Clinical trials: Cardiac Inflammation
Ischemic Heart Disease, Angina Pectoris
Investigation of Leukocyte Trafficking Into Skin Blisters During Cardiopulmonary Bypass
The purpose of this study was to see if the heart-lung machine involved in cardiac surgery increases the movement of activated white blood cells from the bloodstream into the patient's tissues and also to see if aprotinin usage…
- Trial name
- NCT00131040
- Testing
- Aprotinin
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Coronary Artery Disease, Arterial Stiffness, Blood Pressure
Expanded Studies on the SCAPIS Stockholm Reexamination Cohort
The Swedish CArdioPulmonary bioImage Study (SCAPIS) is a unique, large-scale national research initiative involving 30,000 randomly selected individuals aged 50-64, recruited between 2014 and 2018.
- Conditions
- Coronary Artery Disease, Arterial Stiffness, Blood Pressure, AORTIC VALVE DISEASES, Mitral Valve Stenosis and/or Insufficiency
- Trial name
- SCAPIS-ReEx (NCT07476703)
- Testing
- Coronary computer tomography (CCTA), Echocardiograhy and aortic ultrasound, Liver elastography
- Where
- Sweden
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- Danderyd Hospital
Type 2 Diabetes Mellitus
Effect of Exenatide on Liver and Heart Fat and Inflammation
The purpose of this study is to examine the effect of exenatide on liver and heart (myocardial) fat and inflammation.
- Trial name
- NCT01951651
- Testing
- Exenatide, Glipizide
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Baylor College of Medicine
Malaria, Pregnancy Malaria
Cardiac Safety of Dihydroartemisinin-Piperaquine Amongst Pregnant Women in Tanzania
Sulfadoxine-pyrimethamine (SP) is currently recommended by the World Health Organization for use as intermittent preventive treatment against malaria in pregnancy (IPTp) in areas of moderate to high malaria transmission.
- Conditions
- Malaria, Pregnancy Malaria, Cardiotoxicity, Cardiac Safety
- Trial name
- NCT02909712
- Testing
- sulfadoxine-pyrimethamine (SP), dihydroartemisinin-piperaquine (DHA-PQP)
- Where
- Tanzania
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Atherosclerosis, Acute-Phase Reaction
Erythrocyte-Mediated Drug Delivery for the Prevention of Stent Restenosis
The purpose of this study is to determine whether erythrocyte mediated dexamethasone delivery reduces circulating inflammatory markers after coronary stent implantation and improves clinical and angiographic outcomes.
- Trial name
- TROY (NCT00484965)
- Testing
- Coronary stenting
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- University of Rome Tor Vergata
Non-Traumatic Subarachnoid Hemorrhage
Beta-1 Adrenergic Inhibition to Reduce Cardiac Injury and Inflammation After Subarachnoid Hemorrhage (BADCATS)
To determine the effect of early metoprolol administration after non-traumatic subarachnoid hemorrhage (SAH).
- Trial name
- BADCATS (NCT06569212)
- Testing
- Metoprolol
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Madeleine Puissant
Coronary Artery Disease
Effects of DES Platforms on Markers of Endothelial Damage and Inflammation
Percutaneous coronary intervention (PCI) with stenting may induce endothelial damage/dysfunction and inflammatory reactions, which in turn delay healing and endothelialization and may lead to restenosis and atherosclerosis within…
- Trial name
- PLATFORM (NCT01489202)
- Testing
- platinum chromium everolimus-eluting stent, cobalt chromium everolimus-eluting stent
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- University of Roma La Sapienza
Hypertension, Hypertension (HTN)
Syntrillo Telehealth Stroke Risk Reduction Study
A prospective, single-arm, open-label study evaluating the impact of Syntrillo's telehealth program on stroke risk factors, particularly blood pressure, among 68 high-risk patients.
- Conditions
- Hypertension, Hypertension (HTN), Stroke Prevention, Cardiovascular Risk Factor
- Trial name
- NCT07124728
- Testing
- Technology-enabled Telehealth Care Plan, Blood Pressure Monitoring Device, Tenovi Smart Pillbox
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Syntrillo, Inc
Cardiac Arrest, Extracorporeal Circulation
Cytokine Adsorption in Post-cardiac Arrest Syndrome in Patients Requiring Extracorporeal Cardiopulmonary Resuscitation
Almost all patients with refractory cardiac arrest, who are primarily stabilized under ongoing cardiopulmonary resuscitation by transcutaneous implantation of a venoarterial extracorporeal membrane oxygenation system (va-ECMO for…
- Conditions
- Cardiac Arrest, Extracorporeal Circulation, Extracorporeal Membrane Oxygenation, Cytokine Storm
- Trial name
- CYTER (NCT03685383)
- Testing
- Cytosorb removal column in eCPR, standard eCPR (va-ECMO)
- Where
- Germany
- Volunteers
- 41 people
- Sponsor
- University Hospital Freiburg
Coronary Artery Disease
Effect of Acute Statin Treatment in Patients Undergoing Percutaneous Coronary Intervention
The goal of this study is to determine if one dose of simvastatin will decrease the inflammatory response to coronary intervention.
- Trial name
- NCT00588471
- Testing
- Simvastatin
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Mayo Clinic
Delirium, Inflammation
The Role of Ketamine in Preventing Cognitive Dysfunctions in Postoperative Period of Cardiac Surgery
The purpose of this study is to analyze the Ketamine with its anti-inflammatory profile would be able to prevent cognitive disorders in the postoperative period of cardiac surgery, since these disorders contribute to an impact on…
- Conditions
- Delirium, Inflammation, Cognitive Disorders, Amnestic
- Trial name
- KeCoDy (NCT02782429)
- Testing
- Ketamine, Saline
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Flavia orange
Septic Shock
Cardiovascular Effects of Norepinephrine
Previous studies of our team reported the improvement of myocardial contractility both on hemodynamic parameters (by transpulmonary thermodilution) and morphological (by transthoracic echocardiography: TTE), during the early…
- Trial name
- NCT05761522
- Testing
- transthoracic echocardiography
- Where
- France
- Volunteers
- 49 people
- Sponsor
- CHU de Reims
Acute Coronary Syndrome
Targeting Inflammation in Acute Coronary Syndrome Using Colchicine
The purpose of this study is to evaluate the effect of colchicine on high sensitivity C-reactive protein (hs-CRP), a blood marker to measure inflammation, in patients with acute coronary syndromes.
- Trial name
- COOL (NCT00754819)
- Testing
- Colchicine
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Hamilton Health Sciences Corporation
Obesity, Pre-diabetes
SGLT2 Inhibitor Effects on Inflammation and Heart Disease in Obesity Pilot
Obesity is associated with increased cardiometabolic disease risk due, in part, to heightened chronic inflammation arising from adipose tissue.
- Trial name
- NCT04907214
- Testing
- Empagliflozin 25 MG
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Vanderbilt University Medical Center
COPD, AECOPD
The CANadian EXAcerbation of COPD Trial
The natural history of Chronic Obstructive Pulmonary Disease (COPD) is marked by acute, episodic attacks known as exacerbations of COPD.
- Trial name
- CAN-EXACT (NCT07850648)
- Where
- Canada
- Volunteers
- 125 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Congenital Heart Disease, Heart Failure
Gender Difference in NET Activation in Patients With Congenital Heart Disease and Heart Failure
Neutrophil hyperactivation has detrimental effects on cardiac tissue after injuries, leading to fibrosis lesions and cardiac dysfunction.
- Conditions
- Congenital Heart Disease, Heart Failure, Gender
- Trial name
- FIBRONETx (NCT05263843)
- Testing
- Biological markers of myocardial fibrosis
- Where
- 2 sites in France
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Atherosclerosis, Inflammatory Response
Colchicine Effect on Perivascular Inflammation Index on Coronary CTA
Inflammation is an important pillar of atherogenesis in coronary disease. Studies have documented the prognostic power of measuring coronary perivascular adipose tissue attenuation (PVAT) and its good correlation as an early…
- Conditions
- Atherosclerosis, Inflammatory Response, Coronary Disease
- Trial name
- COPIX (NCT05347316)
- Testing
- Colchicine
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- University of Sao Paulo General Hospital
Coronary Artery Disease, Inflammatory Response
Effect of Influenza Vaccination on Global Systemic Inflammatory Markers in Patients With Stable Coronary Artery Disease
Observational and randomized studies suggest that influenza vaccine may reduce future cardiovascular events in patients with cardiovascular disease.
- Conditions
- Coronary Artery Disease, Inflammatory Response, Atherosclerosis
- Trial name
- IVAMI (NCT06508437)
- Testing
- Influenza Vaccination
- Where
- France
- Volunteers
- 47 people
- Sponsor
- University Hospital, Tours
Staphylococcus Lugdunensis, Bacteremia
Virulence of Staphylococcus Lugdunensis in Severe Infections
The main objective is to identify new virulence factors produced by Staphylococcus lugdunensis that can be associated with clinical sign of severe infections and identified symptoms.
- Conditions
- Staphylococcus Lugdunensis, Bacteremia, Endocarditis, Virulence Factors
- Trial name
- VISLISI (NCT02026895)
- Testing
- Genetic blood sample
- Where
- France
- Volunteers
- 82 people
- Sponsor
- University Hospital, Strasbourg, France
Severe Sepsis, Septic Shock
Comparison of Pediatric Septic Shock Treatment With and Without Central Venous Oxygen Saturation Monitoring
The purpose of this study was to compare ACCM/PALS guidelines performed with and without central venous oxygen saturation monitoring on the morbidity and mortality rate of children with severe sepsis and septic shock.
- Trial name
- NCT00407823
- Testing
- Central venous oxygen saturation continuous monitoring
- Where
- 2 sites in Brazil
- Volunteers
- 268 people
- Sponsor
- University of Sao Paulo