Clinical trials: Cardiac Perfusion
Cardiac Arrest
Microcirculatory Perfusion in Patients With Coma After Out-of-hospital Cardiac Arrest
The hypothesis is: In patients after an out of hospital cardiac arrest, treated with therapeutic hypothermia (33°C) will be found significantly more microcirculatory abnormalities, compared to the same group of patients treated…
- Trial name
- NCT01850485
- Testing
- microcirculation by SDF and NIRS, in 33 and 36 degrees
- Where
- Netherlands
- Volunteers
- 22 people
- Sponsor
- Frisius Medisch Centrum
Coronary Artery Disease (CAD)
An International Study to Evaluate Diagnostic Efficacy of Flurpiridaz (18F) Injection PET MPI in the Detection of Coronary Artery Disease (CAD)
This is a Phase 3, prospective, open-label, international, multicentre study of Flurpiridaz (18F) Injection for PET MPI in patients referred for ICA because of suspected CAD.
- Trial name
- NCT03354273
- Testing
- PET MPI, SPECT MPI, Pharmacological stress agents
- Where
- 53 sites in United States, Canada and 5 more
- Volunteers
- 730 people
- Sponsor
- GE Healthcare
Coronary Artery Disease
Stress CT Perfusion in Patients With Chest Pain
Our hypothesis is that quantitative 3D analysis of cardiac CT images obtained during vasodilator stress can accurately identify patients presenting at the emergency department with acute chest pain due to underlying…
- Trial name
- NCT01969916
- Testing
- Regadenoson
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Chicago
Heart Failure, Diastolic, Diastolic Heart Failure
Myocardial Perfusion, Oxidative Metabolism, and Fibrosis in HFpEF
Unlike heart failure with reduced ejection fraction (HFrEF) where several medicines and devices have been demonstrated to reduce mortality, no such therapies have been identified in HFpEF.
- Conditions
- Heart Failure, Diastolic, Diastolic Heart Failure, Hypertension
- Trial name
- HFpEF-PRoF (NCT02589977)
- Testing
- regadenoson
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Marvin W. Kronenberg, M.D.
Cardiac Allograft Vasculopathy
Real Time Myocardial Perfusion Echocardiography for Coronary Allograft Vasculopathy
Is real-time myocardial perfusion echocardiography (RTMPE) a feasible and effective non-invasive method to detect significant Coronary Allograft Vasculopathy in pediatric and adult cardiac transplant recipients? Will perfusion…
- Trial name
- NCT02880137
- Testing
- Perflutren Lipid Microsphere, RTMPE
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Mayo Clinic
Traumatic Brain Injury
Early Propranolol After Traumatic Brain Injury: Phase II
The primary objective of this study is to determine in patients with traumatic brain injury (TBI) the safe dosing of propranolol.
- Trial name
- EPAT: Phase II (NCT01202110)
- Testing
- Propranolol
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Cedars-Sinai Medical Center
Coronary Artery Disease
Transepicardial With Transseptal Autologous CD 133+ Bone Marrow Cell Implantation in Patient Following CABG Surgery
Heart Failure has several etiologies and one of them is coronary artery disease. Coronary artery bypass grafting (CABG) is one of revascularizations method which has been used for decades in coronary artery disease theraphy.
- Trial name
- NCT02870933
- Testing
- Transepicardial with Transseptal CD 133+ Implantation
- Where
- Indonesia
- Volunteers
- 30 people
- Sponsor
- National Cardiovascular Center Harapan Kita Hospital Indonesia
Chronic Ischemic Heart Disease, Left Ventricular Dysfunction
Effectiveness of Stem Cell Treatment for Adults With Ischemic Cardiomyopathy (The FOCUS Study)
Coronary artery disease (CAD) is a common disorder that can lead to heart failure. Not all people with CAD are eligible for today's standard treatments.
- Conditions
- Chronic Ischemic Heart Disease, Left Ventricular Dysfunction, Angina, Ischemic Cardiomyopathy
- Trial name
- NCT00824005
- Testing
- Adult stem cells
- Where
- 5 sites in United States
- Volunteers
- 92 people
- Sponsor
- The University of Texas Health Science Center, Houston
Hypertension, Heart Failure
LSFG-SKIN, Laser Speckle Flowgraphy
The purpose of this project is to quantify normal and abnormal skin blood flow regionally in different areas of the body(face, extremities, over burns and wounds) at baseline and over time in response to treatment or…
- Conditions
- Hypertension, Heart Failure, Vascular Ischemia, Burns
- Trial name
- NCT03660618
- Testing
- laser speckle flowgraphy
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Randy Kardon
Coronary Artery Disease
A Study of 123I-CMICE-013 Radiopharmaceutical in Healthy Volunteers
The need exists for alternatives to 99mTc based perfusion radiotracers for cardiac patient management. An alternative radiotracer, I123-CMICE-013, has been developed at the Canadian Molecular Imaging Center of Excellence (C-MICE)…
- Trial name
- CMICE (NCT01558362)
- Testing
- 123I-CMICE-013
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Ottawa Heart Institute Research Corporation
Coronary Artery Disease, Chest Pain
Effects of Heart Imaging Radiation on DNA Double-Stranded Breaks in Blood Lymphocytes and Hair Follicle Cells
Purpose 1. To investigate the effects of cardiac imaging radiation on the induction of DNA double-strand breaks by enumerating gamma-H2AX foci in blood lymphocytes and plucked hair follicle cells. 2.
- Trial name
- NCT02617888
- Testing
- CCTA ~ BREAST SHIELDS
- Volunteers
- 228 people
- Sponsor
- Walter Reed National Military Medical Center
Cardiac Function
Maximal Bruce Protocol With the Use of Regadenoson For Myocardial Perfusion Stress Testing
It is been known for at least 20 years that the hemodynamic data, the amount of exercise performed as well as symptoms on the treadmill, has significant value to the perfusion stress testing.
- Trial name
- Rega Stress (NCT01026012)
- Testing
- regadenoson
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Maryland, Baltimore
Heart Failure, Nonischemic Dilated Cardiomyopathy
Effect of Aldosterone on Energy Starvation in Heart Failure
We plan to study the concept of "energy starvation" in heart failure by evaluation of patients with nonischemic dilated cardiomyopathy (NIDCM) (heart failure with reduced heart pump function due to causes other than heart…
- Trial name
- NCT00574119
- Testing
- spironolactone
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Vanderbilt University
Coronary Artery Disease (CAD)
A Study of Regadenoson in Subjects Undergoing Stress Myocardial Perfusion Imaging (MPI) Using Multidetector Computed Tomography (MDCT) Compared to Single Photon Emission Computed Tomography (SPECT)
The purpose of this study is to compare Multidetector Computed Tomography (MDCT) and Single Photon Emission Computed Tomography (SPECT) stress myocardial perfusion imaging (MPI) with regadenoson in order to detect the presence or…
- Trial name
- NCT01334918
- Testing
- regadenoson, technetium Tc99m sestamibi /technetium Tc99m tetrafosmin, Contrast
- Where
- 11 sites in United States
- Volunteers
- 124 people
- Sponsor
- Astellas Pharma Inc
Patients Being Assessed With Nuclear Stress Testing of the Heart Using the Stress Agent Regadenoson, Lexiscan
Study With Aminophylline to Attenuate of the Side Effects of Regadenoson
The routine administration of 75 mg of intravenous aminophylline following regadenoson (Lexiscan®), a commonly used medication for nuclear stress testing of the heart, can reduce the gastrointestinal (diarrhea and stomach upset)…
- Trial name
- ASSUAGE (NCT01250496)
- Testing
- Aminophylline
- Where
- United States
- Volunteers
- 248 people
- Sponsor
- Rush University Medical Center
Pulmonary Hypertension
11C-acetate/18Fluorodeoxyglucose-FDG PET/CT and Cardiac MRI in Pulmonary Hypertension
This study is looking at differences in metabolism and functional imaging between pulmonary hypertension subjects with normal right ventricular function and persistent right ventricular dysfunction.
- Trial name
- NCT01917136
- Testing
- 11C-acetate, [18F]Fluoro-2-deoxy-2-D-glucose, Cardiac MRI
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Pennsylvania
Myocardial Ischemia
Absolute Quantification of Coronary Flow Reserve by Stress Perfusion MRI
Coronary artery disease (CAD, coronary heart disease) is the leading cause of death in the U.S., causing 1 in 5 deaths in 2005. The current method for diagnosing coronary artery disease that is considered most accurate is…
- Trial name
- NCT01655043
- Testing
- Regadenoson, gadofoveset trisodium
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Northwestern University
Coronary Artery Disease, Myocardial Perfusion Abnormalities
Regadenoson R-T Perfusion Imaging Trial
To exam the feasibility and accuracy of Regadenoson real time perfusion (RTPE) Imaging during vasodilator stress with Regadenoson for detection of significant coronary artery disease (CAD) in patients scheduled to undergo…
- Trial name
- NCT00837369
- Testing
- Regadenoson
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- University of Nebraska
Lactic Acidosis, Blood Glucose, High
Nitroglycerin Infusion During Cardiac Surgery
Hypothermic cardiopulmonary bypass results in peripheral vasoconstriction and heparin trapping. Hypoperfusion and ischemic-reperfusion injury are associated with systemic inflammatory response, while insufficient and delayed…
- Trial name
- NCT01901419
- Testing
- Nitroglycerin infusion
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Cardiovascular Diseases, Coronary Artery Disease
Use of Lexiscan for Myocardial Stress Perfusion Computed Tomography With a 3rd Generation Dual Source CT System
The purpose of this study is to evaluate the feasibility, tolerability, safety, and image quality of low-radiation, dynamic perfusion CT of the heart in patients with suspected ischemic chest pain and a moderate or severe…
- Trial name
- NCT03103061
- Testing
- Lexiscan
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Medical University of South Carolina