Clinical trials: Cardiac Repolarization in Healthy Subjects
Healthy Subjects
A Study to Evaluate the Effect of Oral Mirabegron on the Heart in Healthy Males and Females
The objective of this study is to evaluate the effect of repeat oral dosing of mirabegron on ECG (electrocardiogram) measurements.
- Trial name
- NCT01199523
- Testing
- mirabegron, moxifloxacin
- Where
- 2 sites in United States
- Volunteers
- 352 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Inc
Healthy
Study to Evaluate The Effect Of Sertraline on the Cardiac Repolarization in Healthy Subjects
The purpose of this study is to demonstrate a lack of effect of sertraline on QTc intervals relative to time-matched placebo in healthy subjects
- Trial name
- Zoloft (NCT02651623)
- Testing
- Sertraline, Moxifloxacin
- Where
- Belgium
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Healthy Subjects
Study Evaluating The Effect of Bosutinib (SKI-606) On Cardiac Repolarization (Rhythms Of The Heart)
The purpose of this study is to examine the effect of SKI-606 on rhythms of the heart (cardiac repolarization)
- Trial name
- NCT00914121
- Testing
- SKI-606, Moxifloxacin
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Hyperuricemia, Gout
Thorough QT (TQT) Study to Evaluate the Effect of LC350189 on Cardiac Repolarization in Healthy Male and Female Subjects
This is a Phase 1, single-center, randomized, partially double-blind, placebo- and positive controlled, 4-way crossover study to evaluate the effect of a therapeutic and a supratherapeutic dose of LC350189 on the QTcF in healthy…
- Conditions
- Hyperuricemia, Gout, Qt Interval, Variation in
- Trial name
- NCT04966325
- Testing
- LC350189 200mg, Moxifloxacin 400mg, LC350189 600mg
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- LG Chem
Healthy Volunteers
A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of BMS-986278 and the Effects of BMS-986278 on Cardiac Repolarization in Healthy Participants
The purpose of this study is to determine the safety, tolerability, and pharmacokinetics (PK) of high dose of BMS-986278 in healthy participants and to assess the effect of BMS-986278 on the ECG intervals in healthy participants.
- Trial name
- NCT06746402
- Testing
- BMS-986278, Moxifloxacin
- Where
- 2 sites in United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Healthy Volunteers
A Two-Part Phase 1 Study to Investigate the Safety and Tolerability of Supratherapeutic Dose of Zanubrutinib and Effect of Zanubrutinib on Cardiac Repolarization in Healthy Subjects
A Two-Part Phase 1 Study to Investigate A) Safety and Tolerability of Supratherapeutic dose of Zanubrutinib (BGB-3111) and B) Effect of Zanubrutinib on Cardiac Repolarization in Healthy Subjects
- Trial name
- NCT03432884
- Testing
- BGB-3111, Moxifloxacin
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- BeiGene
Healthy Adult Subject
A Study of HDM1002 Tablets on Cardiac Repolarization in Healthy Subjects
The aim of this trial is to evaluate the effect of a single oral dose of HDM1002 tablets on the QT/QTc interval in healthy subjects.
- Trial name
- NCT07594847
- Testing
- HDM1002 200 mg, HDM1002 400 mg, Moxifloxacin 400 mg
- Where
- China
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.
Prolonged QTc Interval, Pharmacokinetic
Evaluation of the Effects of Multiple Doses of Cebranopadol on the Electrical Activity of the Heart in Healthy Subjects
The objective of this study was to evaluate the effects of cebranopadol (GRT6005) on the electrical activity of the heart in healthy participants.
- Trial name
- NCT03958123
- Testing
- 100 μg cebranopadol, 200 μg cebranopadol, 400 μg cebranopadol
- Where
- United States
- Volunteers
- 171 people, healthy volunteers welcome
- Sponsor
- Tris Pharma, Inc.
Obstetric Labour, Premature
This Study Will Investigate the Effect of Single Oral Doses of Retosiban on Cardiac Repolarization, With Moxifloxacin as a Positive Control in Healthy Volunteers.
This will be a randomized, placebo-controlled, single, oral dose, four-way Williams crossover study design in healthy male and female subjects.
- Trial name
- NCT01702376
- Testing
- Retosiban 100 mg, Retosiban 800 mg, Moxifloxacin 400 mg
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Normal Healthy Subjects
A Thorough QT/QTc Study to Evaluate the Effects of an Intravenous Infusion of Eravacycline (TP-434) on Cardiac Repolarization
This is a randomized, placebo- and positive-controlled (moxifloxacin), 3-period, 3-way crossover thorough QT study, which includes a Screening Period, Treatment Periods (1 through 3), and a Follow-up Visit.
- Trial name
- NCT01941446
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Tetraphase Pharmaceuticals, Inc