Clinical trials: Cardiac Surgery With Cardiopulmonary Bypass
Coronary Artery Disease
A Study of Hemopure® to Enhance Tissue Preservation During Cardiopulmonary Bypass Surgery
The purpose of this study is to determine if Hemopure® will enhance tissue preservation during Cardiopulmonary Bypass surgery.
- Trial name
- NCT00301535
- Testing
- HBOC-201 (hemoglobin glutamer-250 bovine)
- Where
- 3 sites in Greece, South Africa and 1 more
- Volunteers
- 60 people
- Sponsor
- Biopure Corporation
Acquired Antithrombin III Deficiency, Coronary Artery Bypass
Use of Antithrombin in Cardiac Surgery With Cardiopulmonary Bypass
The purpose of this trial is to study the effects of preoperative antithrombin supplementation in patients undergoing cardiac surgery with cardiopulmonary bypass in order to maintain antithrombin levels in a range greater than…
- Trial name
- NCT00823082
- Testing
- Antithrombin III
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Instituto Grifols, S.A.
Cardiac Surgical Procedures
Dexmedetomidine and the Inflammatory Response in Pediatric Cardiac Surgery
Cardiopulmonary bypass-assisted surgery initiates a systemic inflammatory response induced by extrinsic (e.g. anesthesia, contact activation within the extracorporeal circuit, endotoxemia) and intrinsic (e.g.
- Trial name
- NCT03163238
- Testing
- Dexmedetomidine, Normal saline
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Congenital Cardiomyopathy
Neuropsychomotor Development From Ages 6 to 18 in Children With Early Surgically Treated Congenital Heart Disease
This study will invite parents of children who underwent surgical treatment for congenital heart disease to complete a validated proxy-report questionnaire assessing executive and psychosocial functioning.
- Trial name
- NEUROTECH (NCT07437261)
- Testing
- Questionnaire
- Where
- 2 sites in France
- Volunteers
- 155 people
- Sponsor
- University Hospital, Toulouse
Post Operative Care After Cardiac Surgery With Cardio Pulmonary Bypass
Bio Impedance Electrical Analysis to Predict Outcome After Cardiac Surgery
Phase angle determined by bioelectrical impedance analysis is a strong prognostic factor in several medical areas as clinical nutrition, nephrology, infectious disease, oncology.
- Trial name
- BiPOCS (NCT05229159)
- Testing
- Bioelectrical impedance analysis
- Where
- France
- Volunteers
- 220 people
- Sponsor
- Hospices Civils de Lyon
Congenital Heart Disease (CHD)
Biventricular Pacing in Children With Congenital Heart Disease
Surgery with cardiopulmonary bypass (CPB) for congenital heart disease (CHD) causes low cardiac index (CI). With the increasing success of surgery for CHD, mortality has decreased and emphasis has shifted to post-operative…
- Trial name
- NCT02644824
- Testing
- Biventricular Pacing (BiVp)
- Where
- Canada
- Volunteers
- 43 people
- Sponsor
- The Hospital for Sick Children
Valvular Heart Disease, Aortic Disease
Effect of Anesthetics on CD39 and CD73 After Open-heart Surgery
CD39 and CD73 was known protein expressed on surface of Th1 and Th17 cell and modulate immune related reaction. Cardiopulmonary bypass (CPB) can induce inflammatory reaction during cardiac surgery, and induce immunosuppression.
- Trial name
- NCT02136979
- Testing
- Propofol, Sevoflurane
- Where
- South Korea
- Volunteers
- 2 people
- Sponsor
- Konkuk University Medical Center
Acute Kidney Injury
Effect of Nitric Oxide in Cardiac Surgery Patients With Endothelial Dysfunction.
The purpose of this study is to determine whether nitric oxide is effective in the treatment of acute kidney injury in cardiac surgical patients with sign and laboratory data suggesting endothelial dysfunction undergoing…
- Trial name
- MGHK23 (NCT02836899)
- Testing
- Nitric Oxide
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Massachusetts General Hospital
Congenital Heart Disease
Antithrombin III in Infants With Cardiopulmonary Bypass (CPB)
The purpose of this study is to discern whether supplementation of Antithrombin III will decrease coagulation and inflammation associated with cardiopulmonary bypass in infants undergoing cardiac surgery.
- Trial name
- NCT01698567
- Testing
- Antithrombin III
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Rochester
Single Nucleotide Polymorphism, Acute Lung Injury
Nuclear Factor Kappa-B (NFKB1) Polymorphism and Organ Injury After Cardiac Surgery
NFKB1 -94ins/del polymorphism has been reported to be associated with reduced promoter activity of NFKB1 and several clinical diseases, but the clinical results cannot always be replicated.
- Conditions
- Single Nucleotide Polymorphism, Acute Lung Injury, Kidney Injury
- Trial name
- NCT00819871
- Where
- China
- Volunteers
- 105 people
- Sponsor
- Changhai Hospital
Opioid Free Anaesthesia, Opioid Anaesthesia
LIdocaine veRsus Sufentanil Anaesthesia in Cardiac Surgery With Cardiopulmonary Bypass
Since the 90's the concept of morphine sparing and morphine free anaesthesia (OFA) has progressively developed in non-cardiac surgery.
- Trial name
- LISRACC (NCT05136794)
- Testing
- Data collection
- Where
- France
- Volunteers
- 1,772 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Platelet Function Tests, Thrombin Generation Tests
Point-of-care Assessment of Thrombin Generation and Platelet Function in Children Requiring Cardiopulmonary Bypass
Coagulopathy after cardiopulmonary bypass (CPB) is associated with increased morbidity and mortality. Clot formation and clot stability are important factors in coagulation and hemostasis.
- Conditions
- Platelet Function Tests, Thrombin Generation Tests, Perioperative Coagulopathy
- Trial name
- NCT02833025
- Testing
- Thrombin generation and Platelet Function Testing
- Where
- Canada
- Volunteers
- 130 people
- Sponsor
- The Hospital for Sick Children
Levosimendan, Cardiac Surgery
Interest of Levosimendan Preconditioning for Cardiac Surgery Under CEC in Heart Failure Patients With Impaired Ejection Fraction
Levosimendan, a drug with inotropic, vasodilatory and myocardial protective properties, has been proposed for the prevention and treatment of postoperative low cardiac output syndrome in cardiac surgery.
- Conditions
- Levosimendan, Cardiac Surgery, Heart Failure With Reduced Ejection Fraction
- Trial name
- LevoCV (NCT06021587)
- Testing
- Levosimendan, No Levosimendan
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Central Hospital, Nancy, France
Acute Kidney Injury
Aminophylline to Prevent Acute Kidney Injury in Children After Cardiac Surgery
Children with congenital heart defects often need cardiac surgery with cardiopulmonary bypass (the "heart-lung machine"). Approximately 35 to 50% of these children will have "acute kidney injury," or damage to the kidneys, after…
- Trial name
- KIDPROAM (NCT01245595)
- Testing
- Aminophylline
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- Stanford University
Systemic Inflammation, Cardiopulmonary-bypass
Preventing Systemic Inflammation After Cardiac Surgery With Alkaline Phosphatase
Study should demonstrate that alkaline phosphatase reduces the incidence and extent of acute kidney injury after cardiopulmonary bypass (CPB) as defined by the AKIN criteria.
- Trial name
- APPIRED-III (NCT03050476)
- Testing
- RESCAP®
- Where
- 21 sites in Australia, Austria and 9 more
- Volunteers
- 1,250 people
- Sponsor
- Alloksys Life Sciences B.V.
Hemodynamic Instability, Vasoplegic Syndrome
Hemodynamic Instability Prevented With Polaramine® Infusion Before Extracorporeal Circulation
This single-institution randomized controlled trial prospective will enrolled 48 patients scheduled for an aortic valve replacement.
- Trial name
- HIPPIE (NCT02675374)
- Testing
- dexchlorpheniramine (Polaramine®) injection
- Where
- France
- Volunteers
- 18 people
- Sponsor
- University Hospital, Bordeaux
Airway Ultrasound, Airway Edema
Cuff Pressure and Airway Edema in CABG With CPB
This study investigates how endotracheal tube (ETT) cuff pressure management during cardiopulmonary bypass (CPB) in coronary artery bypass grafting (CABG) affects upper airway edema.
- Conditions
- Airway Ultrasound, Airway Edema, Endotracheal Tube
- Trial name
- NCT07148024
- Testing
- ETT cuff pressure 0 mmHg, ETT cuff pressure 20-30 mmHg
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people
- Sponsor
- Engin Çetin
Heart; Dysfunction Postoperative, Cardiac Surgery, Cytokine Release Syndrome
Peri-operative Prediction of Prolonged Stay in the Cardiac Intensive Care Unit for Adult Cardiac Surgery
The purpose of this study is to create a model using intra-operative modified SOFA score and peri-operative clinical factors to predict prolonged stay in the cardiac intensive care unit (CICU) for adult cardiac surgery with…
- Trial name
- NCT01559870
- Where
- 3 sites in Thailand
- Volunteers
- 164 people
- Sponsor
- Thepakorn Sathitkarnmanee
Cardiac Disease, Blood Transfusion
Predicting CSA-AKI With ACTA-PORT Score
In the scope of this study, it will be determined whether the ACTA-PORT (Association of Cardiothoracic Anesthetists perioperative risk of blood transfusion) scoring system can predict the incidence of events in other organ…
- Conditions
- Cardiac Disease, Blood Transfusion, Acute Kidney Injury
- Trial name
- NCT06484907
- Where
- Turkey (Türkiye)
- Volunteers
- 467 people
- Sponsor
- Ankara City Hospital Bilkent
Vasoplegia, Hypotension
Hemodynamic Effects of Methylene Blue vs Hydroxocobalamin in Patients at Risk of Vasoplegia During Cardiac Surgery
This is a pilot study to determine the hemodynamic effects when hydroxocobalamin vs methylene blue is administered during cardiopulmonary bypass in patients at risk of vasoplegia by measuring mean arterial pressure (MAP)…
- Conditions
- Vasoplegia, Hypotension, Coronary Artery Disease, Cardiac Valve Disease
- Trial name
- NCT03446599
- Testing
- Hydroxocobalamin, Methylene Blue, Normal saline
- Where
- United States
- Sponsor
- Dartmouth-Hitchcock Medical Center