Clinical trials: Cardiac Thrombus
Coronary Disease, Coronary Artery Disease
SPIRIT V: A Clinical Evaluation of the XIENCE V® Everolimus Eluting Coronary Stent System in the Treatment of Patients With de Novo Coronary Artery Lesions (Diabetic Sub-Study)
The purpose of this Clinical Evaluation is a continuation in the assessment of the performance of the XIENCE V® Everolimus Eluting Coronary Stent System (XIENCE V® EECSS) in the treatment of patients with de novo coronary artery…
- Conditions
- Coronary Disease, Coronary Artery Disease, Coronary Restenosis
- Trial name
- NCT01171820
- Testing
- TAXUS® Liberté™, XIENCE V® EECSS
- Where
- 28 sites in Austria, France and 9 more
- Volunteers
- 324 people
- Sponsor
- Abbott Medical Devices
Heart Failure, Community Acquired Pneumonia
Collaborative Healthcare Professionals Approach in Monitoring of Patient Centered Outcomes Through Pathways
The aim of this study is to determine if by providing a collaborative, integrated pathway-based healthcare compared to the usual healthcare, whether or not this would be superior in reducing the length of hospital stay across…
- Conditions
- Heart Failure, Community Acquired Pneumonia, Venous Thromboembolism, Acute Kidney Injury
- Trial name
- CHAMP-Path (NCT01561885)
- Testing
- Pathway-Based Care
- Where
- Saudi Arabia
- Volunteers
- 341 people
- Sponsor
- Majed Aljeraisy
ST-Elevation Myocardial Infarction
Comparison of Intracoronary Versus Intravenous Abciximab in ST-segment Elevation Myocardial Infarction (CICERO)
The primary objective of this study is to investigate whether intracoronary bolus administration of abciximab is superior to intravenous bolus administration in improving myocardial perfusion in patients with ST-segment elevation…
- Trial name
- CICERO (NCT00927615)
- Testing
- abciximab
- Where
- Netherlands
- Volunteers
- 534 people
- Sponsor
- University Medical Center Groningen
Myocardial Infarction
Effect of Thrombus Aspiration in Patients With Myocardial Infarction Presenting Late After Symptom Onset
The purpose of this study is to examine the benefit of thrombus aspiration in patients with ST-elevation myocardial infarction presenting late after symptom onset.
- Trial name
- NCT01379248
- Testing
- manual thrombus aspiration (Export catheter, Medtronic Inc. Minneapolis, Minnesota, USA)
- Where
- Germany
- Volunteers
- 152 people
- Sponsor
- University of Leipzig
Intracranial Embolism and Thrombosis, Postoperative Complications
TCD Detection of Gas and Solid Micro-Emboli in Patients Undergoing Coronary Artery Bypass Grafting (CABG): The Influence of Proximal Anastomosis Technique
The purpose of this study is to test the hypothesis that using three different techniques to anastomose coronary grafts to the aorta: partial occlusion, single cross clamp, or using the Heartstring anastomotic device, will change…
- Trial name
- NCT00294814
- Testing
- Proximal anastomosis using Heartstring anastomotic device
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Rambam Health Care Campus
Acute Myocardial Infarction
Optical Coherence Tomography Assessment of Gender diVersity In Primary Angioplasty: The OCTAVIA Trial
Recent studies suggest important gender differences in the pathophysiology and prognosis of ST-segment elevation myocardial infarction (STEMI).
- Trial name
- OCTAVIA (NCT02577965)
- Testing
- Percutaneous Coronary Intervention, XIENCE PRIME Everolimus Eluting Coronary Stent System
- Volunteers
- 140 people
- Sponsor
- A.O. Ospedale Papa Giovanni XXIII
Pregnancy, Pulmonary Embolism
Identify Clinical Conditions That Increase Circulating DNA Levels
The investigators are developing a test that is expected to measure the amount of radiation a patient has been exposed to after a nuclear bomb.
- Conditions
- Pregnancy, Pulmonary Embolism, Myocardial Infarction, Autoimmune Disease
- Trial name
- BARDA II (NCT01815996)
- Testing
- One time blood draw to look at patient's DNA
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University of Florida
Aortic Valve Stenosis, Extracorporeal Circulation
Cerebral Embolic Load in Patients Undergoing Surgical Aortic Valve Replacement: A Comparison of the Conventional With the Minimized Extracorporeal Circulation Technique Using Transcranial Doppler Ultrasound
In this study, the investigators aim to compare cerebral embolic load in patients undergoing surgical aortic valve replacement using either the minimized extracorporeal circulation or the conventional extracorporeal circulation…
- Trial name
- AKE-MECC (NCT02308566)
- Testing
- Minimized Extracorporeal Circulation (MECC), Conventional Extracorporeal Circulation (CECC)
- Where
- Switzerland
- Volunteers
- 48 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Coronary Artery Disease
Tirofiban in Stenting for Long Coronary Lesion
Periprocedural myonecrosis or infarction are associated with short, intermediate, and long term adverse outcomes. Previous study indicated 12.6% of patients suffered a peri-procedural CK-MB rise by overlapping use of drug-eluting…
- Trial name
- PETITION (NCT01498003)
- Testing
- tirofiban, normal saline solution
- Where
- China
- Volunteers
- 748 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Coronary Artery Disease
Healthy Volunteer Study of Clopidogrel and Rifampicin
The principal research question is: Can platelet P2Y12 receptor blockade by the antithrombotic drug clopidogrel be significantly enhanced by coadministration of the antibiotic rifampicin? Clopidogrel is an antithrombotic drug in…
- Trial name
- NCT00696566
- Testing
- Clopidogrel and Rifampicin
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Atrial Fibrillation, Thrombus Due to Heart Valve Prosthesis
The Effect of Medication Timing on Anticoagulation Stability in Users of Warfarin: The "INRange" RCT
Warfarin is an anticoagulant medication that is highly effective at preventing clotting disorders but which has a narrow therapeutic window.
- Conditions
- Atrial Fibrillation, Thrombus Due to Heart Valve Prosthesis, Deep Venous Thrombosis, Thromboembolism
- Trial name
- NCT02376803
- Testing
- Warfarin
- Where
- 2 sites in Canada
- Volunteers
- 217 people
- Sponsor
- University of Alberta
Bioprosthetic Valve Failure, Prosthetic Heart Valve Dysfunction
REVIVE-FR Registry
This registry aims to investigate treatment options for patients whose previously implanted biological aortic heart valve no longer functions properly.
- Conditions
- Bioprosthetic Valve Failure, Prosthetic Heart Valve Dysfunction, Structural Valve Deterioration, Prosthetic Heart Valve Thrombosis
- Trial name
- NCT07885761
- Testing
- TAVI-in-SAVR (Valve-in-Valve), THV-in-THV (Redo-TAVI), Surgical Explantation of a Failed Transcatheter Heart Valve
- Volunteers
- 200 people
- Sponsor
- Institut für Pharmakologie und Präventive Medizin
Coronary Artery Disease, Angina Pectoris
The OCT SORT-OUT VIII Study
The purpose of this study is to compare early vessel healing after implantation of SYNERGY drug eluting stent (DES) or BioMatrix NeoFlex DES at one and three months in two cohorts.
- Conditions
- Coronary Artery Disease, Angina Pectoris, Myocardial Infarction
- Trial name
- OCT SORT-OUT (NCT02253108)
- Testing
- Everolimus eluting bioresorbable polymer stent, Biolimus eluting bioresorbable polymer stent
- Where
- 2 sites in Denmark
- Volunteers
- 160 people
- Sponsor
- Aarhus University Hospital Skejby
Heparin-Induced Thrombocytopenia
Efficacy and Safety Study of Argatroban to Treat Heparin-Induced Thrombocytopenia
The purpose of the study is to evaluate efficacy and safety of argatroban in the patients with heparin-induced thrombocytopenia (HIT)/ HIT and thrombosis syndrome (HITTS).
- Trial name
- NCT00198588
- Testing
- argatroban
- Where
- 20 sites in Japan
- Volunteers
- 8 people
- Sponsor
- Ministry of Health, Labour and Welfare, Japan
Atrial Fibrillation, Coronary Artery Disease
Assessment of Thrombotic Status in Patients at Risk of Cardiovascular Thrombosis
Patients with coronary artery disease (CAD) and atrial fibrillation (AF) are at increased risk of stroke and heart attack. Such events are usually caused by increased stickiness of the blood causing a blood clot to block the…
- Trial name
- NCT02073396
- Testing
- Blood test
- Where
- United Kingdom
- Volunteers
- 140 people
- Sponsor
- East and North Hertfordshire NHS Trust
Cardiovascular Diseases, Venous Thromboembolism
LEAVE Safe With DOACs
Given the risks associated with direct oral anticoagulants (DOACs) and the lack of defined pathways for patients prescribed this class of medications, the study intervention has the potential for an enormous impact in preventing…
- Conditions
- Cardiovascular Diseases, Venous Thromboembolism, Atrial Fibrillation, Bleeding
- Trial name
- NCT04068727
- Testing
- Clinical Pharmacist Intervention
- Where
- United States
- Volunteers
- 561 people
- Sponsor
- University of Massachusetts, Worcester
Atrial Fibrillation, Left Atrial Appendage Thrombosis
Resolution of Thrombi in Left Atrial Appendage With Edoxaban
Non-valvular (NV) atrial fibrillation (AF) increases the risk of stroke by approximately fivefold. The atrial thrombi associated with AF are seen within the left atrial appendage (LAA) in most cases (> 90%).
- Trial name
- REFLEX (NCT03840291)
- Testing
- Edoxaban
- Where
- 12 sites in South Korea
- Volunteers
- 36 people
- Sponsor
- Keimyung University Dongsan Medical Center
Coronary Artery Disease
A Trial of Bare Metal Stent - Cobalt Chromium Versus Stent Coating With Sirolimus
The objective of this study is to evaluate the security issues and efficacy of coronary stenting Cobalt Chrome covered with sirolimus-eluting Cobalt Chrome platform in patients with coronary artery lesion.
- Trial name
- INSPIRON (NCT01093391)
- Testing
- DRUG ELUTING STENT, BARE METAL STENT
- Where
- 4 sites in Brazil
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Scitech Produtos Medicos SA
Heart Disease
The Effect of a Retrofit Particle Trap on the Vascular Effects of Diesel Exhaust Inhalation
The purpose of this study is to determine whether a retrofit particle trap can reduce the adverse vascular responses to diesel exhaust inhalation
- Trial name
- NCT00745446
- Testing
- Forearm Venous Occlusion Plethysmography
- Where
- Sweden
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Stroke, Venous Thrombosis
Clarification of Optimal Anticoagulation Through Genetics
Individuals taking warfarin often need frequent dose changes as the international normalized ratio (INR) gets too high or too low which could result in a higher risk of thromboembolism, bleeding and early discontinuation of a…
- Conditions
- Stroke, Venous Thrombosis, Atrial Fibrillation, Atrial Flutter
- Trial name
- COAG (NCT00839657)
- Testing
- Genotype-guided dosing algorithm for warfarin, Clinical-guided dosing algorithm for warfarin
- Where
- 18 sites in United States
- Volunteers
- 1,015 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)