Clinical trials: Cardiac Ischemia
Aortic Stenosis, Coronary Artery Disease
Staged Complete Revascularization for Coronary Artery Disease vs Medical Management Alone in Patients With AS Undergoing Transcatheter Aortic Valve Replacement
Patients undergoing transcatheter aortic valve replacement (TAVR) often have concomitant coronary artery disease (CAD) which may adversely affect prognosis.
- Conditions
- Aortic Stenosis, Coronary Artery Disease, Coronary Stenosis
- Trial name
- COMPLETE TAVR (NCT04634240)
- Testing
- Percutaneous Coronary Intervention (PCI)
- Where
- 72 sites in United States, Canada
- Volunteers
- 4,000 people
- Sponsor
- University of British Columbia
Ischemic Heart Disease, Angina Pectoris
Physiology and Residual Ischemia After Percutaneous Coronary Intervention
Despite optimal angiographic result after stent implantation, a number of patients will undergo repeat angiography within 1 year of index procedure.
- Conditions
- Ischemic Heart Disease, Angina Pectoris, Chest Pain, Coronary Artery Disease
- Trial name
- EASY-PRIPCI (NCT04494750)
- Where
- Canada
- Volunteers
- 260 people
- Sponsor
- Laval University
Coronary Artery Disease
Effect of Rotablator on Balloon Resistant Calcified Coronary Lesion
The optimal treatment of calcified coronary lesion remained to be elucidated. A Prospective, randomized controlled trial was perform to explore the immediate effect and long-term outcome of rotational atherectomy in patients with…
- Trial name
- NCT01887704
- Testing
- Rotablator, conventional angioplasty, stenting
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Capital Medical University
Coronary Artery Disease
Efficacy Study of Two Different Strategies for Restenosis in Sirolimus-Eluting Stents
For lesions which develop restenosis after a drug-eluting stent, it is not known which the right strategy to use is, implantation of the same type of DES as the initial one or a DES with a different drug.
- Trial name
- DESIRE-2 (NCT00598715)
- Testing
- Sirolimus eluting stent, Paclitaxel-eluting stent
- Where
- 2 sites in Germany
- Volunteers
- 450 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Acute Coronary Syndrome
Mechanisms of Social Inequalities in Post-hospitalization Rehabilitation in Patients With Acute Coronary Syndrome
Aim: To identify psychological and socioeconomic predictors of cardiac-rehabilitation (CR) attendance and uncover mechanisms of CR non-attendance. Design: Quantitative, observational, prospective study.
- Trial name
- NCT02360189
- Where
- 2 sites in Denmark
- Volunteers
- 310 people
- Sponsor
- Nordsjaellands Hospital
Cardiogenic Shock
Awake Axillary Impella 5.5 Placement - A Feasibility Trial
The Abiomed Impella 5.5 is a surgically placed temporary mechanical support device used in patients in cardiogenic shock. The investigators propose using regional anesthesia (3 separate peripheral nerve blocks) to facilitate…
- Trial name
- NCT05782491
- Testing
- Interscalene Block, PECS II Block, Superficial Cervical Plexus Block
- Where
- 2 sites in United States
- Sponsor
- University of Pennsylvania
Myocardial Infarction
GLP-1 on Non-ST-Segment Elevation Myocardial Infarction
The investigators planned to evaluate the effects of liraglutide on left ventricular function in patients with non-ST-segment elevation myocardial infarction (NSTEMI).
- Trial name
- NCT02577848
- Testing
- GLP-1
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Chinese PLA General Hospital
Coronary Artery Disease, Therapeutics
PEACE Prospective Study of Patients With Three-vessel Disease
Coronary heart disease (CHD) pose a serious health threaten to population. Optimal revascularization strategy in multiple vessel coronary artery disease patients remains a subject of debate between interventional cardiologists…
- Conditions
- Coronary Artery Disease, Therapeutics, Outcome Assessment
- Trial name
- PEACE3VD (NCT01617785)
- Where
- China
- Volunteers
- 4,500 people
- Sponsor
- China National Center for Cardiovascular Diseases
Arthritis of Knee, Arthritis of Hip
Comparison of the Diagnosis Time of VET and SCL in Patients With Intraoperative Coagulopathy
The present study is a prospective, multi-center observational trial comparing the times taken to diagnose coagulopathies using point-of-care (POC) viscoelastic tests or standard central laboratory tests (SCL tests) in patients…
- Conditions
- Arthritis of Knee, Arthritis of Hip, Spine, Prostate Cancer
- Trial name
- NCT06637943
- Testing
- SCL tests, POC viscoelastic tests
- Where
- 4 sites in South Korea
- Volunteers
- 210 people
- Sponsor
- Konkuk University Medical Center
Coronary Artery Disease
Ezetimibe and Atorvastatin Therapy on TCFA
After successful coronary angiography and OCT examination, patients with TCFAs in non-culprit, mild-to-moderate stenotic lesions will be enrolled.
- Trial name
- NCT02588235
- Testing
- Ezetimibe and Atorvastatin, Atorvastatin
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Xijing Hospital
Radiographic Contrast Agent Nephropathy, Renal Failure
Prevention of Contrast Nephropathy During Diagnostic Coronary Angiogram or PCI With Hydratation Based on LEVDP
The goal is to determine if prehydration based on LEVDP is superior to a standard hydratation with NaCl 0.9% or NaHCO3 for the prevention of contrast nephropathy related to a diagnostic coronary angiogram or to PCI.
- Conditions
- Radiographic Contrast Agent Nephropathy, Renal Failure, Coronary Heart Disease
- Trial name
- NEPHRON (NCT00584350)
- Testing
- Hydratation according LVEDP + NaHCO3, normal saline, Sodium bicarbonate
- Where
- Canada
- Volunteers
- 330 people
- Sponsor
- Université de Sherbrooke
Coronary Artery Stenosis
COmplex BifuRcation Lesions: A Comparison Between the AXXESS Device and Culotte Stenting: An Optical Coherence Tomography (OCT) Study
The aim of this study is to compare vessel healing at 9 months using OCT imaging for two different treatment techniques for treating bifurcation lesions.
- Trial name
- COBRA (NCT00895791)
- Testing
- AXXESS Biolimus A9-eluting bifurcation stent, culotte stenting (Xience V)
- Where
- Belgium
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Acute Coronary Syndrome
Identification of Clopidogrel CYP2C19 Metabolizer and Thienopyridine Treatment After an Acute Coronary Syndrome
To demonstrate that a strategy of fast genetic testing performed in outpatient clinic allows to select adequately one of the 2 antiplatelet treatments approved in the same indication (ACS with PCI - prasugrel 10mg MD or…
- Trial name
- GAMMA (NCT01390974)
- Where
- France
- Volunteers
- 270 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Multi Vessel Coronary Artery Disease
Medical Management vs Partial Revascularization in Diffuse Multivessel Coronary Artery Disease
This randomized controlled trial will compare the clinical outcomes of partial revascularization with percutaneous coronary intervention (PCI) versus optimal medical therapy (OMT) alone in patients with diffuse multivessel…
- Trial name
- MPR-CAD (NCT07866404)
- Testing
- Partial per cutaneous coronary intervention, Optimal medical therapy (OMT)
- Where
- Pakistan
- Volunteers
- 140 people
- Sponsor
- CH. Pervaiz Elahi Institute of Cardiology, Multan
Ischemic Heart Disease (IHD), Anxiety
Online Personalized Psychological Intervention for Patients With Heart Disease and Depression or Anxiety (MY-CHOICE)
The goal of this feasibility study is to assess if the personalised online psychological intervention MY-CHOICE is acceptable to adults with ischemic heart disease and anxiety or depression.
- Conditions
- Ischemic Heart Disease (IHD), Anxiety, Depression
- Trial name
- MY-CHOICE (NCT07569458)
- Testing
- Online psychological therapy
- Where
- 3 sites in Denmark
- Volunteers
- 30 people
- Sponsor
- University of Southern Denmark
Chronic Periodontitis, Coronary Artery Disease
Interplay of miRNA-146a and miRNA-126 in Chronic Periodontitis Patients With Coronary Artery Disease
The role of micro-RNAs in chronic periodontitis associated with CAD is still in an incipient stage needs to be explored further.
- Conditions
- Chronic Periodontitis, Coronary Artery Disease, miRNA
- Trial name
- NCT04583085
- Where
- India
- Volunteers
- 75 people
- Sponsor
- Meenakshi Ammal Dental College and Hospital
Coronary Artery Disease
Rubidium-82 - An Alternative Radiopharmaceutical for Myocardial Imaging(Rb-ARMI)
Cardiovascular (CV) disease is the leading cause of death in Canada. Fifty percent of all Tc-99m used in nuclear medicine is for the diagnosis of coronary artery disease (CAD) with SPECT myocardial perfusion imaging (MPI).
- Trial name
- Rb-ARMI (NCT01128023)
- Testing
- Myocardial perfusion imaging using Rb-82 PET or Tc-99m or Tl SPECT
- Where
- Canada
- Volunteers
- 10,000 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Coronary Heart Disease, Angina Pectoris
Safety Study of Kudiezi (a Chinese Medicine Injection) Used in Hospitals in China
This study was advocated by Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences in October 2011.
- Trial name
- RSCMI-Ⅱ (NCT01612559)
- Volunteers
- 30,000 people
- Sponsor
- China Academy of Chinese Medical Sciences
Coronary Artery Disease
Magnetic Resonance Imaging (MRI) Viability: Comparison of Myocardial Viability by Positron Emission Tomography and MRI
The purpose of this study is to compare cardiac MRI with positron emission tomography (PET) with fluorodeoxyglucose (FDG) to determine if cardiac MRI images are as good as, or better, than PET with FDG.
- Trial name
- NCT00166179
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Emory University
MI Related Malignant Ventricular Arrhythmia
Effect of Radiofrequency Ablation in Patients With Ventricular Arrhythmia Undergoing CABG
Patients with myocardial infarction related potential malignant ventricular arrhythmia have high risk of sudden death. The aim of this clinical trial is evaluating therapeutic efficacy of unipolar or bipolar radiofrequency…
- Trial name
- RACAVA (NCT02991170)
- Testing
- unipolar or bipolar radiofrequency ablation+CABG, CABG
- Where
- 3 sites in China
- Volunteers
- 180 people
- Sponsor
- Beijing Anzhen Hospital