Clinical trials: Cardiac Repolarization in Healthy Subjects
Cardiac Repolarization in Healthy Subjects
Thorough QT (TQT) Study of TD-4208 in Healthy Subjects
The purpose of this study is to evaluate if TD-4208, an investigational drug being developed to treat people with chronic obstructive pulmonary disease (COPD), has any effect on the electrical activity of the heart.
- Trial name
- NCT02820311
- Testing
- TD-4208 175 mcg, TD-4208 700 mcg, Moxifloxacin 400 mg
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Mylan Inc.
Diabetes Mellitus
Study Evaluating Single Doses of PPM-204 on the Electrical Pathways of the Heart
A study evaluating the safety of a high and low dose of PPM-204 on the electrical pathways of the heart.
- Trial name
- NCT00447629
- Testing
- PPM-204
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Healthy Volunteers
A Phase 1 Study To Evaluate The Effect Of Glasdegib On The Cardiac Repolarization In Healthy Subjects
This is a Thorough QT study intended to estimate the effect of glasdegib at therapeutic exposure and at supra-therapeutic exposure on cardiac repolarization in healthy subjects.
- Trial name
- B1371023 (NCT03162900)
- Testing
- Glasdegib Therapeutic Exposure, Glasdegib Supra-therapeutic Exposure, Positive Control (Moxifloxacin)
- Where
- Belgium
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Pfizer
Healthy Subjects
A Study to Assess The Effects Of Effexor XR On Cardiac Repolarization In Healthy Adult Subjects
The purpose of this study is to demonstrate a lack of effect of venlafaxine (Effexor XR) on QTc intervals relative to time matched placebo in healthy volunteers
- Trial name
- NCT02637193
- Testing
- Venlafaxine, Moxifloxacin
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Healthy
Study to Evaluate the Effects of Tramadol Hydrochloride on Cardiac Repolarization in Healthy Participants
The purpose of this study is to assess the effects of multiple doses of an immediate release (IR) formulation of tramadol hydrochloride (HCl) at therapeutic and supratherapeutic levels in healthy adult participants on the…
- Trial name
- NCT02307864
- Testing
- Tramadol HCl, Moxifloxacin 400 mg
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Janssen Scientific Affairs, LLC
Symptomatic Neurogenic Orthostatic Hypertension, nOH
Thorough QT Study to Evaluate Ampreloxetine in Healthy Subjects
A double-blind study to characterize the effect of ampreloxetine on cardiac repolarization in healthy subjects.
- Trial name
- NCT04688632
- Testing
- Ampreloxetine <Dose A>, Ampreloxetine <Dose B>, Moxifloxacin
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Theravance Biopharma
Healthy
Study to Evaluate the Effects of Domperidone on Cardiac Repolarization in Chinese Healthy Participants
The purpose of this study is to assess the effects of domperidone on the QTc interval duration in Chinese healthy adult participants after multiple domperidone doses of 10 milligram (mg) 3 times a day (tid) and 20 mg tid.
- Trial name
- NCT02816853
- Testing
- Domperidone, Moxifloxacin
- Where
- China
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Healthy Subjects, Cardiac Repolarization
A Study of the Effect of ASP1941 on Cardiac Repolarization in Healthy Subjects
The objective of this study is to evaluate the effect of repeat oral dosing of ASP1941 on electrocardiogram (ECG) measurements.
- Trial name
- NCT01232413
- Testing
- ASP1941, Moxifloxacin
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Inc
Healthy, Long QT Syndrome
Study Evaluating the Effects of Multiple Oral Doses of ERB-041 on Cardiac Repolarization in Healthy Subjects
To assess the effect of ERB-041 after multiple oral doses on cardiac repolarization as assessed by the QTc interval.
- Trial name
- NCT00316459
- Testing
- ERB-041
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Healthy
A Thorough QT Study of ABBV-CLS-7262 in Healthy Subjects
This is a randomized, blinded, placebo and active-controlled, 4-period, crossover design thorough QT/QTc (TQT) study to evaluate the effect of ABBV-CLS-7262 on cardiac repolarization in healthy adult subjects.
- Trial name
- NCT06310876
- Testing
- ABBV-CLS-7262, Moxifloxacin 400mg
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Calico Life Sciences LLC
Solid Tumors
A Study to Investigate the Effect of Single Dose of AZD6094 (600 mg) on Cardiac Repolarization in Healthy Volunteers
This is a randomized, placebo-controlled, double-blind, 3-way crossover phase I study being conducted on healthy volunteers to investigate the effect of single dose of AZD6094 (600 mg) on cardiac repolarization under…
- Trial name
- NCT03258515
- Testing
- AZD6094 200 mg, Moxifloxacin
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Healthy
A Phase 1 Study to Investigate the Effects of Talampanel on the Heart Rhythm
The purpose of this study is to assess whether multiple doses of Talampanel increase the QT interval when compared to placebo
- Trial name
- NCT00964730
- Testing
- Talampanel, Moxifloxacin
- Where
- United States
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Healthy
A Study to Evaluate the Effects of Ibrutinib on Cardiac Repolarization in Healthy Participants
The purpose of this study is to assess the safety and tolerability of ibrutinib, to compare the pharmacokinetics of ibrutinib after single oral administration of 840 mg and 1680 mg and to assess the effects of a single dose of…
- Trial name
- NCT02271438
- Testing
- Ibrutinib, Moxifloxacin
- Where
- Belgium
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Healthy
A Study to Evaluate the Effect of JNJ-63623872 on Cardiac Repolarization Interval in Healthy Participants
The purpose of this study is to evaluate the effect of JNJ-63623872 on the QT/QTc interval at supratherapeutic exposure in healthy participants (Panel 2).
- Trial name
- NCT02658825
- Testing
- JNJ-63623872 2400 milligram (mg), JNJ-63623872 3000 mg, JNJ-63623872
- Where
- Belgium
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Healthy Subject
Evaluate the Effect of Orelabrutinib on Cardiac Repolarization in Healthy Subjects
This is A Randomized, Blinded, Placebo- and Positive-Controlled, Four-Period, Crossover-Design Thorough QT/QTc (TQT) Study to Evaluate the Effect of Orelabrutinib on Cardiac Repolarization in Healthy Subjects
- Trial name
- NCT05660720
- Testing
- Orelabrutinib, Moxifloxacin hydrochloride
- Where
- China
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Beijing InnoCare Pharma Tech Co., Ltd.
Anaemia
Single Dose, Pharmacokinetic, Safety, Tolerability and QTc Study of GSK1278863 in Healthy Volunteers
This study is being performed to comply with regulatory requirements that all new non-antiarrhythmic drugs must be assessed for potential effects on cardiac repolarization through electrocardiographic evaluation in a 'Thorough…
- Trial name
- NCT02293148
- Testing
- GSK1278863 75 mg, GSK1278863 500 mg, Moxifloxacin 400 mg
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Cardiac Repolarization, Healthy Volunteers
A Study to Evaluate the Effect of Single Oral Dose of Balinatunfib on Cardiac Repolarization in Healthy Adult Participants.
This is a Phase 1, multicenter, randomized, double-blind, double-dummy, single dose, placebo- and positive-controlled, 4-sequence, 4-treatment, 4-period crossover study.
- Trial name
- NCT07272629
- Testing
- Balinatunfib, Moxifloxacin
- Where
- 2 sites in United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Sanofi
Healthy Subjects, Cardiac Repolarization
Phase 1 Study to Assess the Effects of EVP-6124 on the QT/QTc Interval in Healthy Subjects
The purpose of this study is to evaluate the effect of EVP-6124 at therapeutic and supratherapeutic concentrations on cardiac repolarization in healthy subjects.
- Trial name
- TQT (NCT01487135)
- Testing
- EVP-6124, Moxifloxacin
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- FORUM Pharmaceuticals Inc
Human Experimentation (Human Volunteers)
Evaluation of Possible Effects on the QT/ QTc Interval of Rupatadine in Healthy Volunteers
This phase I trial will evaluate the effects of rupatadine, at a dose of 10 mg OD (authorised and marketed dose) and the 100mg/day (supratherapeutic dose) on the ECG parameters with a special focus on its effect on cardiac…
- Trial name
- NCT00199225
- Testing
- Rupatadine, moxifloxacin, Continous electrocardiographic register
- Where
- Spain
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- J. Uriach and Company
Alzheimer Disease, Healthy
Study Evaluating the Effect of Lecozotan SR on the QTc Interval
This is a randomized, double-blind, placebo- and moxifloxacin (open-label)-controlled, 4-period crossover study.
- Trial name
- NCT00499642
- Testing
- Lecozotan SR, Moxifloxacin
- Where
- 2 sites in France
- Volunteers
- healthy volunteers welcome
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer