Clinical trials: Cardiac Magnetic Resonance
Myocardial Infarction
Myocardial Protection of Exenatide in AMI
Experimental evidence suggests exenatide, a glucagon-like peptide 1 receptor analogue, has significant cardiovascular protective effects in various conditions.
- Trial name
- EMPIRE (NCT01580514)
- Testing
- exenatide BYETTA® (Amylin-Lilly), Saline
- Where
- South Korea
- Volunteers
- 127 people
- Sponsor
- Kyunghee University Medical Center
Ischemic Heart Disease, ST-segment Elevation Myocardial Infarction
Late Reperfusion With Percutaneous Coronary Intervention in Patients With ST-segment Elevation Myocardial Infarction
Although recommended therapy for patients with ST-segment elevation myocardial infarction is primary PCI, it remains unestablished whether patients with a symptom duration of more 12 hours benefit from acute revascularisation.
- Trial name
- LATE-MI (NCT02445885)
- Testing
- PCI
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- Thomas Engstrom
Heart Aneurysm
A Novel Ferumoxytol-enhanced Cardiac Magnetic Resonance Imaging for the Detection of Intracardiac Thrombus
The incidence of thrombosis in ventricular aneurysm was reported to be 35%-40%, which may lead to systemic thromboembolism. Patients with ventricular aneurysm without detectable thrombus are not routinely treated with…
- Trial name
- NCT06146751
- Testing
- Superparamagnetic Iron Oxide Nanoparticles
- Where
- China
- Volunteers
- 320 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Atrial Fibrillation, Atrial Inflammation
Inflammation, Fibrosis and Risk of Recurrence After Atrial Fibrillation Ablation
FIBRO-RISK study aims to investigate the impact of inflammatory-mediated myocardial fibrosis on the risk of recurrence after successful ablation of atrial fibrillation.
- Trial name
- FIBRO-RISK (NCT03757741)
- Testing
- Cardiac imaging tests, Venous blood samle collection
- Where
- Romania
- Volunteers
- 100 people
- Sponsor
- Cardio Med Medical Center
Coronary Artery Disease
Breathing-Induced Myocardial Oxygenation Reserve
This is a clinical trial to test the clinical feasibility and safety of a novel CMR protocol, combined with a specific breathing maneuver to identify myocardial regions exposed to severe coronary artery stenosis.
- Trial name
- B-MORE-Pilot (NCT03050346)
- Where
- 6 sites in United States, Canada and 3 more
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Myocardial Infarction, Myocardial Ischemia
Vulnerable Plaque Imaging in NSTEMI
Myocardial infarction (MI) frequently recurs after non-ST elevation MI (NSTEMI) that may be related to insufficient vulnerable plaque identification using invasive coronary angiography.
- Trial name
- CULPRIT (NCT02563964)
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- Maastricht University Medical Center
COVID-19 Pneumonia, COVID-19
Cardiac Magnetic Resonance Tissue Characterization in COVID-19 Survivors
The purpose of this study is to test if visualizing the heart with cardiac MRI/echo will be important in the understanding cardiac function and prediction of cardiopulmonary symptoms, physical effort tolerance, and outcomes in…
- Conditions
- COVID-19 Pneumonia, COVID-19, COVID-19 Respiratory Infection, COVID-19 Acute Respiratory Distress Syndrome
- Trial name
- NCT05164744
- Testing
- Cardiac MRI, Echocardiogram, 6-minute walk test
- Where
- 3 sites in United States
- Volunteers
- 510 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Atrial Fibrillation, Myocardial Infarction, Acute
Prognostic Role of LA Strain in Acute Myocardial Infarction
This is a single-center retrospective observational study in which we consecutively selected patients diagnosed with acute myocardial infarction from September 2019 to March 2024 at the Affiliated Hospital of Xuzhou Medical…
- Conditions
- Atrial Fibrillation, Myocardial Infarction, Acute, Stroke Ischemic, Mortality
- Trial name
- CMR-MI (NCT06408636)
- Testing
- Cardiac MRI
- Where
- China
- Volunteers
- 780 people
- Sponsor
- The Affiliated Hospital of Xuzhou Medical University
Atherosclerosis, Chronic Granulomatous Disease (CGD)
Non-Invasive Assessment of Atherosclerosis in Patients With CGD and Other Disorders of the Immune System
Background: Atherosclerosis, the arterial plaques or blockages that cause heart disease, develops in many people by the time they are in their mid-20s.
- Trial name
- NCT01063309
- Where
- United States
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Diabetes, Cardiovascular Disease
Effects of Empagliflozin on Cardiac Structure in Patients With Type 2 Diabetes
The purpose of this study is to evaluate the effects of Empagliflozin on cardiac structure, function and circulating biomarkers in patients with Type II diabetes.
- Trial name
- EMPA-HEART (NCT02998970)
- Testing
- Empagliflozin
- Where
- Canada
- Volunteers
- 97 people
- Sponsor
- Unity Health Toronto
Pulmonary Hypertension
Integrated Diagnostics Characterization of Right Ventricular Diastolic Flow Dynamics in Pulmonary Arterial Hypertension
Pulmonary hypertension (PH) is a condition in which high blood pressure develops in the lungs and right side of the heart. People with PH suffer from shortness of breath, chest pain, heart failure, heart rhythm problems, and…
- Trial name
- NCT01491646
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- National Jewish Health
Mitral Valve Insufficiency, Mitral Regurgitation
Acquisition of Objective Data During Transapical Neochordae Implantation
Mitral Valve repair (MVr) is the gold standard treatment for primary Mitral Regurgitation. Implantation of artificial Gore-Tex chordae (or neochordae implantation) is often used for MVr.
- Trial name
- TENSCHORD (NCT04709042)
- Testing
- Chordal tension measurement, Cardiac Magnetic Resonance Imaging (MRI)
- Sponsor
- Hospices Civils de Lyon
Heart Failure, Congestive
Using Magnetic Resonance Imaging to Predict People Who Are Likely to Develop Flash Pulmonary Edema (The PREDICT Study)
Flash pulmonary edema is a sudden, abnormal build-up of fluid in the lungs. It is usually caused by heart failure and can be life threatening.
- Trial name
- PREDICT (NCT00542503)
- Where
- United States
- Volunteers
- 579 people
- Sponsor
- Wake Forest University Health Sciences
Mitral Valve Prolapse Syndrome, Arrhythmogenic Bileaflet Mitral Prolapse
Mitro-annular Disjunction in Cardiac Magnetic Resonance
Mitral annular disjunction (MAD) is an abnormal atrial displacement of the mitral valve leaflet hinge point. MAD is gaining clinical importance for several studies reporting its association to mitral valve prolapse (MVP), complex…
- Conditions
- Mitral Valve Prolapse Syndrome, Arrhythmogenic Bileaflet Mitral Prolapse, Mitral Valve Disorder
- Trial name
- NCT06436573
- Where
- Italy
- Volunteers
- 4,000 people
- Sponsor
- IRCCS San Raffaele
Heart Failure With Normal Ejection Fraction
Validation of CMR Against Invasive Haemodynamics in Patients With HFpEF
Heart failure (HF) currently affects app. 2% of the western population and app. 10% of people >75 years. In about 50% of patients with symptomatic HF ejection fraction (EF) is preserved (HF-PEF).
- Trial name
- DECIPHER-HFpEF (NCT03251183)
- Testing
- Comprehensive Cardiovascular magnetic resonance (CMR), Blood sampling, TTE (EchoErgo)
- Where
- 7 sites in Germany
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- Goethe University
Acute Coronary Syndrome (ACS), High On-treatment Platelet Reactivity (HTPR)
The Effect of IV Cangrelor and Oral Ticagrelor Study
Major heart attacks are caused by a number of factors, the two major of which are furring up of a coronary artery with atheroma and then sudden clot formation on this area leading to a blockage and interruption of blood flow.
- Conditions
- Acute Coronary Syndrome (ACS), High On-treatment Platelet Reactivity (HTPR), Microvascular Obstruction (MVO), ST-segment Elevation Myocardial Infarction (STEMI)
- Trial name
- NCT02733341
- Testing
- Cangrelor, Ticagrelor
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- The Royal Wolverhampton Hospitals NHS Trust
Transfusional Iron Overload, Transfusional Hemosiderosis
Evaluating Use of Deferasirox as Compared to Deferoxamine in Treating Cardiac Iron Overload
This is a clinical research study in patients who have iron overload in the heart due to chronic blood transfusions. The study will have 2 treatment groups and will compare the safety and efficacy of chelation therapy with a…
- Trial name
- CORDELIA (NCT00600938)
- Testing
- Core Study: Deferasirox, Core Study: Deferoxamine, Extension: deferoxamine to deferasirox
- Where
- 21 sites in Canada, China and 9 more
- Volunteers
- 197 people
- Sponsor
- Novartis Pharmaceuticals
Healthy Volunteers
Deriving Cardiac Reference Ranges at 3.0Tesla in Healthy Volunteers
Current MRI society guidelines recommend that reference ranges for specific imaging techniques (T1, T2 mapping, perfusion) are acquired on the MRI scanner that clinical work and research studies are being carried out on.
- Trial name
- DECADENT-HV (NCT05241184)
- Testing
- Multiparametric stress CMR protocol
- Where
- United Kingdom
- Volunteers
- 32 people
- Sponsor
- University of Glasgow
Coronary Artery Disease
Use of Stress-CMR Using Regadenoson and GE-267 in Adult Patients with Known or Suspected Coronary Artery Disease
Stress cardiac MRI is crucial for diagnosing coronary artery disease in adults. Currently, it is mainly performed with vasodilators in specialized centers.
- Trial name
- NCT06246188
- Testing
- Cardiac MRI using Regadenoson and GE-267
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- German Heart Institute
Myocardial Injury, LV Dysfunction
Study to Assess Safety and Efficacy of Treating Symptomatic, Ischemic, Chronic Congestive Heart Failure Patients with an LVEF of ≤40% with Fresh, Uncultured, Autologous, Adipose-derived Regenerative Cells Isolated from Lipoaspirate.
To investigate patients suffering from iHF and a LVEF of equal or less than 40% despite best medical treatment safety and efficacy of a single retrograde intra-cardiac venous (i.cv.) injection of UA-ADRCs isolated from…
- Conditions
- Myocardial Injury, LV Dysfunction, Coronary Artery Disease, Heart Failure
- Trial name
- NCT06705023
- Testing
- Uncultured, autologous, adipose-derived regenerative cells (UA-ADRCs), Continuation of patient's best guideline based medical treatment
- Where
- Kazakhstan
- Volunteers
- 36 people
- Sponsor
- Ralf Rothoerl