Clinical trials: Cardiac Inflammation
Myocardial Infarction
The Effects of mETHotrexate Therapy on ST Segment Elevation MYocardial InfarctionS (TETHYS Trial)
Experimental studies suggest that anti-inflammatory and immunomodulatory drugs could reduce the inflammatory profile in acute ischemic disease and reduce the area of ischemia.
- Trial name
- TETHYS (NCT01741558)
- Testing
- Methotrexate, Riboflavin
- Where
- 2 sites in Brazil
- Volunteers
- 80 people
- Sponsor
- Instituto de Cardiologia do Rio Grande do Sul
Myocardial Infarction, Acute Coronary Syndrome
Hydroxychloroquine for the Prevention of Cardiovascular Events in Myocardial Infarction Patients - a Safety Pilot Trial
This safety pilot study evaluates the effect of hydroxychloroquine on preventing recurrent cardiovascular events among myocardial infarction patients.
- Conditions
- Myocardial Infarction, Acute Coronary Syndrome, Inflammation, Hydroxychloroquine
- Trial name
- OXI (NCT02648464)
- Testing
- Hydroxychloroquine
- Where
- 6 sites in Finland
- Volunteers
- 125 people
- Sponsor
- Helsinki University Central Hospital
Tako-tsubo Cardiomyopathy
Pathogenesis of Acute Stress Induced (Tako-tsubo) Cardiomyopathy: Energy Shut-Down or Intense Inflammation?
Tako Tsubo Cardiomyopathy (TTC), also known as "Broken Heart Syndrome", is a disorder of the heart that occurs most commonly in women (although it occasionally occurs in men) and is usually related to a stressful event.
- Trial name
- TERRIFIC (NCT02897739)
- Testing
- Magnetic resonance imaging, Acute Inflammatory Activation study, PET CT
- Where
- United Kingdom
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
Sepsis, Cardiac Arrest
Thigh Muscle Mass and Muscle Wasting in Patients in the Emergency Department
The goal of this observational study is to evaluate whether thigh muscle mass and muscle wasting are associated with mortality in patients who visit the emergency department.
- Conditions
- Sepsis, Cardiac Arrest, Acute Respiratory Failure, Patients Who Visit Emergency Department
- Trial name
- NCT05978154
- Testing
- Thigh muscle mass and muscle wasting (exposure)
- Where
- South Korea
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Korea University Ansan Hospital
Acute Coronary Syndromes
Inflammation and Acute Coronary Syndromes
Subproject 1: Optimize prevention after acute coronary syndromes (ACS) by improving caregiver and patient education (http://elips.hug-ge.ch/eng/index_eng2.htm) Subproject 2: Discover novel genomic biomarkers of ACS in leukocyte…
- Trial name
- SPUM-ACS (NCT01000701)
- Where
- 4 sites in Switzerland
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Atherosclerosis
Comparison of 18F-fluorodeoxyglucose Positron Emission Tomography and Coronary Computed Tomography in Assessing Vascular Inflammation
Vascular inflammation is a key factor in both the pathogenesis and outcome of atherosclerosis. 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is a promising tool for identifying and quantifying vascular…
- Trial name
- NCT01100671
- Testing
- Cross section study
- Where
- South Korea
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Korea University
Acute Coronary Syndrome, Atherosclerosis
The Microbiome as a Target for Precision Medicine in Atherosclerosis
Cardiovascular diseases are the main cause of death in industrialized countries. Among them, atherosclerosis has the highest prevalence and constitutes a common pathological pathway responsible for the majority of cases of…
- Trial name
- MIGATER (NCT03434483)
- Testing
- Assessment of the atherosclerotic plaque in a moderate lession., Gene variants in atherosclerosis, Microbiota analysis
- Where
- Spain
- Volunteers
- 156 people
- Sponsor
- Hospital General Universitario Gregorio Marañon
Major Depressive Disorder, Depression
Anti-INFLammatory to Address Mood and Endothelial Dysfunction (INFLAMED)
The objective of this clinical trial is to evaluate whether an anti-inflammatory medication, pentoxifylline, reduces depressive symptoms and improves artery function.
- Conditions
- Major Depressive Disorder, Depression, Depressive Symptoms, Cardiovascular Disease (CVD)
- Trial name
- INFLAMED (NCT01625845)
- Testing
- Pentoxifylline, Standard Treatment
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Indiana University
Cardiovascular Diseases, Hypertension
Biochemical and Genetic Markers of Hypertension in Women
To investigate biochemical and genetic markers of inflammation and endothelial dysfunction as determinants of hypertension.
- Conditions
- Cardiovascular Diseases, Hypertension, Heart Diseases, Inflammation
- Trial name
- NCT00090467
- Volunteers
- 1,600 people
- Sponsor
- Brigham and Women's Hospital
Atrial Fibrillation, Inflammation
Impact of Inflammatory Indexes and Gene Scores in Prediction of Atrial Fibrillation
Because of the high recurrence rates following electrical cardioversion and high morbidity in AF patients there is a need to explore prediction models for AF recurrence following ECV.
- Conditions
- Atrial Fibrillation, Inflammation, Genetic Predisposition to Disease
- Trial name
- IERV (NCT06399666)
- Testing
- Blood sampling
- Where
- 2 sites in Sweden
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- Vrinnevi Hospital
Oxidative Stress, AKI
Effects of Pentoxifylline After Cardiac Surgery
Acute Kidney Injury (AKI) is a common and serious post operative complication and may occur in up to 50% of all patients undergoing cardiac surgery and is associated with 8% mortality rate compared with 0.9% in non-affected…
- Conditions
- Oxidative Stress, AKI, Inflammation
- Trial name
- NCT03591536
- Testing
- Pentoxifylline
- Volunteers
- 100 people
- Sponsor
- nooshin dalili
Coronary Heart Disease
Glycocalyx and Oxidative Stress in Endothelial Function (Part 2)
The primary research objective of the project is to determine the role of eGC in microvascular reactivity in patients with coronary heart disease (CHD) before and after bypass grafting (cross-sectional study 2).The main objective…
- Trial name
- GlikoOxEND (NCT07451873)
- Where
- Croatia
- Volunteers
- 35 people
- Sponsor
- Josip Juraj Strossmayer University of Osijek
Heart Failure, Congestive, Renal Failure Acute Chronic
Effect of a Focused Point-of-care Ultrasonography Screening Protocol in Hospitalized Patients
This research project aims to establish a real-time focused ultrasound examination protocol for routine assessment of hospitalized patients, including evaluations of the inferior vena cava (IVC), pericardial effusion…
- Conditions
- Heart Failure, Congestive, Renal Failure Acute Chronic, Liver Cirrhosis, Sepsis
- Trial name
- NCT07656428
- Where
- Taiwan
- Volunteers
- 9,000 people
- Sponsor
- National Taiwan University Hospital
COVID-19 Infection
ESICM UNITE COVID-19 Project (UNITE-COVID)
COVID-19 is arguably the biggest challenge critical care medicine has been confronted with since its conception. Critical care services around the world are flooded by patients presenting with severe respiratory failure who…
- Trial name
- UNITE-COVID (NCT04836065)
- Where
- Belgium
- Volunteers
- 4,995 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Zinc Deficiency, Inflammation
Effects of Daily Beef Intake, as a Component of a Heart-Healthy Diet on Cellular Zinc
The objective of the current study is to test the overarching hypothesis that the beef nutritive matrix is uniquely suited to direct dietary zinc to cellular compartments for improved metabolic function, leading to a greater…
- Conditions
- Zinc Deficiency, Inflammation, Metabolic Diseases, Vascular Diseases
- Trial name
- NCT05236374
- Testing
- Beef protein
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Chagas Disease, Colchicine Resistance
Colchicine for Patients With Chagas´ Disease( B1 Stage)
This study evaluate the addition of colchicine in the treatment of patients with Chagas´disease. Forty patients will receive colchicine while twenty patients will receive placebo
- Trial name
- COACH (NCT03704181)
- Testing
- Colchicine 0.5 MG twice day for one year
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo General Hospital
Bacteremia
Bacteria Entering the Blood Stream From Tooth Extractions and Tooth Brushing
The major purposes of this prospective, randomized, clinical study are to: 1. Determine and compare the true incidence, nature, magnitude, and duration (INMD) of bacteremia (bacteria found in the bloodstream) resulting from a…
- Trial name
- NCT00454285
- Testing
- Effect of Amoxicillin on bacteremia following a single-tooth extraction
- Where
- United States
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Acute Respiratory Infection, Sepsis
Capnodynamic Monitoring of Cardiorespiratory Function in Critically Ill Patients
Capnodynamic monitoring has the potential to offer continuous and non-invasive measurements of heart and lung function in patients requiring ventilation in an intensive care setting.
- Conditions
- Acute Respiratory Infection, Sepsis, Postoperative Respiratory Distress
- Trial name
- PROFICIENT (NCT05082168)
- Testing
- Capnodynamic monitoring
- Where
- Australia
- Volunteers
- 100 people
- Sponsor
- South West Sydney Local Health District
Oxidative Stress, Inflammation
Effects of Magnesium and Spinning Training on Echocardiographic, Inflammatory, and Aerobic Outcomes
Regular aerobic exercise may improve cardiorespiratory fitness while modulating systemic inflammation and oxidative stress. Spinning, as a structured indoor cycling modality, provides a practical aerobic exercise model with…
- Conditions
- Oxidative Stress, Inflammation, Physical Fitness, Echocardiography
- Trial name
- NCT07662954
- Testing
- Spinning Training, Magnesium Supplementation
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Karamanoğlu Mehmetbey University
Heart Failure, Inflammation
Efficacy of LoDoCo in Improving Exercise Capacity Among Patients With HFpEF and Inflammation
The purpose of this research study is to determine the effectiveness of low dose colchicine (LoDoCo) on measures of exercise capacity, physical function, frailty, and quality of life, among patients with heart failure with…
- Trial name
- NCT06130059
- Testing
- Low Dose Colchicine
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Texas Southwestern Medical Center