Clinical trials: Cardiac-Related Conditions
ST-elevation Myocardial Infarction, Multi Vessel Disease
Primary PCI in Patients With ST-elevation Myocardial Infarction and Multivessel Disease: Treatment of Culprit Lesion Only or Complete Revascularization
In patients with ST-elevation myocardial infarction (STEMI) the primary treatment is acute angioplasty of the acute occlusion (culprit lesion).
- Trial name
- PRIMULTI (NCT01960933)
- Testing
- Percutaneous coronary intervention, FFR
- Where
- 2 sites in Denmark
- Volunteers
- 650 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Shock, Right Ventricular Dysfunction
Right Ventriculo-Arterial Coupling During Fluid Loading in ICU Patients
Preload responsiveness and venous congestion have largely been investigated independently in recent literature. However, recent data report a similar incidence of venous congestion regardless of fluid responsiveness status…
- Conditions
- Shock, Right Ventricular Dysfunction, Venous Congestion
- Trial name
- RVPA-FLICU (NCT07537621)
- Testing
- Echography
- Where
- France
- Volunteers
- 100 people
- Sponsor
- CHU de Reims
Aging, Mild Cognitive Impairment
A Study of Characterizing Cognitive Decline and Functional Cardiac Senescence in Healthy Korean Volunteers
Although aging process appears to be generally characterized, investigators have been paid much attention to the specific target molecules, which leads to discover the clinical markers of the senescence.
- Conditions
- Aging, Mild Cognitive Impairment, Angina Pectoris
- Trial name
- NCT01590706
- Where
- South Korea
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Korea Institute of Oriental Medicine
Pain, Postoperative, Heart Surgery
Comparison of Ultrasound-Guided Serratus Combination Plane Blocks and Local Wound Infiltration for Postoperative Analgesia Management in Minimally Invasive Cardiac Surgery (MICS)
This randomized, prospective, single-blinded study aims to compare the efficacy of ultrasound-guided serratus anterior plane (SAP) block combined with serratus-intercostal interfascial plane (SIP) block versus local wound…
- Conditions
- Pain, Postoperative, Heart Surgery, Analgesia
- Trial name
- NCT06968065
- Testing
- Ultrasound-guided serratus anterior plane block and serratus-intercostal interfascial plane block with bupivacaine, Local wound infiltration with bupivacaine
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- İstanbul Yeni Yüzyıl Üniversitesi
Covid19, Non Ischemic Myocardial Injury
MYocardial DOmmages Related to COVID-19
Myocardial injury, as assessed by elevation of cardiac troponins (Tnc), is frequent among patients with COVID-19. Although rare autopsy cases reported COVID-19 related myocardial inflammation, the origin of Tnc elevation is…
- Conditions
- Covid19, Non Ischemic Myocardial Injury, Myocardial Infarction, Myocarditis
- Trial name
- DOMY COVID (NCT04498065)
- Testing
- Biological data, Clinical data
- Where
- France
- Volunteers
- 273 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Car T- Cell, Hematologic Malignancy
Early Assessment of Cardiac Function After Treatment With CAR-T Cells
CAR-T cells (Chimeric Antigen Receptor) are a new immunotherapy, based on the genetic modification of autologous T lymphocytes. CAR-T cell therapy is not devoid of complications.
- Conditions
- Car T- Cell, Hematologic Malignancy, Acute Lymphoblastic Leukemia, Lymphoma, B-Cell
- Trial name
- Cardio CAR-T (NCT06350994)
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cardiotoxicity
Cardioprotection on Chemotherapy-Induced Cardiotoxicity
The aim of the present study is to evaluate the protective impact of cardioprotective medications on the chemotherapy- induced cardiotoxicity.
- Trial name
- NCT06853951
- Testing
- ACE Inhibitors, β -Blockers
- Where
- 2 sites in Egypt
- Volunteers
- 30 people
- Sponsor
- Ain Shams University
Heart Failure, Reduced Ejection Fraction
Study on the Effects of Sacubitril/Valsartan on Physical Activity and Sleep in Heart Failure With Reduced Ejection Fraction Patients.
The purpose of this study was to investigate the effects of initiation of sacubitril/valsartan vs enalapril treatment on objective measures of both waking activity and sleep in subjects with heart failure with reduced ejection…
- Trial name
- AWAKE-HF (NCT02970669)
- Testing
- sacubitril/valsartan (LCZ696), enalapril
- Where
- 23 sites in United States
- Volunteers
- 140 people
- Sponsor
- Novartis Pharmaceuticals
Delirium, Postoperative, Cardiac Disease
Optic Nerve Sheath Diameter is Associated With Postoperative Delirium in Patients Undergoing Open Heart Surgery
Although the incidence of delirium after cardiac surgery is high, it is not sufficiently recognized. The long-term effects of delirium are likely to be underestimated.
- Conditions
- Delirium, Postoperative, Cardiac Disease, Cardiac Valve Disease
- Trial name
- NCT05942183
- Testing
- ONSD
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Samsun University
Cardiotoxicity, Antitumor Drugs
Evaluation of Heart Function in Breast Cancer Patients Using Trastuzumab
By dynamically observing the changes of echocardiogram and biomarkers in breast cancer patients using trastuzumab, evaluate the effect of trastuzumab on cardiac function; determine the sensitivity of echocardiography and…
- Conditions
- Cardiotoxicity, Antitumor Drugs, Breast Cancer, Trastuzumab
- Trial name
- NCT04961307
- Testing
- Trastuzumab
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking University Third Hospital
Cardiac Arrest
Cardiopulmonary Resuscitation Witnessing by a Relative
The bereavement generated by the loss of a family member can induce pathological situations: depressive state, anxiety, post-traumatic stress disorder and complicated grief.
- Trial name
- PRESENCE (NCT01009606)
- Testing
- Usual strategy, Modified strategy
- Where
- France
- Volunteers
- 570 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
STEMI
Optical Coherence Tomography in STEMI
The overall objective of this research proposal is to use OCT to investigate those morphological culprit plaque characteristics associated with the risk of developing MVO in reperfused STEMI patients.
- Trial name
- NCT02791178
- Testing
- Optical coherence tomography (OCT), Index of microcirculatory resistance (IMR), Cardiac MRI
- Where
- Singapore
- Volunteers
- 35 people
- Sponsor
- National Heart Centre Singapore
Cardiotoxicity, Heart Failure
Novel On-body Evaluation of Cardiac Health for Oncology
The goal of this study is to develop a wearable sensor system that can estimate left ventricular ejection fraction (LVEF), which is a measurement of the heart's function.
- Trial name
- NOECHO (NCT07158450)
- Where
- 11 sites in United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Skribe Medical
Cancer
Effects of Carvedilol on Cardiotoxicity in Cancer Patients Submitted to Anthracycline Therapy
Neoplasia is the main cause of general death in the Brazilian population. In 2016, they were responsible for approximately 211,343 (16%) deaths, followed by cardiovascular diseases (12.6%).
- Trial name
- CardioTox (NCT04939883)
- Testing
- Carvedilol
- Where
- Brazil
- Volunteers
- 1,018 people
- Sponsor
- Hospital Sirio-Libanes
POSTOPERATIVE DELIRIUM, POSTOPERATIVE COGNITIVE DECLINE
Daridorexant to Prevent Delirium After Heart Surgery
The goal of this phase 2 clinical trial is to demonstrate the feasibility of the current study methods and obtain preliminary data for an adequately powered trial of daridorexant with the aim of preventing delirium after heart…
- Trial name
- NCT06630390
- Testing
- Daridorexant 50 mg
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Rochester
Coronary; Ischemic, Arrhythmias, Cardiac
Influence of a Multi-parametric Optimization Strategy for General Anesthesia on Postoperative Morbidity and Mortality
With the increasing aging population demographics and life expectancies, the number of very elderly patients undergoing surgery is rising.
- Conditions
- Coronary; Ischemic, Arrhythmias, Cardiac, Heart Failure, Peripheral Vascular Diseases
- Trial name
- OPTI-AGED (NCT02668250)
- Testing
- OPTI-AGED, Usual Care
- Where
- 29 sites in France
- Volunteers
- 2,495 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Diabetic Retinopathy, Macular Degeneration
Advancing Understanding of Transportation Options
This Stage II randomized, controlled, longitudinal trial seeks to assess the acceptability, feasibility, and effects of a driving decision aid use among geriatric patients and providers.
- Conditions
- Diabetic Retinopathy, Macular Degeneration, Glaucoma, Retinitis Pigmentosa
- Trial name
- AUTO (NCT04141891)
- Testing
- Driving Decision Aid, Older Drivers Website
- Where
- 3 sites in United States
- Volunteers
- 529 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Heart Failure With Preserved Ejection Fraction
The Relationship Between Blood Pressure and Arterial Stiffness in HFpEF Patients With Different Levels of Obesity
Heart failure with preserved ejection fraction (HFpEF) was considered as a heterogeneous disease with multi-organ and multi-system design, which is related to various complications, such as hypertension, obesity and…
- Trial name
- NCT04535726
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Chongqing Medical University
Coronary Artery Disease
the Change of CEM and the Prognosis of Coronary Artery Disease in Real Clinical Practice
The purpose of this study is to investigate the change of total cholesterol content of erythrocyte membranes (CEM) in patients with coronary artery disease treated with secondary prevention drugs, and the correlation with the…
- Trial name
- CCEMPCAD (NCT03473860)
- Volunteers
- 200 people
- Sponsor
- Lu'an Municipal Hospital
Hodgkin Lymphoma in Remission, Leukemia in Remission
Effects of Dexrazoxane Hydrochloride on Biomarkers Associated With Cardiomyopathy and Heart Failure After Cancer Treatment
This clinical trial studies the effects of dexrazoxane hydrochloride on biomarkers associated with cardiomyopathy and heart failure after cancer treatment.
- Conditions
- Hodgkin Lymphoma in Remission, Leukemia in Remission, Lymphoblastic Lymphoma, Osteosarcoma
- Trial name
- NCT01790152
- Testing
- Assessment of Therapy Complications, Laboratory Biomarker Analysis, Quality-of-Life Assessment
- Where
- 79 sites in United States, Australia and 2 more
- Volunteers
- 420 people
- Sponsor
- Children's Oncology Group