Clinical trials: Cardiac Output, open to volunteers
Healthy Adult
Ivabradine for Heart Rate Reduction During Exercise in Healthy Adults
During exercise, working muscles require more oxygen. The heart meets this demand in two ways: by beating faster (heart rate) and by pumping more blood with each beat (stroke volume).
- Trial name
- NCT07717710
- Testing
- Ivabradine (single oral dose)
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Myocardial Injury
Effects of Remimazolam on Postoperative Myocardial Injury
This study is designed as a prospective, double-blind, randomized controlled trial to investigate the effect of remimazolam on intraoperative cardiac output (CO) in elderly patients undergoing general anesthesia, and to evaluate…
- Trial name
- NCT07725185
- Testing
- Remimazolam, Propofol
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Affiliated Hospital of Jiaxing University
Type 2 Diabetes, Heart Failure, Reduced Ejection Fraction
Acute and Chronic Effects of Oral Ketones in Subjects With HFrEF and Diabetes
This study will provide insight into whether cardiac function changes with oral Ketone Esters (KE) administered to patients with Type 2 Diabetes Mellitus (T2DM) and Heart failure with reduced ejection fraction (HFrEF).
- Trial name
- NCT06108076
- Testing
- Ketone Monoester (KE)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Acute Respiratory Distress Syndrome
Application Study of Individualized Mechanical Power Titration Strategy Based on PiCCO (Pulse Index Continuous Cardiac Output) Monitoring Parameters in ARDS Patients
Based on PiCCO combined with MP, the optimal mechanical power setting of the ventilator for ARDS patients in normal supine/prone position is determined to reduce the damage to lung function during mechanical ventilation.
- Trial name
- NCT07839234
- Testing
- Prone position ventilation
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Xiamen Hospital of Traditional Chinese Medicine
Hypotension During Surgery
The Hypotension Prediction Index in Major Abdominal Surgery
The goal of this randomized clinical trial is to compare different types of advanced hemodynamic monitoring in patients undergoing major abdominal surgery.
- Trial name
- NCT06247384
- Testing
- Hypotension Prediction Index Hemodynamic Monitoring
- Where
- Poland
- Volunteers
- 226 people
- Sponsor
- Jakub Szrama
Heart Failure, Systolic
Paced Heart Rate Acceleration for Cardiac Conditioning
A clinical trial of exercise-similar heart rate acceleration delivered via cardiac pacing vs. sham intervention in subjects at rest will be performed.
- Trial name
- HeartExcel (NCT06332391)
- Testing
- Exercise-similar cardiac pacing
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Denice Hodgson-Zingman, MD
Hypotension (MeSH: D007022)
Carotid Artery Blood Flow, Blood Pressure, and Cardiac Output During Anesthesia in Children Aged 0-5 Years
Blood pressure is routinely monitored during anesthesia in children, but blood pressure alone may not accurately reflect blood flow to vital organs.
- Trial name
- CARFLOW (NCT07847203)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Congenital Heart Disease, Cardiac Output
UltraTrac for Cardiac Output Monitoring in Congenital Heart Disease
This pilot feasibility study will evaluate UltraTrac, an investigational noninvasive wearable device for continuous cardiac output monitoring, in patients with congenital heart disease.
- Conditions
- Congenital Heart Disease, Cardiac Output, Hemodynamic Monitoring, Pediatric Heart Disease
- Trial name
- UltraTrac (NCT07866573)
- Testing
- UltraTrac
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Minnesota
Pulmonary Thromboendarterectomy, Pulmonary Embolism and Thrombosis
Assessment of Pulmonary Perfusion and Hemodynamic Measurements by Electrical Impedance Tomography in Patients Undergoing Pulmonary Thromboendarterectomy.
Chronic thromboembolic pulmonary hypertension (CTEPH) is a condition in which old blood clots block the blood vessels in the lungs, making it harder for the heart to pump blood through the lungs.
- Trial name
- NCT07577700
- Testing
- Electrical Impedance Tomography (EIT)., Pulmonary Perfusion SPECT-CT., Pulmonary Thromboendarterectomy.
- Where
- Brazil
- Volunteers
- 36 people
- Sponsor
- University of Sao Paulo General Hospital
Hemodynamic Monitoring
Evaluation of the UltraTrac System as a Non-Invasive Monitor of Hemodynamic Parameters
This study will test the use of the UltraTrac™ system, a small, noninvasive device that uses electrodes on the skin and a small ultrasound sensor to provide measurements of cardiac function in a wide of subjects.
- Trial name
- NCT07862608
- Testing
- Noninvasive Hemodynamic Monitoring System
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- AcQumen Medical, Inc.
Systolic Hypertension, Pregnancy Related
Effect of Labetalol, Atenolol, and Nifedipine on Maternal Hemodynamics Measured by ICG in Early Pregnancy
The purpose of the research is to characterize the effect of labetalol, atenolol, and nifedipine on maternal hemodynamics early in pregnancy.
- Conditions
- Systolic Hypertension, Pregnancy Related, Diastolic Hypertension, Cardiac Output, Low
- Trial name
- NCT04755764
- Testing
- Labetalol, Atenolol, Nifedipine
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Marshall University
Coronary Computed Tomography Angiography, Contrast Media
Optimization of Patient Preparation and Imaging Techniques for Cardiac CT
The goal of this clinical trial is to compare four different methods of reducing heart rate before cardiac imaging. The diagnostic imaging technique used in this study is called Computed Tomography (CT) of the coronary vessels…
- Conditions
- Coronary Computed Tomography Angiography, Contrast Media, Cardiac Output
- Trial name
- NCT06879769
- Testing
- Metoprolol I.V., Metoprolol I.V. and 1 hour waiting., Music Intervention, Seloken (Recordati) orally and Metoprolol I.V.
- Where
- Sweden
- Volunteers
- 240 people
- Sponsor
- Karolinska University Hospital
Hemodynamic Monitoring
UltraTrac Clinical Pilot Study
This single-center pilot study will evaluate the accuracy and feasibility of non-invasive cardiac output measurement using the UltraTrac device in pediatric patients aged 0-21 years undergoing standard-of-care diagnostic cardiac…
- Trial name
- ULTRA-CO (NCT07864714)
- Testing
- Noninvasive Hemodynamic Monitoring System
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- AcQumen Medical, Inc.
ECMO Treatment, ARDS
Hemodynamic Monitoring and Fluid Responsiveness in Venovenous Extracorporeal Membrane Oxygenation (VV ECMO) - "HemodynamECMOnitoring-VV Study"
In extracorporeal membrane oxygenation (ECMO), blood is drawn out of the body via tubes, oxygenated in an artificial lung; and then pumped back into the blood vessels.
- Conditions
- ECMO Treatment, ARDS, Pneumonia, Intensive Care
- Trial name
- NCT06593717
- Testing
- Transthoracic Echocardiography, Uncalibrated Pulse Contour Analysis, Transpulmonary Thermodilution/Calibrated Pulse Contour Analysis
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Medical University of Vienna
Sleep Deprivation
Effects of Partial Sleep Deprivation on Cardiac Output During Cycling
The goal of this clinical trial is to determine if attenuations in cardiac output drive the blunted blood pressure response during cycling exercise following a night of partial sleep deprivation in young healthy adults (%50…
- Trial name
- NCT06679543
- Testing
- Partial sleep deprivation
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Guelph
Heart Failure, Cardiogenic Shock
Cardiac Power Output in Cardiogenic Shock Patients
The main purpose of this study is to determine whether differences in myocardial reserve predict clinical outcomes for heart failure patients.
- Trial name
- NCT05700617
- Testing
- 1:1 Randomization to receive milrinone
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Chicago
Pulmonary Hypertension, Pulmonary Thromboembolisms
Electrical Impedance Tomography for Assessment of Pulmonary Hypertension
Pulmonary hypertension is a serious and progressive disease that is difficult to treat and diagnose, mainly because its symptoms are nonspecific and often delay recognition. Early diagnosis is a major challenge.
- Trial name
- NCT07453017
- Testing
- Electrical Impedance Tomography (EIT), Right Heart Catheterization
- Where
- Brazil
- Volunteers
- 120 people
- Sponsor
- University of Sao Paulo General Hospital
Healthy Adult, Cardiac Output
Effect of Systematic and Sequential Leg Elevation on Cardiac Output in Healthy Volunteers
Passive leg raising (PLR) transiently increases venous return and cardiac preload and is commonly used to predict fluid responsiveness in critically ill patients.
- Conditions
- Healthy Adult, Cardiac Output, Hemodynamic, Passive Leg Raising
- Trial name
- SYSLE-1 (NCT07860515)
- Testing
- Passive Leg Raising, Non-Invasive Ventilation
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Régional d'Orléans
AKI - Acute Kidney Injury, Cardiac Surgery
Urine Output Response to Fluid and Diuretic Therapy in Cardiac ICU Patients Monitored With FIZE kUO®
This prospective observational study evaluates the real-time urine output response to fluid therapy and diuretics in cardiothoracic intensive care unit (CTICU) patients monitored with the FIZE kUO® device.
- Conditions
- AKI - Acute Kidney Injury, Cardiac Surgery, Fluid Therapy, Hemodynamic Instability
- Trial name
- NCT07022314
- Testing
- FIZE kUO®
- Where
- Israel
- Volunteers
- 45 people
- Sponsor
- FIZE Medical ltd
Cardiac Output Measurement
Discontinuous Echocardiographic Subcostal Cardiac Output Measurement
Cardiac output (CO) monitoring is recommended for the most serious and multiple-failure patients in critical care and allows the diagnosis of acute circulatory failure as well as its etiology and also allows the monitoring of…
- Trial name
- RIGHT WAY (NCT07177391)
- Testing
- Discontinuous subcostal echocardiographic cardiac output assessment
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Rouen