Clinical trials: Cardiac Magnetic Resonance
Cardiovascular Diseases, Heart Diseases
Cardiovascular Magnetic Resonance for the Occluded Infarct-Related Artery Treatment
The purpose of this study is to determine whether opening an occluded infarcted artery 3-28 days after an acute myocardial infarction in high-risk asymptomatic patients with preserved infarct zone viability improves left…
- Conditions
- Cardiovascular Diseases, Heart Diseases, Myocardial Infarction, Heart Failure
- Trial name
- COAT (NCT00968383)
- Testing
- Beta adrenergic blockers, Platelet inhibitors, Statins
- Where
- Poland
- Volunteers
- 11 people
- Sponsor
- National Institute of Cardiology, Warsaw, Poland
Stiffness, Aortic, Cardiac Remodeling, Ventricular
Study of the Aorta Adaptations to Exercise in Triathletes During Sports Season (CoATri)
Regular sustained physical activity creates a cardiac remodelling : it is athlete's heart. In our preliminary work published in 2016, the investigators demonstrated in a small population of triathletes that there is also a…
- Conditions
- Stiffness, Aortic, Cardiac Remodeling, Ventricular, Vascular Remodeling, Magnetic Resonance Imaging, Functional
- Trial name
- CoATri (NCT03356301)
- Testing
- Cardiac MRI, Applanation tonometry
- Where
- France
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Stroke, Aortic Valve Stenosis
INTERvention With Cerebral Embolic Protection in Transcatheter Aortic Valve Implantation (INTERCEPTavi)
The study aims to evaluate the processes of a pilot single-centre randomised controlled trial (RCT) of carbon-dioxide flushing of transcatheter aortic valves (TAVI-CO2) versus standard saline flushing of valves (TAVI-S) and…
- Conditions
- Stroke, Aortic Valve Stenosis, Silent Cerebral Infarct, Vascular Brain Injury
- Trial name
- INTERCEPTavi (NCT05146037)
- Testing
- CO2 and saline flushing, Saline flushing
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Myocardial Ischemia
Electromechanical Mapping to Evaluate Heart Muscle
Patients with narrowed heart arteries who undergo coronary angiography (imaging of the heart's blood vessels) may participate in this "heart mapping" study designed to gain information about the condition of different areas of…
- Trial name
- NCT00001895
- Testing
- FDG, NH(3)
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Cardiomyopathy, Hypertrophic
A Study to Evaluate Mavacamten Impact on Myocardial Structure in Participants With Symptomatic Obstructive Hypertrophic Cardiomyopathy
The purpose of this study is to evaluate the mavacamten impact on myocardial structure with cardiac magnetic resonance imaging (CMR) in adult participants with symptomatic obstructive hypertrophic cardiomyopathy (oHCM) [New York…
- Trial name
- MEMENTO (NCT06112743)
- Testing
- Mavacamten
- Where
- 23 sites in United States, Argentina and 4 more
- Volunteers
- 63 people
- Sponsor
- Bristol-Myers Squibb
Anxiety
Contribution of Hypnosis on Image Quality in Cardiac MRI
The present project aims to explore the effect of a hypnosis session performed on a patient with anxiety during a cardiac MRI examination on image quality.
- Trial name
- HYPNOLINE (NCT05999578)
- Testing
- Hypnosis
- Where
- France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Bordeaux
Myocardial Viability in Ischemic Left Ventricular Dysfunction, Prediction for Improvement in Cardiac Function After Revascularization Therapy
The Use of Myocardial Deformation Imaging
Myocardial deformation imaging allows analysis of myocardial viability in ischemic left ventricular dysfunction. This study will evaluate the predictive value of myocardial deformation imaging for improvement in cardiac function…
- Trial name
- NCT00476320
- Testing
- Magnetic Resonance Imaging, Revascularization, Echocardiography with myocardial deformation imaging
- Where
- Germany
- Sponsor
- RWTH Aachen University
Hypertrophic Cardiomyopathy
HCMR - Novel Markers of Prognosis in Hypertrophic Cardiomyopathy
Hypertrophic cardiomyopathy (HCM) is the most common monogenic heart disease and the most frequent cause of sudden cardiac death (SCD) in the young.
- Trial name
- HCMR (NCT01915615)
- Testing
- None - this is an observational study
- Where
- 44 sites in United States, Canada and 4 more
- Volunteers
- 2,750 people
- Sponsor
- University of Virginia
Heart Failure, Systolic, Left Bundle Branch Block
Optimal Coronary Sinus Lead Implantation Using Intracardiac Impedography and Magnetic Resonance Imaging
Despite the dramatic effect of cardiac resynchronization therapy (CRT) on survival and morbidity in people with congestive heart failure, 50-70% of eligible patients do not respond to this intervention.
- Trial name
- NCT01129635
- Testing
- Cardiac Resynchronization Therapy (CRT) implantation
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Emory University
Myocarditis
FDG-PET/CT Images Comparing to MRI and Endomyocardial Biopsy in Myocarditis
Fifty hospitalized consecutive patients with clinically suspected myocarditis (MC) who meet the inclusion/exclusion criteria will be enrolled to the study.
- Trial name
- STREAM (NCT04085718)
- Volunteers
- 50 people
- Sponsor
- Medical University of Warsaw
Infective Endocarditis
PET/MR Imaging In Patients With Infective Endocarditis
PET scanning (positron emission tomography) is a well-established technique used to identify areas of interest within the body. It involves injecting a radioactive tracer which highlights abnormal areas.
- Trial name
- NCT03626571
- Testing
- 18F-FDG
- Where
- United Kingdom
- Volunteers
- 5 people
- Sponsor
- University of Edinburgh
Acute Myocardial Infarction (AMI)
Dexrazoxane to Protect Against Hemorrhagic STEMI
This Phase Ila trial evaluates whether the intravenous administration of Dexrazoxane can reduce permanent heart muscle damage in patients undergoing standard stent procedures (PCI) for a severe heart attack (STEMI).
- Trial name
- SHIELD-MI (NCT07502521)
- Testing
- Dexrazoxane, Normal Saline
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Rohan Dharmakumar
Adverse Effect of MRI on an Implanted Pacemaker Lead, Adverse Effect of MRI on an Implanted Pacemaker
Safety and Efficacy of the Accent Magnetic Resonance Imaging™ (MRI) Pacemaker and Tendril MRI™ Lead
The MRI Study is a prospective, multi-center, clinical study designed to evaluate the safety and efficacy of the Accent MRI™ System in a patient population indicated for implant of a pacemaker within and outside of the MRI…
- Trial name
- NCT01576016
- Testing
- Accent MRI system (lead safety), Accent MRI system (with MRI scan)
- Where
- 70 sites in United States, Australia and 3 more
- Volunteers
- 950 people
- Sponsor
- Abbott Medical Devices
Sudden Cardiac Death, Implantable Defibrillator User
Implantable Cardioverter Defibrillators - Improving Risk Stratification
Worldwide three million people a year die from sudden cardiac death (SCD). In most cases there is no warning and the heart is stopped by a sudden arrhythmia.
- Conditions
- Sudden Cardiac Death, Implantable Defibrillator User, Myocardial Infarction, Arrhythmias, Cardiac
- Trial name
- ICD-IRS (NCT01944514)
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- University Hospitals, Leicester
Transposition of Great Vessels, Surgery
MRI Study After Arterial Switch Operation in Patients With Transposition of the Great Arteries
This study involves adolescents operated with arterial switch procedure for transposition of the great arteries during the neonatal period.
- Trial name
- NCT01916499
- Testing
- 3 tesla magnetic resonance imaging findings; coronary artery status, 3 tesla magnetic resonance imaging findings; ventricular function and morphology
- Where
- Norway
- Volunteers
- 70 people
- Sponsor
- Oslo University Hospital
Coronary Chronic Total Occlusions
Stress CMR in Patients With Coronary Chronic Total Occlusions
A total chronic occlusion (CTO) is defined as a coronary obstruction with TIMI 0 flow lasting at least 3 months.The prevalence of CTO in patients with coronary disease is about 10-40%.
- Trial name
- CARISMA_CTO (NCT03152825)
- Testing
- PCI
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- Ospedale San Donato
Ventricular Tachycardia, Myocardial Fibrosis
Ventricular Tachycardia Ablation and Myocardial Scar Characterization With Magnetic Resonance
Previous monocentric experiences have already highlighted the role of preoperative cardiac imaging, in particular of cardiac magnetic resonance (CMR) and tomography (CT), in improving the ablation results of scar-related…
- Trial name
- VOYAGE (NCT04694079)
- Testing
- Group 1, CMR-guided/aided VT ablation, Group 2, CMR-aided VT ablation, Group 3, Electroanatomical guided ablation
- Where
- 7 sites in Italy
- Volunteers
- 104 people
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
Aortic Stenosis
Role of Elastin Metabolites in Aortic Remodelling in AS
Around 1-2% of people are born with a 'bicuspid' aortic valve, with only two cusps instead of the common 'tri-leaflet' valve. People with this valve develop dysfunction of the valve (narrowing or leakage) at a much earlier age.
- Trial name
- ELASTIC-AS (NCT03883490)
- Testing
- ECG, Blood test and biobanking, Trans-thoracic Echocardiogram
- Where
- United Kingdom
- Volunteers
- 46 people
- Sponsor
- University of Leicester
Normal and Abnormal Cardiovascular Physiology
Technical and Translational Development of Cardiovascular Magnetic Resonance (CMR) Imaging
Background: Magnetic resonance imaging (MRI) is an important non-invasive tool to study and diagnose cardiovascular disease. MRI scanners use strong magnetic fields and radio waves to create pictures of body organs.
- Trial name
- NCT03581318
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Cardiovascular Diseases, Left Ventricular Hypertrophy
Empagliflozin and Cardiac Remodelling in People Without Diabetes
The purpose of this study is to evaluate the effects of empagliflozin on cardiac structure, function and circulating biomarkers in patients with cardiovascular risk factors, but without diabetes.
- Trial name
- EMPA-HEART 2 (NCT04461041)
- Testing
- Empagliflozin
- Where
- 4 sites in Canada, Taiwan
- Volunteers
- 169 people
- Sponsor
- Unity Health Toronto