NCT07321405
- Testing
- echocardiogram, Electrical cardiometry
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Heart Failure With Preserved Ejection Fraction (HFPEF)
Hearts on Fire: Targeting Inflammation in Heart Failure With Preserved Ejection Fraction
Subjects undergo a gadolinium-based CMR followed by an iron infusion and then a repeat CMR in 72 hours
- Trial name
- NCT07634640
- Testing
- Ferumoxytol infusion
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Florida
Myocardial Infarction, MINOCA
Biomarkers of Inflammation and Endothelial Dysfunction in Patients With Myocardial Infarction With Non-obstructive Coronary Arteries
Around 10% of patients with myocardial infarction (MI) present with nonobstructive coronary arteries (MINOCA) which pathophysiology is often uncertain.
- Conditions
- Myocardial Infarction, MINOCA, Inflammation, Biomarkers
- Trial name
- IMACORN-INFLI (NCT06446895)
- Testing
- Coronariography
- Where
- Spain
- Volunteers
- 400 people
- Sponsor
- Hospital Universitario Getafe
Sepsis, Cardiomyopathies
The Diagnostic and Prognostic Value of Speckle Tracking Imaging in Septic Cardiomyopathy
The aim of this study is to explore if STI technology, especially TMAD, plays an important role in evaluating left ventricular longitudinal systolic function and discriminating SICM in patients with sepsis.
- Conditions
- Sepsis, Cardiomyopathies, Echocardiography
- Trial name
- NCT05624619
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Shanghai Zhongshan Hospital
Respiratory Depression, Blood Pressure
Cardiopulmonary Responses to Exposure to Ozone and Diesel Exhaust
The US EPA Clean Air Multiyear research program is moving toward a multi-pollutant approach to the assessment of air pollution in response to recommendations by the NRC 2004 and the BOSC in 2005.
- Trial name
- DEPOZ (NCT01874834)
- Testing
- ozone
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Environmental Protection Agency (EPA)