Clinical trials: Cardiac Magnetic Resonance
Ventricular Tachycardia, Sudden Death
Feasibility of Contact Force Catheter Mapping and Ablation in Epicardial and Endocardial Ventricular Tachycardias
Ventricular tachycardia is one of the commonest cause of sudden death in chronic chagas disease. As most ventricular tachycardias originate from scar in patients with heart disease, catheter ablation is an important step in…
- Conditions
- Ventricular Tachycardia, Sudden Death, Syncope, Chest Pain
- Trial name
- EPICONTAC-VT (NCT01847378)
- Testing
- Catheter ablation
- Where
- 3 sites in Brazil
- Volunteers
- 10 people
- Sponsor
- Federal University of São Paulo
Cardiomyopathy, Dilated, 3B
CRT-P or CRT-D in Dilated Cardiomyopathy
The ICD-Reality study is a non-commercial, investigator-led, multicenter, prospective, randomized, controlled trial. We aim to determine the effect of CRT-D or CRT-P implantation in non-ischemic cardiomyopathy and heart failure…
- Trial name
- CRT-REALITY (NCT04139460)
- Testing
- CRT-D, CRT-P
- Where
- Czechia
- Volunteers
- 924 people
- Sponsor
- University Hospital Olomouc
Atrial Fibrillation
Evaluation of Ablation Lesions Using Cardiovascular Magnetic Resonance Imaging
Ineffective ablation lesions can cause arrhythmia recurrence after catheter ablation for cardiac arrhythmia. Ablation lesions can be created with various ablation energy modalities.
- Trial name
- ENABLE-CMR (NCT05432024)
- Testing
- Catheter ablation
- Where
- Netherlands
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- R&D Cardiologie
Microvascular Coronary Artery Disease, Heart Failure With Reduced Ejection Fraction
CMR Assessment of Cardiac Microvascular Dysfunction in Patients With HFpEF
Heart failure with preserved ejection fraction (HFpEF) causes hospitalizations, premature mortality and high health care costs. This is also due to poor understanding of HFpEF pathogenesis and, thus, lack of specific therapies.
- Trial name
- MAPPED (NCT06316661)
- Testing
- stress perfusion cardiac magnetic resonance, cardiopulmonary exercise test
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano
Cardiomyopathy, Hypertrophic
Prognosis of Subjects With Unexplainable Precordial Deep T-wave Inversion Without Wall Thickness> 15mm
The investigators sought to evaluate the morphological and functional changes and prognosis of participants with unexplainable precordial deep T-wave inversion on ECG and with apical thickness less than 15mm.
- Trial name
- NCT02692508
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Hemoglobinopathies, Myelodysplastic Syndromes
Magnetic Resonance Imaging (MRI) Assessments of the Heart and Liver Iron Load in Patients With Transfusion Induced Iron Overload
This study will evaluate the change in cardiac iron load over a 53 week period measured by MRI in 2 cohorts of patients
- Conditions
- Hemoglobinopathies, Myelodysplastic Syndromes, Other Inherited or Acquired Anaemia, MPD Syndrome
- Trial name
- NCT00673608
- Testing
- deferasirox
- Where
- 4 sites in Australia
- Volunteers
- 118 people
- Sponsor
- Novartis
Diabetes Mellitus, Heart Failure
Results of Tc99m-Maraciclatide Scintigraphy in Subjects With Diabetes Mellitus and Heart Failure With Preserved Left Ventricular Ejection Fraction
The purpose of this study is to evaluate the results of 99mTc maraciclatide scintigraphy in diabetic subjects with HFPEF. A maximum of 20 subjects with Diabetes Mellitus (DM) and Heart Failure With Preserved Left Ventricular…
- Trial name
- NCT01440517
- Testing
- Tc99m-Maraciclatide
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- GE Healthcare
Cardiac Diseases
Non-Invasive Determination of Cardiac Output by Electrical Velocimetry
The cardiac output (CO) is an important parameter in the diagnosis and therapy of cardiac diseases. The current standard methods for the determination of the CO, however, are either invasive (e.g.
- Trial name
- NCT00945048
- Testing
- electrical velocimetry, inert gas rebreathing, spirometry
- Where
- Germany
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Universitätsmedizin Mannheim
Acute Respiratory Distress Syndrome, Sepsis
Cardiovascular Magnetic Resonance Prognosticators in Pediatric Oncology Patients With Sepsis
The overall purpose of this protocol is to identify subacute sepsis-associated cardiac disease in pediatric patients with cancer by CMR and evaluate the CMR findings during their follow-up.
- Conditions
- Acute Respiratory Distress Syndrome, Sepsis, Cardiovascular Shock
- Trial name
- NCT05930418
- Testing
- Cardiac MRI
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- St. Jude Children's Research Hospital
Chest Pain
Vericiguat in Patients With Coronary Microvascular Dysfunction Causing Stable Chest Pain (V-COM)
This is a randomised controlled trial to determine the effectiveness of Vericiguat to improve stress myocardial blood flow (MBF) and myocardial perfusion reserve as measured by cardiac magnetic resonance (CMR) imaging.
- Trial name
- NCT06239974
- Testing
- Vericiguat, Stress Cardiac Magnetic Resonance
- Where
- Hong Kong
- Volunteers
- 94 people
- Sponsor
- The University of Hong Kong
Mitral Valve Insufficiency
Determinants of the Progression and Outcome of Mitral Regurgitation
Mitral regurgitation (MR) is one of the most frequent valve lesions, both in North America and in Europe, and its prevalence is increasing with the aging of the population.
- Trial name
- PROGRAM (NCT01835054)
- Testing
- Blood biomarkers, DNA collection, Echocardiography
- Where
- 4 sites in Belgium, Canada and 1 more
- Volunteers
- 440 people
- Sponsor
- Laval University
Lupus Erythematosus, Systemic, Coronary Artery Disease
CMR-Lupus Comprehensive Approach by Cardiovascular Magnetic Resonance Tomography
In systemic lupus erythematosus (SLE), cardiac manifestations, e.g. coronary artery disease (CAD) and myocarditis are leading causes of morbidity and mortality. The prevalence of subclinical heart disease in SLE is unknown.
- Conditions
- Lupus Erythematosus, Systemic, Coronary Artery Disease, Myocardial Disease
- Trial name
- NCT03488654
- Testing
- Cardiovascular magnetic resonance
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University Hospital, Basel, Switzerland
Cardiovascular Diseases, Microvascular Complications
Non-invasive Microvascular Assessment in Individuals at High Risk of Cardiovascular Disease From the SCAPIS2 Study
Microvascular dysfunction, particularly endothelial dysfunction, is increasingly recognized as a key mechanism underlying various cardiovascular diseases (CVD), including heart failure, ischemic heart disease, atherosclerosis…
- Trial name
- NCT07359768
- Where
- Sweden
- Volunteers
- 900 people
- Sponsor
- HJN Sverige AB/Neko Health
Magnetic Resonance Imaging (MRI)
Myocardial Injury in Patients With Cardiac Implantable Electronic Devices Following Magnetic Resonance Imaging
Researchers are trying to determine if heart injury occurs in subjects with cardiac implantable electronic device (CIED), such as a pacemaker or implantable cardioverter defibrillator (ICD), who undergo a magnetic resonance…
- Trial name
- NCT04151953
- Testing
- Blood sample collection
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- Mayo Clinic
ST Segment Elevation Myocardial Infarction
Early Prediction of QFR in STEMI-Pharmaco-invasice
The study intends to provide important data on whether the noval method using quantitative flow ratio could predict microvascular dysfunction.
- Trial name
- EARLYmyoQFR-PI (NCT04220736)
- Testing
- Computation of quantitative flow ratio
- Where
- China
- Volunteers
- 200 people
- Sponsor
- RenJi Hospital
Ventricular Function, Left
Assessment of Cardiac Involvement of Common Cold in High Performing Athletes by Cardiac Magnetic Resonance Imaging (MRI)
Cardiovascular magnetic resonance (CMR) imaging will be used to assess the impact of common colds and physical training in high-performing athletes. Healthy individuals from the general public will serve as a comparison group.
- Trial name
- NCT00739895
- Testing
- Cardiac magnetic Resonance study, Blood testing
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Cardiac Disease
DEF-315 Better Accuracy in Ejection Fraction (EF) Assessment With DEFINITY
This is a Phase 3, prospective, open-label, multicenter study to evaluate Left Ventricular Ejection Fraction (LVEF) measurement accuracy and reproducibility of DEFINITY® contrast-enhanced and unenhanced echocardiography as…
- Trial name
- BENEFIT2 (NCT03719612)
- Testing
- DEFINITY®
- Where
- 15 sites in United States
- Volunteers
- 160 people
- Sponsor
- Lantheus Medical Imaging
Myocardial Infarction
Exenatide for Myocardial Protection During Reperfusion Study
This study aims to assess the effect of exenatide on myocardial injury in patients undergoing emergent percutaneous coronary intervention (PCI) for ST segment elevation myocardial infarction or heart attack (STEMI).
- Trial name
- EMPRES (NCT01938235)
- Testing
- Exenatide
- Where
- 10 sites in Canada
- Volunteers
- 198 people
- Sponsor
- University Health Network, Toronto
Stroke, Cognitive Symptoms
Cerebral Lesions and Outcome After Cardiac Surgery (CLOCS)
Between 1 and 5 percent of patients who have coronary artery bypass surgery suffer a stroke following surgery, and 30 percent have new brain lesions that do not produce symptoms and are seen only on MRI.
- Trial name
- NCT00391378
- Where
- United States
- Volunteers
- 363 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Cardiomyopathy With Unknown Etiology
Risk Stratification of Heart Failure in Cardiomyopathies.
The investigators aimed to use CMR technique in helping diagnose the etiology of unknown cardiomyopathy. Try to make a risk stratification of susceptible heart failure based on the extent of myocardial impairment.
- Trial name
- EARLY-MYO-HF (NCT02941315)
- Testing
- etiologic treatment,anti-myocardial remodeling, anti-myocardial remodeling, anti-myocardial remodeling,anti-acute heart failure
- Where
- China
- Volunteers
- 150 people
- Sponsor
- RenJi Hospital