Clinical trials: Cardiac Inflammation
Atrial Fibrillation
Quantification of Endothelial Thrombogenicity in Patients With Atrial Fibrillation
Atrial fibrillation (AF) is the most common cardiac arrhythmia. Because of its major impact on the general morbidity and risk of stroke, AF is a great concern for public health.
- Trial name
- REMI-2 (NCT02756429)
- Testing
- blood samples
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Hospices Civils de Lyon
Acute Coronary Syndrome, Premature Coronary Heart Disease
Markers of Cardiovascular Risk in Patients With Premature Coronary Artery Disease and Treatment
The aim of study is to examine the relationship between lipid subfractions, inflammation and structural-functional properties of the arterial wall in patients with premature coronary heart disease, to study genetic polymorphisms…
- Conditions
- Acute Coronary Syndrome, Premature Coronary Heart Disease, Lipoproteinemia, Inflammation
- Trial name
- GEBI (NCT04613167)
- Testing
- Alirocumab, Evolocumab, Control group
- Where
- Slovenia
- Volunteers
- 70 people
- Sponsor
- University Medical Centre Ljubljana
Acute Coronary Syndrome, Stress Hyperglycemia
Cellular Immunity, Neuroendocrine, and Inflammatory Factors for Clinical Prognosis in Acute Coronary Syndrome
In acute coronary syndrome (ACS), there is an increase in cortisol levels, as an expression of the stress response, and C-reactive protein, as an expression of the inflammatory response, which are in turn associated with changes…
- Conditions
- Acute Coronary Syndrome, Stress Hyperglycemia, Cortisol; Hypersecretion, Inflammatory Response
- Trial name
- NCT06513611
- Testing
- Serum cortisol.
- Where
- Argentina
- Volunteers
- 150 people
- Sponsor
- Hospital de Clinicas José de San Martín
Heart Failure, Inflammation
Colchicine in HFpEF
Heart failure is a growing epidemic that affects up to 500,000 individuals in Canada, with 50,000 new cases being diagnosed each year. Half of these will have HF with preserved ejection fraction (HFpEF).
- Conditions
- Heart Failure, Inflammation, Colchicine
- Trial name
- COLpEF (NCT04857931)
- Testing
- Colchicine
- Where
- Canada
- Volunteers
- 14 people
- Sponsor
- Montreal Heart Institute
Surgery-Complications
Crystalloid Fluids and Cardiac Surgery
All cardiac patients admitted to the intensive care unit after surgery received crystalloid fluids as standard care procedure. 3 crystalloid fluids can be used during their stay: Normal Saline, PlasmaLyte or Ringer's Lactate.
- Trial name
- NCT05834257
- Testing
- Normal Saline for fluid resuscitation, PlasmaLyte for fluid resuscitation, Ringer's Lacatate for fluid resusciation
- Where
- Canada
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Acute Decompensated Heart Failure, Cytokine Storm
Asses the Anti-inflammatory Effects of Short Term Copaxone Therapy on Patients the Acute Decompensated Heart Failure
Assess the anti-inflammatory effects of short-term Copaxone therapy on patients with acute decompensated heart failure. Trial Design An open-label, randomized, prospective trial of patients hospitalized due to acute…
- Conditions
- Acute Decompensated Heart Failure, Cytokine Storm, Inflammatory Response, Heart Failure
- Trial name
- Copaxone (NCT06003972)
- Testing
- Copaxone, guideline directed medical therapy (GDMT)
- Where
- Israel
- Volunteers
- 14 people
- Sponsor
- Hadassah Medical Organization
Preoperative Sleep Disorder, Preoperative Anxiety
Relationship Between Perioperative Related Factors and Inflammatory Markers and Postoperative Delirium in Elderly Patients With Non-cardiac Major Surgery
Perioperative neurocognitive impairment, including postoperative delirium (POD), is common in older patients after anesthesia and surgery and is associated with poorer short- and long-term outcomes, including worsening cognitive…
- Conditions
- Preoperative Sleep Disorder, Preoperative Anxiety, Inflammatory Reaction, Postoperative Delirium
- Trial name
- NCT05341531
- Testing
- elderly patients undergoing non-cardiac surgery
- Volunteers
- 400 people
- Sponsor
- Beijing Friendship Hospital
Heart; Surgery, Heart, Functional Disturbance as Result
The Role of Modified Ultrafiltration Following Open Heart Surgery
This study aims to investigate the effect of combining conventional ultrafiltration and modified ultrafiltration compared to conventional ultrafiltration alone in patients who underwent open heart surgery.
- Trial name
- NCT06085066
- Testing
- Conventional Ultrafiltration alone on Cardiopulmonary bypass, Conventional Ultrafiltration followed by Modified Ultrafitration on Cardiopulmonary bypass
- Where
- Indonesia
- Volunteers
- 38 people
- Sponsor
- Universitas Indonesia
Periodontal Disease (PD), Cardio Vascular Disease
PMPR and Chlorhexidine on Periodontal Disease and Vascular Function
Gum inflammation is called gingivitis. Gum disease, known as periodontal disease, is a long-term inflammation of the gums and bone around teeth, leading to tooth loss.
- Conditions
- Periodontal Disease (PD), Cardio Vascular Disease, Oral-Systemic Link, Vascular Dysfunction
- Trial name
- CHX-PMPR-PERIV (NCT07311512)
- Testing
- Chlorhexidine (0.2%) mouthwash
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Mahdi Mutahar
Bloodstream Infections, Central Nervous System Infections
INfectious DIsease REgistry BIObank
Prospective observational study designed to describe the clinical, laboratory, imaging, microbiological characteristics and treatment of specific infectious diseases, with the addition of a dedicated biobank.
- Conditions
- Bloodstream Infections, Central Nervous System Infections, Bone and Joint Infections, Endovascular Infections
- Trial name
- INDI-REBIO (NCT06418048)
- Where
- Italy
- Volunteers
- 10,000 people
- Sponsor
- IRCCS San Raffaele
Sepsis, Infective Endocarditis
Study of Leukocyte Immunophenotype and the Lipid Transport System as Predictive Biomarkers of Severe Bacterial Infections
Current study evaluates the relationship between cell immunity and lipid transport systems in patients with severe bacterial infections (on the model of pneumonia, infective endocarditis, sepsis) in order to develop new methods…
- Conditions
- Sepsis, Infective Endocarditis, Pneumonia, Bacterial
- Trial name
- NCT04178915
- Testing
- Bood leukocyte subsets, The cholesterol content of the cell membrane of T-cells and monocytes
- Where
- Belarus
- Volunteers
- 100 people
- Sponsor
- The Republican Research and Practical Center for Epidemiology and Microbiology
Coronary Artery Disease
Intravenous Fish Oil in Critically Ill Cardiac Patients
A large body of evidence has accumulated showing that n-3 PUFAs exert extensive cardiac effects. The development of commercial solutions of FO opens perspectives for therapeutic applications in patients with acute cardiac…
- Trial name
- FO-cardiac (NCT00516178)
- Testing
- Fish oil emulsion, Saline
- Where
- 2 sites in Switzerland
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Arrhythmia, Sudden Cardiac Death
Electrophysiological Phenotyping Of Patients at Risk of Ventricular Arrhythmia and Sudden Cardiac Death
Obesity, rheumatoid arthritis (RA) and gene-specific dilated cardiomyopathy (DCM) are common medical conditions. Small-scale studies have shown that these are associated with proarrhythmic changes on 12-lead electrocardiogram…
- Conditions
- Arrhythmia, Sudden Cardiac Death, Cardiomyopathy, Dilated, Obesity
- Trial name
- EPORVA (NCT03910725)
- Testing
- Electrocardiographic imaging
- Where
- 2 sites in United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Sepsis
PICS: Subtitle Cardiac Dysfunction in Older Sepsis Survivors
The purpose of this study is to define the natural history and causes of chronic critical illness (CCI) in surgical intensive care patients who have had sepsis.
- Trial name
- PICS (NCT02276417)
- Testing
- Blood collection, Urine collection, Bioimpedance Analysis
- Where
- United States
- Volunteers
- 668 people, healthy volunteers welcome
- Sponsor
- University of Florida
Diabetic Ketoacidosis, Heart Disease, Ischemic
Effectiveness of Music Intervention on Anxiety and Physiological Responses in Critical Ill Patient
Music intervention is a non-pharmacological and effective intervention that can alleviate anxiety and agitation in patients undergoing weaning.
- Conditions
- Diabetic Ketoacidosis, Heart Disease, Ischemic, Stroke, GastroIntestinal Bleeding
- Trial name
- NCT04977011
- Testing
- relaxing music
- Where
- Taiwan
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Min-Sheng General Hospital
Ischemic Heart Disease, Myocardial Infarction
Rituximab in Patients With Acute ST-elevation Myocardial Infarction Study
RITA-MI aims to develop of a novel therapeutic concept to target the immune response in patients with acute myocardial infarction (MI) by depleting B-cells with a single injection of Rituximab which is approved for clinical use…
- Conditions
- Ischemic Heart Disease, Myocardial Infarction, Inflammation
- Trial name
- RITA-MI (NCT03072199)
- Testing
- RiTUXimab Injection
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- Papworth Hospital NHS Foundation Trust
Arrhythmia, Acute Kidney Injuries
This is an Observational Study That Aims to Demonstrate Postoperative Risk Factors in Pediatric Cardiac Surgery
This retrospective observational study aims to identify risk factors for postoperative complications in children undergoing cardiac surgery at a tertiary hospital in Brazil.
- Conditions
- Arrhythmia, Acute Kidney Injuries, Sepsis, Pneumopathy
- Trial name
- PEDS-CARE (NCT06985082)
- Testing
- THERE IS NOT A INTERVENTION
- Volunteers
- 310 people
- Sponsor
- Instituto de Cardiologia do Rio Grande do Sul
Myocardial Infarction
Ferumoxytol for Magnetic Resonance Imaging of Myocardial Infarction
The investigators wish to examine whether a novel 'nanoparticle' of iron oxide, administered intravenously allows an area of heart muscle damage after heart attack to be visualised using a magnetic resonance scanner.
- Trial name
- NCT01323296
- Testing
- Ferumoxytol
- Where
- 2 sites in United Kingdom
- Volunteers
- 15 people
- Sponsor
- University of Edinburgh
Systemic Inflammatory Response Syndrome (SIRS), Postoperative Vasodilation Syndrome
Prediction of Inflammatory Response and Hypotensive Syndrome After Cardiac Surgery by Preoperative Copeptin Level
The purpose of this study is to find a preoperative biomarker before cardiac surgery with cardiopulmonary bypass related to severe postoperative inflammatory response and circulatory complications.
- Conditions
- Systemic Inflammatory Response Syndrome (SIRS), Postoperative Vasodilation Syndrome, Stress Response, Cardiac Surgery Prognosis
- Trial name
- MicorSIRS (NCT03288610)
- Testing
- Preoperative copeptin level
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Montpellier
Cardiotoxicity, Anthracycline Related Cardiotoxicity in Breast Cancer
ANTthracycline-induced Inflammation and OXidative Stress: 10-year Follow-up
The goal of this observational study is to learn about the long-term effects of anthracycline chemotherapy on inflammation, oxidative stress, and heart function in adult women with breast cancer.
- Conditions
- Cardiotoxicity, Anthracycline Related Cardiotoxicity in Breast Cancer, Breast Cancer
- Trial name
- ANTIOX-10 (NCT07680855)
- Volunteers
- 17 people
- Sponsor
- University of Chile