Clinical trials: Cardiac Repolarization
Congestive Heart Failure, Chronic Heart Failure
Significance of Impedance Cardiography and Early Repolarization Pattern in ECG in Congestive Heart Failure
Congestive heart failure (CHF) is a disorder of the heart when structural or functional heart disease impairs the heart's ability to work properly.
- Conditions
- Congestive Heart Failure, Chronic Heart Failure, Right Ventricular Failure, Heart Failure
- Trial name
- SICERE-CHF (NCT05480345)
- Testing
- Impedance cardiography
- Where
- Lithuania
- Volunteers
- 301 people
- Sponsor
- Lithuanian University of Health Sciences
Healthy Volunteers
Thorough QT/QTc (TQT) Clinical Study to Evaluate the Effects of Ziresovir on Cardiac Repolarization in Healthy Subjects
This is a single-center, randomized, partially double-blind, placebo and active-controlled, 4-period crossover design thorough QT/QTc (TQT) clinical study to evaluate the effects of ziresovir on cardiac repolarization in healthy…
- Trial name
- NCT06591845
- Testing
- Ziresovir 125 mg, Ziresovir 500 mg, Moxifloxacin hydrochloride tablet 400 mg
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Shanghai Ark Biopharmaceutical Co., Ltd.
Healthy
Thorough QT Study to Evaluate the Effect of Rodatristat Ethyl, Rodatristat and Its Major Metabolites on the Heart
To evaluate whether Rodatristat Ethyl prolongs the QTc interval when orally administered to healthy volunteers.
- Trial name
- NCT05933447
- Testing
- Rodatristat Ethyl, Moxifloxacin
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Altavant Sciences GmbH
Arrhythmias, Cardiac, Diabetes Mellitus
Effect of Dapagliflozin on Electrocardiographic Parameters in Type 2 Diabetes Patients: DAPA - ECG Study
The goal of this clinical trial is to evaluate whether dapagliflozin can reduce ventricular electrical remodeling, as measured by electrocardiographic parameters, in patients with type 2 diabetes (T2D).
- Trial name
- DAPA-ECG (NCT06721442)
- Testing
- Dapagliflozin (DAPA)
- Where
- 2 sites in Brazil
- Volunteers
- 174 people
- Sponsor
- Beneficência Portuguesa de São Paulo
QTc Interval, Pharmacokinetics
An Evaluation of Psilocybin's Effect on Cardiac Repolarization and the Effect of Food on Psilocybin's Pharmacokinetics
This study is comprised of two parts. The purpose of the first part of this study is to evaluate the effects of a supratherapeutic dose of psilocybin on cardiac repolarization.
- Trial name
- NCT05478278
- Testing
- Psilocybin, Moxifloxacin, Micro-Crystalline Cellulose
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Usona Institute
Healthy
A Study to Evaluate the Effect of JNJ-63623872 on Cardiac Repolarization Interval in Healthy Participants
The purpose of this study is to evaluate the effect of JNJ-63623872 on the QT/QTc interval at supratherapeutic exposure in healthy participants (Panel 2).
- Trial name
- NCT02658825
- Testing
- JNJ-63623872 2400 milligram (mg), JNJ-63623872 3000 mg, JNJ-63623872
- Where
- Belgium
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Myocardial Repolarization
The Effects of the Anesthetic Drug Propofol on the Way the Heart Recovers Between Beats
We are investigating a new technique for testing the effect of drugs on electrical activity in the heart. Disturbances of this electrical activity can cause life-threatening changes to heart rhythms.
- Trial name
- NCT00358618
- Testing
- Propofol
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Healthy
A Study to Evaluate the Effect of JNJ-53718678 on the Cardiac Repolarization Interval in Healthy Adult Participants
The purpose of this study is to assess the effect of JNJ-53718678 on QT interval corrected for heart rate (QTc) changes using exposure response analysis in healthy adult participants (Part 2).
- Trial name
- NCT03696459
- Testing
- JNJ-53718678, 2000 mg, JNJ-53718678, 3000 mg, JNJ-53718678, 4500 mg or Dose to be decided
- Where
- Belgium
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
RSV Infection, QTc Interval
A Study to Investigate the Effects of Zelicapavir (EDP-938) on QTc Interval in Healthy Adults
The purpose of the study is to assess the effect of a therapeutic and supratherapeutic dose of zelicapavir on the corrected cardiac QT interval relative to a placebo and positive control in healthy participants.
- Trial name
- NCT06601192
- Testing
- zelicapavir (therapeutic dose), zelicapavir (supratherapeutic dose), moxifloxacin
- Where
- 2 sites in United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Enanta Pharmaceuticals, Inc
Infections, Bacterial
A Study to Evaluate the Effect of GSK1322322 on Cardiac Conduction as Assessed by 12-lead Electrocardiogram in Healthy Volunteers
This is a randomized, partially-blinded, placebo and moxifloxacin-controlled, single dose, 4-period, balanced crossover study. The primary objective of this study is to separately assess the effects of a therapeutic and…
- Trial name
- NCT01803399
- Testing
- GSK1322322 1200 mg, GSK1322322 3000 mg, Moxifloxacin
- Volunteers
- healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Cardiovascular Diseases, Electrocardiogram: Electrical Alternans
Gated SPECT Abnormality With J Point Elevation
The investigators present an interesting co-incidence of Gated wall abnormality in the inferolateral wall in normal sestamibi myocardial perfusion images with J wave in the inferior derivations of the ECG in a patient.
- Conditions
- Cardiovascular Diseases, Electrocardiogram: Electrical Alternans, Myocardial Ischemia, Early Repolarization Syndrome
- Trial name
- NCT03472898
- Where
- Turkey (Türkiye)
- Volunteers
- 1 people
- Sponsor
- Ankara Education and Research Hospital
Cardiac Disease, Ventricular Arrythmia
Development of an Artificial Intelligence Algorithm to Detect Pathological Repolarization Disorders on the ECG and the Risk of Ventricular Arrhythmias
Torsades de Pointes (TdP) are potentially fatal ventricular arrhythmias that are promoted by prolonged ventricular repolarization (Long QT, LQT).
- Trial name
- DEEPECG4U (NCT05829993)
- Where
- France
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Healthy Volunteer
A Study to Find Out How Multiple Doses of BIIB091 Affect the Electrical Activity of the Heart in Healthy Participants
In this study, researchers will learn how the heart reacts to multiple doses of BIIB091 in healthy participants. In previous studies looking at BIIB091, researchers have found that a certain range of doses can cause changes in…
- Trial name
- NCT06574828
- Testing
- BIIB091, Moxifloxacin
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Biogen
ST Elevation (STEMI) Myocardial Infarction of Other Sites, Repolarization Indices
Relation of Total Ischemic Time to Repolarization Indices and Their Impact on Outcomes Among STEMI Patients Undergoing Primary PCI
1. Evaluate The impact of early versus late presentation on electrocardiographic ventricular repolarization indices. 2. To assess the association between repolarization indices among early, late presentation in relation to…
- Conditions
- ST Elevation (STEMI) Myocardial Infarction of Other Sites, Repolarization Indices, Total Ischemic Time, Primary Percutaneous Coronary Intervention
- Trial name
- NCT07175259
- Testing
- Echocardiography
- Volunteers
- 500 people
- Sponsor
- Assiut University
Ventricular Tachycardia
Ventricular Tachycardia Mechanisms
The purpose of this study is to understand why certain hearts have ventricular arrhythmias and help identify areas of the heart that cause arrhythmias.
- Trial name
- NCT05478213
- Testing
- Monophasic Action Potential (MAP) Catheter
- Where
- 3 sites in United States
- Volunteers
- 10 people
- Sponsor
- Emory University
Human Experimentation (Human Volunteers)
Evaluation of Possible Effects on the QT/ QTc Interval of Rupatadine in Healthy Volunteers
This phase I trial will evaluate the effects of rupatadine, at a dose of 10 mg OD (authorised and marketed dose) and the 100mg/day (supratherapeutic dose) on the ECG parameters with a special focus on its effect on cardiac…
- Trial name
- NCT00199225
- Testing
- Rupatadine, moxifloxacin, Continous electrocardiographic register
- Where
- Spain
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- J. Uriach and Company
Schizophrenia
Effects of Cariprazine on Cardiac Repolarization in Patients With Schizophrenia
This study will evaluate the effects of sequential multiple dose regimens of cariprazine on cardiac repolarization in patients with schizophrenia.
- Trial name
- NCT01376076
- Testing
- Cariprazine, Risperidone/Moxifloxacin
- Where
- 4 sites in United States
- Volunteers
- 129 people
- Sponsor
- Forest Laboratories
Healthy
A Study to Evaluate the Pharmacokinetics and the Effect on Cardiac Repolarization of Odalasvir Administered as a Single Dose Tablet Under Fed Conditions in Healthy Participants
The purpose of this study is to determine the relationship between the plasma concentrations of odalasvir and changes in the QT interval / QTc interval (QT corrected for heart rate) using exposure-response (ER) analysis.
- Trial name
- NCT02889367
- Testing
- Odalasvir 100 mg, Odalasvir 500 mg, Odalasvir (Up to maximum 1000 mg)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Brugada Syndrome, Early Repolarization Syndrome
VF Mapping in Brugada and Early Repolarization Syndromes
To determine the values and limitations of ECGI in guiding ablation and risk stratification in patients with BrS and Early Repolarization.
- Trial name
- NCT03764592
- Testing
- radiofrequency ablation
- Where
- 2 sites in Thailand
- Volunteers
- 50 people
- Sponsor
- Pacific Rim Electrophysiology Research Institute
Healthy Volunteers
A Phase 1 Study To Evaluate The Effect Of Glasdegib On The Cardiac Repolarization In Healthy Subjects
This is a Thorough QT study intended to estimate the effect of glasdegib at therapeutic exposure and at supra-therapeutic exposure on cardiac repolarization in healthy subjects.
- Trial name
- B1371023 (NCT03162900)
- Testing
- Glasdegib Therapeutic Exposure, Glasdegib Supra-therapeutic Exposure, Positive Control (Moxifloxacin)
- Where
- Belgium
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Pfizer