Clinical trials: Cardio Pulmonary Bypass
Cardiac Surgery and Cardiopulmonary Bypass
Sodium Bicarbonate in Cardiac Surgery
Many patients develop kidney failure after cardiac surgery. Although this kidney failure can usually be treated effectively, a longer stay in intensive care is often required.
- Trial name
- NCT00334191
- Testing
- Sodium Bicarbonate
- Where
- Australia
- Volunteers
- 100 people
- Sponsor
- Austin Health
Cardiopulmonary Bypass, Congenital Defects
Aprotinin in Neonates Undergoing Cardiopulmonary Bypass
This is a retrospective chart review study. The purpose of this study is to review our experience at Children's Healthcare of Atlanta in neonates receiving aprotinin.
- Conditions
- Cardiopulmonary Bypass, Congenital Defects, Hemostasis
- Trial name
- NCT00469742
- Where
- United States
- Volunteers
- 290 people
- Sponsor
- Children's Healthcare of Atlanta
Cardiopulmonary Bypass, Cardiac Surgery
Ulinastatin Improves Postoperative Oxygenation After Cardiopulmonary Bypass
Retrospective study determine whether ulinastatin enhances postoperative pulmonary oxygenation after cardiopulmonary bypass (CPB).
- Trial name
- NCT03154814
- Testing
- ulinastatin, control
- Where
- 2 sites in South Korea
- Volunteers
- 80 people
- Sponsor
- Konkuk University Medical Center
Cardiac Surgery, Cardiopulmonary Bypass
Benefits of GIK in Cardiac Surgery Patients
The purpose of this study is to evaluate the effects of modified glucose - insulin - potassium (GIK) therapy in cardiac surgery patients undergoing cardiopulmonary bypass (CPB).
- Trial name
- NCT01516138
- Testing
- GIK, Control
- Where
- China
- Volunteers
- 930 people
- Sponsor
- Xijing Hospital
Neuromuscular Blockade, Postoperative Pulmonary Atelectasis
Rocuronium vs Cis-atracurium: Do Rocuronium Still 'ROCKS' In Coronary Artery Bypass Grafting
The current trend in most cardiac surgeries was to use rocuronium as it provides faster recovery in train-of-four ratio compared to other aminosteroid non-depolarising neuromuscular blocker.
- Conditions
- Neuromuscular Blockade, Postoperative Pulmonary Atelectasis, Postoperative Pulmonary Complication, Coronary Artery Disease
- Trial name
- NCT06102915
- Testing
- Rocuronium Bromide 10 MG/ML, Nimbex 10 MG in 5 ML Injection
- Where
- Malaysia
- Volunteers
- 289 people
- Sponsor
- Institut Jantung Negara
Acute Kidney Injury, Heart; Dysfunction Postoperative, Cardiac Surgery
Near Infrared Spectroscopy for the Detection of Acute Kidney Injury in Children Following Cardiac Surgery
One in a hundred children is born with a heart defect. Some children require heart surgery within the first few days of life, while others can wait until they are older.
- Conditions
- Acute Kidney Injury, Heart; Dysfunction Postoperative, Cardiac Surgery, Children
- Trial name
- NCT01382758
- Where
- United States
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Cognitive Dysfunction
Effects of Dexmedetomidine on Cognitive Outcome and Brain Injury Markers
Dexmedetomidine is a drug with sedative, anxiolytic, and analgesic properties. Benefits of its use covers good sedations without respiratory suppression, reduced circulating catecholamines due to decreased sympathetic…
- Trial name
- NCT03585452
- Testing
- Dexmedetomidine Infusion, Propofol based general anesthesia
- Where
- Poland
- Volunteers
- 23 people
- Sponsor
- Michał Kowalczyk
Extracorporeal Circulation
Anticoagulation Management in Complex Cardiac Surgery
The goal of this clinical trial is to compare the anticoagulation management with or without heparin concentration level guidance, in patients undergoing valve or complex cardiac surgery during cardiopulmonary bypass using…
- Trial name
- NCT05944107
- Testing
- Activated Clotting Time measurements combined with heparin concentration monitoring, Activated Clotting Time
- Where
- Greece
- Volunteers
- 65 people
- Sponsor
- Aristotle University Of Thessaloniki
Cardiac Surgery Requiring Cardiopulmonary Bypass
Oxygen Consumption, Hypoperfusion and Organ Injury After Cardio-pulmonary Bypass
The goal of this observational study is to understand how oxygen consumption after heart surgery relates to blood flow problems and organ injury.
- Trial name
- VO2-EPOC (NCT06930443)
- Testing
- Oxygen consumption measurement
- Where
- Sweden
- Volunteers
- 65 people
- Sponsor
- Uppsala University Hospital
Ventricular Septal Defect
Bypass Clear Priming VSD Cardiopulmonary Bypass Circuit Reduce Bypass Associated Inflammation?
The purpose of this trial is to study if priming the pump used during cardiac surgery with non-blood fluids instead of donated blood products reduces the inflammation that occurs after heart surgery.
- Trial name
- NCT07393243
- Testing
- Clear priming of the bypass pump
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Seattle Children's Hospital
Heart Defects, Congenital, Cardiopulmonary Bypass
Nesiritide Use Following Cardiac Surgery in Infants
The purpose of this study is to determine the effects of nesiritide on urine output and hemodynamics following cardiopulmonary bypass in infants. Safety and pharmacokinetic data will also be obtained.
- Trial name
- NCT00281671
- Testing
- nesiritide
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Boston Children's Hospital
Monitored Anesthesia Care, Cardiac Surgery
Monitored Anesthesia Care Versus Intubated General Anesthesia for Open Heart Surgery Under Cardiopulmonary Bypass
Though Cardiac surgery under cardiopulmonary bypass (CPB) under epidural anesthesia in conscious patients is associated with increased risk of epidural hematoma.
- Conditions
- Monitored Anesthesia Care, Cardiac Surgery, Postoperative Recovery
- Trial name
- NCT05011617
- Testing
- Non-intubation and monitoring anesthesia care (MAC)
- Where
- China
- Volunteers
- 30 people
- Sponsor
- ShuGuang Hospital
Cardiac Output
Cardiac Output Measurement at the Conclusion of Cardiopulmonary Bypass
Cardiac output, the amount of blood pumped by the heart in one minute, will be measured in pediatric patients undergoing surgery involving cardiopulmonary bypass (CPB).
- Trial name
- NCT01103908
- Testing
- HCE101 Cardiopulmonary Support Monitor
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Transonic Systems Inc.
Respiratory Complication, Respiration, Artificial
Ventilation in Cardiac Surgery
The purpose of this study is to evaluate prospectively ventilatory practices in the perioperative cardiac surgery period.
- Conditions
- Respiratory Complication, Respiration, Artificial, Anesthesia, General, Bypass, Cardiopulmonary
- Trial name
- VENICE (NCT03255356)
- Testing
- Survey
- Where
- 10 sites in Belgium, Brazil and 8 more
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Caen
Cardiopulmonary Arrest
Measurement of Cerebral Flow Using Transfontanellar Doppler in Infants Under Cardiopulmonary Bypass
Transfontanellar Doppler can measure the velocity at both the carotid artery and the anterior cerebral artery during cardiopulmonary bypass in congenital heart disease patients.
- Trial name
- NCT01996020
- Where
- South Korea
- Volunteers
- 43 people
- Sponsor
- Seoul National University Hospital
Cardiopulmonary Bypass, Hemorrhage
Processed Residual Pump Blood in Cardiac Surgery: The PRBC Trial
The study is an randomized controlled trial (RCT) of 198 coronary artery bypass graft (CABG) patients, exploring whether ultrafiltration of residual blood in the cardiopulmonary bypass circuit reduces transfusion and bleeding.
- Conditions
- Cardiopulmonary Bypass, Hemorrhage, Surgery
- Trial name
- PRBC (NCT01173822)
- Testing
- Ultrafiltration of residual blood
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Hamilton Health Sciences Corporation
Heart Valve Diseases, Coronary Artery Disease
Performance of the CARDIOGARD Cannula
This is a single center, prospective study: The 'CardioGard Cannula' Gaseous emboli capture results - shows an improvement from the control group.
- Trial name
- GECG (NCT02764645)
- Testing
- CardioGard Cannula, 22Fr curved Cannula
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Bypass Complications, Disorder of Blood Gas
Difference Between Central and Peripheral Arterial Blood Oxygen Saturation With Different CPB Strategy
Femoro-femoral cardiopulmonary bypass with retrograde perfusion is needed for totally thoracoscopic cardiac surgery. one of the major complication of retrograde perfusion is organ hypoperfusion.
- Trial name
- NCT01698853
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xijing Hospital
Atrial Septal Defect, Ventricular Septal Defects
Comparison of Dynamic Compliance and Airway Resistance in Pressure-Controlled Versus Volume-Controlled Ventilation in Children Undergoing Corrective Heart Surgery
The goal of this clinical trial was to compare two settings on a breathing machine used during heart surgery in children. The children in this study were born with a hole inside the heart.
- Conditions
- Atrial Septal Defect, Ventricular Septal Defects, Pulmonary Hypertension, Intracardiac and Septal Defects
- Trial name
- NCT07754591
- Testing
- Pressure Controlled Ventilation, Volume Controlled Ventilation
- Where
- India
- Volunteers
- 72 people
- Sponsor
- Nilratan Sircar Medical College
Atrial Fibrillation
Heart Rhythm Changes in Patients With Atrial Fibrillation After Cardiopulmonary Bypass: a Retrospective Analysis
The goal of this observational study is to learn about the lthe effect of the tetralogy of medication regimen on intraoperative cardioversion in patients with persistent AF.
- Trial name
- NCT06553391
- Testing
- The tetralogy of medication regimen
- Where
- China
- Volunteers
- 106 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital