Clinical trials: Cardio Pulmonary Bypass
Cardiac Surgery Requiring Cardiopulmonary Bypass, Extracorporeal Circulation
Biocompatible Versus Non-coated Extracorporeal Circuits in Cardiac Surgery
The aim of the present strudy is to investigate whether the use of biocompatible extracorporeal circulation circuits with a special hydrophilic polymer coating without heparin causes a reduction in the activation of the…
- Trial name
- BALANCE (NCT06612060)
- Testing
- Cardiac surgery with the use of extracorporeal circulation
- Where
- Greece
- Volunteers
- 50 people
- Sponsor
- Polychronis Antonitsis
Inflammation, Thoracic Surgery
The Importance of Wnt-signaling After Cardiac Surgery
Cardiac surgery saves lives when patients suffer from cardiac disease. Local inflammation is important for tissue repair and wound healing after such an operation.
- Trial name
- NCT04058496
- Testing
- Blood sampling
- Where
- Switzerland
- Volunteers
- 64 people
- Sponsor
- Alain Rudiger
Hemodilution, Coronary Artery Disease
Retrograde Autologous Priming and Mannitol for Reducing Hemodilution in Cardiac Surgery
Hemodilution reduces concentrations of blood constituents: concentration of hemoglobin, red blood cells (hematocrit), physiological ions and coagulation factors that can contribute to impaired hemostasis and increasing the risk…
- Conditions
- Hemodilution, Coronary Artery Disease, Fluid Overload
- Trial name
- RAPPER-MAN (NCT04870073)
- Testing
- Retrograde autologous priming, Mannitol, Conventional Priming
- Where
- Canada
- Sponsor
- Hamilton Health Sciences Corporation
Heparin Resistance, Cardiac Surgery
Antithrombin as a Predictor of Heparin Resistance in Cardiac Surgery With Cardiopulmonary Bypass
This study aims to investigate whether the level of antithrombin (AT) in the blood before cardiac surgery can predict how well patients respond to heparin, a medication used to prevent blood clotting during surgery with a…
- Conditions
- Heparin Resistance, Cardiac Surgery, Cardiopulmonary Bypass
- Trial name
- NCT07549568
- Testing
- No intervention (observational study)
- Where
- Sweden
- Volunteers
- 300 people
- Sponsor
- Sahlgrenska University Hospital
Bloodloss
This Study Will Compare the Effect of Starch Containing to Non-Starch Containing Intravenous Fluid on Blood Loss During Coronary Artery Bypass Graft Surgery
The overall aim of this study is to determine if there is a bleeding risk associated with the use of starch-containing fluids during cardiac surgery.
- Trial name
- NCT00801190
- Testing
- HES (130/0.4), Ringer's Lactate
- Volunteers
- 500 people
- Sponsor
- St. Boniface Hospital
Cardiac Surgical Procedures, Cardiac Surgical Procedures (Postoperative Population)
Vasoactive Inotropic Score in Adult Cardiac Surgery Outcomes
This study looked at whether a bedside score called the Vasoactive Inotropic Score (VIS) could help doctors predict which adult patients are at higher risk of complications after heart surgery that uses a heart-lung machine…
- Trial name
- NCT07745283
- Where
- India
- Volunteers
- 635 people
- Sponsor
- Sir Ganga Ram Hospital
Patient Outcome Assessment
Effect of Perioperative Dexmedetomidine Administration on Outcome in Cardiac Surgery Patients
Investigation of effect of perioperative Dexmedetomedine administration on mortality, length of ICU and hospital stay, delirium onset, major adverse cardiac and cerebrovascular events, acute kidney injury in cardiac surgery…
- Trial name
- NCT03091166
- Testing
- Dexmedetomidine
- Where
- Russia
- Volunteers
- 169 people
- Sponsor
- Moscow Regional Research and Clinical Institute (MONIKI)
Valvular Heart Disease, Aortic Arch Aneurysm
The Effects of Intermittent Hypoxic-hyperoxic Preconditioning for Patients Undergoing Cardiopulmonary Bypass.
The aim of the study is to evaluate the effects of intermittent hypoxic-hyperoxic training (IHHT) to protect myocardium against perioperative myocardial injury during cardiac surgery using cardiopulmonary bypass.
- Conditions
- Valvular Heart Disease, Aortic Arch Aneurysm, Surgery
- Trial name
- NCT04833283
- Testing
- ReOxy Cardio device, intermittent hypoxic-hyperoxic training ( IHHT), ReOxy Cardio device
- Where
- Russia
- Volunteers
- 115 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Heart Failure, Vasoplegia
Prevention of Low Blood Pressure After Cardiac Surgery in Heart Failure Patients With a Filter Called CytoSorb.
Vasoplegia is a common complication after heart surgery for heart failure. With vasoplegia, the blood vessels can no longer squeeze properly, causing low blood pressure that is sometimes difficult to treat with medication.
- Trial name
- CytoSorb-HF (NCT04812717)
- Testing
- CytoSorb device
- Where
- Netherlands
- Volunteers
- 36 people
- Sponsor
- Leiden University Medical Center
Open Heart Surgery, Cardiopulmonary Bypass
Procalcitonin and Postoperative Outcome After Open-heart Surgery
The aim of this study was to investigate the impact of serum values of procalcitonin (PCT), C-reactive protein (CRP) and lactate to predict postoperative complications in the early postoperative period after open-heart surgery…
- Conditions
- Open Heart Surgery, Cardiopulmonary Bypass, Procalcitonin, C-reactive Protein
- Trial name
- NCT04213040
- Testing
- Serum levels of Procalcitonin, C-reactive protein, lactate
- Volunteers
- 214 people
- Sponsor
- Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital
Cardiac Surgery, Cardiopulmonary Bypass
Dexmedetomidine and Myocardial Protection
Dexmedetomidine, an alpha-2 agonist, is a sedative that is widely used in various clinical settings because, compared to benzodiazepines, it preserves respiratory function better and its duration of action is short.
- Trial name
- DEXCARD (NCT04871308)
- Testing
- Dexmedetomidine, Control
- Where
- South Korea
- Volunteers
- 224 people
- Sponsor
- Seoul National University Hospital
Hypoxia
Nitric Oxide During Cardiopulmonary Bypass in Adult Surgery
Inhaled nitric oxide is a widely accepted standard of care for pulmonary hypertension, and has been studied in the context of cardiac surgery.
- Trial name
- NCT04807413
- Testing
- Nitric Oxide, standard of care treatment
- Where
- Israel
- Volunteers
- 300 people
- Sponsor
- Rabin Medical Center
Emergent Cardiothoracic Surgery, Bleeding
Ticagrelor CytoSorb Hemoadsorption
TISORB is a study to show that the CytoSorb device removes ticagrelor from blood during surgery in patients who need emergency surgery on their heart.
- Conditions
- Emergent Cardiothoracic Surgery, Bleeding, Drug Removal
- Trial name
- TISORB (NCT04131959)
- Testing
- CytoSorb 300 mL device
- Where
- 8 sites in United Kingdom
- Volunteers
- 5 people
- Sponsor
- CytoSorbents, Inc
Cardiac Transplantation, Cardiopulmonary Bypass
Intraoperative Use of Extracorporeal Cytokine Adsorption During Orthotopic Heart Transplantation
There are several factors initiating cytokine storm and dysregulated systemic inflammatory response during cardiac transplantation.
- Trial name
- NCT03145441
- Testing
- CytoSorb®
- Where
- Hungary
- Volunteers
- 60 people
- Sponsor
- Semmelweis University
Coronary Artery Disease, Surgery--Complications
Cardiopulmonary Exercise Testing as an Outcome Predictor in Coronary Artery Bypass Surgery
This is a prospective cohort study of patients undergoing coronary artery bypass graft surgery. Prior to surgery, participants will undergo submaximal cardiopulmonary exercise testing on a treadmill.
- Trial name
- NCT03376542
- Testing
- Cardiopulmonary Exercise Testing
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Eduardo Tibirica, MD, PhD
Cardiopulmonary Bypass
Does Sildenafil Protect Against Pulmonary Related Complications Following Cardiopulmonary Bypass?
Does pre-operative administration of Sildenafil (Viagra, Pfizer) reduce the lung injury associated with cardiopulmonary bypass in children undergoing corrective surgical repair of congenital heart disease.
- Trial name
- NCT00350441
- Testing
- Sildenafil Citrate
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- NHS Greater Glasgow Yorkhill Division
Priming, Cardiac Surgery
Comparison of Two Different Heart-lung Machine Filling Methods: Precoating Versus Colloidal Fluids
The study is a single-center, randomized, un-blinded treatment study in which patients (>78 years) with the use off a heart-lung machine were provided into two study arms.
- Conditions
- Priming, Cardiac Surgery, Cardio Pulmonary Bypass
- Trial name
- NCT01247051
- Testing
- Precoating, Standard priming
- Where
- Germany
- Volunteers
- 90 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Heparin-induced Thrombocytopenia
Comparison of Pre-test Probability Model for Heparin-induced Thrombocytopenia in Post-operative Cardiac Surgery
Heparin-induced thrombocytopenia (HIT) is a pro-thrombotic immunological condition that occurs in some patients exposed to heparin.
- Trial name
- TicTac (NCT05783895)
- Testing
- Post screening diagnostic test
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Central Hospital, Nancy, France
Post Coronary Artery Bypass Grafting, Post-Cardiac Surgery Patients
Effect of Respiratory Trainer on Cardiopulmonary Functions in Patients with Upper Cross Syndrome Post-Cardiac Surgery
The purpose of this study is to investigate if there is any effect of the respiratory training on cardiopulmonary functions in patients with upper cross syndrome post-cardiac surgery.
- Conditions
- Post Coronary Artery Bypass Grafting, Post-Cardiac Surgery Patients, Upper Cross Syndrome, Respiratory Muscle Weakness
- Trial name
- NCT06673953
- Testing
- Respiratory Muscle Training by (The Breather), Traditional physical therapy program
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Cardiac Surgery
Individualized Blood Pressure Management in Patients Undergoing Cardiac Surgery
This pilot randomized-controlled study will determine the feasibility of large study comparing individualized versus standard blood pressure (BP) management in patients undergoing cardiac surgery under cardiopulmonary bypass…
- Trial name
- PRECISE (NCT03784690)
- Testing
- Individualized intraoperative BP management, Standard intraoperative BP management
- Where
- Russia
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation