Clinical trials: Cardiac Repolarization
Healthy Volunteers
A Study to Evaluate the Effect of BMS-986278 on Cardiac Repolarization in Healthy Participants
The purpose of this study is to evaluate the effect of BMS-986278 on the cardiac repolarization in healthy participants.
- Trial name
- NCT07422298
- Testing
- BMS-986278, Moxifloxacin
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Cardiac Repolarization in Healthy Subjects
A TQT Study to Evaluate the Electrocardiographic Effects of Carbidopa in Healthy Subjects
The purpose of this trial is to assess the effects of a single supratherapeutic dose of carbidopa on cardiac repolarization relative to placebo in healthy adult subjects.
- Trial name
- NCT06161220
- Testing
- Carbidopa capsule, Moxifloxacin Tablets, USP
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Impax Laboratories, LLC
Fatigue, Tachycardia
Effect of Caffeine on Heart Function
The primary objective of this study is to assess the effect of an energy drink on ventricular repolarization as measured by the interval between the cardiac Q wave and the cardiac T wave (QT interval)obtained from the body…
- Trial name
- NCT02401776
- Testing
- Monster Energy Drink, Coffee
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Symptomatic Neurogenic Orthostatic Hypertension, nOH
Thorough QT Study to Evaluate Ampreloxetine in Healthy Subjects
A double-blind study to characterize the effect of ampreloxetine on cardiac repolarization in healthy subjects.
- Trial name
- NCT04688632
- Testing
- Ampreloxetine <Dose A>, Ampreloxetine <Dose B>, Moxifloxacin
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Theravance Biopharma
Healthy Adult Subject
A Study of HDM1002 Tablets on Cardiac Repolarization in Healthy Subjects
The aim of this trial is to evaluate the effect of a single oral dose of HDM1002 tablets on the QT/QTc interval in healthy subjects.
- Trial name
- NCT07594847
- Testing
- HDM1002 200 mg, HDM1002 400 mg, Moxifloxacin 400 mg
- Where
- China
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.
Influence of Nebulized Bronchodilatators on Selected, Electrophysiological Parameters
Nebulized Bronchodilators and Cardiac Repolarization
Patients of the ICU's often require bronchodilatory treatment due to bronchospasm caused by conditions like : acute respiratory distress syndrome (ARDS), chronic obstructive pulmonary disease (COPD) or asthma.
- Trial name
- NCT01714401
- Testing
- Salbutamol 2,5 mg, Salbutamol 5mg
- Where
- 2 sites in Poland
- Volunteers
- 50 people
- Sponsor
- Medical University of Gdansk
Azithromycin Adverse Reaction, Covid19
The Effect of Azithromycin Use on Conduction System of Heart in COVID-19 Positive Children
Azithromycin (AZ) is used in the pediatric group in COVID-19 diseas. It has been reported to cause prolongation in the QT interval in adult age group.
- Conditions
- Azithromycin Adverse Reaction, Covid19, Long QT Syndrome
- Trial name
- NCT04699097
- Testing
- Azithromycin
- Where
- Turkey (Türkiye)
- Volunteers
- 105 people
- Sponsor
- Kayseri City Hospital
Alternating Hemiplegia of Childhood
HEmiplegia Arrhythmia Retrospective Trial
Alternating Hemiplegia of Childhood (AHC) is a rare and severe disease that is in need of effective, and hopefully even curative, therapies.
- Trial name
- HEART (NCT04944927)
- Testing
- Recording of clinical parameters and electrocardiogram parameters
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Hospices Civils de Lyon
Inherited Cardiac Arrythmias, Long QT Syndrome (LQTS)
Derivation of Human Induced Pluripotent Stem (iPS) Cells to Heritable Cardiac Arrhythmias
Human induced pluripotent stem cells (hiPSCs) have driven a paradigm shift in the modeling of human disease; the ability to reprogram patient-specific cells holds the promise of an enhanced understanding of disease mechanisms and…
- Conditions
- Inherited Cardiac Arrythmias, Long QT Syndrome (LQTS), Brugada Syndrome (BrS), Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)
- Trial name
- NCT02413450
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Pregnancy, Long QT Syndrome
Ventricular Repolarization During the Pregnancy-to-Postpartum Transition (QuTe)
Pregnancy and the postpartum period are accompanied by marked changes in heart rate, circulating hormones, and electrolyte balance that may influence ventricular repolarization.
- Trial name
- QuTe (NCT02931695)
- Testing
- Evaluation of QT interval duration, Circulating sex hormones levels sample
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- French Cardiology Society
Healthy Subjects
A Study to Assess The Effects Of Effexor XR On Cardiac Repolarization In Healthy Adult Subjects
The purpose of this study is to demonstrate a lack of effect of venlafaxine (Effexor XR) on QTc intervals relative to time matched placebo in healthy volunteers
- Trial name
- NCT02637193
- Testing
- Venlafaxine, Moxifloxacin
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Healthy
A Study of the Cardiac Effects of ALXN1840 in Healthy Adults
This study will evaluate the effect of a supratherapeutic dose of ALXN1840 on the heart rate (HR)-corrected QT interval (QTc) in healthy adult participants. Moxifloxacin will be used as the active control.
- Trial name
- NCT04560816
- Testing
- ALXN1840, Moxifloxacin
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Alexion Pharmaceuticals, Inc.
Cancer
A Study to Look at the Electrical Activity of the Heart in Subjects With Solid Tumor Cancers, Before and After Receiving the Study Treatment, GSK1120212
A multicenter, non-randomized, placebo-controlled, single dosing schedule, subject-blinded study to evaluate the effect of GSK1120212 on the electrical activity of the heart as compared to placebo in subjects with solid tumor…
- Trial name
- NCT01658553
- Testing
- GSK1120212
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- GlaxoSmithKline
Epilepsy
Trial to Evaluate the Effect of Eslicarbazepine Acetate on Cardiac Repolarization
A randomized, double-blind, placebo-controlled and open label active-controlled, 4 period crossover trial to evaluate the effect of eslicarbazepine acetate on cardiac repolarization in healthy adult men and women
- Trial name
- NCT02283788
- Testing
- BIA 2-093, Moxifloxacin
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Bial - Portela C S.A.
Healthy
A Study of Lasmiditan on the Heart in Healthy Participants
The purpose of this study was to determine how two doses of lasmiditan affected the heart in healthy participants. The study also evaluated how much lasmiditan got into the blood stream and how long it took the body to get rid of…
- Trial name
- NCT03465436
- Testing
- Lasmiditan, Moxifloxacin
- Where
- Germany
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Post COVID-19, Ventricular Repolarization
Changes in Electrocardiographic (ECG) Ventricular Repolarization and Transthoracic Impedance Cardiography (ICG) Parameters in Patients with COVID-19 and After the Disease: Persistence and Prognostic Significance of These Changes
The aim of this study is to determine the relationship between changes in resting electrocardiography (ECG) ventricular repolarization parameters, transthoracic impedance cardiography (ICG) parameters, and COVID-19, to assess the…
- Conditions
- Post COVID-19, Ventricular Repolarization, Arrhythmias, Impedance Cradiography
- Trial name
- NCT06674278
- Volunteers
- 215 people
- Sponsor
- Lithuanian University of Health Sciences
Healthy
A TQT Study to Investigate the Effect of Enpatoran on Cardiac Repolarization in Healthy Participants
The purpose of this study is to assess potential effects of enpatoran on cardiac repolarization (i.e. prolongation of QT interval).
- Trial name
- NCT06589726
- Testing
- Moxifloxacin, Enpatoran low dose, Enpatoran high dose
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany
Disease, Hodgkin, Lymphoma, Large-Cell, Anaplastic
Cardiac Safety Study of Brentuximab Vedotin (SGN-35)
The purpose of this study is to evaluate cardiac safety of brentuximab vedotin (SGN-35) in patients with CD30-positive cancers. The study will assess electrical activity of the heart before and after brentuximab vedotin…
- Conditions
- Disease, Hodgkin, Lymphoma, Large-Cell, Anaplastic, Lymphoma, Non-Hodgkin
- Trial name
- NCT01026233
- Testing
- brentuximab vedotin
- Where
- 9 sites in United States, Germany
- Volunteers
- 52 people
- Sponsor
- Seagen Inc.
Healthy
A TQT Study of Effect of M2951 on Cardiac Repolarization
The purpose of this study is to assess potential effects of M2951 on cardiac repolarization (i.e. prolongation of QT interval).
- Trial name
- NCT07214935
- Testing
- Moxifloxacin, M2951 Low Dose, M2951 High Dose
- Where
- Germany
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany
Heart Repolarization
Study to Evaluate the Effect of Naltrexone and Bupropion Extended-Release Combination on Cardiac Repolarization in Healthy Participants
The purpose of this study is to evaluate the potential effect of naltrexone and bupropion extended-release combination on cardiac repolarization in healthy participants.
- Trial name
- NCT02735603
- Testing
- Naltrexone HCl/bupropion HCl, Moxifloxacin
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Orexigen Therapeutics, Inc