Clinical trials: Cardiac Transplant
Cardiac Transplant Disorder
Study on Heart Rate Variability in Cardiac Transplant Recipients With Exercise and After Exercise Training
The purpose of the study was to investigate the changes on heart rate variability, exercise capacity, activities of daily living, and quality of life after aerobic exercise training in cardiac transplant recipients.
- Trial name
- NCT01760538
- Testing
- Exercise training, usual care
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- National Taiwan University Hospital
Heart Transplantation
Multi-Drug Desensitization Protocol for Heart Transplant Candidates
Background: Patients may develop antibodies (human leukocyte antigen [HLA] alloantibodies) to other human tissues via pregnancy, transfusions or previous transplantation, which limits the ability to find an acceptable donor heart…
- Trial name
- NCT01556347
- Testing
- Bortezomib, Thymoglobulin, Rituximab, Gamimune N, (IVIG), Plasmapheresis
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Providence Health & Services
Postoperative Pain Following Coronary Artery Bypass Grafting (CABG)
Combined SPSP and TTP Blocks for Postoperative Analgesia Post-CABG
The goal of this clinical trial is to learn if combining two ultrasound-guided nerve blocks - one for the front of the chest and one for the side of the chest - works better than standard pain medications alone to treat pain…
- Trial name
- PACT (NCT07658521)
- Testing
- Transversus Thoracic Plane Block, Transversus Thoracic Plane (TTP) Block, Conventional Systemic Analgesia
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Ain Shams University
COPD, Interstitial Pneumonia
Perioperative Risk Factors Related to the Prognosis of Lung Transplantation: A Retrospective Study
This study analyzes patients who underwent lung transplantation at the First Affiliated Hospital of Zhejiang University from 2017 to 2024, focusing on anesthesia's impact on post-op results.
- Conditions
- COPD, Interstitial Pneumonia, Bronchiectasis, Respiratory Failure
- Trial name
- NCT06922916
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Zhejiang University
IHD, LV Dysfunction
Coronary Artery Bypass Grafts or Percutaneous Coronary Intervention for High Risk Patients
Most patients with Left Ventricular Systolic Dysfunction (LVSD) or heart failure (HF) have coronary artery disease (CAD) while some patients also have renal disease.
- Trial name
- NCT05534698
- Testing
- PCI, CABG
- Where
- Denmark
- Volunteers
- 1,550 people
- Sponsor
- Danish Study Group
Cardiac Allograft Vasculopathy, Antibody Mediated Rejection
Endothelial Injury and Development of Coronary Intimal Thickening After Heart Transplantation
Coronary allograft vasculopathy (CAV) is the leading cause of late graft failure and second leading cause of late mortality after heart transplantation.
- Trial name
- NCT01848301
- Testing
- Optical Coherence Tomography, Acetylcholine, Brachial Artery Flow Mediated Dilation
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Gladwin, Mark, MD
Cardiac Hypertrophy, Immunosuppression
Cardiac Allograft Remodeling and Effects of Sirolimus
Cardiac allograft remodeling causes poor quality of life, allograft failure and increased mortality after heart transplantation.
- Trial name
- CAR (NCT01889992)
- Testing
- Cardiac MRI, Coronary angiography with IVUS, Cardiac Allograft Remodeling
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of Nebraska
Coronary Artery Bypass Graft Surgery, Presence of Heparin/Platelet Factor 4 Antibody
Significance of Antibodies to Heparin/Platelet Factor 4 Complex in Vein Graft Patency and Potential Role of Argatroban for Prevention of Vein Graft Occlusion
Heparin/Platelet Factor 4 (PF4) antibody testing will be performed in subjects who have just undergone coronary artery bypass grafting (CABG) surgery.
- Trial name
- NCT01246011
- Testing
- Argatroban and warfarin
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Massachusetts General Hospital
Coronary Artery Disease, Coronary Artery Stenosis
Study of the No-touch Saphenous Vein Graft
Authors hypothesize that "no-touch" saphenous vein as I graft is superior over conventional "no-touch" saphenous vein as free graft in the incidence of graft patency.
- Conditions
- Coronary Artery Disease, Coronary Artery Stenosis, Graft Failure, Cardiac Ischemia
- Trial name
- NCT05757947
- Testing
- Сoronary bypass surgery according to the I-graft method, Сoronary bypass surgery by the method of free conduit
- Where
- Russia
- Volunteers
- 106 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Coronary Artery Disease
REvascularization CHoices Among Under-Represented Groups Evaluation: The RECHARGE Trial - Women
This is a research study in women to compare the outcomes of two procedures that restore blood flow to the arteries of the heart.
- Trial name
- RECHARGE:W (NCT06399692)
- Testing
- Coronary artery bypass grafting (CABG), Percutaneous coronary intervention (PCI)
- Where
- 18 sites in United States
- Volunteers
- 600 people
- Sponsor
- Weill Medical College of Cornell University
Bypass Graft Stenosis
The Impact of Pericardial Closure on the Grafts, in the Context of Coronary Artery Bypass Grafting
Once the pericardium is closed, there is no information on the hemodynamics of the grafts after coronary artery bypass grafting.
- Trial name
- NCT06181565
- Testing
- Datas of Medistim machine
- Where
- France
- Volunteers
- 34 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
CABG, Coronary Artery Disease
Study of the Use of a Single Dose of Erythropoietin to Treat Acute Myocardial Ischemia
This is a phase 2 study that evaluates the effect of intravenous administration of a bolus EPO on the activation of EPOR-signal transduction cascades and myocardial apoptosis during cardiopulmonary bypass surgery.
- Trial name
- DREAM (NCT00524901)
- Testing
- Epoetin alpha, NaCl 0.9%
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- University Medical Center Groningen
Cardiovascular Disease, Mitral Valve Repair
Carbon Dioxide Insufflation on Cerebral Microemboli
The purpose of this study is to determine if blowing carbon dioxide into the surgical field during open-heart surgery to displace retained chest cavity air from the atmosphere will decrease the number of microembolic being…
- Conditions
- Cardiovascular Disease, Mitral Valve Repair, Cerebral Microemboli, Cognitive Decline
- Trial name
- NCT00715845
- Testing
- Carbon dioxide insufflation
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University Health Network, Toronto
Coronary Disease, Heart Diseases
Effects of Magnesium on Individuals Undergoing Coronary Artery Bypass Graft Surgery
The purpose of this study is to examine the effects of supplemental magnesium on the neurocognitive function of individuals undergoing coronary artery bypass graft (CABG) surgery.
- Conditions
- Coronary Disease, Heart Diseases, Cardiovascular Diseases, Neurologic Manifestations
- Trial name
- POINT (NCT00041392)
- Testing
- Magnesium, 0.9% saline
- Where
- United States
- Volunteers
- 389 people
- Sponsor
- Duke University
Testicular Cancer, Survivorship
Late Subclinical Cardiovascular Disease in Testicular Cancer Survivors
Late subclinical cardiovascular disease in testicular cancer survivors exposed to cisplatin-based chemotherapy and bone marrow transplant
- Conditions
- Testicular Cancer, Survivorship, ASCVD, Coronary Artery Disease
- Trial name
- NCT05611307
- Testing
- Lipid profile, Coronary artery assessment, Hormone levels for hypogonadism
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Indiana University
Coronary Artery Bypass Grafting, Left Ventricular Dysfonction
Preoperative Levosimendan in CABG Patients With Poor LV Function
The investigators want to test the hypothesis that an infusion of levosimendan started prior to CABG surgery can reduce incidence and severity of low cardiac output syndrome in patients with poor LV function (EF 40% or less).
- Trial name
- LICORN (NCT02184819)
- Testing
- levosimendan
- Where
- France
- Volunteers
- 335 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Ultrasound of IJV, Electrical Cardiometry
IJV Sonogram VS Cardiometry in Fluid Responsiveness In CABG
The primary aim of the study is to assess the reliability of predicting fluid responsiveness in adults undergoing coronary artery bypass graft surgery using sonogram of the internal jugular vein for assessment of vessel…
- Trial name
- NCT04618419
- Testing
- internal jugular vein distensibility index
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ahmed Abd El-Rahim Abd El-Hamid Hammad
Intraoperative Hypotension, Postoperative Hypotension
Hypotension Prediction 2 Study in Cardiac Surgery and Postoperative ICU Admission
This trial registration serves as an amendment incorporating the IPD Sharing Statement. This study already has a trial registration (2021 April 30) in the Netherlands Trial Registry (Reference number NL9449…
- Conditions
- Intraoperative Hypotension, Postoperative Hypotension, Hypotension
- Trial name
- HYPE-2 (NCT05821647)
- Testing
- HPI guided treatment advice
- Where
- Netherlands
- Volunteers
- 130 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Cardiac Transplantation
Anatomical and Functional Assessment of Ex-vivo Coronary Perfusion
Heart transplantation is the gold standard treatment for advanced heart failure, with a survival rate >60% at 10 years. Heart transplantation activity has tended to decline significantly in France since 2017, with -5% of…
- Trial name
- ECHORONEX (NCT05904678)
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Coronary Artery Occlusive Disease
The Effect of Carotid IMT (Intima Media Thickness) on Postoperative Cognitive Dysfunction in Patients Undergoing Off-Pump Coronary Artery Bypass Graft Surgery
The patients who have undergone cardiac surgery have higher likelihood of postoperative cognitive dysfunction (POCD). The carotid intima-media thickness (IMT) is associated with cognitive dysfunction in the old.
- Trial name
- NCT02456493
- Where
- South Korea
- Volunteers
- 224 people
- Sponsor
- Yonsei University