Clinical trials: Cardio Pulmonary Bypass
Hypertension
Esmolol or Nitroglycerin Infusion for Blood Pressure Control Prior to Cardiopulmonary Bypass (CPB) in Cardiac Surgery
This is an investigator initiated, sponsored, open label, prospective randomized controlled trial to be performed in adult patients undergoing scheduled cardiac surgery.
- Trial name
- NCT01212874
- Testing
- nitroglycerin, esmolol
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Loma Linda University
Cardiopulmonary Bypass
Extracorporeal Cytokine Adsorption in Cardiac Surgery
The modern era of cardiac surgery began in early 1950s with the introduction of cardiopulmonary bypass (CPB). Although it has been clearly shown that CPB is almost unavoidable for most open heart operations, an undesirable…
- Trial name
- IMEECCACS (NCT02666703)
- Testing
- CytoSorb, Methylprednisolone
- Where
- Slovenia
- Volunteers
- 60 people
- Sponsor
- University Medical Centre Ljubljana
Hyperlactatemia, Cardiac Disease
Influence of High Vitamin C Dose on Lactate During and After Extracorporeal Circulation
The aim of our study is to find out whether high doses of vitamin C before cardiopulmonary bypass and during the first 24 hours after that have and impact of lowering the incidence of hyperlactatemia.
- Conditions
- Hyperlactatemia, Cardiac Disease, Bypass Complication, Valve Disease, Heart
- Trial name
- NCT04046861
- Testing
- ascorbic acid,
- Where
- Slovenia
- Volunteers
- 70 people
- Sponsor
- University Medical Centre Maribor
Hematologic Changes
Effect of Blood Harvesting and Administration at End of CPB on Coagulation Profile
Blood transfusions after pediatric heart surgery is a relatively common practice occurring in up to 46% of patients, however its use has been associated with increased morbidity.
- Trial name
- NCT01958242
- Testing
- Preoperative blood harvesting
- Where
- Israel
- Sponsor
- Rabin Medical Center
Mitral Regurgitation, Aortic Regurgitation
Expiratory Flow Limitation and Mechanical Ventilation During Cardiopulmonary Bypass in Cardiac Surgery
During general anesthesia a reduction of Functional Residual Capacity (FRC) was observed. The reduction of FRC could imply that respiratory system closing capacity (CC) exceeds the FRC and leads to a phenomenon called expiratory…
- Trial name
- NCT02633423
- Testing
- Use of PEEP before and after CPB, No use of PEEP before and after CPB(ZEEP), Ventilation with CPAP during CPB
- Where
- Italy
- Volunteers
- 204 people
- Sponsor
- Ospedale San Raffaele
Heart; Surgery, Heart, Functional Disturbance as Result
The Role of Modified Ultrafiltration Following Open Heart Surgery
This study aims to investigate the effect of combining conventional ultrafiltration and modified ultrafiltration compared to conventional ultrafiltration alone in patients who underwent open heart surgery.
- Trial name
- NCT06085066
- Testing
- Conventional Ultrafiltration alone on Cardiopulmonary bypass, Conventional Ultrafiltration followed by Modified Ultrafitration on Cardiopulmonary bypass
- Where
- Indonesia
- Volunteers
- 38 people
- Sponsor
- Universitas Indonesia
Congenital Cardiomyopathy
Neuropsychomotor Development From Ages 6 to 18 in Children With Early Surgically Treated Congenital Heart Disease
This study will invite parents of children who underwent surgical treatment for congenital heart disease to complete a validated proxy-report questionnaire assessing executive and psychosocial functioning.
- Trial name
- NEUROTECH (NCT07437261)
- Testing
- Questionnaire
- Where
- 2 sites in France
- Volunteers
- 155 people
- Sponsor
- University Hospital, Toulouse
Acute Kidney Injury
The Goal dIrected perFusion Trial in Cardiac Surgery
Previous studies (1-5) have demonstrated that oxygen delivery (DO2) and carbon dioxide production (VCO2) during cardiopulmonary bypass (CPB) are associated with renal outcome in cardiac surgery.
- Trial name
- GIFT (NCT02250131)
- Testing
- Perfusion targeted at oxygen delivery
- Where
- Italy
- Volunteers
- 350 people
- Sponsor
- IRCCS Policlinico S. Donato
Cerebral Autoregulation Impairment, Postoperative Cognitive Dysfunction
BrainProtect-guided, Real-time Cerebral Autoregulation Monitoring and Protection of Brain During Cardiac Surgery With Cardiopulmonary Bypass Requiring Heart-lung Machine
The purpose of this clinical investigation is to evaluate the clinical performance, safety, and clinical benefit of the BrainProtect System in reducing early postoperative neurological complications in adult participants…
- Conditions
- Cerebral Autoregulation Impairment, Postoperative Cognitive Dysfunction, Postoperative Delirium
- Trial name
- BrainProtect (NCT07872982)
- Testing
- BrainProtect System, Standard perioperative management
- Where
- 4 sites in United States, Austria and 2 more
- Volunteers
- 304 people
- Sponsor
- Scienceforbrain, UAB
Congenital Heart Disease
Pharmacokinetics of Tranexamic Acid (TXA) in Children Undergoing Repair of Congenital Heart Defects Utilizing Cardiopulmonary Bypass
The purpose of this study is to measure blood levels of TXA in children having cardiac surgery which requires cardiopulmonary bypass. TXA is used to reduce bleeding during surgery.
- Trial name
- NCT01045356
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Cardiovascular Disease
Ulinastatin's Anti-inflammatory Reaction in Cardiac Surgery
The purpose of the present study is to determine whether ulinastatin, urinary anti-trypsin inhibitor, attenuates cardiopulmonary bypass (CPB)-activated systemic inflammatory response in cardiac surgery with CPB.
- Trial name
- ulistin (NCT01518569)
- Testing
- ulinastatin
- Where
- South Korea
- Volunteers
- 26 people
- Sponsor
- Konkuk University Medical Center
Ultrasound, Pectoral Nerve Block
Ultrasound Guided Bilateral Pectoral Nerve Block Versus Bilateral Transverse Thoracic Plane Block In Pediatric Patients Undergoing Corrective Cardiac Surgeries Requiring Cardiopulmonary Bypass Via Median Sternotomy
This randomized, double-blinded, study aims to compare the efficacy of intraoperative and postoperative pain control while using bilateral ultrasound guided the pectoral nerves (PECS) versus transversus thoracic muscle plane…
- Conditions
- Ultrasound, Pectoral Nerve Block, Transverse Thoracic Plane Block, Pediatric Patients
- Trial name
- NCT06984276
- Testing
- Control, Pectoral nerves (PECS), Transversus thoracic muscle plane block (TTPB)
- Where
- Egypt
- Volunteers
- 81 people
- Sponsor
- Cairo University
Chronic Kidney Disease, CKD
ARTEMIS: Ravulizumab to Protect Patients With CKD From CSA-AKI and MAKE
The primary objective of this study is to assess the efficacy of a single dose of ravulizumab IV compared with placebo in reducing the risk of the clinical consequences of AKI (MAKE) at 90 days in adult participants with CKD who…
- Conditions
- Chronic Kidney Disease, CKD, Cardiac Disease, Cardiopulmonary Bypass
- Trial name
- ARTEMIS (NCT05746559)
- Testing
- Ravulizumab
- Where
- 130 sites in United States, Argentina and 18 more
- Volunteers
- 555 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Acute Kidney Injury
Nitrite Infusion in High Risk Patients Undergoing Cardiopulmonary Bypass
The main objective of this study is to evaluate the efficacy of intravenous sodium nitrite compared with placebo in reducing the occurrence of CSA-AK as diagnosed by KDIGO criteria during the first 72 hrs after cardiac surgery in…
- Trial name
- NCT03331146
- Testing
- Saline, Sodium Nitrite
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Elective Cardiac Surgical Interventions
Cytokine Removal in Cardiopulmonary Bypass Patients
Cardiopulmonary bypass (CPB) surgery initiates a systemic inflammatory response induced by extrinsic (e.g. anesthesia, contact activation within the extracorporeal circuit, endotoxemia) and intrinsic (e.g.
- Trial name
- CytoSorb (NCT01879176)
- Testing
- CytoSorb
- Where
- Austria
- Volunteers
- 46 people
- Sponsor
- Medical University of Vienna
Coagulopathy, Congenital Heart Disease
FFP Usage in Pediatric CV Surgery
When small children undergo heart surgery with the heart-lung machine, in the past, blood products to help the blood clot such as Fresh Frozen Plasma (FFP) was routinely used in children under 10kg.
- Trial name
- NCT05819788
- Where
- Canada
- Volunteers
- 431 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Coronary Artery Disease
Heparin Dose and Post Operative Bleeding in Cardiopulmonary Bypass Patients
Blood is anticoagulated using a drug named heparin during open-heart surgery to allow it to safely pass through the heart-lung machine which pumps the blood throughout the body during the surgery.
- Trial name
- NCT01574105
- Where
- 2 sites in Canada
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Cardiac Surgery, Cardiopulmonary Bypass
Voluven® in Paediatric Patients
This study will compare the clinical efficacy and safety of Voluven® and Human Albumin during elective open-heart surgery in pediatric patients.
- Trial name
- NCT00860405
- Testing
- HES 130/0.4 (6%) in sodium chloride (Voluven®, solution for infusion), Human serum albumin (HSA 50g/L), Human serum albumin (HSA 50g/L)
- Where
- 2 sites in Austria, Belgium
- Volunteers
- 61 people
- Sponsor
- Fresenius Kabi
Pain Management Following Cardiopulmonary Bypass Surgery
Use of Ketorolac in Management of Post-Operative Pain After Heart Surgery
This study evaluates the safety and efficacy of ketorolac for post-operative pain management after heart surgery. Ketorolac appears to provide enhanced pain relief while also decreasing the requirements for morphine during the…
- Trial name
- NCT00161577
- Testing
- Ketorolac
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Weill Medical College of Cornell University
Cardiac Arrest
Emergency Cardiopulmonary Bypass for Cardiac Arrest
Cardiac arrest ist associated with a very poor prognosis. Even though resuscitation algorithms and postcardiac arrest care have been improved there is an urgent need for measures leading to a higher survival rate.
- Trial name
- ECPB4OHCA (NCT01605409)
- Testing
- Emergency cardiopulmonary bypass under ongoing CPR, Standard ACLS
- Where
- Austria
- Volunteers
- 40 people
- Sponsor
- Medical University of Vienna