Clinical trials: Cardiac Thrombus
Prosthetic Cardiac Valve Thrombosis, Cerebrovascular Accident
Rule Out Transcatheter Aortic Valve Thrombosis With Post Implantation Computed Tomography (RETORIC)
The RETORIC study is a prospective cohort study with a primary aim to assess the incidence and independent predictors of reduced leaflet motion and valve thrombosis after TAVI procedure using multimodality imaging strategy…
- Conditions
- Prosthetic Cardiac Valve Thrombosis, Cerebrovascular Accident, Prosthetic Valve Malfunction
- Trial name
- RETORIC (NCT02826200)
- Testing
- Acenocoumarol, Standard of care
- Where
- Hungary
- Volunteers
- 200 people
- Sponsor
- Semmelweis University Heart and Vascular Center
Diagnostic Coronary Angiography
Effect of Heparin on Femoral Arterial Sheaths Thrombosis During Diagnostic Coronary Angiography
The project tests the incidence of femoral arterial sheath thrombus formation during diagnostic coronary angiography and effect of intravenous (iv) heparin bolus administration in reducing this risk in comparison to placebo.
- Trial name
- NCT01260519
- Testing
- Heparin
- Where
- Saudi Arabia
- Volunteers
- 304 people
- Sponsor
- Prince Sultan Cardiac Center, Adult Cardiology Department.
Covid19, Thrombosis Embolism
COVID-19 Registry to Assess Frequency, Risk Factors, Management, and Outcomes of Arterial and Venous Thromboembolic Complications
Novel coronavirus 2019 (COVID-19) has emerged as a major international public health concern. While much of the morbidity and mortality associated with COVID-19 has been attributed to acute respiratory distress syndrome (ARDS) or…
- Conditions
- Covid19, Thrombosis Embolism, DVT, Pulmonary Embolism
- Trial name
- CORONA-VTE NET (NCT04535128)
- Testing
- No intervention
- Where
- United States
- Volunteers
- 11,000 people
- Sponsor
- Brigham and Women's Hospital
Coronary Thrombosis
Periprocedural Myocardial Infarction: the Role of Human Neutrophil Peptide-1 to 3
The aim of this study is to determine the role of human neutrophil peptide-1 to 3 in the occurrence of periprocedural myocardial infarction.
- Trial name
- NCT02591264
- Testing
- Blood sample
- Where
- Israel
- Volunteers
- 120 people
- Sponsor
- Hillel Yaffe Medical Center
Cardiovascular Diseases, Heart Diseases
Prevention of Recurrent Venous Thromboembolism (PREVENT)
A multicenter randomized, double blind placebo controlled trial to determine the efficacy of long-term, low dose warfarin in the secondary prevention of venous thromboembolism.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Peripheral Vascular Diseases, Thromboembolism
- Trial name
- NCT00000614
- Testing
- warfarin
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Atrial Fibrillation, Deep Vein Thrombosis
A Pharmacogenetic Study of Warfarin Dosing, "The COUMA-GEN Study"
Anticoagulation with warfarin is a common and potentially hazardous therapeutic intervention. It is a leading cause of iatrogenic bleeding events and, hence, of malpractice claims.
- Conditions
- Atrial Fibrillation, Deep Vein Thrombosis, Pulmonary Embolism
- Trial name
- NCT00334464
- Testing
- Standard of care or genotyping dosing of warfarin dosing
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Intermountain Health Care, Inc.
Coronary Artery Disease, Percutaneous Coronary Intervention
Patient Centered Machine Learning Model for Bleeding and Ischemic Risk
Dual antiplatelet therapy (DAPT) is indicated in all patients undergoing coronary stent implantation to prevent ischemic recurrencies despite an increased risk of bleeding.
- Trial name
- xDAPT (NCT06089304)
- Testing
- Percutaneous coronary intervention
- Where
- United States
- Volunteers
- 19,000 people
- Sponsor
- Abbott Medical Devices
Aortic Stenosis, Inflammation
Inflammation and Thrombosis in Patients With Severe Aortic Stenosis After Transcatheter Aortic Valve Replacement (TAVR)
The central hypothesis of this study is that TAVR leads to platelet deposition and inflammatory cell activation that can be attenuated by the potent anti-platelet and/or pleiotropic effects of ticagrelor.
- Conditions
- Aortic Stenosis, Inflammation, Thrombosis
- Trial name
- NCT02486367
- Testing
- Clopidogrel, Ticagrelor
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University Hospitals Cleveland Medical Center
Multiple Myeloma, Myelodysplastic Syndromes
A Study of Special Use Results Surveillance of Revlimid 5mg Capsules
To understand the safety and efficacy of Revlimid® 5 mg Capsules (hereinafter referred to as Revlimid) in all patients who are treated with it under the actual condition of use pursuant to the conditions of approval. 1.
- Trial name
- NCT02921802
- Where
- Japan
- Volunteers
- 4,626 people
- Sponsor
- Celgene
Stroke, Ischemic, Device Related Thrombosis
APPEND-CT Registry
The APPEND-CT registry is an investigator-driven multicenter retrospective observational database intended to compile cardiac CT follow-up data after Watchman FLX device implantation and function as a platform for answering…
- Conditions
- Stroke, Ischemic, Device Related Thrombosis, Atrial Fibrillation
- Trial name
- APPEND-CT (NCT06213285)
- Testing
- Watchman FLX left atrial appendage occlusion
- Where
- 2 sites in United States, Denmark
- Volunteers
- 2,000 people
- Sponsor
- Aarhus University Hospital
Vaccine Adverse Reaction
Genomics and COVID-19 Vaccine Adverse Events
Vaccines routinely used are extremely safe; however, severe adverse events to vaccines do occur. As vaccination against COVID-19 has begun, adverse events to the vaccine, particularly Guillain-Barré syndrome (GBS)…
- Trial name
- NCT05212792
- Testing
- COVID-19 vaccines
- Where
- Canada
- Volunteers
- 6,325 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Coagulation, Platelet Function
RapidTEG MA Validation
During normal physiological conditions hemostasis (the ability of blood to clot) is kept in homeostatic balance by feedback mechanisms.
- Trial name
- R-TEG MA (NCT01428102)
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- Haemonetics Corporation
Coronary Thrombosis, Tomography, Optical Coherence
Independent OCT Registry on Very Late Bioresorbable Scaffold Thrombosis
Bioresorbable vascular scaffold (BVS, ABSORB BVS1.1, Abbott Vascular) has been approved (CE mark) and is used in daily clinical practice.
- Conditions
- Coronary Thrombosis, Tomography, Optical Coherence, Drug-Eluting Stents
- Trial name
- INVEST (NCT03180931)
- Testing
- Bioresorbable vascular scaffold
- Where
- 19 sites in Austria, Belgium and 8 more
- Volunteers
- 36 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Ischemic Stroke, Ischemia
Biomarkers of Acute Stroke in Clinic
The proposed study will investigate the clinical use of the ISCDX test that may differentiate between diverse stroke etiologies as listed below: Aim 1: Differentiate between cardioembolic and large artery atherosclerotic ischemic…
- Conditions
- Ischemic Stroke, Ischemia, Atrial Fibrillation, Transient Ischemic Attack
- Trial name
- BASIC (NCT03897478)
- Testing
- ISCDX blood test
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Ischemia Care LLC
Pulmonary Embolism, Deep Vein Thrombosis
Study to Develop a Reliable Nomogram That Incorporates Clinical and Genetic Information
In this research study, the investigators are trying to find a better way to set the dose of a common blood-thinning medication.
- Conditions
- Pulmonary Embolism, Deep Vein Thrombosis, Atrial Fibrillation
- Trial name
- NCT00401414
- Testing
- Warfarin
- Where
- 2 sites in United States
- Volunteers
- 344 people
- Sponsor
- Brigham and Women's Hospital
Angioplasty
Aspiration Device in Myocardial Infarction Trial
Early promising data are published focusing on the role of manual thrombus aspiration devices in patients with ST segment elevation (STEMI).
- Trial name
- NCT00370578
- Testing
- repeated thrombus aspiration during primary PCI
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- HaEmek Medical Center, Israel
Coronary Disease, Coronary Artery Disease
SIROOP Registry - A Prospective Registry Study to Evaluate the Outcomes of Coronary Artery Disease Patients Treated With SIROlimus Or Paclitaxel Eluting Balloon Catheters
The purpose of the SIROOP Registry is to retrospectively and prospectively collect baseline, clinical and procedural characteristics of patients who have undergone PCI and are treated with either currently available sirolimus or…
- Conditions
- Coronary Disease, Coronary Artery Disease, Coronary Restenosis, Coronary Arteriosclerosis
- Trial name
- SIROOP (NCT04988685)
- Testing
- Sirolimus Eluting Balloon
- Where
- Switzerland
- Volunteers
- 2,000 people
- Sponsor
- Luzerner Kantonsspital
Aortic Valve Stenosis, Transcatheter Aortic Valve Replacement
Evaluation of Cerebral Thrombembolism After TAVR
EARTH-TAVR is a diagnostic multicenter study to evaluate the occurrence and extent of cerebral embolization (total new lesion volume) in patients before TAVR versus 3 months after TAVR.
- Conditions
- Aortic Valve Stenosis, Transcatheter Aortic Valve Replacement, Intracranial Embolism
- Trial name
- EARTH - TAVR (NCT02758964)
- Testing
- MRI, neurocognitive Testing
- Where
- 2 sites in Germany
- Volunteers
- 55 people
- Sponsor
- Charite University, Berlin, Germany
Thromboprophylaxis, Thromboembolism, Venous
Thromboembolic Risk Assessment in Patients Admitted With Acute Medical Diseases to Conventional and At Home Hospitalization
The thromboembolic disease is a common complication of patients admitted to conventional hospitalization units. To prevent such complications, thromboprophylaxis is indicated in high-risk patients identified with validated…
- Conditions
- Thromboprophylaxis, Thromboembolism, Venous, Atrial Fibrillation, Physical Inactivity
- Trial name
- TROMBODOM (NCT06110949)
- Testing
- Triaxial accelerometry
- Where
- Spain
- Volunteers
- 1,953 people
- Sponsor
- Universidad Pública de Navarra
Cardiac Valve Disease
Prothrombin Complex Concentrate vs Fresh Frozen Plasma in Goal-directed Bleeding Management in Cardiac Surgery
The primary endpoint of this study is the completion time of hemostasis treatment when administered Fresh frozen plasma (FFP) and frozen powder coagulation factor concentrate (PCC) in goal-directed bleeding management for cardiac…
- Trial name
- NCT06144125
- Testing
- fresh frozen plasma, prothrombin complex concentrate
- Where
- South Korea
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Konkuk University Medical Center