Clinical trials: Cardiac Surgery With Extracorporeal Circulation
Aortic Surgery, Extracorporeal Circulation
Clindamycin as an Alternative to Vancomycin in Patients Undergoing Aortic Cardiac Surgery With Extracorporeal Circulation (ECC)
Antibiotic prophylaxis is essential for all types of cardiac surgery under Extracorporeal Circulation (ECC), in order to reduce the incidence of surgical site infection (SSI).
- Trial name
- CLINDAPASS (NCT07267013)
- Testing
- Clindamycin
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Nantes University Hospital
Extracorporeal Circulation, Cardiac Surgery
Priming of Cardiopulmonary Bypass With Hydroxyethyl Starch 130/0.4 or Sodium Chloride 0.9% : Pilot Study in Adult Elective Conventional Cardiac Surgery
Best priming for cardiopulmonary bypass in cardiac surgery is unknown. Efficacy and toxicity of Hydroxyethyl Starch 130/0.4 used in this context are uncertain.
- Trial name
- OPTIMUS-PRIME (NCT02906514)
- Testing
- Non balanced Hydroxyethyl starch 130/0.4 (Voluven®, Fresenius), Sodium Chloride 0.9% (Fresenius)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Hospices Civils de Lyon
Cardiac Surgery, Extracorporeal Circulation
RRI Compared With NephroCheckTM to Predict Acute Renal Failure After Cardiac Surgery.
Postoperative acute renal failure is a frequent complication after cardiac surgery. The current practice cannot predict Acute Kidney Injuries (AKI) early enough to reduce a significant kidney assault and prevent an organic…
- Conditions
- Cardiac Surgery, Extracorporeal Circulation, Nephrocheck, Renal Failure
- Trial name
- NCT02325726
- Testing
- Renal Resistive Index compared with NephroCheckTM
- Where
- France
- Volunteers
- 51 people
- Sponsor
- University Hospital, Bordeaux
Inflammatory Response
Removal Of CytoKines With cytoSorbenTs After Inflammatory Response Reaction During Cardiac Surgery
Detailed knowledge about the association between systemic inflammation and endothelial progenitor cell (EPCs) activation during extracorporeal circulation (ECC) is lacking.
- Trial name
- ROCKSTAR (NCT06286280)
- Testing
- cytokine adsorber (CytoSorb®)
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- University of Giessen
Cardiac Surgery, Ischemia Limb
Safety of the IPERF Femoral Arterial Cannula in Patients Undergoing Planned Cardiac Surgery With Extracorporeal Circulation Via Femoral Approach
This is a first-in-human, prospective, single-arm, phase I clinical study evaluating the safety of the iPerf femoral arterial cannula in patients undergoing planned cardiac surgery requiring extracorporeal circulation (ECC) via a…
- Trial name
- FIH IPERF-01 (NCT07163234)
- Testing
- Cardiac surgery
- Where
- 2 sites in France
- Volunteers
- 15 people
- Sponsor
- IPERF SAS
Cardiac Surgery With Extracorporeal Circulation
Preload Dependency by Impedance Cardiography After Cardiac Surgery
The primary purpose of this study is to investigate wether the measure of stroke volume (SV) variations by impedance cardiography during passive leg raising (PLR) can reliably predict preload dependency after cardiac surgery, in…
- Trial name
- NCT02132871
- Testing
- Impedance cardiography Physioflow ®
- Where
- France
- Volunteers
- 65 people
- Sponsor
- University Hospital, Strasbourg, France
Extracorporeal Circulation, Hemofiltration
Removal of Cytokines in Patients Undergoing Cardiac Surgery With CPB
In a lot of cases during cardiac surgery cardiopulmonary bypass initiates SIRS due to release of cytokines during immunological response. They are induced by different types of inductors ( intrinsic and extrinsic).
- Trial name
- REMOTE (NCT03104179)
- Testing
- Cytosorb Adsorber
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Klinikum Nürnberg
Hypoxia
Efficacy and Safety of Using Noninvasive Ventilation Associated With Recruitment Maneuver in Cardiac Surgery.
Cardiac surgery can evolve with complications in the postoperative period, atelectasis and hypoxemia are the major pulmonary dysfunctions.
- Trial name
- NCT02913391
- Testing
- recruitment group (RG), control group (CG)
- Where
- Brazil
- Volunteers
- 34 people
- Sponsor
- Mieko Cláudia Miura
Cardiac Surgery, Hypertension, Pulmonary
The Effect of Pituitrin on the Patients With Pulmonary Hypertension Undergoing Cardiac Surgery
This study is a parallel group, single blind, randomized controlled trial. Patients with pulmonary hypertension who met the inclusion criteria and planned to undergo elective cardiac surgery under cardiopulmonary bypass from July…
- Trial name
- NCT05727618
- Testing
- Pituitrin, normal saline
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Qianfoshan Hospital
Cardiac Surgery With Extracorporeal Circulation, Thoracic Surgery
Evaluation of the Prognostic Value of Preoperative Quadriceps and Respiratory Muscle Thickness by Ultrasound Measurement in Cardiac and Thoracic Surgery Patients
Cardiac and thoracic surgery are major procedures. In order to estimate the operative risk, many scores have been developed, including the Euroscore 2 in cardiac surgery.
- Trial name
- MUSCA (NCT05412095)
- Testing
- Ultrasound of the abdominal wall muscles, Ultrasound quadricipital, Ultrasound of the diaphragm
- Where
- France
- Volunteers
- 301 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Delirium - Postoperative, BDNF
The Relationship Between Delirium and BDNF in Coronary Artery Bypass Graft Surgery
This study is aimed at finding a correlation between postoperative delirium occurrence, severity and duration after cardiac surgery and the level of brain-derived neurotrophic factor (BDNF) in plasma as a marker of brain injury…
- Conditions
- Delirium - Postoperative, BDNF, CABG
- Trial name
- NCT06967779
- Where
- Poland
- Volunteers
- 107 people
- Sponsor
- Pomeranian Medical University Szczecin
Patients Requiring Cardiac Surgery
Contribution of Preoperative Biological Data in Risk Assessment in Cardiac Surgery in Addition to the EuroSCORE (EuroSCOREbio)
In cardiac surgery, the assessment of operative risk and quality of care is a major challenge for both patient, and surgical team.
- Trial name
- EuroSCOREbio (NCT02783781)
- Testing
- Cardiac surgery (extracorporeal circulation; beating heart)
- Where
- 10 sites in France
- Volunteers
- 9,500 people
- Sponsor
- University Hospital Center of Martinique
PtCO2, Extracorporeal Ventilation
Assessment of the Evolutions of Transcutaneous CO2 With the Modification of Blood Flow During On-pump Cardiac Surgery
There are no available criteria for determining the optimal flow rate and mean arterial pressure level in patients under cardiopulmonary bypass (CPB).
- Trial name
- NCT02362841
- Volunteers
- 41 people
- Sponsor
- European Georges Pompidou Hospital
Cardiac Surgery, Heart Surgery
Safety and Performance Evaluation of CPB Venous and Arterial Cannulas
This is a two-phase study evaluating the Eurosets arterial and venous cannulas for use during cardiopulmonary bypass (CPB) procedures. Phase 1 is a pilot study focused on assessing cannula safety.
- Conditions
- Cardiac Surgery, Heart Surgery, Cardiopulmonary Bypass, Coronary Surgery
- Trial name
- NCT07354841
- Testing
- Eurosets Venous and Arterial Cannula, Control Arterial and Venous Cannulas
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Eurosets S.r.l.
Myocardial Stunning, Transesophageal Echocardiography
Rate of Left Ventricular Systolic Function's Recuperation After Cardiac Surgery With Extracorporeal Circulation.
The rational of the study is the description of the evolution of systolic cardiac function post-stunning, evaluated by transesophageal minimally invasive echocardiography (hTEE).
- Conditions
- Myocardial Stunning, Transesophageal Echocardiography, Circulation, Extracorporeal
- Trial name
- Imacor-1 (NCT02770183)
- Testing
- Imacor
- Sponsor
- University Hospital, Geneva
Vasoplegia, Endothelial Dysfunction
Evaluation of the Association Between Pre-existing Endothelial Dysfunction and the Onset of Vasoplegia During Cardiac Surgery With Cardiopulmonary Bypass
Cardiac surgery patients have many risk factors for endothelial dysfunction (hypertension, atherosclerosis, dyslipidemia, chronic renal failure ...).
- Trial name
- DYVA (NCT02965339)
- Where
- France
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Coronary Artery Disease
Coronary Bypass Grafting With Minimal Extracorporeal Circulation System Versus Off-pump Coronary Surgery
The investigators aimed to evaluate the clinical results and the inflammatory response of the minimal extracorporeal circulation system (MECC) Compared with off-pump coronary revascularization (OPCABG).
- Trial name
- NCT02118025
- Testing
- Off-pump coronary artery bypass graft, Mini extracorporeal circulation bypass
- Where
- Spain
- Volunteers
- 230 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Biomarkers, Coronary Artery Bypass Surgery
Dynamics of microRNA Expression and Systemic Inflammatory Response in POCD After Cardiac Surgery
Postoperative cognitive decline (POCD) is one of the most common complications after cardiac surgery. It is characterized by impaired memory, attention, and executive functions and can have long-term consequences.
- Conditions
- Biomarkers, Coronary Artery Bypass Surgery, Interleukin-6, MicroRNAs
- Trial name
- NCT07231731
- Where
- Croatia
- Volunteers
- 48 people
- Sponsor
- Osijek University Hospital
Opioid-free Anesthesia, Cardiac Surgery
Evaluation of Non-opioid Balanced General Anesthesia in Cardiac Surgery With Extracorporeal Circulation: a Randomized, Controlled, Multicenter Superiority Trial
Opioid-free anesthesia (OFA) is a general anesthesia based on the use of hypnotics and non-opioid analgesics (lidocaine, ketamine, dexamethasone, esmolol).
- Trial name
- OFACAR (NCT04886453)
- Testing
- Balanced general anesthesia without morphine, Standard general anesthesia balanced with morphine, Data collection
- Where
- France
- Volunteers
- 321 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Pulmonary Valve Insufficiency
Pulmonary Valve Replacement in Large Right Ventricular Outflow Tract
The purpose of this study is to compare 2 techniques of pulmonary valve replacement in patients with a large right ventricular outflow tract: a standard surgical treatment using cardiopulmonary bypass versus a medico-surgical…
- Trial name
- NCT00259207
- Testing
- Pulmonary valve insertion, medical surgery hybride
- Where
- France
- Volunteers
- 8 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris