Clinical trials: Cardiac Thrombus
Atrial Fibrillation, Venous Thromboembolism
Warfarin Patient Self-management Implementation in the US Healthcare System
In the US, patients receiving warfarin therapy are rarely allowed to engage in patient self-management (PSM) which is less burdensome, less expensive, and safer than standard clinic-directed warfarin management.
- Conditions
- Atrial Fibrillation, Venous Thromboembolism, Heart Valve Diseases
- Trial name
- NCT04766216
- Testing
- Patient self-management, Usual care provided by anticoagulation providers
- Where
- 4 sites in United States
- Volunteers
- 150 people
- Sponsor
- University of Utah
Cardiac Surgery
Quantra Determination of Coagulation Parameters in Arterial and Venous Blood
The Quantra™ System is a novel point-of-care diagnostic device designed to perform whole blood coagulation analysis. This study compares Quantra measurements determined in arterial versus venous blood samples obtained from…
- Trial name
- NCT02978872
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- HemoSonics LLC
Diagnostic Coronary Angiography
Effect of Heparin on Femoral Arterial Sheaths Thrombosis During Diagnostic Coronary Angiography
The project tests the incidence of femoral arterial sheath thrombus formation during diagnostic coronary angiography and effect of intravenous (iv) heparin bolus administration in reducing this risk in comparison to placebo.
- Trial name
- NCT01260519
- Testing
- Heparin
- Where
- Saudi Arabia
- Volunteers
- 304 people
- Sponsor
- Prince Sultan Cardiac Center, Adult Cardiology Department.
Coronary Artery Disease, Myocardial Ischemia
EXCEL-II Stent Vesus EXCEL Stent to Treat the Patients With de Novo Coronary Artery Lesions.
The purpose of this Randomized Study to evaluate the safety and efficacy of the Excel-II DES compared to the EXCEL DES in the treatment of patients with de novo coronary artery lesions.
- Conditions
- Coronary Artery Disease, Myocardial Ischemia, Coronary Disease, Heart Diseases
- Trial name
- CREDIT-II (NCT02057978)
- Testing
- EXCEL DES implatation, EXCEL-II DES implantation
- Where
- China
- Volunteers
- 419 people
- Sponsor
- JW Medical Systems Ltd
Atrial Fibrillation, Pulmonary Embolism
Blood Donation From Warfarin Users for the Development of POC INR Monitor
This study is to further develop and optimise the design and manufacturing process of a handheld device to monitor and manage Warfarin (blood thinning anticoagulation drug) therapy.
- Conditions
- Atrial Fibrillation, Pulmonary Embolism, Deep Vein Thrombosis
- Trial name
- NCT02355730
- Testing
- Venepuncture
- Where
- United Kingdom
- Volunteers
- 1,560 people
- Sponsor
- Microvisk Technologies Ltd
Embolism, Paradoxical, Heart Septal Defects, Atrial
PC-Trial: Patent Foramen Ovale and Cryptogenic Embolism
The purpose of this study is to compare two treatments strategies to prevent further attacks in patients who have suffered an stroke or occlusion of a major artery with no obvious reason other than a persistent small opening…
- Trial name
- NCT00166257
- Testing
- Percutaneous closure of patent foramen ovale, Medical antitrhombotic treatment
- Where
- 6 sites in Australia, Austria and 2 more
- Volunteers
- 414 people
- Sponsor
- Foundation for Cardiovascular Research, Zurich
Myocardial Infarction
Anti-inflammatory Effects of Intracoronary and Intravenous Abciximab Administration During Primary Percutaneous Coronary Intervention
Intracoronary abciximab administration during primary percutaneous coronary intervention (pPCI) could offer clinical advantages over the intravenous route.
- Trial name
- NCT01757457
- Testing
- Intracoronary administration of an abciximab bolus during primary PCI, Intravenous administration of an abciximab bolus during primary PCI
- Where
- Italy
- Volunteers
- 89 people
- Sponsor
- Azienda Ospedaliero Universitaria Maggiore della Carita
Pulmonary Embolism, Embolism
Aventus Thrombectomy System Pulmonary Embolism Clinical Study
Evaluate the safety and efficacy of the Aventus Thrombectomy System for aspiration thrombectomy in subjects with acute pulmonary embolism.
- Conditions
- Pulmonary Embolism, Embolism, Embolism and Thrombosis, Vascular Diseases
- Trial name
- NCT05907564
- Testing
- Thrombectomy
- Where
- 26 sites in United States
- Volunteers
- 120 people
- Sponsor
- Inquis Medical, Inc.
Prevention of Venous Thromboembolism, Congenital Heart Disease
An Observational Study to Learn More About How Safe Rivaroxaban is And How Well it Works in Children With Congenital Heart Disease Who Had a Heart Surgery Called the Fontan Procedure
This is an observational study in which the data from children with congenital heart disease will be collected and studied. These children will include those who are prescribed rivaroxaban by their doctors after a heart surgery…
- Conditions
- Prevention of Venous Thromboembolism, Congenital Heart Disease, Fontan Procedure, Children
- Trial name
- NCT06193863
- Testing
- Rivaroxaban (Xarelto, BAY59-7939)
- Where
- Japan
- Volunteers
- 61 people
- Sponsor
- Bayer
Cardiac Death, Myocardial Infarction
Leaders Free III: BioFreedom™ Clinical Trial
A study evaluating the safety and efficacy of the BioFreedom™ Biolimus A9™ coated Cobalt Chromium coronary stent system in patients at high risk of bleeding
- Conditions
- Cardiac Death, Myocardial Infarction, Stent Thrombosis, Bleeding
- Trial name
- NCT03118895
- Testing
- BioFreedom™ BA9™ drug-coated stent
- Where
- 2 sites in France, Switzerland
- Volunteers
- 404 people
- Sponsor
- Biosensors Europe SA
Pulmonary Embolism
Comparison of Thrombgolytic and Anticoagulation Therapy in Submassive Pulmonary Embolism
Currently there is no clear guidance for the treatment of moderate risk of pulmonary embolism. The aim of the study is to compare two different therapeutic modalities - standard anticoagulation versus thrombolytic treatment…
- Trial name
- CONTACT-SPE (NCT02132689)
- Testing
- Actilyse (Thrombolytic therapy), Heparine (Standard anticoagulation therapy)
- Where
- 2 sites in Czechia
- Volunteers
- 100 people
- Sponsor
- University Hospital Ostrava
Left Sided Heart Failure, Left Ventricular Assist Device
Ventricular Assist Device Anti-Factor Xa (VAD ANTIX) Monitoring Study: a Prospective Randomized Feasibility Trial
This study evaluates two different methods for monitoring a patient's anti-clotting [heparin] therapy after they receive a heart pump implant [left ventricular assist device -LVAD].
- Conditions
- Left Sided Heart Failure, Left Ventricular Assist Device, Anticoagulant Therapy, Gastro Intestinal Bleeding
- Trial name
- VAD-ANTIX (NCT03143569)
- Testing
- aPTT guided heparin management, Anti-factor Xa guided heparin management
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Washington University School of Medicine
Pregnancy, Heart; Complications, Valve, Prosthesis
Anticoagulation Regimens in Pregnant Patients With Prosthetic Heart Valves
Pregnancy is associated with increased risk of thrombosis among women with mechanical prosthetic heart valves.However, the best anticoagulant treatment strategies for pregnant patients with prosthetic heart valves have been…
- Trial name
- NCT02240927
- Testing
- Low Molecular Weight Heparine : Enoxaparine, Enoxaparine and 2.5 mg Warfarin, Enoxaparine and 4mg Warfarin
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital
Stroke, Venous Thrombosis
Pharmacogenetic Dosing of Warfarin
Purpose: Warfarin is now the most commonly used oral anticoagulant. This drug has inter-individual variability due to the genetic polymorphisms in the warfarin metabolizing enzyme, CYP2C9 and warfarin target, VKORC1.
- Conditions
- Stroke, Venous Thrombosis, Atrial Fibrillation, Atrial Flutter
- Trial name
- NCT02065388
- Testing
- Standard of care dosing for warfarin, Genotype-guided dosingTaiwan algorithm for warfarin, Genotype-guided dosing IWPC algorithm for warfarin
- Where
- 3 sites in Taiwan
- Volunteers
- 300 people
- Sponsor
- Academia Sinica, Taiwan
Sudden Cardiac Death, Acute Myocardial Infarction
Thrombus and Inflammation Study in Sudden Cardiac DEath
Sudden death is a natural death occurring within one hour after the onset of symptoms. It remains a major public health problem and accounts for 5 to 10 % of the annual total mortality ie about 300.000 in the United States.
- Trial name
- TIDE (NCT00748111)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 380 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Myocardial Infarction of Anterior Wall, Left Ventricular Thrombus
Apixaban Prophylaxis for Prevention of Left Ventricular Thrombus Following Anterior Myocardial Infarction
The objective of this randomized controlled trial is to compare the safety and efficacy of low dose Apixaban (2.5 mg bid) in addition to guideline directed medical therapy vs guideline directed medical therapy alone in the…
- Conditions
- Acute Myocardial Infarction of Anterior Wall, Left Ventricular Thrombus, Prophylaxis
- Trial name
- POTAMI (NCT06742567)
- Testing
- Apixaban 2.5 MG PO BID, Control (Standard treatment)
- Where
- Pakistan
- Volunteers
- 472 people
- Sponsor
- National Institute of Cardiovascular Diseases, Pakistan
Atrial Fibrillation (AF), Pulmonary Embolism (PE)
Exclusion of Left Atrial Appendage Thrombus in Emergency Department Patients With Atrial Fibrillation Undergoing CT to Assess for Pulmonary Embolus: A Feasibility Study
This study aims to investigate whether a quick, additional CT scan of the heart, performed immediately after a standard CT scan for pulmonary embolism, can effectively detect blood clots in the left atrial appendage (LAA) in…
- Conditions
- Atrial Fibrillation (AF), Pulmonary Embolism (PE), Left Atrial Appendage Thrombosis
- Trial name
- ELATE-AF (NCT07647939)
- Testing
- Delayed Un-gated CT Scan for Left Atrial Appendage Thrombus, Delayed Gated CT Scan for Left Atrial Appendage Thrombus
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Northwell Health
Intracardiac Thrombus, STEMI
Anticoagulation Therapy in Non-device-related Intra-cardiac Thrombus
Left ventricular thrombus is found in 10 to 25% of patients with impaired left ventricular function following ST-segment elevation myocardial infarction and up to 20% in dilated cardiomyopathy in observational studies.
- Conditions
- Intracardiac Thrombus, STEMI, Heart Failure
- Trial name
- ARGONAUT (NCT05825573)
- Testing
- Vitamin K antagonist, Direct oral anticoagulant
- Where
- 35 sites in France, Reunion
- Volunteers
- 340 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Diabetes Type 2, Hypertriglyceridemia
Study of the Efficacy and Safety of EPA in Patients With Type-2 Diabetes
Investigation of the efficacy and safety of an Eicosapentaenoic acid (EPA) supplement versus a placebo supplement on plasma triglyceride levels as well as inflammatory, thrombotic, endothelial and platelet activation markers, in…
- Conditions
- Diabetes Type 2, Hypertriglyceridemia, Diabetes Mellitus
- Trial name
- SEASIDE (NCT06129526)
- Testing
- EPAVasc, Corn Oil
- Where
- Greece
- Volunteers
- 450 people
- Sponsor
- University of Ioannina
Coronary Bifurcation Lesions, Death
Mini-Crush Or Controlled Balloon-Crush For True Coronary Bifurcation Lesions
The mini-crush technique is one of the leading 2-stent techniques frequently applied by interventional cardiologists to treat complex bifurcation lesions.
- Conditions
- Coronary Bifurcation Lesions, Death, Myocardial Infarction (MI), Stent Thrombosis
- Trial name
- NCT06880978
- Where
- Turkey (Türkiye)
- Volunteers
- 400 people
- Sponsor
- Istanbul Mehmet Akif Ersoy Educational and Training Hospital