Clinical trials: Cardiac Transplant Disorder
Hematopoietic Stem Cell Transplant
Prehabilitation Program to Improve Cardiac Reserve in High-Risk Patients Undergoing Hematopoietic Stem Cell Transplantation
To assess the feasibility and preliminary effectiveness of a Cardio-Oncology Prehabilitation program in patients at high-risk of developing Cardiovascular (CV) events in improving Cardiorespiratory fitness (CRF) and reducing…
- Trial name
- NCT05945121
- Testing
- Cardio-oncology program
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Michigan Rogel Cancer Center
Acute Kidney Injuries, Hemoglobin A1c Protein, Human
The Association Between Preoperative HbA1c Levels and Postoperative Acute Kidney Injury in Isolated Coronary Artery Bypass Surgery
Renal complications are frequently encountered in cardiac surgery and constitute significant causes of morbidity and mortality. They most commonly present in the form of acute kidney injury (AKI).
- Conditions
- Acute Kidney Injuries, Hemoglobin A1c Protein, Human, Coronary Bypass Graft Surgery, Renal Resistive Index
- Trial name
- NCT07445997
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Osman Sila Aydin
Graft Rejection, Kidney Failure
Study Of The Safety And Efficacy Of Conversion From A CNI To Sirolimus In Renally-Impaired Heart Transplant Recipients
The primary purpose of this study is to determine whether converting from calcineurin inhibitor (CNI) therapy to sirolimus therapy will be more effective than continuing calcineurin inhibitor therapy with respect to renal…
- Trial name
- NCT00369382
- Testing
- cyclosporine or tacrolimus, sirolimus
- Where
- 23 sites in United States, Australia and 5 more
- Volunteers
- 121 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Coronary Heart Disease
Coronary Flow Rate Measurement in T-Grafts
Is the surgical treatment of patients with coronary heart disease using the T-graft technique an adequate solution that provides a sufficient myocardial flow reserve? A magnetic resonance examination (MRI) is required.
- Trial name
- NCT01170988
- Testing
- T-Graft
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Immunosuppression
Safety Outcomes of Lower Immunosuppression Versus Traditional Immunosuppression in Heart Transplant Recipients
This was a study to compare less intense immunosuppression with a more traditional approach. The hypothesis was that less immunosuppression will provide similar protection against rejection than typical 2-3 drug therapy.
- Trial name
- TICTAC (NCT00299221)
- Testing
- Tacrolimus, combination therapy
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- Newark Beth Israel Medical Center
Arrhythmia, Cardiovascular Diseases
Coronary Artery Bypass Graft (CABG) Patch Trial
To test the hypothesis that implantable cardioverter defibrillator (ICD) therapy will improve survival in coronary heart disease patients at high risk of death, especially arrhythmic death.
- Conditions
- Arrhythmia, Cardiovascular Diseases, Coronary Disease, Death, Sudden, Cardiac
- Trial name
- NCT00000540
- Testing
- defibrillators, implantable
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Coronary Artery Disease, Cardiopulmonary Bypass
Propofol Pharmacokinetics and Pharmacodynamics During Cardiopulmonary Bypass
Cardiopulmonary bypass (CPB) is known to alter pharmacokinetics (PK) and brain sensitivity to several drugs, including propofol.
- Conditions
- Coronary Artery Disease, Cardiopulmonary Bypass, Coronary Artery Bypass Graft
- Trial name
- NCT00622791
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- University of Sao Paulo
Atrial Fibrillation
Fish Oil for Reduction of Atrial Fibrillation After Cardiac Surgery
The primary objective of this study is to determine if omega-3 polyunsaturated fatty acids reduce atrial fibrillation and other outcomes after cardiac surgery.
- Trial name
- FISH (NCT00446966)
- Testing
- Omega Three Polyunsaturated fatty acids
- Where
- United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Chirag Sandesara
Kidney Failure
AKIN Criteria: Acute Kidney Injury After On-Pump Coronary Artery Bypass Graft (CABG)
The purpose of this study is evaluate clinical outcomes and 30-day mortality after on-pump CABG.
- Trial name
- NCT00780845
- Volunteers
- 817 people
- Sponsor
- Hospital de Base
Left Ventricular Function Systolic Dysfunction, Left Ventricular Function Diastolic Dysfunction
Cell Therapy in Diabetic Patients With ST-Segment Elevation Myocardial Infarction(STEMI)
The purpose of this study is to investigate the efficacy and mechanism of bone marrow mononuclear cells (BMMNC) transplantation for diabetic and non-diabetic patients with ST-segment elevation myocardial infarction (STEMI)who…
- Conditions
- Left Ventricular Function Systolic Dysfunction, Left Ventricular Function Diastolic Dysfunction, Death, Myocardial Reperfusion Injury
- Trial name
- NCT01307371
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Xijing Hospital
Coronary Artery Bypass Surgery, Cognitive Impairment
Evaluation of the Safety and Efficacy of Ang-(1-7) to Enhance Cognitive Function in Participants Undergoing CABG
Coronary Artery Bypass Graft (CABG) is a surgical procedure known to be associated with cognitive impairment. Mechanisms of cognitive impairment are complex but may include insufficient oxygenation and inflammation due to…
- Trial name
- NCT03252093
- Testing
- Angiotensin-(1-7)
- Where
- 5 sites in United States
- Volunteers
- 6 people
- Sponsor
- University of Arizona
Coronary Artery Bypass, Thrombosis
Evaluating the Role of Thrombin in Saphenous Vein Graft Failure After Heart Bypass Surgery
Heart bypass surgery, also known as coronary artery bypass graft (CABG) surgery, creates a detour around the blocked part of a heart artery to restore blood supply to the heart muscle.
- Trial name
- NCT00481806
- Where
- United States
- Volunteers
- 450 people
- Sponsor
- University of Arizona
Anxiety, Postoperative Pain
The Effect of Video-assisted Mobilisation Training on Mobility, Anxiety and Pain After Coronary Artery Bypass Surgery
This study is a Randomized Controlled trial.The aim of this study was to investigate the effect of preoperative routine patient education and video-assisted mobilization training on postoperative mobility, anxiety level and pain…
- Trial name
- NCT06117033
- Testing
- video assisted mobilization training
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Namik Kemal University
Coronary Artery Disease
Bypass Surgery Versus Everolimus-Eluting Stent Implantation for Multivessel Coronary Artery Disease (BEST)
The purpose of this study is to determine whether the safety and efficacy of coronary stent implantation using Everolimus-Eluting Coronary Stent System (Abbott, Boston Scientific) is not inferior to coronary artery bypass…
- Trial name
- BEST (NCT00997828)
- Testing
- everolimus-eluting stent, coronary artery bypass graft surgery
- Where
- 27 sites in China, Malaysia and 2 more
- Volunteers
- 888 people
- Sponsor
- Seung-Jung Park
Atrial Fibrillation
Effect of Venous Cannulation on the Incidence of Atrial Fibrillation in Patients Undergoing Coronary Artery Bypass
Context Atrial fibrillation is the most frequent arrhythmia following coronary artery bypass grafting. POAF is associated with worse outcomes following CABG.
- Trial name
- NCT04641611
- Testing
- Bicaval cannulation, Cavoatrial cannulation
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Dr. Jean-Francois Morin
Coronary Artery Disease, Postoperative Complications
Intraoperative Targeted Versus Liberal Blood Pressure Management in Patients Undergoing Off-pump Coronary Artery Bypass Grafting
The goal of this clinical trial is to learn whether two approaches to anesthesia and blood pressure management can improve care for adults having off-pump coronary artery bypass grafting (OPCAB).
- Trial name
- NCT07787364
- Testing
- Targeted Blood Pressure Management, Liberal Blood Pressure Management, Remimazolam
- Volunteers
- 416 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Renal Transplant
Effects of Zortress® + Tacrolimus vs. Standard Immunosuppression on Progression of Coronary Artery Calcifications and Bone Disease in de Novo Renal Transplant Recipients
Primary objectives: A. To evaluate the effect of Zortress® versus standard immunosuppression therapy on progression of CAC as evidenced by changes in Agatston scores from baseline and at 6, and 12 months in renal transplantation…
- Trial name
- NCT01612299
- Testing
- Zortress® /Everolimus
- Where
- United States
- Sponsor
- University of Kentucky
Coronary Artery Bypass Graft, CABG
High-intensity Inspiratory Muscle Training as a Pre-cardiac Rehabilitation in Heart Disease
Background/aim: Endothelial function is closely associated with coronary artery health among individuals being treated for heart disease.
- Trial name
- NCT06127147
- Testing
- IMT
- Where
- 2 sites in United States
- Volunteers
- 11 people
- Sponsor
- University of Illinois at Chicago
Unconscious State
The Effect of BIS Monitorization to Intraoperative Anesthetic Consumption During Coronary Artery Surgery
213 patients undergoing elective on-pump coronary artery bypass grafting (CABG) were enrolled into this prospective-clinical trial.After hundred and sixty three patients were excluded due to various reasons, 50 patients were…
- Trial name
- NCT02520947
- Testing
- BIS, Desflurane
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Baskent University Ankara Hospital
Coronary Artery Disease, Coronary Artery Bypass
Glycemic Control Using Mobile-based Intervention in Patients With Diabetes Undergoing Coronary Artery Bypass to Promote Self-management
The study is a two-arm parallel, randomized clinical trial. The purpose of the study is to evaluate the effectiveness and feasibility of using high-quality medication reminder smartphone application as a tool for secondary…
- Conditions
- Coronary Artery Disease, Coronary Artery Bypass, Diabetes Mellitus
- Trial name
- GUIDEME (NCT04192409)
- Testing
- Smartphone Application
- Where
- China
- Volunteers
- 1,038 people
- Sponsor
- China National Center for Cardiovascular Diseases