Clinical trials: Cardio/Pulm: Heart Failure
Amyloidosis Cardiac, Heart Failure
Screening, Characterization, and Longitudinal Follow-up of Patients With Cardiac Amyloidosis
Cardiac amyloidosis is a progressive disorder caused by extracellular deposition of amyloid fibrils in the heart, leading to heart failure and impaired cardiac function.
- Conditions
- Amyloidosis Cardiac, Heart Failure, Cardiac MRI, Spectroscopic Analysis
- Trial name
- NCT07577466
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Cardiac Surgery
Goal Directed Hemodynamic Management of Acute Heart Failure After Cardiac Surgery in Children
Goal directed therapy (GDT) utilises various monitoring techniques to assess cardiovascular performance and allows for timely interventions based on predetermined algorithms.
- Trial name
- NCT02617602
- Testing
- Goal directed therapy, Control
- Where
- Russia
- Volunteers
- 40 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Heart Failure
Effects of Echo-optimization of Left Ventricular Assist Devices on Functional Capacity (VAFRACT)
After the implantation of a left ventricular assist device (LVAD), many patients continue to experience exercise intolerance. LVAD echo guided optimization (EO) determines a more favorable hemodynamic profile and could provide an…
- Trial name
- VAFRACT (NCT03937570)
- Testing
- echo-optimization
- Where
- Italy
- Volunteers
- 27 people
- Sponsor
- Universita di Verona
Diabetic Cardiomyopathies
Safety and Efficacy of AT-001 in Patients With Diabetic Cardiomyopathy
This is a multicenter, randomized, placebo-controlled, 2-part study to evaluate the safety and efficacy of AT-001 in adult patients (N=675) with Diabetic Cardiomyopathy at high risk of progression to overt heart failure.
- Trial name
- NCT04083339
- Testing
- AT-001
- Where
- 79 sites in United States, Australia and 8 more
- Volunteers
- 675 people
- Sponsor
- Applied Therapeutics, Inc.
Heart Failure With Preserved Ejection Fraction (HFPEF)
Role of Cardiopulmonary Exercise Testing in People With Heart Failure With Preserved Ejection Fraction
Heart failure affects 1-2% of the adult population. Up to half of these patients have apparently normal heart pumping function, known as heart failure with preserved ejection fraction (HFpEF).
- Trial name
- NCT07394010
- Testing
- Cardiopulmonary Exercise Test
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Ulster
Heart Failure With Reduced Ejection Fraction, Chronic Heart Failure
Vericiguat and Exercise Hemodynamics in Patients With HFrEF
Heart failure with reduced ejection fraction (HFrEF) is associated with impaired exercise capacity and abnormal exercise hemodynamics despite contemporary guideline-directed medical therapy (GDMT).
- Trial name
- EVERHETT-HF (NCT07697365)
- Testing
- Vericiguat, Guideline-directed medical therapy (GDMT) for heart failure
- Where
- Greece
- Volunteers
- 40 people
- Sponsor
- Argyrios Ntalianis
Heart Failure
Effects of Early Cardiopulmonary Rehabilitation in Patients With Acute Decompensated Heart Failure
Acute decompensated heart failure (ADHF) is a severe condition characterized by rapid deterioration of cardiac function, leading to impaired oxygen delivery and multi-organ dysfunction.
- Trial name
- NCT07155421
- Testing
- Early Cardiopulmonary Rehabilitation, Routine in-hospital care
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Izmir Bakircay University
Diabetes Mellitus, Type 2
Effect of Rosiglitazone Versus Placebo on Cardiovascular Performance and Myocardial Triglyceride
The purpose of this study is to determine if rosiglitazone treatment improves integrated cardiovascular performance in patients at risk for congestive heart failure.
- Trial name
- NCT00424762
- Testing
- rosiglitazone
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Texas Southwestern Medical Center
Atrial Fibrillation, Heart Failure
Cardiopulmonary Bypass and Ventricular Remodeling
The goal of this observational study is determine if reduced ventricular ejection fraction is a factor that determines a pro-oxidant imbalance in patients subjected to cardiac surgery with cardiopulmonary bypass.
- Trial name
- CBP-VR (NCT06256965)
- Testing
- Detection of peri-operative atrial fibrillation
- Where
- Chile
- Volunteers
- 12 people
- Sponsor
- University of Chile
Chronic Heart Failure
Effects of Growth Hormone on Exercise Capacity
The purpose of this study was to assess whether Growth Hormone(GH)improves exercise capacity and cardiopulmonary performance in patients with chronic heart failure.
- Trial name
- NCT00501514
- Testing
- Growth hormone
- Where
- Italy
- Volunteers
- 22 people
- Sponsor
- Federico II University
Chronic Obstructive Pulmonary Disease, Chronic Heart Failure
Mindful Steps 2.0: Promoting Physical Activity in Patients With COPD and HF
The goal of this fully-remote randomized controlled trial is to test the efficacy of Mindful Steps in facilitating physical activity compared to usual standard of care among 136 patients with COPD and/or HF.
- Trial name
- NCT05934565
- Testing
- Mindful Steps
- Where
- 2 sites in United States
- Volunteers
- 136 people
- Sponsor
- Beth Israel Deaconess Medical Center
Kidney Failure, Acute
Fenoldopam in Pediatric Cardiac Surgery
The purpose of this study is to determine whether fenoldopam infusion during cardiopulmonary bypass in young children with congenital heart disease is able to reduce indicators of acute kidney injury (biomarkers reduction…
- Trial name
- NCT00982527
- Testing
- Fenoldopam
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Bambino Gesù Hospital and Research Institute
Copd, Heart Failure
Mindful Steps: Promoting Physical Activity
This is a developmental project with two phases. The first phase will adapt an existing web-based intervention to incorporate mind-body exercises to develop a multi-modal intervention to promote physical activity in patients with…
- Trial name
- NCT03003780
- Testing
- Mindful Steps
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Beth Israel Deaconess Medical Center
Heart Failure, Vasoplegia
Prevention of Low Blood Pressure After Cardiac Surgery in Heart Failure Patients With a Filter Called CytoSorb.
Vasoplegia is a common complication after heart surgery for heart failure. With vasoplegia, the blood vessels can no longer squeeze properly, causing low blood pressure that is sometimes difficult to treat with medication.
- Trial name
- CytoSorb-HF (NCT04812717)
- Testing
- CytoSorb device
- Where
- Netherlands
- Volunteers
- 36 people
- Sponsor
- Leiden University Medical Center
Heart Failure With Reduced Ejection Fraction
CPET Predicts Long-term Survival and Positive Response to CRT
The study tested the usefulness of cardiopulmonary exercise test (CPET) in selection of potential responders to CRT.
- Trial name
- CPET-CRT (NCT03870074)
- Volunteers
- 122 people
- Sponsor
- National Institute of Cardiology, Warsaw, Poland
Coronary Artery Bypass Surgery, Coronary Heart Disease
Clinical Study to Evaluate Nesiritide in Patients Undergoing Coronary Artery Bypass Graft (CABG) Surgery A014 / NAPA
The purpose of this study is to assess the effects of nesiritide compared to placebo when given with standard of care therapies, on kidney function, heart function and the need of other treatments in heart failure patients…
- Conditions
- Coronary Artery Bypass Surgery, Coronary Heart Disease, Coronary Artery Bypass Grafting, Cardiopulmonary Bypass
- Trial name
- NCT00653042
- Testing
- Nesiritide
- Volunteers
- 305 people
- Sponsor
- Scios, Inc.
Heart Failure
Study of ADI CardioPulmonary Management (CPM) System
This study is meant primarily collect CardioPulmonary Management (CPM) data from daily usage and compare it to the clinical course of a patient.
- Trial name
- NCT06024369
- Testing
- CPM Device
- Where
- United States
- Sponsor
- Analog Device, Inc.
Heart Failure, Heart Failure With Reduced Ejection Fraction
Effects of Dapagliflozin on Cardiorespiratory Parameters in Heart Failure
Dapagliflozin is a molecule belonging to the class of sodium-glucose transporter type 2 (SGLT2-i) inhibitors. This type of drug, initially used in the treatment of diabetes mellitus, has in recent years demonstrated significant…
- Conditions
- Heart Failure, Heart Failure With Reduced Ejection Fraction, Left Ventricle Remodeling, Sleep Apnea
- Trial name
- NCT05770167
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- Centro Cardiologico Monzino
Mitral Regurgitation, Mitral Valve Regurgitation
Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients With Functional Mitral Regurgitation (The COAPT Trial) and COAPT CAS
The purpose of the Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients with Functional Mitral Regurgitation (COAPT) Trial is to confirm the safety and effectiveness of the MitraClip…
- Conditions
- Mitral Regurgitation, Mitral Valve Regurgitation, Treatment of Functional Mitral Regurgitation in Symptomatic Heart Failure Subjects, Heart Failure
- Trial name
- COAPT (NCT01626079)
- Testing
- MitraClip System
- Where
- 86 sites in United States, Canada
- Volunteers
- 776 people
- Sponsor
- Abbott Medical Devices
Heart Failure
Exercise Oscillatory Breathing and Sildenafil in Heart Failure
Exercise oscillatory breathing (EOB) is a ventilatory abnormality that occurs in approximately 20% of heart failure (HF) patients and carries a very unfavourable prognosis.
- Trial name
- NCT01185925
- Testing
- Sildenafil
- Volunteers
- 32 people
- Sponsor
- University of Milan