Clinical trials: Cardiac Perfusion
Coronary Artery Disease
Safety and Efficacy Study of PB127 Ultrasound Contrast Agent in Patients With Suspected Coronary Artery Disease
This trial is to compare PB127 echocardiography to other heart imaging studies.
- Trial name
- NCT00595244
- Testing
- PB127 for injectable suspension
- Where
- 15 sites in United States
- Volunteers
- 456 people
- Sponsor
- Point Biomedical
Hypertrophic Obstructive Cardiomyopathy \(HOCM\)
Myocardial Perfusion Changes Following Optimal Medical Treatment in Symptomatic Hypertrophic Cardiomyopathy
Background: Microvascular dysfunction is a hallmark of hypertrophic obstructive cardiomyopathy (HOCM) and can be visualized non-invasively using cardiac magnetic resonance (CMR) perfusion imaging.
- Trial name
- oHCM (NCT07150299)
- Testing
- Mavacamten in clinical routine use
- Where
- Austria
- Volunteers
- 20 people
- Sponsor
- Medical University of Vienna
Carbon Dioxide
Validation of Continuous Transcutaneous Carbon Dioxide Monitoring in VA-ECMO Patients
Carbon dioxide in patients on veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is eliminated via respirator as well as via the oxygenator's membrane of the ECMO machine.
- Trial name
- NCT04445909
- Testing
- VA-ECMO
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Medical University of Vienna
Stable Angina, Non-ST-elevation Acute Coronary Syndrome
Japanese Coronary Intervention Using Drug Eluting and Perfusion Therapy for Left Main Disease (JDEPTH-LM Registry)
JDEPTH-LM Registry is a prospective, observational, multi-center study designed for the efficacy and safety of Double-effect kissing balloon technique (W-KBT) in left main (LM) bifurcation percutaneous coronary intervention (PCI)…
- Conditions
- Stable Angina, Non-ST-elevation Acute Coronary Syndrome, Unstable Angina
- Trial name
- NCT06436092
- Where
- 32 sites in Japan
- Volunteers
- 280 people
- Sponsor
- TCROSS Co., Ltd.
Angina Pectoris
Effect of Increased Oxygenation in the Air During Endurance Training in Stable Angina Pectoris Patients
The study investigates whether endurance training breathing 100% oxygen gives a additional improvement of maximal oxygen uptake in stable Angina Pectoris patients, compared to training without extra oxygen supplementation.
- Trial name
- NCT00184444
- Testing
- Hypoxic interval training, Normoxic interval training
- Where
- Norway
- Volunteers
- 25 people
- Sponsor
- Norwegian University of Science and Technology
Chronic Coronary Syndrome, Coronary Artery Disease
Hyperemic mYocardial Perfusion by adEnosine at diffeRent Doses
Adenosine is a commonly used pharmaceutical stressor at cardiac magnetic resonance examinations to assess suspected chronic coronary syndrome (CCS).
- Conditions
- Chronic Coronary Syndrome, Coronary Artery Disease, Ischemic Heart Disease
- Trial name
- HYPER (NCT06578234)
- Testing
- Adenosine
- Where
- Sweden
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Region Skane
Non-ST-Elevation Myocardial Infarction
Contrast Echocardiography in Non-ST Elevation Myocardial Infarction
In patients with acute myocardial infarction, treatment logistics are primarily defined based upon ST segment shift in the electrocardiogram.
- Trial name
- NCT01122069
- Testing
- Perflutren Lipid Microsphere ultrasound contrast
- Where
- Norway
- Volunteers
- 110 people
- Sponsor
- University of Bergen
Coronary Artery Disease
Quantitative Analysis of Functional CT Imaging of Coronary Atherosclerosis
The purpose of this prospective observational study is to evaluate the diagnostic and prognostic performance of a "one-stop" comprehensive coronary artery anatomy and function assessment for CAD.
- Trial name
- NCT04986410
- Testing
- CCTA, CT-MPI, CT-FFR, SPECT-MPI
- Where
- China
- Volunteers
- 640 people, healthy volunteers welcome
- Sponsor
- Qilu Hospital of Shandong University
Cerebral Perfusion
Transpharyngeal Doppler Sonography for Cerebral Perfusion Monitoring
This prospective interventional study investigates transpharyngeal sonography (TPS) as an additional neuromonitoring strategy to assess cerebral perfusion during cardiovascular surgery.
- Trial name
- TaPaS (NCT03494413)
- Testing
- Transpharyngeal Doppler sonography (TPS), Conventional colour-coded Duplex sonography (CDS)
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
CT Perfusion
Prognostic Value of CT dynamIc Myocardial Perfusion in Patients With Obstructive Coronary Artery Stenosis
VALIDITY is a prospective, open-label, multicenter, randomized controlled trial （ClinicalTrials.gov number）. The study was designed to evaluate the value of noninvasive anatomic CTA combined with functional CTP for the next…
- Trial name
- VALIDITY (NCT03250455)
- Testing
- CTA CTP, CTA
- Where
- 5 sites in China
- Volunteers
- 1,748 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Critical Congenital Heart Disease, High Altitude
Oxygen Saturation and Perfusion Index ın Neonates at High Altitude
Congenital heart diseases are among the most common congenital anomalies and occur with an incidence of approximately 8ınd12 / 1,000 live births worldwide.
- Trial name
- NCT04290481
- Testing
- oxygen saturation and perfusion index screening
- Where
- Turkey (Türkiye)
- Volunteers
- 501 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Coronary Artery Perforation
Investigation of the Ringer Perfusion Balloon Catheter
The objective of this study is to demonstrate reasonable assurance that the Ringer catheter can be safely used to manage hemorrhage due to coronary vessel perforations while facilitating distal perfusion under the conditions of…
- Trial name
- NCT04849169
- Testing
- Experimental
- Where
- 6 sites in United States
- Volunteers
- 30 people
- Sponsor
- Vascular Solutions LLC
Cardiac Allograft Vasculopathy
Real Time Myocardial Perfusion Echocardiography for Coronary Allograft Vasculopathy
Is real-time myocardial perfusion echocardiography (RTMPE) a feasible and effective non-invasive method to detect significant Coronary Allograft Vasculopathy in pediatric and adult cardiac transplant recipients? Will perfusion…
- Trial name
- NCT02880137
- Testing
- Perflutren Lipid Microsphere, RTMPE
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Mayo Clinic
Coronary Artery Disease, Myocardial Perfusion
E-Cigarette Aerosol, Conventional Cigarette Smoke, and Myocardial Perfusion
E-cigarettes deliver nicotine by creating an aerosol of ultrafine particles. Many questions remain about the size and composition and especially about the potential toxicity of these particles.
- Trial name
- NCT02612701
- Testing
- Cigarettes, E-cigarettes (nicotine free e-liquid), E-cigarettes (low nicotine e-liquid)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Peripheral Arterial Disease, Critical Limb Ischemia
Leg Ischaemia Management Collaboration
Single-centre prospective cohort study of patients presenting with severe limb ischaemia (SLI). The primary outcome measure will be 12 month major amputation rate.
- Conditions
- Peripheral Arterial Disease, Critical Limb Ischemia, Frailty, Cognitive Impairment
- Trial name
- LIMb (NCT04027244)
- Where
- United Kingdom
- Volunteers
- 420 people
- Sponsor
- University of Leicester
Coronary Artery Disease
Familiarization and Safety Study of PB127 Ultrasound Contrast Agent
The purpose of this study is to evaluate preparation and administration of PB127, echocardiographic images obtained during PB127 administration, and evaluate the safety of PB127.
- Trial name
- NCT00594698
- Testing
- PB127 for injectable suspension
- Where
- 34 sites in United States
- Volunteers
- 150 people
- Sponsor
- Point Biomedical
Myocardial Ischemia
A Study on Improved Dynamic Myocardial Perfusion With Less Effective Radiation Dose in CT (SIMPLE CT)
Among the current myocardial CT perfusion techniques, dynamic CT perfusion technique is most advantageous in obtaining information on myocardial blood flow and volume.
- Trial name
- NCT02161081
- Testing
- Myocardial CT perfusion
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- Samsung Medical Center
Coronary Artery Disease
CArdiac cT in the Treatment of Acute CHest Pain 2 - Myocardial CT Perfusion
The aim of this study is to assess whether the clinical management of patients with recent acute-onset chest pain without acute coronary syndrome may be optimized by a combined coronary CT angiography (CTA) + CT myocardial…
- Trial name
- CATCH2 (NCT02014311)
- Testing
- CTA+CTP guided treatment strategy, CTA guided treatment strategy
- Where
- 7 sites in Denmark
- Volunteers
- 600 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Cerebral Hypoxia
Feasibility Trial to Maintain Normal Cerebral Oxygen Saturation in High-Risk Cardiac Surgery
Using the brain and the heart as index organs, perioperative interventions to optimize cerebral oxygen saturation and cardiac contractility in high-risk patients undergoing cardiac surgery should have a beneficial systemic effect…
- Trial name
- Tête-à-coeur (NCT01432184)
- Testing
- strategies to reverse decrease in rSO2
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Montreal Heart Institute
Coronary Artery Disease
Implementing Myocardial Computed Tomographic Perfusion in a Community Hospital Setting
The objective of this study is to carefully monitor all patients undergoing Computed Tomographic Perfusion (CTP) at Lancaster General Hospital for safety, and determine the efficiency of the CTP procedure in a community setting.
- Trial name
- NCT02756234
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Lancaster General Hospital