Clinical trials: Cardiac-Related Conditions
Myocardial Infarction
Red Cell Distribution Width,,NT-proBNP and cTnT in Acute Myocardial Infraction Patient
the study is to investigate the relationship of several parameters of complete blood count (CBC) including RDW with N-terminal pro-B-type natriuretic peptide (NT-proBNP) and cardiac troponin T (cTnT) in a cohort of acute…
- Trial name
- NCT05595278
- Testing
- (CBC) ,(NT-proBNP) ,(cTnT)
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Sohag University
Cancer, Immune-related Adverse Event
Extensive CArdioVAscular Characterization and Follow-up of Patients Receiving Immune Checkpoint Inhibitors
The goal of this prospective, multicentre study is to investigate short- and long-term cardiovascular effects in cancer patients treated with immune checkpoint inhibitors (ICIs).
- Conditions
- Cancer, Immune-related Adverse Event, Cardiac Abnormalities, Variable, Immune Checkpoint Inhibitor-Related Myocarditis
- Trial name
- CAVACI (NCT05699915)
- Testing
- Cardiology consultation, Chest Computed Tomography (CT) without contrast, Non-invasive endothelial function tests
- Where
- 4 sites in Belgium
- Volunteers
- 105 people
- Sponsor
- Algemeen Ziekenhuis Maria Middelares
Brain Ischemia, Acute Stroke
Heart and Ischemic STrOke Relationship studY
Although cardio-embolic etiology of ischemic stroke (IS) is largely respected, there is still no clear recommendation for routine complex cardiological examination in all IS patients.
- Conditions
- Brain Ischemia, Acute Stroke, Heart Diseases
- Trial name
- HISTORY (NCT01541163)
- Where
- Czechia
- Volunteers
- 500 people
- Sponsor
- University Hospital Olomouc
Cardiotoxicity, Chemotherapy Effect
New Biomarkers in the Prediction of Chemotherapy-induced Cardiotoxicity.
Early detection and thus rapid therapy of cardiotoxicity related to chemotherapy are essential for restoring cardiovascular function.
- Conditions
- Cardiotoxicity, Chemotherapy Effect, Chemotherapy Induced Systolic Dysfunction
- Trial name
- NCT05992337
- Testing
- Blood sampling, Echocardiography, Cardio MRI
- Where
- 2 sites in Czechia
- Volunteers
- 200 people
- Sponsor
- Cardiology Prague
Atrial Fibrillation
Atrial Fibrillation in Relationship to Plasma Biomarkers
The general objective of this study is to: A. To identify novel plasmatic biomarkers associated with prevalent/incident atrial fibrillation in patients with high risk for AF and stroke. B.
- Trial name
- AFISBIO II (NCT04710745)
- Testing
- Peripheral blood samples for routine analysis including NT-proBNP and plasmatic biomarkers., Echocardiography, ECG Holter monitor
- Where
- 6 sites in Slovakia
- Volunteers
- 300 people
- Sponsor
- Premedix Academy
Hypotension, Tachycardia
Processing and Effects of Cannabis
The purpose of this study is to investigate the processing of cannabis, and to investigate the occurrence of effects of cannabis on the cardiovascular system and the central nervous system; at higher levels of exposure.
- Trial name
- NCT00225407
- Testing
- Smoking of cannabis cigarettes (different strength)
- Where
- Netherlands
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Medication Adherence, Medication Nonadherence
Determining the Impact of a Medication Delivery Unit on Medication Adherence of Adults With Common Cardiac Conditions
The research study is a randomized controlled trial (RCT). The primary endpoint is to compare medication adherence of adult patients recently hospitalized with a diagnosis of common cardiac conditions who require medication…
- Conditions
- Medication Adherence, Medication Nonadherence, Adverse Reaction to Drug
- Trial name
- EMMA-RCT (NCT01600677)
- Testing
- Computerized medication delivery unit, Usual care
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Pittsburgh
Breast Cancer, Cardiotoxicity
Exercise Prescription Guided by Heart Rate Variability in Breast Cancer Patients
Breast cancer is a chronic disease that has seen a boom in research into its treatments, improvements and effects in recent decades.
- Conditions
- Breast Cancer, Cardiotoxicity, Autonomic Imbalance
- Trial name
- NCT05040867
- Testing
- Physical exercise program
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- GO fit Lab- Ingesport
Carbon Monoxide Poisoning
The Efficacy of L-Carnitine in the Management of Acute Carbon Monoxide Poisoning
Carbon monoxide (CO) poisoning results in high morbidity and mortality worldwide. CO is described as a "silent killer" because CO is colorless, odorless, and tasteless but highly toxic.
- Trial name
- NCT05647707
- Testing
- L-Carnitine
- Volunteers
- 72 people
- Sponsor
- Alexandria University
Coronary Artery Disease, Internal Mammary-Coronary Artery Anastomosis
Fibrin Clot Properties and Blood Loss Following Coronary Artery By-pass Grafting
Up to 15% of operations in cardio-pulmonary by-pass are complicated by excessive postoperative blood loss, which negatively affects the outcomes.
- Conditions
- Coronary Artery Disease, Internal Mammary-Coronary Artery Anastomosis, Coronary Artery Bypass, Blood Loss, Postoperative
- Trial name
- NCT03622671
- Testing
- Skeletonized LIMA, Pedicled LIMA
- Where
- Poland
- Volunteers
- 62 people
- Sponsor
- Jagiellonian University
Pregnancy, Labor Pain
Association Between Fluid Administration, Oxytocin Administration, and Fetal Heart Rate Changes
Fetal heart rate patterns are an important parameter in the diagnosis of non-reassuring fetal status. Combined-spinal epidural analgesia is a method of initiating labor analgesia used by approximately 90% of the parturients at…
- Trial name
- NCT02121184
- Testing
- Routine oxytocin, Half-dose oxytocin
- Where
- United States
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Northwestern University
STEMI
Optical Coherence Tomography in STEMI
The overall objective of this research proposal is to use OCT to investigate those morphological culprit plaque characteristics associated with the risk of developing MVO in reperfused STEMI patients.
- Trial name
- NCT02791178
- Testing
- Optical coherence tomography (OCT), Index of microcirculatory resistance (IMR), Cardiac MRI
- Where
- Singapore
- Volunteers
- 35 people
- Sponsor
- National Heart Centre Singapore
Cardiac Arrhythmia, Diagnostic/Monitoring Devices Related to Adverse Incidents
Cardiac Arrhythmia Telemetry; Conventional vs HeartWatch
Heart rhythm disorders are common and significantly impact the lives of those affected and their families. The main problems can be categorized as: a) atrial fibrillation or AF and atrial flutter, b) supra-ventricular tachycardia…
- Conditions
- Cardiac Arrhythmia, Diagnostic/Monitoring Devices Related to Adverse Incidents, Atrial Fibrillation (AF)
- Trial name
- CATCH (NCT06164808)
- Testing
- HeartWatch
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- HelpWear Inc.
Sleep Disorder; Breathing-Related, Heart Failure
Patients With Heart Failure With Preserved Ejection Fraction Adherence to ASV Therapy (PEP ASV)
This is a prospective, single-arm, unblinded pilot study and registry that aims to demonstrate adherence to adaptive servo-ventilation (ASV) therapy in patients with moderate to severe sleep disordered breathing who have been…
- Trial name
- PEP-ASV (NCT04133350)
- Testing
- Active Patient Engagement
- Where
- 4 sites in United States, Germany
- Volunteers
- 2 people
- Sponsor
- Thomas Jefferson University
Heart Failure, Ventricular Tachycardia
Biomarkers in Risk Stratification of Sustainted Ventricular Tachycardia or Electrical Storm After Ablation
Prevalence of HF reaches 1-2% of developed populations, and consequently a significant problem becomes more frequent occurrence of ventricular arrhythmias (VA) - sustained ventricular tachycardia (sVT) and electrical storm (ES)…
- Conditions
- Heart Failure, Ventricular Tachycardia, Ventricular Dysfunction
- Trial name
- STORM (NCT02784912)
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Medical University of Warsaw
Breast Cancer
Generation of Heart Muscle Cells From Blood or Skin Cells of Breast Cancer Patients
The purpose of this study is to investigate whether cells from a biopsy taken from the patient skin can be transformed into cardiomyocytes the changes in cardiomyocyte (heart muscle cells) when grown in a special culture medium…
- Trial name
- NCT02772367
- Testing
- skin punch biopsy
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Myocardial Infarction, Cerebrovascular Accident
Analyzing Gene Regions That May Interact With the Effectiveness of High Blood Pressure Drugs
High blood pressure is one of the most common health problems in the United States. There are many drug treatment options for high blood pressure, but these medications are not always effective.
- Conditions
- Myocardial Infarction, Cerebrovascular Accident, Death, Sudden, Cardiac
- Trial name
- NCT00573092
- Where
- United States
- Sponsor
- University of Washington
Breast Cancer
Evaluating the Effect of Candesartan vs Placebo in Prevention of Trastuzumab-associated Cardiotoxicity
Evaluating the effect of the angiotensin II-receptor (AT1) blocker candesartan vs placebo in prevention of trastuzumab-associated cardiotoxicity in patients with primary breast cancer treated with trastuzumab.
- Trial name
- NCT00459771
- Testing
- AT1 blocker candesartan
- Where
- 19 sites in Netherlands
- Volunteers
- 210 people
- Sponsor
- The Netherlands Cancer Institute
Adult Disease
Relationship of the Physical Activity Practice and Its Different Domains With Cardiac Autonomic Modulation
Overall objective: To analyze the relationship of the physical activity practice measured directly with the autonomic cardiac modulation in adults.
- Trial name
- NCT03986879
- Where
- Brazil
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- Bruna Thamyres Ciccotti Saraiva
Cardiac Disease, Delirium
A Study to Identify the Incidence of Post Traumatic Stress Symptoms in Patients With Delirium Following Cardiac Surgery
'Post perfusion syndrome' was a term historically associated to cardiac surgery in view of the transient neuro-cognitive deficits attributed to cardio pulmonary bypass pump.
- Conditions
- Cardiac Disease, Delirium, Stress Disorders, Post-Traumatic
- Trial name
- NCT02954861
- Testing
- No intervention
- Volunteers
- 406 people
- Sponsor
- University of Edinburgh