Clinical trials: Cardiac Perfusion, open to volunteers
HCM - Hypertrophic Cardiomyopathy, Anderson Fabry Disease
Myocardial Perfusion CMR for Differentiating and Characterizing Hypertrophic Cardiomyopathy Phenotypes
This observational study aims to evaluate myocardial perfusion abnormalities using quantitative and qualitative cardiac magnetic resonance (CMR) perfusion imaging in patients with hypertrophic cardiomyopathy (HCM) phenotypes…
- Conditions
- HCM - Hypertrophic Cardiomyopathy, Anderson Fabry Disease, Cardiac Magnetic Resonance Imaging, Amyloid Cardiomyopathy
- Trial name
- MyoPerf-HCM (NCT07382128)
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Heart Failure and Reduced Ejection Fraction, Heart Failure
PRIMA-HF: Predicting Myocardial Recovery in Heart Failure Using Cardiac Imaging HAI-HF: High Dosing vs. Standard Dosing Adenosine During Myocardial Perfusion in Heart Failure
Background: Heart failure with reduced ejection fraction (HFrEF) is a heterogeneous condition with variable potential for left ventricular ejection fraction (LVEF) recovery.
- Trial name
- PRIMA-HF (NCT07243119)
- Testing
- HAI-HF: Adenosine Stress [¹⁵O]H₂O PET Imaging, Two different doses of adenosine
- Where
- Denmark
- Volunteers
- 180 people
- Sponsor
- Gødstrup Hospital
Sickle Cell Disease
Relationship Between Abnormal Myocardial Perfusion and Diastolic Dysfunction in Sickle Cell Disease Using PET
There is limited information on what causes injury to the heart in individuals with Sickle Cell Disease (SCD). Researchers in this study want to see if decreased blood flow to the heart during stress could be causing the heart…
- Trial name
- NCT05583721
- Testing
- [13N]NH3, Lexiscan, Positron emission tomography
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- St. Jude Children's Research Hospital
Ventricular Tachycardia, Monomorphic, Ventricular Tachycardia (V-Tach)
Imaging and Treatment Planning for Cardiac Radioablation
Cardiac radioablation is a new treatment for ventricular tachycardia (VT), which uses beams of radiation to treat heart scar that causes VT.
- Conditions
- Ventricular Tachycardia, Monomorphic, Ventricular Tachycardia (V-Tach), Ischemia, Myocardial
- Trial name
- ITPCR (NCT06938074)
- Testing
- CT and MRI
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Stewart Gaede
Congenital Heart Disease
Dynamic Critical Congenital Heart Screening With Addition of Perfusion Measurements
The purpose of this study is to implement and externally validate an inpatient ML algorithm that combines pulse oximetry features for critical congenital heart disease (CCHD) screening.
- Trial name
- NCT05637814
- Testing
- SpO2/PIx Measurement and ML Algorithm
- Where
- 3 sites in United States
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Clinical Outcomes, Cardiac Surgery
Predictors Of Outcome After Coronary Artery Bypass Graft Surgery Using Cardiopulmonary Bypass
In cardiac operations, high values of blood lactate have been associated with bad outcomes if detected both during CPB and at the arrival in the intensive care unit (ICU) in adult patients.
- Conditions
- Clinical Outcomes, Cardiac Surgery, Cardio-pulmonary Bypass
- Trial name
- NCT07034716
- Testing
- CORONARY BYPASS SURGERY USING CARDIOPULMONARY BYPASS, cardiac surgical patients who will undergo isolated elective cardiopulmonary bypass
- Volunteers
- 60 people
- Sponsor
- Alexandria University
Cancer, Chemotherapeutic Toxicity
Serial PET MPI in Patients Undergoing Cancer Treatment
This study aims to evaluate the effects of cardiotoxic cancer therapies on myocardial blood flow (MBF) and perfusion in a prospective sample of VA patients.
- Conditions
- Cancer, Chemotherapeutic Toxicity, Coronary Artery Disease, Coronary Microvascular Disease
- Trial name
- NCT05913999
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of California, Los Angeles
Heart Failure With Reduced Ejection Fraction (HFrEF), Chronic Heart Failure
Vericiguat and Reverse Remodeling Indices in Heart Failure
The goal of this clinical trial is to investigate how vericiguat benefits adults with stable heart failure with reduced ejection fraction (HFrEF) who are already receiving guideline-directed medical therapy.
- Trial name
- VERI-PATH (NCT07405944)
- Testing
- Vericiguat, Guideline Directed Medical Therapy for Heart Failure (GDMT)
- Where
- 4 sites in Slovenia
- Volunteers
- 70 people
- Sponsor
- University Medical Centre Ljubljana
Heart Transplant
US National OCS Heart Perfusion (OHP) Registry
This Registry is a sponsor initiated, multi-center, observational post-approval registry with independent academic oversight.
- Trial name
- NCT05915299
- Testing
- OCS Heart
- Where
- 37 sites in United States
- Volunteers
- 100,000 people
- Sponsor
- TransMedics
Cardiac Arrest
Monitoring and Optimization of Cerebral Perfusion Pressure in Post-cardiac Arrest Patients: a Pilot Study
The goal of this study is to establish the ICP and CPP monitoring process and analyze the results in post-arrest patients, to validate the correlation between direct and non-invasive ICP monitoring indicators, to establish a…
- Trial name
- NCT06601842
- Testing
- ICP monitoring
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- National Taiwan University Hospital
ST-segment Elevation Myocardial Infarction (STEMI)
Intracoronary rhTNK-tPA Versus Tirofiban in Patients With STEMI and High Thrombus Burden
The goal of this clinical trial is to compare the efficacy and safety of intracoronary rhTNK-tPA or Tirofiban in patients with ST-segment elevation myocardial infarction and high thrombus burden.
- Trial name
- H2-THROMBUS (NCT06769256)
- Testing
- rhTNK-tPA, 4-8 mg, Tirofiban
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Henan Institute of Cardiovascular Epidemiology
Microcirculatory Perfusion
Hemodynamic Evaluation and Assessment of DIRECT myocaRdial and Sublingual Capillary Perfusion in Thoracic Surgery Patients on Cardiopulmonary Bypass
After cardiac surgery, some people may experience problems with their circulation or how well the heart pumps. This can occur because the smallest blood vessels in the heart do not function properly.
- Trial name
- DIRECT-HEART (NCT07135700)
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Coronary Artery Disease
Chronic Coronary Syndrome in Swedish Primary Care
The goal of this clinical trial is to learn about a new procedure for investigation of possible coronary heart disease and to see if it is faster, cheaper or more expensive, promotes healthier behavior, mental well-being…
- Trial name
- COSPRI (NCT05782582)
- Testing
- Package investigation, Sound registration with Cadscore® and added risk calculation, Standard investigation
- Where
- 3 sites in Sweden
- Volunteers
- 500 people
- Sponsor
- Region Östergötland
Cardiac Surgery Intensive Care Treatment, Hemodynamics
Correlation Between Postoperative Blood Pressure Variability, Perfusion Index and Perioperative Adverse Events in Cardiac Surgery
In patients after cardiac surgery, disturbances in macrocirculatory fluctuations and tissue perfusion commonly coexist. The stress state induced by factors such as surgical manipulation, cardiopulmonary bypass, anesthetic agents…
- Trial name
- NCT07316634
- Testing
- Blood Pressure Variability and Perfusion Index
- Volunteers
- 1,200 people
- Sponsor
- Beijing Anzhen Hospital
Perfusion Index and Cerebral NIRS Trends in Low Cardiac Output Syndrome
Can Perfusion Index and Cerebral Oxygen Saturation Trends Predict Low Cardiac Output in Pediatric Cardiovascular Surgeries
In this prospective, observational study, we aim to investigate whether routinely monitored Perfusion Index (PI) and cerebral oxygen saturation (NIRS) values in pediatric patients aged 0-6 undergoing congenital heart surgery are…
- Trial name
- NCT06759506
- Volunteers
- 40 people
- Sponsor
- Bozyaka Training and Research Hospital
Heart Transplantation
Study of Organ Perfusion in Heart Transplantation in Children
The goal of this prospective randomized single blind multicenter phase II study is to compare organ perfusion with Custodiol-N and Custodiol in heart transplantation in children of all ages (birth to <18 years) being listed on…
- Trial name
- NCT06032195
- Testing
- Custodiol-N, Custodiol
- Where
- 3 sites in Germany
- Volunteers
- 15 people
- Sponsor
- Dr. F. Köhler Chemie GmbH
Coronary Artery Disease
A Head-to-Head Comparison of A New Perfusion Tracer, 99mTc-4BOH vs. 13N-NH3 to Evaluate Diagnostic Efficacy of Ischemic Heart Disease
The objective of the study is to assess the diagnostic efficacy (specificity and sensitivity) of 99mTc-4BOH SPECT myocardial perfusion imaging (MPI) compared to 13N-ammonia PET MPI in the detection of significant coronary artery…
- Trial name
- NCT06980194
- Testing
- 99mTc-4BOH SPECT myocardial perfusion imaging, 13N-ammonia PET myocardial perfusion imaging
- Volunteers
- 300 people
- Sponsor
- China National Center for Cardiovascular Diseases
Microvascular Disease, Microvascular Complications
Test of Reproducibility of [15O]H20-PET Assessment of Brain Perfusion
In the aging population, ischemic heart disease, stroke and dementia are increasingly prevalent. Diagnosis and treatment of the former two i.e., large-vessel coronary heart disease and endovascular thrombectomy of the brain in…
- Conditions
- Microvascular Disease, Microvascular Complications, Diabetes Mellitus Type 2, Cerebral Hypoperfusion
- Trial name
- SVAT (NCT06624267)
- Testing
- PET
- Where
- Denmark
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University Hospital Bispebjerg and Frederiksberg
Cardiac Disease
Replacing Spatial Filtering With Deep-learning Noise Reduction
Spatial filtering is routinely required to reduce the statistical noise of gated SPECT myocardial perfusion imaging, but at the expense of image blurring.
- Trial name
- DEEPLAIM (NCT07888218)
- Where
- France
- Volunteers
- 49 people
- Sponsor
- Central Hospital, Nancy, France
Coronary Artery Disease, Chronic Coronary Syndrome
Quantitative Myocardial Perfusion Imaging Assessment by SPECT/CT
Myocardial perfusion single-photon emission computed tomography (SPECT) is a well-established functional imaging technique for the assessment of coronary artery disease.
- Trial name
- SUV-RESERVE (NCT07708805)
- Testing
- stress SPECT/CT, rest SPECT/CT
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Régional d'Orléans