Clinical trials: Cardiac Resynchronization
Heart Failure
Renal Denervation in Patients With Chronic Heart Failure and Resynchronization Therapy
Chronic heart failure is becoming more and more common disease and activation of sympathetic nervous system plays a crucial role in its development.
- Trial name
- NCT02329145
- Testing
- renal denervation
- Where
- Poland
- Volunteers
- 20 people
- Sponsor
- Jagiellonian University
Heart Failure, Ischemic Cardiomyopathy
Viability and Cardiac Resynchronization Therapy
30% of heart failure patients that receive a device for cardiac resynchronization therapy fail to show clinical improvement. The reason for lack of response is still unclear but factors such as scar tissue in the heart…
- Trial name
- NCT00955539
- Testing
- AV-optimization followed by AV- and VV-optimization, AV- and VV-optimization followed by AV-optimization only.
- Where
- 2 sites in Denmark, Sweden
- Volunteers
- 100 people
- Sponsor
- University Hospital, Gentofte, Copenhagen
Cardiac Resynchronization Therapy, Left Bundle Branch Area Pacing
Feasibility and Outcomes Registry of Lumenless dEfibrillation Leads for Conduction System Pacing
The recent development and market introduction of small diameter implantable defibrillation leads able to deliver left bundle branch area pacing (LBBAP) has opened the possibility of achieving cardiac resynchronization therapy…
- Trial name
- FORGE CSP (NCT07406737)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Caen
Heart Failure
Evaluation of Multisensor Data in Heart Failure Patients With Implanted Devices
The goal of the MultiSENSE study is to collect chronic information from multiple sensors in an implanted device for evaluation in heart failure patients.
- Trial name
- MultiSENSE (NCT01128166)
- Testing
- COGNIS CRT-D
- Where
- 99 sites in United States, Czechia and 10 more
- Volunteers
- 975 people
- Sponsor
- Boston Scientific Corporation
Heart Failure, Atrial Fibrillation
Cardiac Resynchronisation Therapy and AV Nodal Ablation Trial in Atrial Fibrillation Patients (CAAN-AF)
Cardiac resynchronization therapy (CRT) is a treatment for heart failure in patients who also suffer from ventricular dyssynchrony, a form of uncoordinated contraction of the ventricle (lower pumping chamber of the heart).
- Trial name
- CAAN-AF (NCT01522898)
- Testing
- AV nodal ablation, Medical Ventricular Rate Control
- Where
- 33 sites in Australia, Germany and 3 more
- Volunteers
- 145 people
- Sponsor
- University of Adelaide
Heart Failure, Cardiac Resynchronization Therapy
Safety and Performance Aspects of CRT-DX System in Patients With Sinus Rhythm
The conventional CRT-D system consists of 3 leads in patients with Heart Failure (HF). A part of HF patients have non-impaired sinus node function and will not be stimulated in the right atrium.
- Trial name
- BIO|REDUCE (NCT03839121)
- Testing
- Cardiac Resynchronization Therapy (CRT)
- Where
- 21 sites in Austria, Czechia and 2 more
- Volunteers
- 113 people
- Sponsor
- Biotronik SE & Co. KG
Heart Failure, Intraventricular Block
A Randomized Controlled Trial of LOT-CRT Versus conventionaL BiVP in Heart Failure Patients With NICD
BATTLE study has been designed as a prospective, multi-center, randomized, controlled trial. This study will enroll 83 patients with chronic heart failure accompanied by intraventricular block (NICD) over an estimated recruitment…
- Trial name
- BATTLE (NCT06061627)
- Testing
- LOT-CRT group, BiVP group
- Where
- China
- Volunteers
- 86 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Heart Failure
CardioInsight 1 RBBB
Cardiac resynchronization therapy (CRT) is an established therapy for symptomatic heart failure patients. However, there are still 30 to 40% of studied patients being nonresponder to CRT.
- Trial name
- CardioInsight1 (NCT05555966)
- Testing
- Electrical Activation Mapping Guided Cardiac resynchronization therapy
- Where
- Hong Kong
- Volunteers
- 93 people
- Sponsor
- Chinese University of Hong Kong
Bundle-Branch Block
The CRT-KIR Study (Cardiac Resynchronization Therapy [CRT] in the Early Phase After Heart Surgery)
In patients with broad QRS complexes on electrocardiogram (ECG), the delayed electrical activation of the left heart chamber will cause abnormal contraction.This has been shown to be possible to treat by a special pacemaker…
- Trial name
- NCT00192946
- Testing
- Temporary cardiac resynchronization therapy
- Volunteers
- 60 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Non-ischemic Cardiomyopathy, Cardiac Resynchronisation Therapy (CRT)
Withdrawal of Heart Failure Treatment Patients With Non-ischemic Cardiomyopathy Who Have Been Super-responders to Cardiac Resynchronization Therapy.
Multicenter, prospective, non-inferiority, randomized, single-blind (primary endpoint evaluators blinded, patients not blinded) clinical trial.
- Trial name
- DRUGLESS-CRT (NCT07851779)
- Testing
- Withdrawal of Heart failure medications
- Where
- 4 sites in Spain
- Volunteers
- 64 people
- Sponsor
- Institut d'Investigació Biomèdica de Bellvitge
Heart Failure
Clinical Investigation on Differences in the Magnitude of CRT Response in WOmen Versus MEN
BIOWOMEN is a study designed to compare the Cardiac Resynchronization Therapy (CRT) response rate in a Heart Failure (HF) population with an equal distribution of men and women.
- Trial name
- BIOWOMEN (NCT02344420)
- Testing
- Echocardiography, Minnesota Living Heart Failure Questionnaire (MLHF), Six minute walk test
- Where
- Spain
- Volunteers
- 494 people
- Sponsor
- Biotronik SE & Co. KG
Atrioventricular Block, Second and Third Degree, Heart Failure
Safety and Effectiveness of Left Bundle Branch Pacing in Patients With Cardiac Dysfunction and AV Block
This study is a multicenter, prospective, randomized study to assess if cardiac dysfunction patients with LVEF <50% and the estimated ventricular pacing percentage >40% with LBBP have the non-inferior safety and efficacy than CRT…
- Conditions
- Atrioventricular Block, Second and Third Degree, Heart Failure, Left Bundle Branch Pacing
- Trial name
- NCT05553626
- Testing
- Left bundle branch pacing, Bi-ventricular pacing
- Where
- China
- Volunteers
- 160 people
- Sponsor
- First Affiliated Hospital of Wenzhou Medical University
Postoperative Cardiac Complication, Heart Failure
More Options Available With a Quadripolar LV Lead pRovidE In-clinic Solutions to CRT Challenges
This investigation is designed with the hypothesis that using a quadripolar left ventricular lead results in less interventions when dealing with high pacing thresholds and Phrenic Nerve Stimulation (PNS), both at implant and…
- Conditions
- Postoperative Cardiac Complication, Heart Failure, Left Ventricular Cardiac Dysfunction, Inappropriate Phrenic Nerve Stimulation
- Trial name
- MORE-CRT (NCT01510652)
- Testing
- BiP Group, Quad Group
- Where
- 64 sites in Belgium, Canada and 11 more
- Volunteers
- 1,078 people
- Sponsor
- Abbott Medical Devices
Heart Failure，Congestive, Cardiomyopathies
HIS-Purkinje Conduction System Pacing Optimized Trial of Cardiac Resynchronization Therapy
This is a randomized, prospective, single-blinded trial to determine the overall rate of successful His-Purkinje conduction system pacing Optimized Trial of Cardiac Resynchronization Therapy (HOT-CRT) versus biventricular pacing…
- Conditions
- Heart Failure，Congestive, Cardiomyopathies, Left Ventricular Dysfunction
- Trial name
- HOT-CRT (NCT04561778)
- Testing
- HOT-CRT, Biventricular Pacing
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Pugazhendhi Vijayaraman
Congestive Heart Failure Treated
Clinical Benefits in Optimized Remote HF Patient Management
The Study Purpose is to demonstrate the superiority of optimized remote patient management compared to optimized standard care in the management and prognosis of heart failure, in the prevention of recurrent atrial tachycardia or…
- Trial name
- COR-HF (NCT01482598)
- Testing
- Remote Care Follow up
- Where
- 18 sites in Italy
- Volunteers
- 144 people
- Sponsor
- Abbott Medical Devices
Heart Failure
Strategic Management to Optimize Response To Cardiac Resynchronization Therapy
The primary objective is to evaluate the benefit of the SmartDelay™ algorithm in patients with a prolonged RV-LV interval.
- Trial name
- SMART CRT (NCT03089281)
- Testing
- CRT-D
- Where
- 72 sites in United States, Canada and 9 more
- Volunteers
- 699 people, healthy volunteers welcome
- Sponsor
- Boston Scientific Corporation
Cardiac Insufficiency
Cardiac Resynchronization Therapy: Relevance of the Surgical Approach in the Implantation of the Left Ventricular Probe
Heart failure is very common and reaches more than 56 million people worldwide. 17 to 45 percent die in the first year of hospitalization. The most affected populations live in Western countries like Europe or the USA.
- Trial name
- NCT03083301
- Testing
- Medical Files data extraction
- Where
- Belgium
- Volunteers
- 155 people
- Sponsor
- Pierre Wauthy
Heart Failure, Systolic, Left Bundle Branch Block
Acute Hemodynamic Effects of Pacing the His Bundle in Heart Failure
Cardiac resynchronization therapy (CRT) with biventricular pacing (BVP) is indicated for patients with low ejection fraction and persistent symptoms of heart failure despite medical therapy and a wide QRS-complex, preferably with…
- Conditions
- Heart Failure, Systolic, Left Bundle Branch Block, Wide QRS Complex
- Trial name
- HEPA-His (NCT04701112)
- Testing
- Temporary His bundle pacing
- Where
- Sweden
- Volunteers
- 2 people
- Sponsor
- Region Skane
Type 2 Diabetes Mellitus, Heart Failure
SGLT2i and Incretin and CRTd.
Incretin therapy and sodium-glucose- transporter2 inhibitors (SGLT2i) are a treatment for type 2 diabetes (T2DM) affected by heart failure (HF) and treated with cardiac resynchromization therapy (CRT).
- Trial name
- NCT03282136
- Testing
- Incretin Effect, Cardiac Resynchronization therapy defibrillator device, SGLT-2 inhibitor
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- University of Campania Luigi Vanvitelli
Heart Failure
The Application of Negative Atrioventricular Hysteresis in Cardiac Resynchronization Therapy With MultiPoint Pacing
The purpose of this study is to evaluate the application of Negative AV Hysteresis (NAVH) to improve electrical synchrony in MultiPoint Pacing (MPP) Cardiac Resynchronization Therapy (CRT) patients.
- Trial name
- NCT02782598
- Testing
- CRT+NAVH
- Where
- Italy
- Volunteers
- 17 people
- Sponsor
- Abbott Medical Devices