Clinical trials: Cardiac-Related Conditions
Aortic Stenosis, Cardiac Death
Endothelial Progenitors in Aortic Stenosis: Association With Aortic Stenosis Progression and Severity
There is a correlation between endothelial progenitor cells (stem cells) and stenosis of the aortic valve.
- Trial name
- NCT02060071
- Testing
- Blood test
- Where
- Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Kaplan Medical Center
Scar-related Atrial Tachycardia, Persistent Atrial Fibrillation
A Study Assessing Arrhythmia Mapping With a Multi-Electrode Mapping Catheter
The purpose of this study is to assess the safety and feasibility of the investigational catheter for mapping the atrial and ventricular regions of the heart.
- Conditions
- Scar-related Atrial Tachycardia, Persistent Atrial Fibrillation, Paroxysmal Atrial Fibrillation, Ventricular Tachycardia
- Trial name
- FEATHER (NCT07116525)
- Testing
- Paddle-Shaped, High-Density, Multi-Electrode Mapping Catheter
- Where
- 5 sites in Belgium, France and 1 more
- Volunteers
- 90 people
- Sponsor
- Biosense Webster, Inc.
PTSD, Depression
Effectiveness of Combined Intervention Approaches in the Treatment of Affective Disorders and Chronic Pain in War Victims
This study will measure the effects of biofeedback supported cognitive behavioral therapy (BF-CBT) and group physiotherapy intervention in victims of torture and massive violence in Kosovo.
- Conditions
- PTSD, Depression, Anxiety, Chronic Pain
- Trial name
- NCT01696578
- Testing
- BF-CBT and group physiotherapy
- Where
- Kosovo
- Volunteers
- 31 people
- Sponsor
- Rehabilitation and Research Centre for Torture Victims
STEMI
Relationship Between Level of GPCR Autoantibodies and Cardiac Structure & Funtions Based on UCG and CMR
This study is a prospective cohort study，we want to observe the changes of different cardiovascular antibody levels in STEMI patients undergoing emergency PCI;and combined with different cardiovascular antibody levels and various…
- Trial name
- NCT05368584
- Where
- China
- Volunteers
- 1 people
- Sponsor
- Beijing Friendship Hospital
Immune Checkpoint Inhibitors, Cardiotoxicity
Cardiac Magnetic Resonance Monitoring of Immune Checkpoint Inhibitor-related Cardiotoxicity
This study is a prospective cohort clinical research that analyzes the changes in CMR parameters before and after immune checkpoint inhibitors (ICIs) therapy in patients with gynecologic malignancies.
- Trial name
- NCT06132984
- Testing
- Cardiac magnetic resonance
- Where
- China
- Volunteers
- 22 people
- Sponsor
- West China Second University Hospital
Avascular Necrosis of the Femoral Head, Coronary Artery Disease (CAD)
Desflurane Potentially Induces Postoperative Cognitive Dysfunction in Elderly Patients Undergoing Perioperative Procedures by Modulating Cdc42 and Clock Proteins
This clinical trial investigates whether desflurane induces postoperative cognitive dysfunction (POCD) in elderly patients undergoing perioperative procedures by modulating Cdc42 and Clock proteins.
- Conditions
- Avascular Necrosis of the Femoral Head, Coronary Artery Disease (CAD), Benign Prostatic Hyperplasia (BPH), Cholecystitis
- Trial name
- NCT06772558
- Testing
- Desflurane Inhalation, mechanical ventilation (MV)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xiaguang Duan
Child Maltreatment, Interpersonal Relations
Beneficial or Fostering Future Struggles (B.F.F.s)? Characterizing the Role of Friends in the Development of 13- to 17-Year-Old Adolescents
The goal of this clinical trial is to investigate how the friendship experiences of maltreated (i.e., abused and/or neglected) and non-maltreated adolescents differentially influence their risk for adverse outcomes.
- Conditions
- Child Maltreatment, Interpersonal Relations, Victimisation, Psychopathology
- Trial name
- BFFs (NCT05893459)
- Testing
- Debrief
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Bleeding, Cardiac Defect
ZEPLAST- PED: ZEro_PLASma Trial in Small Infants Undergoing Cardiac Surgery
In pediatric patients (newborns and infants weighing less than 10 kg) undergoing cardiac surgery with extracorporeal circulation postoperative bleeding represents a known complication with a significant impact on outcome.
- Conditions
- Bleeding, Cardiac Defect, Surgery--Complications, Fibrinogenopenia; Acquired
- Trial name
- ZEPLAST-PED (NCT04434001)
- Testing
- Fibrinogen Concentrate Human, Prothrombin Complex Concentrate, Fresh Frozen Plasma
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- IRCCS Policlinico S. Donato
Emergence Delirium
The Association of Cardiac Ion Channel Related Gene Polymorphism and Prolonged QTc Interval After Endotracheal Intubation
The QTc interval is affected by heart rate, medications and changes in the autonomic nervous system. The endotracheal laryngoscopy, the necessary step during general anesthesia, prolongs QTc interval.
- Trial name
- NCT03788564
- Where
- South Korea
- Volunteers
- 315 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Cardiac Surgery, Nutritional Risk
ERAS Compliance and Hospital Stay After Open Heart Surgery
This prospective observational study will evaluate the association between compliance with an Enhanced Recovery After Surgery (ERAS) protocol and length of hospital stay in 120 adults undergoing elective open heart surgery.
- Conditions
- Cardiac Surgery, Nutritional Risk, Frailty
- Trial name
- ERAS-CARD (NCT07783204)
- Testing
- ERAS Protocol Compliance Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Bursa City Hospital
Menopause Related Conditions
Menopause Racing Heart Study
Palpitations occur in more than 25% of women as they approach menopause and after menopause. However, the etiology of menopausal palpitations has not been studied, and it is unknown whether palpitations in menopausal women are…
- Trial name
- NCT05062057
- Testing
- Adhesive ambulatory ECG recording patches
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Indiana University
Disorder Related to Renal Transplantation
The Effects of Omega-3 Fatty Acids in Renal Transplantation
Omega-3 fatty acids are provided through dietary intake of fish and seafood. Several dietary supplements containing omega-3 fatty acids are also commercially available.
- Trial name
- ORENTRA (NCT01744067)
- Testing
- Omega-3 fatty acids
- Where
- 2 sites in Norway
- Volunteers
- 132 people
- Sponsor
- Oslo University Hospital
Hemodialysis Complication, Haemolyses and Related Conditions
Effect of Triflow Breathing Training
This study aims to explore whether an 8-week Triflow breath training program reduced the anxiety levels and improved the heart rate variability and quality of life of patients receiving hemodialysis.
- Trial name
- NCT05809765
- Testing
- 8-week breath training program
- Where
- Taiwan
- Volunteers
- 63 people
- Sponsor
- Taipei Medical University WanFang Hospital
Cardiac Implantable Electronic Device Infections, Infective Endocarditis
Oritavancin for CIED Infections With MDR Gram-positive Cocci
The study aimed to conduct a randomized, non-inferiority controlled trial to compare the short- and medium-term efficacy and safety of two antibiotic dosage regimens in cardiac implantable electronic devices (CIED) infections…
- Conditions
- Cardiac Implantable Electronic Device Infections, Infective Endocarditis, Multidrug-resistant Bacteria Screening, Gram Positive Bacterial Infection
- Trial name
- ORI-4-CIEDi (NCT07013552)
- Testing
- Administration of a single or repeated dose of a long half-life antibiotic - oritavancin, Administration of a repeated dose of a short half-life antibiotic - vancomycin
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Medical University of Silesia
Cardiogenic Shock, Extracorporeal Membrane Oxygenation
Effect of Reduced Vasopressors on Mortality in ECMO-supported Cardiogenic Shock Patients
The goal of this observational study is to learn about the association between vasopressor exposure levels and outcomes in adults with cardiogenic shock receiving VA-ECMO.
- Conditions
- Cardiogenic Shock, Extracorporeal Membrane Oxygenation, Vasopressors, Hemodynamic Management
- Trial name
- VREM-CS (NCT06862700)
- Testing
- Vasopressor Exposure Levels
- Where
- China
- Volunteers
- 534 people
- Sponsor
- Xiaotong Hou
Breast Cancer, Thalassemia Minor
Cardiac Management of Patients With Thalassemia Minor and Breast Cancer
This retrospective study aimed to evaluate the demographic characteristics, clinical conditions in term of physical examination findings), functional status, and laboratory results of patients with thalassemia minor (TM) and…
- Conditions
- Breast Cancer, Thalassemia Minor, Heart Diseases
- Trial name
- AQUA (NCT05960214)
- Where
- Turkey (Türkiye)
- Volunteers
- 26 people
- Sponsor
- Istanbul University
Heart Failure, Atrial Fibrillation
Prevalence of Subclinical Atrial Fibrillation in Heart Failure Patients and Its Relationship With Hospital Readmission
Multicentre, prospective cohort study in patients with a history of HF with preserved or reduced ejection fraction admitted to hospital with acutely decompensated HF.
- Trial name
- PROTECT-HF (NCT03541616)
- Testing
- ECG Patch, pocket ECG monitor
- Where
- 5 sites in Canada
- Volunteers
- 242 people
- Sponsor
- Population Health Research Institute
Cardiotoxicity
Exercise for Ameliorating Chemotherapy Cardiotoxicity
Chemotherapy is a common treatment for breast cancer but can damage the heart and blood vessels. Exercise, such as cycling, may stop chemotherapy from damaging the heart and blood vessels.
- Trial name
- NCT06595316
- Testing
- Exercise intervention group
- Volunteers
- 30 people
- Sponsor
- University of Hull
Atrial Fibrillation
Relationship Between Renal Function and Pharmacokinetics of Apixaban and Clinical Outcome of Apixaban in Thai Non-valvular Atrial Fibrillation Patients
The purpose of this study is to assess pharmacokinetics and pharmacodynamics of Apixaban and clinical outcome of Apixaban in Thai patients with nonvalvular atrial fibrillation with varying degree of creatinine clearance
- Trial name
- NCT04684732
- Where
- Thailand
- Volunteers
- 241 people
- Sponsor
- Chulalongkorn University
Ischemic Heart Disease, Microvascular Coronary Artery Disease
The Cerebral-Coronary Connection (C3) Study
This is a prospective cohort blinded study with the aim to investigate the prevalence and clinical impact of coronary microcirculatory dysfunction (CMD) in patients with ischemic heart disease, and its association with cerebral…
- Conditions
- Ischemic Heart Disease, Microvascular Coronary Artery Disease, Depression, Endothelial Dysfunction
- Trial name
- C3 (NCT04131075)
- Testing
- Coronary Angiography and Multimodal Coronary Physiology Study (FFR, CFR, HMR)
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Instituto de Salud Carlos III