Clinical trials: Cardio Pulmonary Bypass
Coronary Surgery With Cardiopulmonary Bypass
Effects of a Goal-directed Hemodynamic Therapy Driven by ECOM on Morbidity and Mortality After Cardiac Surgery?
Goal-directed hemodynamic and fluid optimizations are shown to be a key factor of the medical care during anesthesia.According to medical literature, goal-directed fluid and hemodynamic optimizations are more efficient when based…
- Trial name
- ECOMIII (NCT01535716)
- Testing
- hemodynamic optimization strategy driven by the ECOM, standard management strategy
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Caen
Cardiovascular Disease
FEIBA and Use of Blood Products in Cardiac Surgery
The purpose of this pilot study is to evaluate the feasibility of the prophylactic administration of Factor VIII Inhibitor Bypass Activity (FEIBA) at termination of cardiopulmonary bypass (CPB) period.
- Trial name
- FEIBA (NCT02577614)
- Testing
- FEIBA, Normal Saline
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Oregon Health and Science University
Congenital Heart Disease (CHD), Hypoxic Encephalopathy
Early Detection of Brain Injury After Congenital Heart Surgery in Infants
Infants with congenital heart disease undergoing cardiac surgery with extracorporeal circulation are at risk for perioperative hypoxic-ischaemic brain injury.
- Trial name
- NCT07424976
- Testing
- Observational study: blood analisys, EEG, MRI
- Where
- Slovenia
- Volunteers
- 30 people
- Sponsor
- University Medical Centre Ljubljana
Cardiac Surgery Requiring Cardiopulmonary Bypass
Oxygen Consumption, Hypoperfusion and Organ Injury After Cardio-pulmonary Bypass
The goal of this observational study is to understand how oxygen consumption after heart surgery relates to blood flow problems and organ injury.
- Trial name
- VO2-EPOC (NCT06930443)
- Testing
- Oxygen consumption measurement
- Where
- Sweden
- Volunteers
- 65 people
- Sponsor
- Uppsala University Hospital
Cardiac Surgery Associated - Acute Kidney Injury
Efficacy and Safety of ENN0403 in Patients At High Risk for Acute Kidney Injury Following Elective Cardiac Surgery
The is a two-stage study. Stage 1 is to evaluate the safety, tolerability, PK and PD of ENN0403 in patients at high risk of AKI following elective cardiac surgery requring cardiopulmonary bypass.
- Trial name
- NCT06632613
- Testing
- ENN0403 capsules, low dose, ENN0403 capsules, high dose
- Where
- China
- Volunteers
- 200 people
- Sponsor
- EnnovaBio
Patients Who Underwent CPB for MICS
EIT Based Regional Lung Ventilation in Minimally Invasive Cardiac Surgery
Electrical impedance tomography (EIT) is a non-invasive, radiation-free imaging technique that measures local pulmonary ventilation and ventilation distribution through potential changes on the skin surface of the chest wall…
- Trial name
- NCT04985513
- Testing
- Ventilation during cardiopulmonary bypass
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Pusan National University Yangsan Hospital
Thoracic Surgery, Cardiopulmonary Bypass
Cerebral Autoregulation Monitoring During Cardiac Surgery
Neurological complications from cardiac surgery are an important source of operative mortality, prolonged hospitalization, health care expenditure, and impaired quality of life.
- Trial name
- NCT00981474
- Testing
- blood pressure maintenance based on cerebral blood flow autoregulation measurement, Control group
- Where
- United States
- Volunteers
- 460 people
- Sponsor
- Northwestern University
Postoperative; Dysfunction Following Cardiac Surgery
Cerebral Energy State in Cardiac Surgery
Impaired cerebral function remains an important complication of cardiopulmonary bypass (CPB) during cardiac surgery. The aim of the present study is to investigate whether the lactate to pyruvate (LP) ratio obtained by…
- Trial name
- NCT02846818
- Testing
- Microdialysis
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- Odense University Hospital
Cardiovascular Diseases
Continuous Hemofiltration During Cardiopulmonary Bypass and Its Effect on Lactatemia
This study aims to analyze the impact of using polysulfone membranes on continuous ultrafiltration with volume replacement in patients undergoing cardiac surgery.
- Trial name
- CPB-LACTATE (NCT03412968)
- Testing
- Polysulfone Filter, Procedure/ Surgery: without Polysulfone Filter
- Where
- Spain
- Volunteers
- 76 people
- Sponsor
- University of Cadiz
Cardiopulmonary Bypass
Antithrombin Enhancement May Improve Anticoagulation Efficiency in Infants Undergoing Cardiopulmonary Bypass for Cardiac Surgery
The primary objective of this study is: 1. To evaluate the use of Antithrombin (AT) concentrate in infants less than one year of age undergoing cardiopulmonary bypass (CPB) for cardiac surgery The secondary objectives of this…
- Trial name
- NCT01530737
- Testing
- Antithrombin III
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- The Hospital for Sick Children
Ischemic Heart Disease
Randomized Clinical Trial Comparing Coronary Bypass Grafting With or Without Cardiopulmonary Bypass
Coronary artery bypass grafting (CABG) is a well established treatment modality for patients with coronary artery disease. For 30 years now CABG operations have been performed with the help of the heart lung machine…
- Trial name
- NCT00216957
- Testing
- Coronary bypass surgery without cardiopulmonary bypass
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- Maritime Heart Centre
Ischemia-Reperfusion Injury
Effect of Dexmedetomidine Preconditioning on Myocardial Ischemia-reperfusion Injury in Patients Undergoing Open Heart Surgery With Cardiopulmonary Bypass
About 200000 cardiac operations are performed in China every year. Cardiopulmonary bypass is the basic strategy of open-heart surgery, which may lead to myocardial ischemia-reperfusion injury and low cardiac output syndrome.
- Trial name
- NCT05598177
- Testing
- dexmedetomidine
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Affiliated Hospital of Nantong University
Congenital Cardiovascular Defects, Low Cardiac Output Syndrome
Levosimendan in Congenital Cardiac Surgery
Many pediatric patients undergoing cardiac surgery under cardiopulmonary bypass for repair of complex congenital malformations, require inotropic support for low cardiac output syndrome.
- Trial name
- NCT00695929
- Testing
- Levosimendan, Milrinone
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Congenital Heart Disease, Acute Kidney Injury
Nitric Oxide During CPB to Reduce AKI in Neonates
This is a prospective, randomized, double-blind, placebo-controlled pilot study to investigate whether supplemental Nitric Oxide (NO) gas delivered during cardiac surgery with cardiopulmonary bypass (CPB) reduces the incidence…
- Trial name
- NCT03946462
- Testing
- NO gas delivered during cardiac surgery
- Where
- United States
- Sponsor
- Fabio Savorgnan
Dexmedetomidine, Postoperative Acute Kidney Injury
Renoprotective Effects of Dexmedetomidine Preconditioning in CABG Surgery
Acute kidney injury (AKI) is one of the most frequent complications of coronary artery bypass graft (CABG) surgery performed with cardiopulmonary bypass (CPB).
- Conditions
- Dexmedetomidine, Postoperative Acute Kidney Injury, Cardiopulmonary Bypass Graft, Postoperative Complications
- Trial name
- NCT07841054
- Testing
- Dexmedetomidine, 0.9 % sodium chloride
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Bursa City Hospital
Myocardial Ischemia, Coronary Arteriosclerosis
Safety and Efficacy of TP10, a Complement Inhibitor, in Adult Women Undergoing Cardiopulmonary Bypass Surgery
The purpose of this study is to determine if the study drug (TP10), which blocks complement release, can reduce such side effects of complement inflammation as chest pain or heart attacks and be taken safely in women who undergo…
- Conditions
- Myocardial Ischemia, Coronary Arteriosclerosis, Aortic Valve Insufficiency, Mitral Valve Insufficiency
- Trial name
- NCT00082121
- Testing
- TP10
- Where
- 18 sites in United States
- Volunteers
- 300 people
- Sponsor
- Avant Immunotherapeutics
Coronary Artery Bypass Graft (CABG), Cardioplegia
Cardioplegic Protection of the Heart
This study seek to compare two different solutions used to protect the heart during cardiac surgery. 40 adult patients planned for coronary artery bypass surgery with cardiopulmonary bypass machine assistance will be included in…
- Conditions
- Coronary Artery Bypass Graft (CABG), Cardioplegia, Cardiopulmonary Bypass, Perioperative Myocardial Injury
- Trial name
- NCT07386990
- Testing
- Modified Buckberg cardioplegic solution, Modified St Thomas´ cardioplegic solution
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Region Skane
Cardiopulmonary Bypass
Comparison of Tranexamic to Epsilon Aminocaproic Acid: a Prospective Analysis of Blood Conservation in Cardiac Surgery
We designed a prospective double-blinded randomized trial in an attempt to detect a difference between tranexamic acid (TXA) and epsilon aminocaproic acid (EACA) in reducing transfusion in patients undergoing cardiac surgery.
- Trial name
- NCT01248104
- Testing
- Tranexamic Acid, Aminocaproic Acid
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Loma Linda University
Cardiovascular Diseases
Groin Complications in Open Vs. Percutaneous Peripheral Cannulation in Minimally Invasive Cardiac Surgery
The aim of this randomized trial is to investigate the groin complications in open vs percutaneous peripheral cannulation for cardiopulmonary bypass in minimally invasive cardiac surgery
- Trial name
- ProGlide-II (NCT05598385)
- Testing
- Open cannulation, Percutaneous cannulation
- Sponsor
- Jessa Hospital
Cardiac Surgery, Cardiac Surgery Requiring Cardiopulmonary Bypass
Clinical Outcomes Between Pulsatile and Non-Pulsatile Flow During Cardiopulmonary Bypass
The aim of this prospective, randomized study was to compare clinical outcomes of Pulsatile and non-pulsatile flow during Cardiopulmonary Bypass.
- Trial name
- NCT07009730
- Testing
- Bypassing Agents
- Where
- Nepal
- Volunteers
- 80 people
- Sponsor
- Tribhuvan University Teaching Hospital, Institute Of Medicine.