Clinical trials: Cardiac Resynchronization
Heart Failure
ECG Optimization of CRT: Evaluation of Mid-term Response
New simpler methods to optimize cardiac resynchronization therapy (CRT) are being evaluated, such as the use of the electrocardiogram.
- Trial name
- BEST (NCT01439529)
- Testing
- Device programming: nominal, Programming optimization by QRS
- Where
- Spain
- Volunteers
- 180 people
- Sponsor
- Hospital Clinic of Barcelona
Cardiac Resynchronization Therapy, Heart Failure
Conduction System Pacing vs Biventricular Pacing in Systolic Dysfunction and Wide QRS: Mortality, Heart Failure Hospitalization or Cardiac Transplant
Conduction system pacing vs biventricular resynchronization therapy in systolic dysfunction and wide QRS: mortality, heart failure hospitalization or cardiac transplant (CONSYST-CRT II trial).
- Trial name
- CONSYST-CRT II (NCT06105580)
- Testing
- Conduction system pacing, Biventricular pacing
- Where
- Spain
- Volunteers
- 320 people
- Sponsor
- Hospital Clinic of Barcelona
Heart Failure
A Comparison of Two Techniques for Choosing the Best Place to Put a Pacing Lead for Cardiac Resynchronisation Therapy
Cardiac resynchronisation therapy (CRT) using biventricular pacing (BiVP) is established as an effective treatment for heart failure.
- Trial name
- IDEAL-CRT (NCT02061241)
- Testing
- Pacing in vein at site of latest mechanical activation, Pacing in other suitable vein
- Where
- United Kingdom
- Volunteers
- 22 people
- Sponsor
- Oxford University Hospitals NHS Trust
Heart Failure
Withdrawal of Pharmacological Treatment in Patients Responding to Cardiac Resynchronization Therapy:
The purpose of this randomized trial is to investigate the effect of the complete removal of pharmacological treatment in patients responding to cardiac resynchronization therapy with recuperated LVEF in terms of imaging…
- Trial name
- REMOVE (NCT05151861)
- Testing
- Complete removal of pharmacological treatment, Control
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Fundacion para la Formacion e Investigacion Sanitarias de la Region de Murcia
Heart Failure
Biomarkers to Predict CRT Response in Patients With HF (BIOCRT)
The prospective study aims: 1. To determine the role and mechanism of biomarkers for prediction of response to CRT 2. To determine the role of biomarkers and their effect on left ventricular remodeling in patients undergoing CRT.
- Trial name
- BIOCRT (NCT01949246)
- Where
- United States
- Volunteers
- 221 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Heart Failure, Implantable Cardioverter Defibrillator (ICD)
Comparison of the Effects of Different Upper Extremity Aerobic Exercise Training Protocols on Arm Functional Capacity in Patients With Heart Failure With Cardiac Implantable Electronic Devices
1. To determine the most suitable exercise protocol for upper extremity aerobic exercise training, a widely used type of aerobic exercise to improve reduced upper extremity functional capacity in individuals with CIED and HF. 2.
- Conditions
- Heart Failure, Implantable Cardioverter Defibrillator (ICD), Cardiac Resynchronization Therapy Devices
- Trial name
- NCT07592494
- Testing
- High-Intensity Interval Upper Extremity Aerobic Exercise Training, Moderate Intensity Continuous Upper Extremity Aerobic Exercise Training, Lower Extremity Aerobic Exercise Training
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Erol Olcok Corum Training and Research Hospital
First Degree Atrioventricular Block
BiventRicular Pacing in prolongEd Atrio-Ventricular intervaL: the REAL-CRT Study
This study was designed to evaluate the potential benefits of treatment with biventricular device in patients with normal systolic function , indication for pacing and impaired atrio-ventricular conduction , by comparing the…
- Trial name
- REAL-CRT (NCT02150538)
- Testing
- Cardiac resynchronization therapy pacemaker, Dual chamber pacemaker
- Where
- Italy
- Volunteers
- 164 people
- Sponsor
- Gianluca Botto
Heart Failure, Systolic
Quartet Lead With Defibrillator Multisite Algorithmic Cardiac Resynchronisation Therapy Optimisation
Cardiac resynchronisation therapy (CRT) improves outcomes and symptoms in selected patients with heart failure. However, around one third of suitable patients do not demonstrate benefit following device implantation when assessed…
- Trial name
- QUARTRMASTER (NCT02997670)
- Testing
- Algorithmic Cardiac Resynchronisation Therapy Optimisation
- Where
- United Kingdom
- Sponsor
- Cardiff and Vale University Health Board
Heart Failure, Cardiac Arrhythmia
Evaluation of the BIOTRONIK AutoAdapt Algorithm for Continuous Automatic Adaptive Cardiac Resynchronization
BIO|Adapt study is designed to provide evidence for the clinical benefit of the CRT AutoAdapt feature. This feature provides continuous adaptation of AV delay and biventricular pacing modality.
- Conditions
- Heart Failure, Cardiac Arrhythmia, Left Ventricular Dysfunction
- Trial name
- BIO|Adapt (NCT04774523)
- Testing
- Echo-based assessment of the acute hemodynamic effect of the CRT AutoAdapt feature., Echocardiography AV optimization, Echocardiography
- Where
- Spain
- Volunteers
- 198 people
- Sponsor
- Biotronik SE & Co. KG
Congestive Heart Failure, Atrial Fibrillation
APAF: Assessment of Cardiac Resynchronization Therapy in Patients With Permanent Atrial Fibrillation
A suboptimal level of resynchronization (cardiac resynchronization therapy [CRT]) achieved in many patients with actual standards and techniques based on tissue-Doppler echocardiography could be more effective to obtain better…
- Trial name
- NCT00111527
- Testing
- Optimized echo-guided CRT pacing, normal RV pacing
- Where
- 2 sites in Italy
- Volunteers
- 458 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Chronic Heart Failure
Tailoring Pacemaker Output to Physiology in Chronic Heart Failure
Aims: To explore the clinical effect on exercise tolerance and quality of life, safety and tolerability of pacing at higher outputs in patients with chronic heart failure and a pacemaker.
- Trial name
- NCT03781427
- Testing
- Cardiac resynchronization therapy
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- University of Leeds
Heart Failure, Cardiomyopathy
Clinical Evaluation on Advanced Resynchronization
The aim of the study is to compare clinical benefits of the cardiac resynchronisation (CRT) achieved by the PEA optimised pacing configuration and a CRT optimised by standard clinical procedure.
- Trial name
- NCT00658203
- Testing
- New Living CHF
- Where
- 36 sites in France, Germany and 4 more
- Volunteers
- 310 people
- Sponsor
- LivaNova
Congestive Heart Failure
Oxidative Stress Markers and Cardiac Resynchronization Therapy (CRT) Outcomes
This is a research study that is evaluating blood markers which may predict which patients who receive CRT will improve. Congestive heart failure (CHF) is associated with increased oxidative stress, a condition where abnormal…
- Trial name
- NCT01151553
- Testing
- CRT Therapy
- Volunteers
- 5 people
- Sponsor
- Emory University
Heart Failure
Effect of His-Ventricular (HV) Interval Optimisation in Cardiac Resynchronisation Therapy
Cardiac resynchronisation therapy (CRT) is a specialised type of pacemaker used in patients with severe heart failure to improve symptoms and survival.
- Trial name
- NCT02748876
- Testing
- His-Ventricular (HV) optimisation
- Where
- United Kingdom
- Volunteers
- 14 people
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Change in LDS Signals Due to Cardiac Synchronization Therapy
Changes in Doppler Signals From the Lung Due to Cardiac Resynchronization in Heart Failure Patients
Study Purpose and Rationale The purpose of this study is to evaluate the lung Doppler signals changes during cardiac resynchronization procedure.
- Trial name
- NCT02179203
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Echosense Ltd.
Cardiovascular Diseases, Arrhythmias, Cardiac
Multicenter Evaluation of Patients Using LATITUDE Monitoring System
The Multitude is a registry of patients who receive commercially available CIEDs that remotely communicate through the LATITUDE monitoring system and transfer data to a central database.
- Conditions
- Cardiovascular Diseases, Arrhythmias, Cardiac, Heart Failure, Sudden Cardiac Death
- Trial name
- Multitude (NCT06311149)
- Where
- 3 sites in Italy
- Volunteers
- 20,000 people
- Sponsor
- University Hospital of Ferrara
Cardiac Resynchronization Therapy, Heart Failure
POsition of Leads in Advanced heaRt Failure: the POLAR Study
The primary objective is to determine if lead positioning in the lateral wall of the left ventricle in patients meeting criteria for cardiac resynchronization therapy plays a role in determining myocardial function and affects…
- Trial name
- POLAR (NCT01515761)
- Testing
- Postero-lateral, Antero-Lateral
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Sergio Thal, M.D.
Heart Failure
AI-Guided Left Bundle Branch Area Pacing
The purpose of this study is to compare the effectiveness of AI-guided LBBAP versus conventional LBBAP (not AI-guided) in improving CRT response rates and clinical outcomes.
- Trial name
- NCT07206602
- Testing
- AI-assisted Left Bundle Branch Area Pacing, Left Bundle Branch Area Pacing
- Where
- United States
- Volunteers
- 224 people
- Sponsor
- Mayo Clinic
Heart Failure
CT Guided WiSE-CRT
This feasibility study will use CT scanning to identify the optimal location for placement of the WiSE-CRT system.
- Trial name
- NCT03495505
- Testing
- WiSE-CRT
- Where
- United Kingdom
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Cardiovascular Disease
Comparison of Cyanoacrylate Tissue Adhesive and Suture for Closure of Cardiac Device Pockets
The purpose of this study is to determine whether cyanoacrylate tissue adhesive is as effective as polyglactin 910 suture for surgical closure of cardiac device pockets.
- Trial name
- NCT00674128
- Testing
- Cyanoacrylate tissue adhesive (Dermabond), Polyglactin 910 suture (Vicryl)
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- Mayo Clinic