Clinical trials: Cardiac Inflammation
Heart; Dysfunction Postoperative, Cardiac Surgery, Cytokine Release Syndrome
Peri-operative Prediction of Prolonged Stay in the Cardiac Intensive Care Unit for Adult Cardiac Surgery
The purpose of this study is to create a model using intra-operative modified SOFA score and peri-operative clinical factors to predict prolonged stay in the cardiac intensive care unit (CICU) for adult cardiac surgery with…
- Trial name
- NCT01559870
- Where
- 3 sites in Thailand
- Volunteers
- 164 people
- Sponsor
- Thepakorn Sathitkarnmanee
Acute Coronary Syndrome, Myocardial Infarction
Telmisartan Versus Ramipril After Acute Coronary Syndrome
The purpose of this study is to compare the antinflammatory and endothelial progenitor cell (EPC) mobilizing effect of Ramipril and Telmisartan in patients presenting with acute coronary syndrome
- Conditions
- Acute Coronary Syndrome, Myocardial Infarction, Coronary Disease
- Trial name
- TERACS (NCT00702936)
- Testing
- TELMISARTAN, RAMIPRIL
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Catholic University of the Sacred Heart
Pleural Effusion, Malignant, Pleural Mesothelioma
A Comparative Study Between Regional Anesthesia in Thoracoscopes and the Conventional General Anesthesia
Video-assisted thoracic surgery (VATS) is usually performed with general anesthesia and single lung ventilation. However, performing thoracic surgery under awake regional anesthesia has several potential advantages including…
- Conditions
- Pleural Effusion, Malignant, Pleural Mesothelioma, Pleural Empyema, Pulmonary Diseases or Conditions
- Trial name
- VATS (NCT05077111)
- Testing
- Thoracic Epidural Anesthesia, General Anesthesia with One Lung Ventilation
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mohamed Reda Ashour
Myocardial Ischemic Reperfusion Injury
Erythropoietin Effect on Ischemic_ Reperfusion Injury in Coronary Artery Bypass Graft Surgery
The aim of this trail is to assess the safety and therapeutic effects of single EPO intervention in different times during coronary surgery in changes of inflammatory response.
- Trial name
- NCT02984111
- Testing
- normal saline, erythropoietin
- Where
- Iran
- Volunteers
- 97 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Coronary Disease, Inflammation
Genetic Predisposition of Coronary Artery Disease -- The COROGENE-Study
The aim of this study is to identify genetic loci,or gene variations contributing to inflammation and to the development of CHD.
- Trial name
- NCT00417534
- Where
- Finland
- Volunteers
- 5,000 people
- Sponsor
- University of Helsinki
Coronary Artery Disease
Novel Imaging Approaches To Identify Unstable Coronary Plaques
Cardiovascular disease is the leading cause of death in Scotland and the Western World. Approaches to improve the identification of vulnerable or ruptured coronary atherosclerotic plaques are urgently needed to help risk…
- Trial name
- NCT01749254
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- University of Edinburgh
Cardiac Arrhythmia
New Onset Cardiac Arrhythmias in Septic Patients in Critical Care Setting, Predictors and Outcomes.
New Onset Cardiac Arrhythmias in Septic Patients in Critical Care Setting, Predictors and Outcomes
- Trial name
- NCT06351956
- Volunteers
- 72 people
- Sponsor
- Assiut University
Septic Shock
Esmolol Effects on Heart and Inflammation in Septic Shock
Beta adrenergic system, over-activated in septic shock patients, is a key modulator of the inflammatory response. Experimental works demonstrated that Esmolol, an highly selective beta-1 blocker, reduces heart rate and regulates…
- Trial name
- ESMOSEPSIS (NCT02068287)
- Testing
- Esmolol
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Central Hospital, Nancy, France
Myocarditis, Cardiomyopathy
Recurrent Acute Myocarditis Registry
The association between myocardial inflammation (clinically represented by acute myocarditis episodes) and the later development of an arrhythmogenic cardiomyopathy is widely elusive.
- Trial name
- RAM (NCT04589156)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Caen
Cardiovascular Morbidity
Experimental Exposure to Air Pollutants and Sympathetic Nerve Activity in Human Subjects
The primary hypothesis of the study is that in healthy elderly subjects experimental exposure to air pollutants increases sympathetic nervous system activity compared with sham (clean air) exposure.
- Trial name
- Particles (NCT01914783)
- Testing
- ultrafine particles, ultrafine particles and ozone, clean air
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hannover Medical School
Non ST Segment Elevation Acute Coronary Syndrome
COLchicine On-admission to Reduce Inflammation in Acute Coronary Syndrome (COLOR-ACS)
Since colchicine is known to have anti-inflammatory effects and inflammation is an early component of acute coronary syndrome (ACS), this study aims to evaluate the acute effects of low-dose colchicine, in addition to…
- Trial name
- COLOR-ACS (NCT05250596)
- Testing
- Colchicine, Atorvastatin
- Where
- 3 sites in Italy
- Volunteers
- 182 people
- Sponsor
- Azienda USL Toscana Centro
Perinatal HIV Infection, Cardiac Fibrosis
Immune Correlates of Cardiac Structure and Function
The purpose of this study is to determine the occurrence of scarring of the heart (cardiac fibrosis) and inflammation in those with perinatally acquired Human Immunodeficiency Virus (HIV) infection compared to people not infected…
- Conditions
- Perinatal HIV Infection, Cardiac Fibrosis, Cardiac Inflammation
- Trial name
- NCT05328713
- Testing
- Cardiac MRI
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Duke University
Systemic Inflammatory Response Syndrome, Acute Kidney Injury
High Cut Off Dialysis in Systemic Inflammatory Response Syndrome Patients After Cardiac Surgery
A high cut off dialyzer (septeX) is tested in patients after cardio-thoracic surgery with incidence of "systemic inflammatory response syndrome" (SIRS) and associated increased risk for acute kidney injury (AKI).
- Trial name
- HICOSIRS (NCT01579396)
- Testing
- septeX, standard therapy
- Where
- Germany
- Sponsor
- Vantive Health LLC
Heart Failure and ST Elevation Myocardial Infarction
Predictors of Heart Failure After ST-segment Elevation Myocardial Infarction (HF-EXPRESS)
Objective: The purpose of this project is to study the post miyocardial infaction (MI) damage and subsequently developed post-infarct cardiac repair process on the basis of cellular, molecular and imaging techniques.
- Trial name
- HF-EXPRESS (NCT02650934)
- Testing
- Percutanous coronary intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 312 people
- Sponsor
- Dr. Nafiz Korez Sincan State Hospital
Thoracic Surgery, Prehabilitation
Preoperative Inspiratory Muscle Training Effects on the Perioperative Inflammatory Reaction in Cardiac Surgery.
This study evaluates the impact of preoperative high-intensity inspiratory muscle training (IMThi) before cardiac surgery on perioperative inflammatory response.
- Conditions
- Thoracic Surgery, Prehabilitation, Respiratory Therapy
- Trial name
- EMI HiPo (NCT03158402)
- Testing
- Prehabilitation with inspiratory muscle training
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Angers
Acute Heart Failure, NSTEMI - Non-ST Segment Elevation MI
Metabolomics and Microbiomics in Cardiovascular Diseases
"MEtabolomics and MicrObiomics in caRdIovAscular diseases Mannheim (MEMORIAM) " is a single-center, prospective and observational study investigating to identify disease-specific metabolic, respectively microbiomic, patterns of…
- Conditions
- Acute Heart Failure, NSTEMI - Non-ST Segment Elevation MI, STEMI - ST Elevation Myocardial Infarction, Myocardial Infarction, Acute
- Trial name
- MEMORIA (NCT04146701)
- Testing
- Blood draw
- Where
- Germany
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- Universitätsmedizin Mannheim
Enterovirus Infections
Urinary Excretion of Enteroviruses From Children With a Presumed Enteroviral Infection
Enteroviruses can infect most human organ systems, especially the heart, nervous system and pancreas. Whether Enteroviruses can also affect the kidneys is not known yet.
- Trial name
- NCT00426699
- Where
- Switzerland
- Volunteers
- 82 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Inflammation
Effects of Transvenous Vagus Nerve Stimulation on Immune Response: a Pilot Study
The purpose of this study is to assess the effect of transvenous vagus nerve stimulation (tVNS) on the immune response. In the human endotoxemia model, intravenously administered endotoxin (lipopolysaccharide [LPS]) elicits a…
- Trial name
- NoSIRS (NCT01944228)
- Testing
- Vagal Nerve Stimulation
- Where
- Netherlands
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Myocardial Inflammation, Myocardial Infarction
Mer-TK in Human Cardiac Cells
The relationship between the immune system and the myocardium after myocardial ischemia is an evolving field of research. Crosstalk occurs between macrophages and cardiac myocytes to promote cardio-protection and resolution of…
- Trial name
- NCT04322630
- Testing
- Change in Soluble MER Concentration
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Atherosclerosis, Coronary Artery Disease
Treatment of Patients With Atherosclerotic Disease With Methotrexate-associated to LDL Like Nanoparticles
The investigators propose a prospective, randomized, double-blind, placebo-controlled study. The purpose of the study is to evaluate the safety and efficacy of an anti-inflammatory agent methotrexate in a cholesterol-rich…
- Conditions
- Atherosclerosis, Coronary Artery Disease, Inflammation
- Trial name
- NCT04616872
- Testing
- Methotrexate-LDE
- Where
- 2 sites in Brazil
- Volunteers
- 40 people
- Sponsor
- University of Sao Paulo General Hospital