Clinical trials: Cardiac-Related Conditions
Chemotherapy-Induced Peripheral Neuropathy, Radiation Toxicity
Patients Referred to the Chronic Pain Unit for Palliative Treatment With Ozone Therapy Between 2026 and 2029.
The main objective of this study is to analyze the impact on the health-related quality of life of patients with refractory symptoms who have been referred to the Dr.
- Conditions
- Chemotherapy-Induced Peripheral Neuropathy, Radiation Toxicity, Chronic Pain, Delayed Wound Healing
- Trial name
- EPOOzo-2 (NCT07325851)
- Testing
- Ozone Therapy
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Bernardino Clavo, MD, PhD
Obesity and Obesity-related Medical Conditions, Diabetes
Routine Validation and Reproducibility Testing of Laboratory Assays and Research Techniques Used for Endocrine, Cardiometabolic, and Musculoskeletal Disorder Research (VALD)
The purpose of this research study is to validate (check the accuracy of) laboratory assays, intravenous catheter insertion, and equipment or devices and their reproducibility, which is necessary to perform high quality research…
- Conditions
- Obesity and Obesity-related Medical Conditions, Diabetes, Atherosclerotic Disease, Heart Failure
- Trial name
- VALD (NCT07083557)
- Testing
- Endothelial cell collection
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Bettina Mittendorfer
Cardiotoxicity
Empagliflozin in the Prevention of Cardiotoxicity in Cancer Patients Undergoing Chemotherapy Based on Anthracyclines
EMPACT (EMPAgliflozin in prevention of chemotherapy-related CardioToxicity) study is a randomized, multi-center, placebo-controlled, double-blind trial to evaluate efficacy of empagliflozin in prevention of left ventricular (LV)…
- Trial name
- EMPACT (NCT05271162)
- Testing
- Empagliflozin 10 MG
- Where
- 2 sites in Poland
- Volunteers
- 220 people
- Sponsor
- Maria Sklodowska-Curie National Research Institute of Oncology
Heart Failure
MAP( Mean Arterial Pressure) and Mortality Relation in Patients With Heart Failure
Aim of this observational study is to evaluate the relationship between mean arterial pressure (MAP) and mortality in patients presenting to the emergency department with acute heart failure, focusing on emergency department…
- Trial name
- NCT06515366
- Where
- Turkey (Türkiye)
- Volunteers
- 280 people
- Sponsor
- Saglik Bilimleri Universitesi
Atrial Fibrillation (AF)
Association Between Early Recurrence and Long-Term Recurrence After Pulsed Field Ablation for Atrial Fibrillation: Prospective Real-World Evidence From China
The goal of this observational study is to analyze the predictive value of early recurrence within different time windows for late recurrence, ultimately providing evidence-based support for defining the blanking period after…
- Trial name
- NCT07518966
- Testing
- pulsed field ablation
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- West China Hospital
Stable Angina, Myocardial Infarction
Heart Rate and Cardiovascular Diseases Prognosis in People With Stable Coronary Artery Disease
The Cardiovascular disease research using Linked Bespoke studies and Electronic Records (CALIBER) e-health database was the data resource for this study.
- Conditions
- Stable Angina, Myocardial Infarction, Coronary Heart Disease, Heart Failure
- Trial name
- NCT02244853
- Where
- United Kingdom
- Volunteers
- 51,703 people, healthy volunteers welcome
- Sponsor
- University College, London
Sudden Death, Sudden Cardiac Arrest
Impact of an Intensive Care Diary on Post-traumatic Stress Disorder After a Resuscitated Sudden Death
Sudden death is a public health problem with more than 300,000 cases per year in USA and 40,000 cases per year in France. Moreover, despite all recent therapeutic improvements (therapeutic hypothermia, new techniques of…
- Trial name
- COREABOR (NCT02874469)
- Testing
- Diary
- Where
- France
- Volunteers
- 173 people
- Sponsor
- University Hospital, Lille
Cardiovascular Diseases, Cardiotoxicity
Cancer Treatment Related Cardiovascular Toxicity: Comprehensive Myocardial and Vascular Phenotyping
Observational prospective cohort study designed to assess the mechanisms of fluoropyrimidine induced cardiovascular toxicity.
- Conditions
- Cardiovascular Diseases, Cardiotoxicity, Fluorouracil Adverse Reaction, Malignancy
- Trial name
- PC-TOX (NCT06048458)
- Testing
- Cardiovascular magnetic resonance with stress perfusion, CT coronary angiography, Retinal OCT angiography
- Where
- United Kingdom
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University College, London
Breast Cancer, Cardiotoxicity
Cardiotoxicity in Breast Cancer Patients Treated With Proton or Photon Radiotherapy: A RadComp Companion Study
This is a companion study to the "Pragmatic Randomized Trial of Proton vs Photon Therapy for Patients with non-Metastatic Breast Cancer Receiving Comprehensive Nodal Radiation: A Radiotherapy Comparative Effectiveness (RadComp)…
- Trial name
- NCT04361240
- Testing
- Proton vs Photon Radiation
- Where
- 6 sites in United States
- Volunteers
- 172 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Atrial Fibrillation
The Relationship Between Left Atrial Pressure and Cardiac Function After Atrioventricular Node Ablation
Effects of left atrial pressure-guided ventricular rate changes on cardiac function after atrioventricular node ablation combined with left bundle branch pacing
- Trial name
- LAP-TOP (NCT05449158)
- Testing
- left atrial pressure regulation
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Shanghai 10th People's Hospital
Atrial Fibrillation Paroxysmal
The Effect of Pulse Field Ablation on Atrial Mechanics in Catheter Ablation of Paroxysmal Atrial Fibrillation
The goal of this clinical trial is to compare the effect of pulmonary vein isolation on atrial function between pulse-field and cryoablation in patients over the age of 18 with paroxysmal atrial fibrillation.
- Trial name
- PF-MRI (NCT06557876)
- Testing
- Pulmonary vein isolation by pulse field ablation, Pulmonary vein isolation by cryoablation
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Heart Failure, Congestive, Pulmonary Disease, Chronic Obstructive
Capturing Outcomes of Clinical Activities Performed by a Rounding Pharmacist Practising in a Team Environment
We, the researchers, propose to link a clinical pharmacist with an internal medicine or family medicine team to provide pharmaceutical care to all patients assigned to the team.
- Conditions
- Heart Failure, Congestive, Pulmonary Disease, Chronic Obstructive, Pneumonia, Diabetes Mellitus, Type 2
- Trial name
- NCT00351676
- Testing
- Integration of a team based clinical pharmacist, Optimizing therapeutic treatments, Optimizing processes of care
- Where
- 3 sites in Canada
- Volunteers
- 452 people
- Sponsor
- University of Alberta
Arteriovenous Fistula, Arteriovenous Graft
Access Creation for Hemodialysis: Association With Structural Changes of the Heart
The purpose of this study is to determine if the creation of a fistula or a graft plays a role in the development of heart disease for patients undergoing hemodialysis
- Conditions
- Arteriovenous Fistula, Arteriovenous Graft, Left Ventricular Hypertrophy, Brain Natriuretic Peptide
- Trial name
- NCT00368147
- Where
- Canada
- Volunteers
- 84 people
- Sponsor
- Ottawa Hospital Research Institute
Cardiovascular Diseases, Coronary Heart Disease
Umbrella Review and Updated Systematic Review and Meta-analysis of Pulses/Legumes and Incident Cardiometabolic Diseases
The European Association for the Study of Diabetes (EASD) guidelines have not made any specific recommendations regarding dietary pulses.
- Conditions
- Cardiovascular Diseases, Coronary Heart Disease, Stroke, Diabetes Mellitus, Type 2
- Trial name
- NCT03555734
- Testing
- Dietary pulses or legumes
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Migraine With Aura
Neurogenetic And Hemodynamic Of Migraine Aura And Pfo
The PFOCUS Study aims to clarify the relationship between patent foramen ovale (PFO) and migraine with aura (MA). Patients diagnosed with MA according to ICHD-3 criteria will be classified as cases (PFO+) or controls (PFO-) based…
- Trial name
- PFOCUS (NCT07349004)
- Testing
- Intervention
- Where
- Italy
- Volunteers
- 240 people
- Sponsor
- Azienda Usl di Bologna
Breast Cancer, Cardiac Toxicity
Side Effects Involving the Heart in Women With Breast Cancer Receiving Doxorubicin and Trastuzumab
RATIONALE: Studying samples of blood and tissue in the laboratory from women receiving doxorubicin and trastuzumab for breast cancer may help doctors learn more about changes that occur in DNA and identify biomarkers for…
- Conditions
- Breast Cancer, Cardiac Toxicity, Cardiovascular Complications
- Trial name
- PACE in BC (NCT00875238)
- Testing
- trastuzumab, doxorubicin hydrochloride, polymorphism analysis
- Where
- 4 sites in United States
- Volunteers
- 133 people
- Sponsor
- Vanderbilt University
Stroke, Ischemic, Device Related Thrombosis
APPEND-CT Registry
The APPEND-CT registry is an investigator-driven multicenter retrospective observational database intended to compile cardiac CT follow-up data after Watchman FLX device implantation and function as a platform for answering…
- Conditions
- Stroke, Ischemic, Device Related Thrombosis, Atrial Fibrillation
- Trial name
- APPEND-CT (NCT06213285)
- Testing
- Watchman FLX left atrial appendage occlusion
- Where
- 2 sites in United States, Denmark
- Volunteers
- 2,000 people
- Sponsor
- Aarhus University Hospital
Substance Use Disorder
Project IMPACT: In-the-Moment Protection From Automatic Capture by Trigger
Despite conscious intentions to remain abstinent, persons with substance use disorders often find that negative emotions and environmental cues automatically "trigger" drinking and other substance use.
- Trial name
- NCT02579317
- Testing
- Resonance Breathing, Non-Resonance Breathing
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- Rutgers, The State University of New Jersey
Atrial Fibrillation
Diaphragmatic Evaluation by Fluoroscopy to Identify Phrenic Nerve Dysfunction Related to Electroporation
Pulsed Field Ablation (PFA) represents a recent advance in the treatment of atrial fibrillation (AF), with a safety profile potentially superior to traditional thermal techniques, such as radiofrequency or cryoablation.
- Trial name
- DEFINE-PFA (NCT07462910)
- Testing
- Dynamic fluoroscopy
- Where
- 9 sites in Canada, France and 1 more
- Volunteers
- 250 people
- Sponsor
- French Cardiology Society
Coronary Artery Disease, Stable Coronary Artery Disease
Cardiovascular Events Related to Treated Coronary Arteries in Stable Multivessel CAD
This retrospective cohort study evaluates cardiovascular events directly related to treated coronary arteries in patients with stable multivessel coronary artery disease.
- Conditions
- Coronary Artery Disease, Stable Coronary Artery Disease, Multivessel Coronary Artery Disease, Myocardial Ischemia
- Trial name
- NCT07362108
- Testing
- Coronary Artery Bypass Grafting, Percutaneous Coronary Intervention, Optimized Medical Therapy
- Volunteers
- 1,695 people
- Sponsor
- Instituto do Coracao