Clinical trials: Cardiac-Related Conditions
Disorder Related to Renal Transplantation
The Effects of Omega-3 Fatty Acids in Renal Transplantation
Omega-3 fatty acids are provided through dietary intake of fish and seafood. Several dietary supplements containing omega-3 fatty acids are also commercially available.
- Trial name
- ORENTRA (NCT01744067)
- Testing
- Omega-3 fatty acids
- Where
- 2 sites in Norway
- Volunteers
- 132 people
- Sponsor
- Oslo University Hospital
Coronary Artery Disease, Atrial Fibrillation
Postoperative Lactate and Atrial Fibrillation After CABG
Postoperative atrial fibrillation (POAF) is associated with increased mortality and morbidity in patients undergoing isolated coronary artery bypass grafting (CABG).
- Trial name
- NCT05448521
- Where
- Turkey (Türkiye)
- Volunteers
- 250 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Breast Cancer, Cardiotoxicity
A Study of Blood Pressure Control During Cancer Treatment
The purpose of this study to find out whether an intensive approach to treating high blood pressure during breast cancer treatment is safe and more effective than standard blood pressure treatment at lowering blood pressure…
- Trial name
- NCT06023576
- Testing
- antihypertensive medications, Blood pressure measurement, Echocardiogram
- Where
- 7 sites in United States
- Volunteers
- 130 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Heart Failure, Cardiomyopathies
Multimodal Physiologic State Intelligence Study
The OMNIPHYS study will investigate whether multimodal ultrasound and other routinely collected clinical and physiologic data can be combined with artificial intelligence to characterize changes in a person's physiologic state…
- Conditions
- Heart Failure, Cardiomyopathies, Pulmonary Hypertension, Myocarditis; Acute or Subacute
- Trial name
- OMNIPHYS (NCT07814118)
- Testing
- OMNIPHYS Multimodal Ultrasound Imaging System
- Where
- United States
- Volunteers
- 25,000 people, healthy volunteers welcome
- Sponsor
- Truway Health, Inc.
Cardiotoxicity, Elderly
Cardiotoxicity in the Elderly
CARTIER (Cardiotoxicity in the elderly) is a prospective cohort study of newly diagnosed elderly cancer patients equal or greater than 65 years of age conduced in one tertiary center (Hospital Universitario de Salamanca at Spain.
- Conditions
- Cardiotoxicity, Elderly, Cardiac Magnetic Resonance
- Trial name
- CARTIER (NCT03981588)
- Testing
- Imaging studies
- Where
- 2 sites in Spain
- Volunteers
- 110 people
- Sponsor
- AORTICA Group
Atrial Fibrillation Paroxysmal
Physiotherapist-led Exercise Within Cardiac Rehabilitation and Paroxysmal Atrial Fibrillation and COVID-19.
Paroxysmal atrial fibrillation (AF) induce, in the affected patient, a prominent negative effect on health-related quality of life (HR-QoL) and physical fitness.
- Trial name
- NCT04600713
- Testing
- PT-X and IMT
- Sponsor
- Vastra Gotaland Region
Atrial Fibrillation
Use of Volta Medical AI-software During Atrial Fibrillation Ablation to Identify Patients Who May Need More Than Pulmonary Vein Isolation.
DISPLAY-AF is a prospective, multicenter, single-arm post-market clinical follow-up investigation designed to evaluate whether spatiotemporal dispersion areas identified by the Volta AF-Xplorer II artificial intelligence (AI)…
- Trial name
- DISPLAY-AF (NCT07807423)
- Testing
- Complete biatrial mapping
- Where
- 5 sites in France
- Volunteers
- 125 people
- Sponsor
- Volta Medical
Spinal Muscular Atrophy, Fragile X Syndrome
Early Check: Expanded Screening in Newborns
Early Check provides voluntary screening of newborns for a selected panel of conditions. The study has three main objectives: 1) develop and implement an approach to identify affected infants, 2) address the impact on infants and…
- Conditions
- Spinal Muscular Atrophy, Fragile X Syndrome, Fragile X - Premutation, Duchenne Muscular Dystrophy
- Trial name
- NCT03655223
- Testing
- Confirmatory Testing
- Where
- United States
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- RTI International
Atrial Fibrillation
Symptom Preoccupation in Atrial Fibrillation (AF) and Its Role in AF-related Disability
A cross-sectional study (N=400) will investigate the prevalence of symptom preoccupation and its role in AF-related disability. Subjectively-rated assessments will be gathered from 400 AF patients.
- Trial name
- NCT04123327
- Where
- Sweden
- Volunteers
- 400 people
- Sponsor
- Karolinska Institutet
Intracardiac Thrombus, STEMI
Anticoagulation Therapy in Non-device-related Intra-cardiac Thrombus
Left ventricular thrombus is found in 10 to 25% of patients with impaired left ventricular function following ST-segment elevation myocardial infarction and up to 20% in dilated cardiomyopathy in observational studies.
- Conditions
- Intracardiac Thrombus, STEMI, Heart Failure
- Trial name
- ARGONAUT (NCT05825573)
- Testing
- Vitamin K antagonist, Direct oral anticoagulant
- Where
- 35 sites in France, Reunion
- Volunteers
- 340 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Prosthesis-Related Infections, Equipment Failure
Medico-economic Evaluation of Strategies for the Lead Extraction of Implantable Defibrillator and Pacemakers
The growing use and the expanding indications for cardiovascular implantable electronic devices (CIEDs) have been associated to an increase of device removal.
- Conditions
- Prosthesis-Related Infections, Equipment Failure, Heart Failure, Arrhythmias
- Trial name
- GAINE LASER (NCT03121183)
- Testing
- Laser sheath, Implantable Cardiac Device lead extraction
- Where
- France
- Volunteers
- 45 people
- Sponsor
- University Hospital, Clermont-Ferrand
Atrial Fibrillation New Onset, Postoperative Cardiovascular Complications
Intelligent Monitoring to Predict Atrial Fibrillation
Atrial Fibrillation (AF) is the commonest arrhythmia worldwide, affects 5% of people over the age of 65 and increases the risk of stroke and heart failure.
- Conditions
- Atrial Fibrillation New Onset, Postoperative Cardiovascular Complications, Atrial Fibrillation
- Trial name
- NOTE-AF (NCT06600620)
- Testing
- Monitoring patients heart rythms with a wireless patch device
- Where
- 2 sites in United Kingdom
- Volunteers
- 1,200 people
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Breast Cancer, Neoplasm Metastasis
Liposomal Doxorubicin, Trastuzumab, and Docetaxel in HER2 Positive Metastatic Breast Cancer
This is an open phase II study evaluating the efficacy and safety of the non pegylated liposomal doxorubicin (Myocet®), trastuzumab (Herceptin®), and docetaxel (Taxotere®) combination as first-line treatment of patients with…
- Trial name
- MYOHERTAX (NCT00377780)
- Testing
- Non pegylated liposomal doxorubicin, trastuzumab, docetaxel
- Where
- 7 sites in Netherlands
- Volunteers
- 60 people
- Sponsor
- Laurence J.C. van Warmerdam
Coronary Artery Disease, Cardiac Disease
The CAROLE (CArdiac Related Oncologic Late Effects) Study
CAROLE seeks to evaluate the relationship between chest Radiation Therapy and coronary artery disease. The purpose of CAROLE is to check the heart health of women who received breast cancer treatments in the past and protect them…
- Conditions
- Coronary Artery Disease, Cardiac Disease, Cardiac Toxicity, Radiation
- Trial name
- CAROLE (NCT03235427)
- Where
- United States
- Volunteers
- 201 people
- Sponsor
- Northwell Health
Cardiotoxicity, HER2/Neu Positive
S1501 Dual Observational and Randomized Cohort Study of Patients With Metastatic HER-2+ Breast Cancer at Risk of Cardiac Toxicity
This trial has two cohorts of patients with human epidermal growth factor receptor (HER)-2-positive breast cancer that has spread to other places in the body. All patients must be receiving trastuzumab-based treatment.
- Conditions
- Cardiotoxicity, HER2/Neu Positive, Metastatic Malignant Neoplasm in the Brain, Recurrent Breast Carcinoma
- Trial name
- NCT03418961
- Testing
- Carvedilol, Laboratory Biomarker Analysis, Patient Observation
- Where
- 590 sites in United States, Puerto Rico and 2 more
- Volunteers
- 491 people
- Sponsor
- SWOG Cancer Research Network
Breast Cancer, HER2-positive Breast Cancer
Investigating the Long-term Cardiac Sequelae of Trastuzumab Therapy
The introduction of trastuzumab for the treatment of patients with human epidermal growth factor receptor 2 (HER2) positive breast cancer has had a major impact upon cancer outcomes.
- Conditions
- Breast Cancer, HER2-positive Breast Cancer, Cardiotoxicity
- Trial name
- NCT05019365
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
Refractory Ischemia
Quality of Life in Patients With Refractory Angina
The health and well being of patients with refractory angina will be assessed using validated questionnaires (SF-36 and Seattle Angina Questionnaire [SAQ]) at baseline and one year.
- Trial name
- NCT00840437
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Minneapolis Heart Institute Foundation
Biomarkers, Coronary Artery Bypass Surgery
Dynamics of microRNA Expression and Systemic Inflammatory Response in POCD After Cardiac Surgery
Postoperative cognitive decline (POCD) is one of the most common complications after cardiac surgery. It is characterized by impaired memory, attention, and executive functions and can have long-term consequences.
- Conditions
- Biomarkers, Coronary Artery Bypass Surgery, Interleukin-6, MicroRNAs
- Trial name
- NCT07231731
- Where
- Croatia
- Volunteers
- 48 people
- Sponsor
- Osijek University Hospital
Lipid Metabolism Disorders, Postoperative Complications
Pre-operative Blood Lipid Level and Post-operative Major Adverse Cardiac Event
Whether the pre-operative blood lipid level and post-operative cardiovascular events is associated is unknown. This study is to find out the main blood lipid and relative protein level change and the post-operative cardiovascular…
- Trial name
- NCT03344224
- Testing
- laboratory test
- Volunteers
- 50,000 people
- Sponsor
- Peking University First Hospital
Coronary Artery Disease, ST-segment Elevation Myocardial Infarction
Post-Marketing Safety Study in ST-Segment Elevation Myocardial Infarction (STEMI) Participants Undergoing Primary Percutaneous Coronary Intervention (PCI) Procedure With VISIPAQUE® as the Contrast Medium
The purpose of this study is to prospectively observe the incidence rate of acute kidney injury (AKI), major adverse renal and cardiovascular events (MARCE) in participants who were diagnosed with ST-segment elevation myocardial…
- Trial name
- NCT03671603
- Testing
- Iodixanol
- Where
- 36 sites in China, South Korea
- Volunteers
- 2,755 people
- Sponsor
- GE Healthcare