Clinical trials: Cardiac-Related Conditions
Hypertension, Atherosclerosis
Age-Related Changes in Body Composition
Background: Advancing age is associated with greater risk of heart disease. High blood pressure and hardening of the arteries also have more complications with age.
- Trial name
- NCT01517113
- Where
- 2 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Mitochondrial Diseases, Kearns-Sayre Syndrome
Global Registry and Natural History Study for Mitochondrial Disorders
The main goal of the project is provision of a global registry for mitochondrial disorders to harmonize previous national registries, enable world-wide participation and facilitate natural history studies, definition of outcome…
- Conditions
- Mitochondrial Diseases, Kearns-Sayre Syndrome, MIDD, SANDO
- Trial name
- GENOMIT (NCT05554835)
- Where
- 34 sites in Austria, Germany and 1 more
- Volunteers
- 6,000 people
- Sponsor
- LMU Klinikum
Cystic Fibrosis, Cystic Fibrosis-related Diabetes
Cardiac Structure and Function in Patients with Cystic Fibrosis
In a prospective observational cohort study (n = 100), the investigators aim to assess the correlation between cardiac biomarkers, advanced echocardiography and cystic fibrosis genotype and severity and determine whether these…
- Conditions
- Cystic Fibrosis, Cystic Fibrosis-related Diabetes, Cystic Fibrosis, Pulmonary, Cystic Fibrosis of Pancreas
- Trial name
- NCT06084468
- Where
- 2 sites in Denmark
- Volunteers
- 104 people
- Sponsor
- Herlev and Gentofte Hospital
Multiple Myeloma, Shortness of Breath
Dyspnea and Cardiotoxicity in Multiple Myeloma Patients Who Receive Carfilzomib
This study will explore why some multiple myeloma patients who receive carfilzomib (an anti-cancer medication) experience shortness of breath while others do not.
- Conditions
- Multiple Myeloma, Shortness of Breath, Dyspnea, Cardiotoxicity
- Trial name
- NCT04827563
- Testing
- EndoPAT, Blood Pressure Cuff, Echocardiogram
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Chicago
Ventricular Tachycardia
Percutaneous Hemodynamic Support With Impella 2.5 During Scar-related Ventricular Tachycardia Ablation
The purpose of this research study is to evaluate the safety and feasibility of the Impella 2.5 Circulatory Support System for use during mapping and ablation of ventricular tachycardia in the setting of Ventricular dysfunction.
- Trial name
- PERMIT1 (NCT01294267)
- Testing
- Circulatory Support System
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Vivek Reddy
Inflammatory Arthritis, Rheumatoid Arthritis
The Relationship Between Inflammatory ARTritis and CArdiac DIseAse
The goal of this prospective cohort study is to investigate cardiac comorbidity in a random sample of approximately 1200 patients from a population of outpatients with rheumatoid arthritis and axial spondyloarthritis referred to…
- Conditions
- Inflammatory Arthritis, Rheumatoid Arthritis, Spondylitis, Ankylosing, Axial Spondyloarthritis
- Trial name
- ARTCADIA (NCT05647577)
- Where
- Denmark
- Volunteers
- 1,285 people
- Sponsor
- University Hospital, Gentofte, Copenhagen
Arrhythmias, Cardiac, Heart Failure, Systolic
Reasons for Variations in Health Related Quality of Life and Symptom Burden in Patients With Atrial Fibrillation
Atrial fibrillation is the most common cardiac arrhythmia. There is a large variation in symptoms; from almost none to severe but the reason for this is unclear.
- Conditions
- Arrhythmias, Cardiac, Heart Failure, Systolic, Atrial Fibrillation
- Trial name
- SMURF (NCT01553045)
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- University Hospital, Linkoeping
Critical Illness
Critical Illness Related Cardiac Arrest (CIRCA)
CIRCA aims to determine the incidence and outcomes of in-hospital cardiac arrest (IHCA) in UK intensive care units (ICUs) and explore associated risk factors with ICU and hospital survival and quality of survival following…
- Trial name
- CIRCA (NCT04219384)
- Where
- United Kingdom
- Volunteers
- 1,800 people
- Sponsor
- Intensive Care National Audit & Research Centre
Hematological Malignancy, Atrial Fibrillation
Is Ibrutinib-related Atrial Fibrillation Dose Dependent
Ibrutinib, an oral inhibitor of Bruton tyrosine kinase (BTK), has recently revolutionized the treatment of various chronic B-cell malignancies and particularly chronic lymphocytic leukemia (CLL).
- Trial name
- NCT06224452
- Testing
- ibrutinib exposure
- Where
- France
- Volunteers
- 18,000 people
- Sponsor
- University Hospital, Caen
Major Adverse Cardiac Events, Acute Myocardial Infarction (AMI)
Preoperative Cardiology Consultation and the Incidence of Major Adverse Cardiac Events（MACE）
This cohort study aims to determine when preoperative cardiology consultation is needed to reduce the incidence of major adverse cardiac events (MACE) in elderly patients undergoing non-cardiac surgery.
- Conditions
- Major Adverse Cardiac Events, Acute Myocardial Infarction (AMI), Cardiac Death, Sudden, Cardiac Arrest (CA)
- Trial name
- MACE (NCT06884436)
- Where
- China
- Volunteers
- 22,000 people
- Sponsor
- Chinese PLA General Hospital
Immune Checkpoint Inhibitors, Cardiotoxicity
Cardiac Magnetic Resonance Monitoring of Immune Checkpoint Inhibitor-related Cardiotoxicity
This study is a prospective cohort clinical research that analyzes the changes in CMR parameters before and after immune checkpoint inhibitors (ICIs) therapy in patients with gynecologic malignancies.
- Trial name
- NCT06132984
- Testing
- Cardiac magnetic resonance
- Where
- China
- Volunteers
- 22 people
- Sponsor
- West China Second University Hospital
Coronary Disease, Myocardial Infarction
Chronical Illness-related Limitations of the Ability to Cope With Rising Temperatures: an Observational Study
The CLIMATE Observational Study examines to what extent chronically ill patients experience adverse health effects because of heat and whether the patients' specific efforts, somatosensory amplification, self-efficacy, health…
- Conditions
- Coronary Disease, Myocardial Infarction, Heart Failure, Arrhythmias, Cardiac
- Trial name
- CLIMATE (NCT05961163)
- Where
- Germany
- Volunteers
- 61 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Post Traumatic Stress Disorder, Resuscitated Sudden Cardiac Death
Psychological Sequelae After Sudden Cardiac Death in the Patient and His Relatives
This study will evaluate and describe the occurrence of Acute traumatic stress and persistence of Post Traumatic Stress Disorder (PTSD) after resuscitated sudden cardiac death (SCD) in patient and relatives present during the…
- Trial name
- TEMPO (NCT04921514)
- Testing
- SASRQ questionnaire, PCL-5 with LEC-5 questionnaire
- Where
- France
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Atrial Fibrillation
Person Centered Nurse Led Atrial Fibrillation Care
The aim of the study is to evaluate the effect of a person-centred nurse-led outpatient clinic on health related quality of life, for persons with AF.
- Trial name
- NCT04609202
- Testing
- Nurse led person centred care, Usual care
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Umeå University
Asthma, Atrial Fibrillation
The Living With a Long-Term Condition Study
Psychological distress (anxiety and depression) is common in and experienced differently by people living with long-term health conditions (LTCs).
- Conditions
- Asthma, Atrial Fibrillation, Cancer, Cerebrovascular Disorders
- Trial name
- LTC (NCT06072287)
- Testing
- Living with LTC Questionnaire
- Where
- United Kingdom
- Volunteers
- 600 people
- Sponsor
- King's College London
Hyperkalemia
Effect of Sodium Zirconium Cyclosilicate on Arrythmia-related Cardiovascular Outcomes in Participants on Chronic Hemodialysis With Recurrent Hyperkalemia (DIALIZE-Outcomes)
The purpose of this study is to evaluate the effect of Sodium Zirconium Cyclosilicate (SZC) on arrhythmia-related cardiovascular outcomes in participants on chronic hemodialysis with recurrent hyperkalemia.
- Trial name
- NCT04847232
- Testing
- Sodium Zirconium Cyclosilicate (SZC)
- Where
- 340 sites in United States, Argentina and 24 more
- Volunteers
- 2,690 people
- Sponsor
- AstraZeneca
Anxiety, PTSD
Rapid Entrainment and Signal-guided Neuromodulation for Behavioral Health
RESYNC-BH is a research study evaluating a personalized, non-drug brain-and-body treatment approach for adults with ongoing behavioral health symptoms such as depression, anxiety, trauma-related symptoms, sleep problems…
- Conditions
- Anxiety, PTSD, ADHD, Depression Disorders
- Trial name
- RESYNC-BH (NCT07812987)
- Testing
- AIP-Informed Integrative Psychotherapy, Transcutaneous Auricular Vagus Nerve Stimulation, Regulated Breathing and Autonomic Regulation
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Tactical Mind Research Coalition, Inc.
Myocardial Ischemia, Acute Coronary Syndrome
Myeloid-Related Protein in Evaluation of Acute Chest Pain in the Emergency Departement
The purpose of the study is the evaluation of multiple biomarkers related to acute coronary syndromes, including myeloid-related protein 8/14 (MRP 8/14), along with established clinical markers, for early diagnosis and risk…
- Conditions
- Myocardial Ischemia, Acute Coronary Syndrome, Myocardial Infarction, Coronary Occlusion
- Trial name
- MyRiAD (NCT00657436)
- Where
- Switzerland
- Volunteers
- 403 people
- Sponsor
- University of Zurich
Heart Disease
Assessment of Cardiac Function and Anesthesia Depth in Patients Undergoing Cardiac Surgery
The SHAPE study is a prospective, randomized study evaluating changes in cardiac function in adult patients undergoing cardiac surgery with cardiopulmonary bypass.
- Trial name
- SHAPE (NCT07770269)
- Testing
- BIS-guided anesthesia: BIS 45-55, BIS-guided anesthesia: BIS 30-35
- Where
- Greece
- Volunteers
- 70 people
- Sponsor
- AHEPA University Hospital
Obesity, Hypertrophic Cardiomyopathy
Association of Obesity and Cardiovascular Outcomes in Hypertrophic Cardiomyopathy
In this study, the investigators evaluated the association between various measures of adiposity [BMI and waist circumference (WC)] and clinical outcomes in Asian patients with hypertrophic cardiomyopathy, using a nationwide…
- Conditions
- Obesity, Hypertrophic Cardiomyopathy, Cardiovascular Morbidity
- Trial name
- Paradox (NCT05645939)
- Testing
- Diasgnosis of hypertrophic cardiomyopathy
- Where
- South Korea
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- Ajou University School of Medicine