Clinical trials: Cardio Pulmonary Bypass
Minimally Invasive Coronary Revascularization Surgery, Elective Surgery
Impact of Total Coronary Revascularization Via Left Anterior Thoracotomy (TCRAT) vs. Robotic-Assisted Harvesting of LIMA (ITcrats)
The two types of total coronary revascularization via left anterior thoracotomy (TCRAT) might have their potential benefits and disadvantages.
- Trial name
- ITcrats (NCT06988735)
- Testing
- Nonrobotic TCRAT, Robotic TCRAT
- Where
- Saudi Arabia
- Volunteers
- 182 people
- Sponsor
- Mohamed R El Tahan
Acquired Bleeding Disorder, Cardiac Surgery Requiring Cardiopulmonary Bypass
Activated Recombinant Human Factor VII Following Cardiac Bypass Surgery for Paediatric Congenital Heart Disease
This trial is conducted in Oceania. The aim of this trial is to investigate the efficacy of activated recombinant human factor VII and standard treatment compared with standard haemostatic replacement therapy in cardiopulmonary…
- Trial name
- NCT01562574
- Testing
- activated recombinant human factor VII
- Where
- Australia
- Volunteers
- 82 people
- Sponsor
- Novo Nordisk A/S
Vasoplegia, Endothelial Dysfunction
Evaluation of the Association Between Pre-existing Endothelial Dysfunction and the Onset of Vasoplegia During Cardiac Surgery With Cardiopulmonary Bypass
Cardiac surgery patients have many risk factors for endothelial dysfunction (hypertension, atherosclerosis, dyslipidemia, chronic renal failure ...).
- Trial name
- DYVA (NCT02965339)
- Where
- France
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Postoperative Hemorrhage
Antithrombin III Supplementation for Cardiopulmonary Bypass in Neonates
A prospective, randomized, placebo-controlled, double-blinded pilot study is planned. Neonates undergoing surgeries requiring cardiopulmonary bypass will receive antithrombin III (ATIII) supplementation or placebo in addition to…
- Trial name
- NCT01158729
- Testing
- Antithrombin (Recombinant)
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Medical College of Wisconsin
Congenital Heart Disease
Evaluating Precision of Therapy - Milrinone
Children with congenital heart disease have significant morbidity including low cardiac output syndrome and subsequent organ dysfunction that may be prevented by optimization of circulatory function.
- Trial name
- NCT01841177
- Testing
- Milrinone
- Where
- 2 sites in Canada
- Volunteers
- 52 people
- Sponsor
- The Hospital for Sick Children
Coronary Disease
Impact of Pumps on Internal Thoracic Arteries (IPITA)
Cardiopulmonary bypass (CPB) induces a systemic inflammatory response and affects the organ vascular bed. Experimentally, the lack of pulsatility alters myogenic tone of resistance arteries and increases the parietal inflammatory…
- Trial name
- IPITA (NCT04168853)
- Testing
- vascular reactivity of internal thoracic arteries
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Adrenal Insufficiency Neonatal
Impact of Pre-operative Steroids on Adrenal Insufficiency
Little is known regarding the incidence and clinical impact of AI in neonates during the acute postoperative period following separation from CPB.
- Trial name
- NCT02956707
- Testing
- No pre-operative steroids
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Alabama at Birmingham
Acute Respiratory Distress Syndrome
Plasma Biomarkers of Cardiopulmonary Bypass Induced Acute Respiratory Distress Syndrome (CPB-ARDS)
The investigators aimed to establish a prospective cohort of patients undergoing cardiopulmonary bypass (CPB) in cardiac surgery from April 2021 to September 2022, in Wuhan.
- Trial name
- PBOARDS (NCT04696172)
- Where
- 2 sites in China
- Volunteers
- 525 people
- Sponsor
- Huazhong University of Science and Technology
Cardiac Surgery
Goal Directed Hemodynamic Management of Acute Heart Failure After Cardiac Surgery in Children
Goal directed therapy (GDT) utilises various monitoring techniques to assess cardiovascular performance and allows for timely interventions based on predetermined algorithms.
- Trial name
- NCT02617602
- Testing
- Goal directed therapy, Control
- Where
- Russia
- Volunteers
- 40 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Ischemia-Reperfusion Injury
Effect of Dexmedetomidine Preconditioning on Myocardial Ischemia-reperfusion Injury in Patients Undergoing Open Heart Surgery With Cardiopulmonary Bypass
About 200000 cardiac operations are performed in China every year. Cardiopulmonary bypass is the basic strategy of open-heart surgery, which may lead to myocardial ischemia-reperfusion injury and low cardiac output syndrome.
- Trial name
- NCT05598177
- Testing
- dexmedetomidine
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Affiliated Hospital of Nantong University
Postoperative Delirium
Cerebral Blood Supply During Cardiopulmonary Bypass
Postoperative delirium is an acute and fluctuating state of confusion and disorientation with an incidence of 25-70% after cardiac surgery.
- Trial name
- NCT03117712
- Testing
- Delirium Scores, Carotis duplex sonography, TCD for detection of HITS
- Where
- Austria
- Volunteers
- 40 people
- Sponsor
- Medical University of Vienna
Coronary Artery Bypass
Comparison of Minimal Versus Conventional Extracorporeal Circulation in Coronary Surgery
The aim of this study is to assess the effect of minimal (MiECC) versus conventional (CECC) extracorporeal circulation on perfusion characteristics and remote end-organ protection (lungs, brain, kidneys, liver, stomach…
- Trial name
- NCT01603589
- Testing
- Coronary artery bypass grafting with the use of minimal invasive extracorporeal circulation, Coronary artery bypass grafting under conventional extracorporeal circulation
- Where
- Greece
- Volunteers
- 150 people
- Sponsor
- AHEPA University Hospital
Heart Valve Diseases
Prolonged Cardiopulmonary Bypass Time as a Predictive Factor for AGI After Heart Valve Replacement
In this retrospective study, the investigators will analyze the correlation between cardiopulmonary bypass (CPB) time and acute gastrointestinal injury (AGI), and the outcomes of AGI in patients undergoing heart valve replacement.
- Trial name
- NCT05498935
- Testing
- CPB time
- Where
- China
- Volunteers
- 1,070 people
- Sponsor
- Hepatopancreatobiliary Surgery Institute of Gansu Province
Elective Cardiac Surgical Interventions
Cytokine Removal in Cardiopulmonary Bypass Patients
Cardiopulmonary bypass (CPB) surgery initiates a systemic inflammatory response induced by extrinsic (e.g. anesthesia, contact activation within the extracorporeal circuit, endotoxemia) and intrinsic (e.g.
- Trial name
- CytoSorb (NCT01879176)
- Testing
- CytoSorb
- Where
- Austria
- Volunteers
- 46 people
- Sponsor
- Medical University of Vienna
Heart Valve Diseases
Normothermiс Cardiopulmonary Bypass Increases Cerebral Oxygenation During Valve Surgery
The aim of our study was to evaluate the effect of different temperature regimens of cardiopulmonary bypass on systemic oxygen transport and cerebral oxygenation during surgical correction of acquired heart diseases.
- Trial name
- NCT01685554
- Testing
- hypothermic CPB, normothermic CPB
- Where
- Russia
- Volunteers
- 40 people
- Sponsor
- Northern State Medical University
Coronary Artery Bypass Surgery, Cardiopulmonary Bypass
Safety and Effectiveness of the Medtronic Resting Heart Bypass System in Heart Surgery Patients
The purpose of this study is to determine if the Medtronic Resting Heart Bypass system is safer and results in less inflammatory reaction than traditional bypass machines used in coronary artery bypass surgery.
- Trial name
- NCT00303641
- Testing
- Medtronic Resting Heart Bypass System
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Heart Valve Surgery
Effect of Lithium Carbonate on Postoperative Sleep and Cognitive Function in Patients Undergoing Heart Valve Surgery With Cardiopulmonary Bypass
It has been proved that lithium carbonate can prolong slow wave sleep with few or no side-effects. The aim of the present study is to evaluate postoperative sleep quality of patients undergoing heart valve surgery with…
- Trial name
- NCT05593627
- Testing
- Lithium Carbonate 250 MG Oral Tablet, Calcium Carbonate 500 MG Oral Tablet
- Where
- China
- Volunteers
- 62 people
- Sponsor
- China Medical University, China
Cardiopulmonary Bypass, Intensive Care Units
Preventive Narrative Exposure Intervention for PTSD in ICU Patients After Cardiopulmonary Bypass Cardiac Surgery
This clinical trial aims to evaluate whether an ICU-based preventive narrative exposure intervention can help prevent posttraumatic stress symptoms in adult patients after cardiac surgery with cardiopulmonary bypass.
- Conditions
- Cardiopulmonary Bypass, Intensive Care Units, Stress Disorders, Post-Traumatic
- Trial name
- ICU-pNET (NCT07632131)
- Testing
- ICU-Based Preventive Narrative Exposure Intervention
- Where
- China
- Volunteers
- 100 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Post-cardiac Surgery, Inflammation
Cytokine Adsorption During Complex Cardiac Surgery: a Controlled Randomized Trial
This prospective single-centre randomized controlled trial aims at evaluating the safety and efficacy of hemoadsorption with HA-380® during cardio-pulmonary bypass in 40 patients undergoing complex cardiac surgery.
- Conditions
- Post-cardiac Surgery, Inflammation, Organ Dysfunction Syndrome, Cardiac Disease
- Trial name
- JACCS (NCT06512623)
- Testing
- Hemoadsoprtion
- Where
- Switzerland
- Volunteers
- 41 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Coronary Artery Disease, Coronary Artery Bypass
Nitric Oxide-mediated Cardioprotection During Cardiac Surgery With Cardiopulmonary Bypass
This prospective randomized study elucidates the effects of exogenous nitric oxide delivered to the extracorporeal circulation circuit for cardioprotection against ischemia-reperfusion injury during coronary artery bypass graft…
- Conditions
- Coronary Artery Disease, Coronary Artery Bypass, Cardiopulmonary Bypass, Nitric Oxide
- Trial name
- NOinCPB (NCT03500783)
- Testing
- Nitric Oxide, Standard CPB
- Volunteers
- 60 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences