Clinical trials: Cardiac Rhythm Disturbance
Paroxysmal Atrial Fibrillation
Computed Tomogram Myocardial Thickness Map Guided pulmOnary Vein iSolaTion vs. Empirical Pulmonary Vein Isolation in Cryoballoon Ablation for Paroxysmal Atrial Fibrillation (UTMOST AF II)
New parameters or methods, such as ablation index, have been developed for the quantification of high-frequency energy used in pulmonary vein isolation, but there is no known method for atrial fibrillation considering individual…
- Trial name
- NCT03912324
- Testing
- Unipolar voltage subtraction map guided PV isolation group, CT myocardial thickness map guided PV isolation group, Empirical PV isolation group
- Where
- South Korea
- Volunteers
- 220 people
- Sponsor
- Yonsei University
Defibrillators, Implantable, Myocardial Infarction
Risk of Life-threatening Heart Rhythm Disturbances in Siblings
The purpose of this study is to determine if heredity influences the risk of life-threatening heart rhythms (ventricular tachycardia and ventricular fibrillation) after heart attack (myocardial infarction).
- Conditions
- Defibrillators, Implantable, Myocardial Infarction, Tachycardias, Ventricular
- Trial name
- SIBFIB (NCT00498524)
- Testing
- ICD
- Where
- United States
- Volunteers
- 2,047 people
- Sponsor
- Duke University
Atrial Fibrillation
A Phase III Superiority Study of Vernakalant vs Amiodarone in Subjects With Recent Onset Atrial Fibrillation
The primary objective of the study is to demonstrate the superiority of vernakalant injection over amiodarone injection in the conversion of atrial fibrillation (AF) to sinus rhythm (SR) within 90 minutes of the start of drug…
- Trial name
- AVRO (NCT00668759)
- Testing
- Vernakalant Injection, Amiodarone Injection:
- Where
- 100 sites in Australia, Canada and 14 more
- Volunteers
- 254 people
- Sponsor
- Advanz Pharma
Atrial Fibrillation (AF)
Prospective Remapping With Concomitant Left Atrial Appendage Occlusion to Ensure Durable Electroporation Study
This is a single-arm, open label, clinical outcome study to research the durability (success) of receiving a pulsed field ablation (PFA) per standard of care for treatment of atrial fibrillation during a subsequent procedure for…
- Trial name
- PRECLUDE (NCT07620262)
- Testing
- Remapping Procedure
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Northwell Health
Atrial Fibrillation
CPVI Alone Versus CPVI Plus Low-Voltage Areas Ablation During SR Versus CPVI Plus Low-Voltage Areas Ablation During AF for the Treatment of CAF
The primary objective of this investigation is to compare the efficacy of Three different AF ablation strategies in patients with Persistent atrial fibrillation: CPVI plus Low-Voltage Areas ablation during sinus rhythm Versus.
- Trial name
- NCT06499818
- Testing
- STABLE-SR, STABLE-AF, CPVI
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Yantai Yuhuangding Hospital
Atrial Fibrillation
ABC-Scores for Reduction of Stroke and Mortality in Atrial Fibrillation - The ABC-AF Study
The primary study objective is to evaluate if personalized treatment by decision support, based on the biomarker-based risk prediction (ABC-scores) guided strategy, reduces the occurrence of the composite outcome of stroke or…
- Trial name
- ABC-AF (NCT03753490)
- Testing
- ABC score guided therapy, Standard care
- Where
- Sweden
- Volunteers
- 3,933 people
- Sponsor
- Uppsala University
Paroxysmal Atrial Fibrillation
Clinical Investigation of the VytronUS Ablation System for Treatment of Paroxysmal Atrial Fibrillation
The study is a single center, open-label, single arm, prospective pre-market study designed to assess the safety and efficacy of the VytronUS Ablation System (VAS) for the treatment of atrial fibrillation in patients with drug…
- Trial name
- VALUE (NCT03639597)
- Testing
- VytronUS Ablation System
- Where
- Czechia
- Volunteers
- 53 people
- Sponsor
- VytronUS, Inc.
Atrial Fibrillation, Cerebrothromboembolus
Anticoagulation in AF Ablation and Effects on Neurocognitive Function
Atrial fibrillation (AF) is the most common cardiac arrhythmia in the United States, and treatment by AF ablation is quickly becoming the favored definitive therapy.
- Conditions
- Atrial Fibrillation, Cerebrothromboembolus, Neurocognitive Function
- Trial name
- NCT02120560
- Testing
- Atrial Fibrillation Ablation
- Where
- United States
- Sponsor
- University of California, San Francisco
Atrial Fibrillation, Thrombus; Embolism
Study on the Significance of Auricular Clip in Prevention and Treatment of Valvular Heart Disease Atrial Thrombosis
To evaluate the safety and clinical efficacy of left atrial appendage in the prevention of thrombus in patients with valvular heart disease, to improve the product according to clinical conditions, to achieve clinically accurate…
- Conditions
- Atrial Fibrillation, Thrombus; Embolism, Warfarin, Atrial Appendage
- Trial name
- NCT05263024
- Testing
- atrial appendage clip
- Volunteers
- 118 people
- Sponsor
- Second Affiliated Hospital of Nanchang University
Atrial Fibrillation
Post-Market Clinical Study of the CardioFocus Endoscopic Ablation System - Adaptive Contact (CF-EAS-AC) for the Treatment of Symptomatic Atrial Fibrillation
The purpose of this study is to confirm the safety and effectiveness of the CardioFocus Endoscopic Ablation System with Adaptive Contact in the treatment of atrial fibrillation.
- Trial name
- NCT01196923
- Testing
- Endoscopically Guided Ablation
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- CardioFocus
Coronary Heart Disease, Congestive Heart Failure
Standard Drug Therapy vs. Implanted Defibrillator for Primary Prevention of Sudden Cardiac Death
Recent ACC/AHA/ESC guidelines recommend prophylactic ICD implantation in most patients with coronary heart disease and LVEF < 40%.
- Conditions
- Coronary Heart Disease, Congestive Heart Failure, Ventricular Dysfunction, Low Cardiac Output
- Trial name
- SMART-ICD (NCT00524862)
- Testing
- Optimized medical therapy, Implantable Cardioverter Defibrillator
- Where
- 10 sites in Canada
- Volunteers
- 5,000 people
- Sponsor
- Unity Health Toronto
Atrial Fibrillation
High-Intensity Aerobic Lifelong Training--AF
This study is a single-center RCT. Potential subjects with symptomatic non-permanent AF will be enrolled to determine the effect of sprint interval training (SIT) in comparison to moderate-intensity continuous training (MICT) and…
- Trial name
- HALT-AF (NCT03241433)
- Testing
- High intensity interval training, Moderate intensity continuous training, No Exercise
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Minnesota
Atrial Fibrillation and Flutter
Direct Oral Anticoagulants Pharmacodynamics in Octogenarian Patients With Atrial Fibrillation
Background: The incidence of atrial fibrillation(AF) increases substantially with age and it is estimated that more than one third of AF patients are octogenarians.
- Trial name
- NCT02623049
- Testing
- New oral anticoagulant pharmacodynamic analysis (blood level assesment)
- Where
- 2 sites in Israel
- Volunteers
- 150 people
- Sponsor
- Rabin Medical Center
Atrial Fibrillation
Shared Decision Making to Address Racial Disparities in Oral Anticoagulation in NVAF
The study is a pilot analysis using a decision on the risk and benefits of oral anticoagulation for stroke reduction for patients with non-valvular atrial fibrillation.
- Trial name
- NCT04956978
- Testing
- Patient Decision Support Tool
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Duke University
Fatigue, Tachycardia
Effect of Caffeine on Heart Function
The primary objective of this study is to assess the effect of an energy drink on ventricular repolarization as measured by the interval between the cardiac Q wave and the cardiac T wave (QT interval)obtained from the body…
- Trial name
- NCT02401776
- Testing
- Monster Energy Drink, Coffee
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Hypertrophic Cardiomyopathy
Pirfenidone to Treat Hypertrophic Cardiomyopathy
This study will examine the effectiveness of the drug pirfenidone (Deskar) in improving heart function in patients with hypertrophic cardiomyopathy (HCM).
- Trial name
- NCT00011076
- Testing
- Pirfenidone
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Atrial Fibrillation
Comparison of Contact-force Monitoring Irrigated Tip Catheter and Mesh-like Irrigated Tip Catheter in Atrial Fibrillation Ablation: Prospective Randomized Trial (COMMIC Trial)
Mesh-type flexible tip (MFT) catheter is developed to generate bigger radiofrequency (RF) lesion, and contract force (CF) catheter improves the maintenance of catheter-tissue contact during atrial fibrillation catheter ablation…
- Trial name
- NCT04264117
- Testing
- FlexAbility (Mesh-like irrigated tip catheter) group, TactiCath (Contract force monitoring catheter) group
- Where
- South Korea
- Volunteers
- 360 people
- Sponsor
- Yonsei University
Ventricular Premature Complexes
Personalized Treatment for Patients With Premature Ventricular Beats
Frequent premature ventricular beats (PVBs) are common, negatively affects the quality of life for many patients, and can lead to impaired contractile function.
- Trial name
- NCT04617717
- Testing
- Invasive cardiac electrophysiological study and ablation therapy, Cardiopulmonary exercise testing, Cardiac MRI
- Where
- Norway
- Volunteers
- 224 people
- Sponsor
- Oslo University Hospital
Atrial Fibrillation (Paroxysmal)
Biofeedback Intervention for Paroxysmal Atrial Fibrillation
This project aims to bridge the gap between technology and healthcare by developing a biofeedback intervention that enables daily monitoring of atrial fibrillation episodes and physical activity levels.
- Trial name
- BI-PAF (NCT07454317)
- Testing
- Biofeedback intervention
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Liverpool John Moores University
Tachycardia, Atrial Fibrillation
Observation of Clinical Routine Care for Patients With BIOTRONIK Implantable Cardiac Monitors (ICMs)
This registry is performed for the long-term assessment of outcome, performance and residual safety aspects of the BIOMONITOR III and possible successors in a real-life clinical set-up.
- Conditions
- Tachycardia, Atrial Fibrillation, Syncope, Bradycardia
- Trial name
- BIOSTREAM-ICM (NCT04075084)
- Where
- 31 sites in Australia, Czechia and 7 more
- Volunteers
- 1,400 people
- Sponsor
- Biotronik SE & Co. KG